Indicate by check mark whether the registrant files
or will file annual reports under cover Form 20-F or Form 40-F.
On September 30, 2026, Sol-Gel Technologies Ltd. issued a press
release announcing the hosting of a KOL Investor Day for SGT-610 on October 14, 2026.
Pursuant to the requirements of the Securities
Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.
Exhibit 99.1

Sol-Gel Technologies
to Host KOL Investor Day for SGT-610 on October 14, 2026
NESS ZIONA, Israel, Sept. 30, 2026 (GLOBE NEWSWIRE) –
Sol-Gel Technologies, Ltd. (NASDAQ: SLGL), a dermatology company, pioneering treatments for patients with rare and severe skin conditions,
today announced it will host a KOL Investor Event on SGT-610 (patidegib gel, 2%) on Wednesday, October 14, 2026 in New York.
The event will feature Julie Breneiser, PA-C (Gorlin Syndrome Alliance),
Ervin Epstein Jr., MD (Alta Bates Summit Medical Center), Kavita Sarin, MD, PhD (Stanford Cancer Institute), and Elizabeth M. Billingsley,
MD, FAAD, FACMS, FASDS (Penn State College of Medicine), who will discuss the significant disease burden of Gorlin Syndrome patients and
lack of effective therapies.
A live webcast of the event will be available through the Sol-Gel
Investor Relations website beginning at 12:00 p.m. ET. A replay of the webcast and supporting materials will be available after the
conclusion of the event.
Investors and other interested parties may email sol-gel@gilmartinir.com
to register for in-person attendance.
About Julie Breneiser, PA-C
Julie Breneiser is the Associate Director of the Gorlin Syndrome Alliance
(GSA). Prior to this, she was Executive Director for five years, and President of the Board of Directors. Her early career began as a
Physician Assistant. Julie and her two children are affected with Gorlin Syndrome, a rare genetic disorder caused by a tumor suppressant
mutation that can affect every organ system. Julie’s work with the GSA focuses on collaboration with industry to bring potential
treatments to clinical trial. Under her leadership, the GSA conducted a Listening Session and Patient Focused Drug Development Meeting
for the FDA. Julie previously served as a consumer reviewer for the National Institutes of Health (NIH) and the Department
of Defense’s Congressionally Directed Medical Research Programs (DOD-CDMRP). She speaks nationally and internationally, raising
awareness of Gorlin Syndrome and the burdens of this multi-system disorder as well as advancing drug development for rare diseases.
About Ervin Epstein, Jr., MD
Dr. Ervin Epstein, Jr., MD was a practicing dermatologist for more
than 50 years in the San Francisco Bay Area. He led an academic research lab funded by the National Institutes of Health for 45 years.
He served as the Co-Founder, Medical Advisor, and Director at PellePharm, Inc. He also served as Research Dermatologist and Clinical Professor
of Dermatology at the University of California, San Francisco, and as President of the Society for Investigative Dermatology. His research
interests have focused on the molecular biology of inherited and neoplastic skin diseases. Ervin Epstein has also served on the boards
of numerous dermatological organizations including the American Dermatological Association. His publications have appeared in New England
Journal of Medicine, Nature, and Science. He received his medical degree from University of California (San Francisco) School
of Medicine.
About Kavita Sarin, MD, PhD
Dr. Kavita Sarin, MD, PhD is a Professor of Dermatology and is the
Director of the Stanford Skin Cancer Genetics Program at the Stanford Cancer Institute. She received her medical degree from Stanford
University School of Medicine and holds a PhD in Genetics from Stanford University. She has an academic interest in Precision Medicine,
focused on the integration of genetic and clinical patient data to inform susceptibility, prognosis, and treatments in skin cancer and
other rare dermatologic disorders. Her lab applies cutting-edge sequencing and imaging technologies to better understand skin cancer and
rare immunologic skin diseases.
About Elizabeth M. Billingsley, MD, FAAD, FACMS, FASDS
Dr. Elizabeth M. Billingsley, MD, FAAD, FACMS, FASDS is a Professor
of Dermatology at Penn State University College of Medicine and practices dermatologic surgery and Mohs micrographic surgery with Penn
State Health. She received her medical degree from Penn State College of Medicine. She does clinical research and trials in cutaneous
oncology and Gorlin Syndrome and is a past President of the American College of Mohs Surgery. Dr. Billingsley is a Fellow of the American
Academy of Dermatology (FAAD), the American College of Mohs Surgery (FACMS), and the American Society for Dermatologic Surgery (FASDS),
and her clinical practice focuses on the surgical management of skin cancer.
About Sol-Gel Technologies
Sol-Gel is a specialized dermatology company advancing innovative therapies
for rare and serios skin diseases. Its lead investigational candidate, SGT-610 (patidegib gel 2%), is a Phase 3, orphan- and breakthrough-designated
topical hedgehog inhibitor being developed for the prevention of new basal cell carcinoma (BCC) lesions in patients with Gorlin Syndrome,
with the potential to offer an improved safety profile relative to oral hedgehog inhibitors. Subject to regulatory approval in Gorlin
Syndrome, SGT-610 may also represent a future opportunity in high-frequency BCC. Sol-Gel is also advancing SGT-210, and investigational
topical EGFR inhibitor for indications with significant unmet need, and has developed two FDA-approved dermatology products, TWYNEO®
and EPSOLAY®.
Forward Looking Statements
This press release contains “forward-looking statements”
within the meaning of the Private Securities Litigation Reform Act of 1995. All statements contained in this press release that do not
relate to matters of historical fact should be considered forward-looking statements. In some cases, you can identify forward-looking
statements by terminology such as “believe,” “may,” “estimate,” “continue,” “anticipate,”
“intend,” “should,” “plan,” “expect,” “predict,” “potential,”
or the negative of these terms or other similar expressions. Forward-looking statements are based on information we have when those statements
are made or our management’s current expectations and are subject to risks and uncertainties that could cause actual performance
or results to differ materially from those expressed in or suggested by the forward-looking statements. Important factors that could cause
such differences include, but are not limited to, the risk of a delay in reporting the top-line results of Sol-Gel’s pivotal Phase
3 clinical trial of SGT-610 (patidegib gel, 2%) for Gorlin syndrome, that we will not successfully complete the Gorlin Phase 3 clinical
trial or that such clinical trial will fail to meet its primary endpoint or one or more of its secondary endpoints as well as the following
factors: (i) the adequacy of our financial and other resources, particularly in light of our history of recurring losses; (ii) our ability
to complete the development of our product candidates; (iii) our ability to find suitable co-development partners; (iv) our ability to
obtain and maintain regulatory approvals for our product candidates in our target markets, the potential delay in receiving such regulatory
approvals and the possibility of adverse regulatory or legal actions relating to our product candidates even if regulatory approval is
obtained; (v) our collaborators’ ability to commercialize our pharmaceutical product candidates; (vi) our ability to obtain and
maintain adequate protection of our intellectual property; (vii) our collaborators’ ability to manufacture our product candidates
in commercial quantities, at an adequate quality or at an acceptable cost; (viii) our collaborators’ ability to establish adequate
sales, marketing and distribution channels; (ix) acceptance of our product candidates by healthcare professionals and patients; (x) the
possibility that we may face third-party claims of intellectual property infringement; (xi) the timing and results of clinical trials
that we may conduct or that our competitors and others may conduct relating to our or their products; (xii) intense competition in our
industry, with competitors having substantially greater financial, technological, research and development, regulatory and clinical, manufacturing,
marketing and sales, distribution and personnel resources than we do; (xiii) potential product liability claims; (xiv) potential adverse
federal, state and local government regulation in the United States, China, Europe or Israel; and (xv) loss or retirement of key executives
and research scientists; (xvi) general market, political and economic conditions in the countries in which the Company operates; and,
(xvii) the security situation in Israel. These factors and other important factors discussed in the Company's Annual Report on Form 20-F
filed with the Securities and Exchange Commission (“SEC”) on March 19, 2026, and our other reports filed with the SEC, could
cause actual results to differ materially from those indicated by the forward-looking statements made in this press release. Except as
required by law, we undertake no obligation to update any forward-looking statements in this press release.
Sol-Gel Investor Relations:
Eyal Ben-Or
Chief Financial Officer
ir@sol-gel.com
For Investor Event Inquiries:
Ami Bavishi or Nick Colangelo
Gilmartin Group, LLC
Sol-gel@gilmartinir.com