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Opaleye Management (SLGL) adds Sol-Gel stake with open-market share purchases

Filing Impact
(Neutral)
Filing Sentiment
(Positive)
Form Type
4

Rhea-AI Filing Summary

Opaleye Management Inc., a more than ten percent owner of Sol-Gel Technologies Ltd., reported open-market purchases of the company’s ordinary shares. On July 8, 2026, an affiliated fund bought 300 shares at $73.69 per share, and on July 10, 2026 it bought an additional 229 shares at $73.95 per share. After these trades, the fund held 492,241 shares indirectly attributed to Opaleye Management Inc., and a separately managed account associated with it held 15,000 shares, with Opaleye Management Inc. disclaiming beneficial ownership beyond its pecuniary interest.

Positive

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Negative

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Insights

Opaleye-linked accounts modestly increased their Sol-Gel stake through open-market purchases.

Opaleye-related entities acquired 529 Sol-Gel ordinary shares in open-market transactions at prices of $73.69 and $73.95 per share. These purchases were made by Opaleye, L.P., with Opaleye Management Inc. reported as investment manager and more than ten percent owner.

Following the trades, the fund held 492,241 shares, while a separately managed account associated with Opaleye Management Inc. held 15,000 shares. Opaleye Management Inc. states it may be deemed to beneficially own these positions but disclaims beneficial ownership except to the extent of its pecuniary interest, which limits how directly these holdings reflect its own economic exposure.

Insider Opaleye Management Inc.
Role null
Bought 529 shs ($39K)
Type Security Shares Price Value
Purchase Ordinary Shares, par value NIS 1.00 per share 229 $73.95 $17K
Purchase Ordinary Shares, par value NIS 1.00 per share 300 $73.69 $22K
holding Ordinary Shares, par value NIS 1.00 per share -- -- --
Holdings After Transaction: Ordinary Shares, par value NIS 1.00 per share — 492,241 shares (Indirect, By Opaleye, L.P.)
Footnotes (1)
  1. Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund. Securities owned by a separately managed account (the "Managed Account"). As the portfolio manager of the Managed Account, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Managed Account. The price reported in column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $73.475-$73.845 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range. Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose.
Shares purchased 2026-07-08 300 shares at $73.69 per share Open-market purchase by Opaleye, L.P. on July 8, 2026
Shares purchased 2026-07-10 229 shares at $73.95 per share Open-market purchase by Opaleye, L.P. on July 10, 2026
Total net shares bought 529 shares Net buy volume across reported transactions
Fund holdings after trades 492,241 shares Ordinary shares held by Opaleye, L.P. after reported purchases
Managed account holdings 15,000 shares Ordinary shares held by separately managed account as of July 8, 2026
weighted average price financial
"The price reported in column 4 is a weighted average price."
Weighted average price is the average price of a security where each trade or component is counted according to its size, so bigger trades pull the average more than smaller ones. Think of it like calculating the average cost of a grocery haul where items you bought more of have greater influence on the final per-item cost. Investors use it to understand the true average price paid or received, judge execution quality, and compare trading performance against market movement.
separately managed account financial
"Securities owned by a separately managed account (the "Managed Account")."
A separately managed account (SMA) is a personalized investment portfolio owned by a single investor and run by a professional manager who buys and sells securities on that investor’s behalf. It matters to investors because an SMA offers tailored asset selection, tax handling, and transparency—like hiring a personal chef who prepares meals to your dietary needs rather than sharing a set menu—so you can align holdings with your goals and see exactly what you own.
beneficially own financial
"may be deemed to beneficially own the securities owned directly by the Fund."
Beneficially own means having the economic rights and risks of a security—such as the right to receive dividends, sell the shares, or profit from price changes—whether or not your name appears on the official share register. Think of it like renting a car: you use it and reap the benefits even if the title lists someone else. Investors care because beneficial ownership determines who truly controls value, must be disclosed under securities rules, and can signal potential influence or trading activity that affects a stock’s price.
pecuniary interest financial
"disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein"
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FAQ

What insider transactions did Opaleye Management Inc. report for Sol-Gel Technologies (SLGL)?

Opaleye-related entities reported two open-market purchases of Sol-Gel ordinary shares, totaling 529 shares, on July 8, 2026 and July 10, 2026 at prices around the mid-$70s per share.

How many Sol-Gel (SLGL) shares did Opaleye-linked entities buy and at what prices?

They purchased 300 shares at $73.69 per share on July 8, 2026 and 229 shares at $73.95 per share on July 10, 2026, all as open-market transactions.

What is the total Sol-Gel (SLGL) position reported by Opaleye’s fund after these trades?

After the reported purchases, Opaleye, L.P. held 492,241 Sol-Gel ordinary shares. This position is attributed indirectly to Opaleye Management Inc. as the fund’s investment manager, subject to its beneficial ownership disclaimer.

What additional Sol-Gel (SLGL) holdings are reported in Opaleye’s managed account?

A separately managed account associated with Opaleye Management Inc. held 15,000 Sol-Gel ordinary shares as of July 8, 2026, reported as an indirect holding through that managed account.

How does Opaleye Management Inc. describe its beneficial ownership of Sol-Gel (SLGL) shares?

Opaleye Management Inc. states it may be deemed to beneficially own shares held by Opaleye, L.P. and a managed account, but disclaims beneficial ownership except to the extent of its pecuniary interest in those securities.
SEC Form 4
FORM 4UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
OMB APPROVAL
OMB Number:3235-0287
Estimated average burden
hours per response:0.5
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.
1. Name and Address of Reporting Person*
Opaleye Management Inc.

(Last)(First)(Middle)
ONE BOSTON PLACE, 26TH FLOOR

(Street)
BOSTON MASSACHUSETTS 02108

(City)(State)(Zip)

UNITED STATES

(Country)
2. Issuer Name and Ticker or Trading Symbol
Sol-Gel Technologies Ltd. [ SLGL ]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
DirectorX10% Owner
Officer (give title below)Other (specify below)
2a. Foreign Trading Symbol
3. Date of Earliest Transaction (Month/Day/Year)
07/08/2026
6. Individual or Joint/Group Filing (Check Applicable Line)
XForm filed by One Reporting Person
Form filed by More than One Reporting Person
4. If Amendment, Date of Original Filed (Month/Day/Year)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year)2A. Deemed Execution Date, if any (Month/Day/Year)3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeVAmount(A) or (D)Price
Ordinary Shares, par value NIS 1.00 per share07/08/2026P300A$73.69(3)492,012IBy Opaleye, L.P.(1)(4)
Ordinary Shares, par value NIS 1.00 per share07/10/2026P229A$73.95492,241IBy Opaleye, L.P.(1)(4)
Ordinary Shares, par value NIS 1.00 per share15,000IBy Managed Account(2)(4)
Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year)3A. Deemed Execution Date, if any (Month/Day/Year)4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 6. Date Exercisable and Expiration Date (Month/Day/Year)7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeV(A)(D)Date ExercisableExpiration DateTitleAmount or Number of Shares
Explanation of Responses:
1. Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund.
2. Securities owned by a separately managed account (the "Managed Account"). As the portfolio manager of the Managed Account, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Managed Account.
3. The price reported in column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $73.475-$73.845 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range.
4. Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose.
Opaleye Management, Inc., By: /s/ James Silverman, President07/10/2026
** Signature of Reporting PersonDate
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
* Form 4: SEC 1474 (03-26)