[Form 4] SmartKem, Inc. Insider Trading Activity

Rhea-AI Filing Summary

Insider option grant reported for SmartKem, Inc. (SMTK). Director Melisa Denis was granted a stock option to buy 22,466 shares of common stock at an exercise price of $1.16 per share, with a transaction date of 09/03/2025 and an expiration date of 09/03/2035. The option vests 25% on the grant date and the remaining shares vest in equal monthly installments over 36 months beginning 09/03/2025. The reporting was filed on 09/05/2025 and signed by an attorney-in-fact.

Positive

• Option grant disclosed: 22,466-share stock option for a director is clearly reported
• Complete vesting schedule provided: 25% at grant and monthly vesting over 36 months beginning 09/03/2025
• Full exercise and expiration terms included: exercise price $1.16 and expiration 09/03/2035

Negative

• None.

Insights

Securities Analyst

TL;DR: Director granted a 10-year option for 22,466 shares at $1.16 with standard multi-year vesting.

The Form 4 discloses a non-derivative award structured as a stock option: exercise price $1.16, 22,466 shares underlying, exercisable through 09/03/2035. Vesting is 25% at grant then equal monthly installments over 36 months commencing 09/03/2025. This is a routine equity compensation disclosure for a director, recorded on 09/05/2025. The filing identifies the reporting person as Melisa Denis and shows the transaction was reported by an attorney-in-fact.

Corporate Governance Expert

TL;DR: Typical director option grant with time-based vesting; disclosure meets Section 16 reporting requirements.

The submission is concise and includes key plan terms required for Section 16 reporting: grant date, amount (22,466 shares), exercise price ($1.16), vesting schedule (25% at grant; monthly over 36 months), and expiration date (09/03/2035). The form is signed via attorney-in-fact and indicates the filer is a director. No other transactions, dispositions, or indirect holdings are reported.

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:			3235-0287
Estimated average burden
hours per response:			0.5

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

Denis Melisa

(Last) (First) (Middle)

C/O SMARTKEM, MANCHESTER TECHNOLOGY CTR

HEXAGON TOWER DELAUNAYS ROAD, BLACKLEY

(Street)

MANCHESTER X0 M9 8GQ

(City) (State) (Zip)

2. Issuer Name and Ticker or Trading Symbol
SmartKem, Inc. [ SMTK ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

X	Director		10% Owner
	Officer (give title below)		Other (specify below)

3. Date of Earliest Transaction (Month/Day/Year)
09/03/2025

4. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Stock Option (right to buy)	$1.16	09/03/2025		A		22,466		(1)	09/03/2035	Common Stock	22,466	$0	22,466	D

Explanation of Responses:

1. The option vests as follows: 25% on the date of grant with the remaining shares to vest in equal monthly installments over a period of 36 months commencing on September 3, 2025 and on the 3rd date of each month thereafter.

	/s/ Barbra Keck, attorney-in-fact for Melisa A. Denis	09/05/2025
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

FAQ

Who filed the Form 4 for SmartKem (SMTK)?

Melisa Denis is the reporting person; the form was signed by an attorney-in-fact on 09/05/2025.

What security and amount were reported on the Form 4 for SMTK?

A stock option to purchase 22,466 shares of common stock was reported.

What are the exercise price and expiration date of the option reported for SMTK?

The option has an exercise price of $1.16 and an expiration date of 09/03/2035.

What is the vesting schedule for the reported option on SMTK Form 4?

The option vests 25% on the grant date, with the remainder vesting in equal monthly installments over 36 months beginning 09/03/2025.

When was the transaction date and when was the Form 4 filed?

Transaction date is 09/03/2025; the Form 4 was filed and signed on 09/05/2025.