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Sol-Gel holder Opaleye buys 9,976 shares near $69

A ten percent owner of Sol-Gel Technologies Ltd. reported open-market purchases totaling 9,976 ordinary shares in early September 2026 at prices near $68–$70 per share.

(Very High)
(Positive)
Form Type
4

Rhea-AI Filing Summary

Sol-Gel Technologies Ltd. (SLGL) reports that Opaleye Management Inc., a ten percent owner, indirectly purchased additional ordinary shares over several days in September 2026. Through Opaleye, L.P., it bought a total of 9,976 ordinary shares between September 4 and September 9, 2026 at prices generally around $68–$70 per share, including weighted-average purchases with disclosed price ranges. Opaleye Management Inc. reports these positions as indirectly held and disclaims beneficial ownership beyond its pecuniary interest, and no Rule 10b5-1 trading plan is reported.

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Insider Opaleye Management Inc.
Role 10% Owner
Bought 9,976 shs ($687K)
Type Security Shares Price Value
Purchase Ordinary Shares, par value NIS 1.00 per share F1, F5 3,097 $68.705 $213K
Purchase Ordinary Shares, par value NIS 1.00 per share F3, F1, F5 3,390 $68.7403 $233K
Purchase Ordinary Shares, par value NIS 1.00 per share F1, F5 471 $69.37 $33K
Purchase Ordinary Shares, par value NIS 1.00 per share F1, F4 918 $69.52 $64K
Purchase Ordinary Shares, par value NIS 1.00 per share F1, F5 2,100 $68.98 $145K
holding Ordinary Shares, par value NIS 1.00 per share F2, F5 -- -- --
Holdings After Transaction: Ordinary Shares, par value NIS 1.00 per share — 536,876 shares (Indirect, By Opaleye, L.P.); Ordinary Shares, par value NIS 1.00 per share — 15,000 shares (Indirect, By Managed Account)
Footnotes (5)
  1. F1. Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund.
  2. F2. Securities owned by a separately managed account (the "Managed Account"). As the portfolio manager of the Managed Account, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Managed Account.
  3. F3. The price reported in column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $68.50-$68.99 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range.
  4. F4. The price reported in column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $68.42-$68.75 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range.
  5. F5. Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose.
Total shares purchased 9,976 shares Ordinary shares of Sol-Gel Technologies Ltd. bought between September 4–9, 2026
Purchase on September 9, 2026 3,097 shares at $68.705 per share Indirectly held by Opaleye, L.P. as reported by Opaleye Management Inc.
Purchases on September 8, 2026 3,390 shares at $68.7403 and 471 shares at $69.37 3,390-share price is a weighted average; transactions reported as open-market or private purchases
Purchases on September 4, 2026 918 shares at $69.52 and 2,100 shares at $68.98 918-share price is a weighted average with trades between $68.42–$68.75
Weighted average price range (3,390-share lot) $68.50–$68.99 per share Range of prices for the September 8, 2026 3,390-share purchase, reported on a weighted-average basis
Managed account holding 15,000 shares Ordinary shares of Sol-Gel Technologies Ltd. held by a separately managed account as of September 4, 2026
weighted average price financial
"The price reported in column 4 is a weighted average price."
Weighted average price is the average price of a security where each trade or component is counted according to its size, so bigger trades pull the average more than smaller ones. Think of it like calculating the average cost of a grocery haul where items you bought more of have greater influence on the final per-item cost. Investors use it to understand the true average price paid or received, judge execution quality, and compare trading performance against market movement.
separately managed account financial
"Securities owned by a separately managed account (the "Managed Account")."
A separately managed account (SMA) is a personalized investment portfolio owned by a single investor and run by a professional manager who buys and sells securities on that investor’s behalf. It matters to investors because an SMA offers tailored asset selection, tax handling, and transparency—like hiring a personal chef who prepares meals to your dietary needs rather than sharing a set menu—so you can align holdings with your goals and see exactly what you own.
pecuniary interest financial
"disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest"
beneficially own financial
"may be deemed to beneficially own the securities owned directly by the Fund."
Beneficially own means having the economic rights and risks of a security—such as the right to receive dividends, sell the shares, or profit from price changes—whether or not your name appears on the official share register. Think of it like renting a car: you use it and reap the benefits even if the title lists someone else. Investors care because beneficial ownership determines who truly controls value, must be disclosed under securities rules, and can signal potential influence or trading activity that affects a stock’s price.

FAQ

AI-generated questions and answers. How Rhea-AI works. Not financial advice.

What insider activity did SLGL report for Opaleye Management Inc. in this Form 4?

The Form 4 reports that Opaleye Management Inc., a ten percent owner of SLGL, indirectly purchased 9,976 ordinary shares of Sol-Gel Technologies Ltd. between September 4 and September 9, 2026 through entities it manages, primarily Opaleye, L.P.

How many Sol-Gel Technologies (SLGL) shares were bought and on which dates?

Opaleye-related entities bought 9,976 ordinary shares on three dates: 918 and 2,100 shares on September 4, 2026; 3,390 and 471 shares on September 8, 2026; and 3,097 shares on September 9, 2026, all reported as open-market or private purchases.

Were the Sol-Gel Technologies (SLGL) insider purchases made under a Rule 10b5-1 plan?

No. The filing indicates no Rule 10b5-1 trading plan for these transactions. The Rule 10b5-1 checkbox is not marked as affirming a plan, and no footnote states that the purchases were executed pursuant to a pre-arranged trading plan.

How are the SLGL shares held by Opaleye Management Inc. characterized in the Form 4?

The purchased shares are held indirectly, primarily "by Opaleye, L.P." and also in a "Managed Account." Opaleye Management Inc. may be deemed to beneficially own these securities but disclaims beneficial ownership except to the extent of its pecuniary interest.

What position in SLGL is reported for the separately managed account associated with Opaleye?

A holding entry shows that a separately managed account associated with Opaleye Management Inc. held 15,000 ordinary shares of Sol-Gel Technologies Ltd. as of September 4, 2026, reported as indirectly owned with a pecuniary-interest-only beneficial ownership disclaimer.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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Learn about SEC filing dates
SEC Form 4
FORM 4UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
OMB APPROVAL
OMB Number:3235-0287
Estimated average burden
hours per response:0.5
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.
1. Name and Address of Reporting Person*
Opaleye Management Inc.

(Last)(First)(Middle)
ONE BOSTON PLACE, 26TH FLOOR

(Street)
BOSTON MASSACHUSETTS 02108

(City)(State)(Zip)

UNITED STATES

(Country)
2. Issuer Name and Ticker or Trading Symbol
Sol-Gel Technologies Ltd. [ SLGL ]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
DirectorX10% Owner
Officer (give title below)Other (specify below)
2a. Foreign Trading Symbol
3. Date of Earliest Transaction (Month/Day/Year)
09/04/2026
6. Individual or Joint/Group Filing (Check Applicable Line)
XForm filed by One Reporting Person
Form filed by More than One Reporting Person
4. If Amendment, Date of Original Filed (Month/Day/Year)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year)2A. Deemed Execution Date, if any (Month/Day/Year)3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeVAmount(A) or (D)Price
Ordinary Shares, par value NIS 1.00 per share09/04/2026P918A$69.52527,818IBy Opaleye, L.P.(1)(4)
Ordinary Shares, par value NIS 1.00 per share09/04/2026P2,100A$68.98529,918IBy Opaleye, L.P.(1)(5)
Ordinary Shares, par value NIS 1.00 per share09/08/2026P3,390A$68.7403(3)533,308IBy Opaleye, L.P.(1)(5)
Ordinary Shares, par value NIS 1.00 per share09/08/2026P471A$69.37533,779IBy Opaleye, L.P.(1)(5)
Ordinary Shares, par value NIS 1.00 per share09/09/2026P3,097A$68.705536,876IBy Opaleye, L.P.(1)(5)
Ordinary Shares, par value NIS 1.00 per share15,000IBy Managed Account(2)(5)
Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year)3A. Deemed Execution Date, if any (Month/Day/Year)4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 6. Date Exercisable and Expiration Date (Month/Day/Year)7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeV(A)(D)Date ExercisableExpiration DateTitleAmount or Number of Shares
Explanation of Responses:
1. Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund.
2. Securities owned by a separately managed account (the "Managed Account"). As the portfolio manager of the Managed Account, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Managed Account.
3. The price reported in column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $68.50-$68.99 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range.
4. The price reported in column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $68.42-$68.75 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range.
5. Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose.
Opaleye Management, Inc., By: /s/ James Silverman, President09/09/2026
** Signature of Reporting PersonDate
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
* Form 4: SEC 1474 (03-26)

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