Opaleye boosts Sol-Gel (SLGL) stake with 1,712-share open-market buy

Rhea-AI Filing Summary

Opaleye Management Inc., a more than ten percent owner of Sol-Gel Technologies Ltd., reported additional indirect purchases of the company’s ordinary shares. Through Opaleye, L.P., it completed open-market purchases totaling 1,712 shares at prices ranging from $71.96 to $71.99 per share. After these trades, Opaleye, L.P. held 491,712 ordinary shares, while a separately managed account overseen by Opaleye Management held 15,000 shares, both positions being reported as indirect holdings. Opaleye Management disclaims beneficial ownership of these shares beyond any pecuniary interest.

Insider Trade Summary

Net Buyer: 1,712 shares ($123,220)

Net Buy 3 txns

Insider Opaleye Management Inc.

Role null

Bought 1,712 shs ($123K)

Type	Security	Shares	Price	Value
Purchase	Ordinary Shares, par value NIS 1.00 per share	1,400	$71.9707	$101K
Purchase	Ordinary Shares, par value NIS 1.00 per share	312	$71.99	$22K
holding	Ordinary Shares, par value NIS 1.00 per share	--	--	--

Holdings After Transaction: Ordinary Shares, par value NIS 1.00 per share — 491,712 shares (Indirect, By Opaleye, L.P.)

Footnotes (1)

1. Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund. Securities owned by a separately managed account (the "Managed Account"). As the portfolio manager of the Managed Account, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Managed Account. The price reported in column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $71.96-$71.99 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range. Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose.

Key Figures

Shares purchased: 1,712 shares Purchase price range: $71.96–$71.99 per share Fund holdings after trades: 491,712 shares +1 more

4 metrics

Shares purchased 1,712 shares Total open-market buys reported on Form 4

Purchase price range $71.96–$71.99 per share Multiple open-market transactions with weighted average price

Fund holdings after trades 491,712 shares Ordinary shares held by Opaleye, L.P. after purchases

Managed account holdings 15,000 shares Ordinary shares in separately managed account

Key Terms

open-market purchase, weighted average price, separately managed account, beneficial ownership, +1 more

5 terms

open-market purchase financial

"transaction_action: open-market purchase"

An open-market purchase is when an investor or a company buys shares on a public stock exchange at the going market price, rather than through a private deal. It matters to investors because these purchases change how many shares are available, can push the stock price up or signal confidence from large buyers, and often affect per-share metrics like earnings—think of it like someone buying lots of apples off a grocery shelf, reducing supply and potentially raising the price.

weighted average price financial

"The price reported in column 4 is a weighted average price."

Weighted average price is the average price of a security where each trade or component is counted according to its size, so bigger trades pull the average more than smaller ones. Think of it like calculating the average cost of a grocery haul where items you bought more of have greater influence on the final per-item cost. Investors use it to understand the true average price paid or received, judge execution quality, and compare trading performance against market movement.

separately managed account financial

"Securities owned by a separately managed account (the "Managed Account")."

A separately managed account (SMA) is a personalized investment portfolio owned by a single investor and run by a professional manager who buys and sells securities on that investor’s behalf. It matters to investors because an SMA offers tailored asset selection, tax handling, and transparency—like hiring a personal chef who prepares meals to your dietary needs rather than sharing a set menu—so you can align holdings with your goals and see exactly what you own.

beneficial ownership financial

"may be deemed to beneficially own the securities owned directly by the Fund."

Beneficial ownership means the person or entity that actually enjoys the benefits of owning shares or other assets — such as receiving dividends, voting rights, or price gains — even if the legal title is held in another name. For investors it matters because knowing who truly controls and profits from a company reveals who can influence decisions, exposes potential conflicts of interest or hidden concentration of power, and affects transparency and risk in the stock.

Section 16(a) regulatory

"beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act"

See more from StockTitan in Google Search and AI answers. Adds StockTitan as a preferred source · opens Google

Add on Google Not now

Form 4 Insider Transactions: What Each Field Means →

Available on EDGAR 07/02/2026 - 06:11 PM Accepted by SEC EDGAR 07/02/2026 - 06:11 PM Learn about SEC filing dates

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:			3235-0287
Estimated average burden
hours per response:			0.5

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

Opaleye Management Inc.

(Last) (First) (Middle)

ONE BOSTON PLACE, 26TH FLOOR

(Street)

BOSTON MASSACHUSETTS 02108

(City) (State) (Zip)

UNITED STATES

(Country)

2. Issuer Name and Ticker or Trading Symbol
Sol-Gel Technologies Ltd. [ SLGL ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

	Director	X	10% Owner
	Officer (give title below)		Other (specify below)

2a. Foreign Trading Symbol

3. Date of Earliest Transaction (Month/Day/Year)
07/01/2026

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

4. If Amendment, Date of Original Filed (Month/Day/Year)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Ordinary Shares, par value NIS 1.00 per share	07/01/2026		P		312	A	$71.99	490,312	I	By Opaleye, L.P.(1)(4)
Ordinary Shares, par value NIS 1.00 per share	07/02/2026		P		1,400	A	$71.9707(3)	491,712	I	By Opaleye, L.P.(1)(4)
Ordinary Shares, par value NIS 1.00 per share								15,000	I	By Managed Account(2)(4)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares

Explanation of Responses:

1. Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund.

2. Securities owned by a separately managed account (the "Managed Account"). As the portfolio manager of the Managed Account, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Managed Account.

3. The price reported in column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $71.96-$71.99 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range.

4. Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose.

	Opaleye Management, Inc., By: /s/ James Silverman, President	07/02/2026
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
* Form 4: SEC 1474 (03-26)

FAQ

What insider transactions did Opaleye report for Sol-Gel Technologies (SLGL)?

Opaleye reported open-market purchases totaling 1,712 Sol-Gel ordinary shares. These trades occurred through Opaleye, L.P. at prices between $71.96 and $71.99 per share, increasing an already large indirect ownership position reported on this Form 4.

At what prices did Opaleye buy Sol-Gel Technologies (SLGL) shares?

Opaleye’s purchases were executed at prices ranging from $71.96 to $71.99 per share. The filing notes a weighted average price within this range and states the shares were bought in multiple transactions at those prices in the open market.

How many Sol-Gel Technologies (SLGL) shares does Opaleye, L.P. hold after these trades?

Following the reported open-market purchases, Opaleye, L.P. held 491,712 ordinary shares of Sol-Gel Technologies. This figure reflects the total indirect position in the fund after buying an additional 1,712 shares across the reported transactions.

What is the separately managed account position related to Sol-Gel Technologies (SLGL)?

A separately managed account overseen by Opaleye Management held 15,000 Sol-Gel ordinary shares. The filing states these securities are owned by the managed account, with Opaleye Management as portfolio manager and potential beneficial owner through its pecuniary interest.

How does Opaleye Management describe its beneficial ownership of SLGL shares?

Opaleye Management states it may be deemed to beneficially own securities held by Opaleye, L.P. and the managed account, but disclaims beneficial ownership of the reported shares except to the extent of its pecuniary interest in those holdings.

Were the Sol-Gel (SLGL) purchases by Opaleye open-market transactions?

Yes. The Form 4 identifies the transactions with code P, described as open-market purchases or private transactions. The accompanying footnote clarifies the reported prices are weighted averages of multiple trades within the disclosed price range.