SYRE Form 144: Proposed sale of 45,000 common shares

SYRE submitted a Form 144 notice concerning the proposed sale of 45,000 shares of Common Stock.

Rhea-AI Filing Summary

SYRE submitted a Form 144 notice concerning the proposed sale of 45,000 shares of Common Stock. The filing shows these shares trace to previously exercised stock options dated 06/15/2023.

The excerpt also records two Rule 10b5-1 transactions by Cameron W. Turtle: 15,000 shares sold on 05/01/2026 for $1,070,506.50 and 15,000 shares sold on 06/01/2026 for $1,056,508.50. Shares outstanding are listed as 86,841,253 as of 07/01/2026.

Key Figures

Proposed sale: 45,000 shares Shares sold (May 2026): 15,000 shares Shares sold (June 2026): 15,000 shares +2 more

5 metrics

Proposed sale 45,000 shares Common Stock; tied to previously exercised options dated 06/15/2023

Shares sold (May 2026) 15,000 shares 10b5-1 sale on 05/01/2026 for $1,070,506.50

Shares sold (June 2026) 15,000 shares 10b5-1 sale on 06/01/2026 for $1,056,508.50

Aggregate value (line item) $3,995,100.00 Value shown on the securities line associated with 45,000 shares

Shares outstanding 86,841,253 Outstanding as of 07/01/2026

Key Terms

10b5-1, Previously Exercised Stock Options, Form 144

3 terms

10b5-1 regulatory

"10b5-1 Sales for CAMERON W TURTLE ... 06/01/2026"

A 10b5-1 plan is a pre-set schedule that lets company insiders buy or sell shares according to written instructions made when they do not possess material, nonpublic information. Think of it as a timed automatic payment for stock trades: it helps insiders avoid accusations of trading on secret information and gives outside investors a clearer signal about whether sales are routine or potentially informative about the company’s prospects.

Previously Exercised Stock Options financial

"Previously Exercised Stock Options | Issuer | 45000 | 06/15/2023"

Form 144 regulatory

"Filer Information ... 144: Filer Information"

Form 144 is a document that investors must file with the government when they plan to sell a large number of shares of a company's stock. It helps ensure transparency so everyone knows how many shares are being sold and when, which can impact the stock's price.

FAQ

What does the SYRE Form 144 notice report?

It reports a proposed sale of 45,000 common shares tied to previously exercised options dated 06/15/2023. The filing itemizes the holding source and recent sales by the holder.

Did any insider sales already occur for SYRE?

Yes. The filing lists two 10b5-1 sales by Cameron W. Turtle: 15,000 shares on 05/01/2026 for $1,070,506.50 and 15,000 shares on 06/01/2026 for $1,056,508.50. These are recorded transactions.

Who is the broker or intermediary listed on the Form 144 for SYRE?

The filing shows Morgan Stanley Smith Barney LLC Executive Financial Services at 1 New York Plaza as the listed broker/intermediary. The broker name appears on the securities and filer lines.

How many SYRE shares were outstanding per this excerpt?

The excerpt lists 86,841,253 shares outstanding as of 07/01/2026. That figure appears on the same line reporting the security and the proposed sale amount.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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Accepted by SEC EDGAR 07/01/2026 - 05:02 PM Learn about SEC filing dates

Form 144 Filer Information	UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 144 NOTICE OF PROPOSED SALE OF SECURITIES PURSUANT TO RULE 144 UNDER THE SECURITIES ACT OF 1933
FORM 144

144: Filer Information

Filer CIK	0001758363
Filer CCC	XXXXXXXX
Is this a LIVE or TEST Filing?	LIVE TEST
Submission Contact Information
Name
Phone
E-Mail Address

144: Issuer Information

Name of Issuer	SPYRE THERAPEUTICS INC
SEC File Number	001-37722
Address of Issuer	221 Crescent Street Building 23 Waltham MASSACHUSETTS 02453
Phone	617-651-5940
Name of Person for Whose Account the Securities are To Be Sold	CAMERON TURTLE
See the definition of "person" in paragraph (a) of Rule 144. Information is to be given not only as to the person for whose account the securities are to be sold but also as to all other persons included in that definition. In addition, information shall be given as to sales by all persons whose sales are required by paragraph (e) of Rule 144 to be aggregated with sales for the account of the person filing this notice.
Relationship to Issuer	Director
Relationship to Issuer	Officer

144: Securities Information

Title of the Class of Securities To Be Sold	Name and Address of the Broker	Number of Shares or Other Units To Be Sold	Aggregate Market Value	Number of Shares or Other Units Outstanding	Approximate Date of Sale	Name the Securities Exchange
Common	Morgan Stanley Smith Barney LLC Executive Financial Services 1 New York Plaza 8th Floor New York NY 10004	45000	3995100.00	86841253	07/01/2026	NASDAQ

Furnish the following information with respect to the acquisition of the securities to be sold and with respect to the payment of all or any part of the purchase price or other consideration therefor:

144: Securities To Be Sold

Title of the Class	Date you Acquired	Nature of Acquisition Transaction	Name of Person from Whom Acquired	Is this a Gift?	Date Donor Acquired	Amount of Securities Acquired	Date of Payment	Nature of Payment *
Common	06/15/2023	Previously Exercised Stock Options	Issuer			45000	06/15/2023	N/A

* If the securities were purchased and full payment therefor was not made in cash at the time of purchase, explain in the table or in a note thereto the nature of the consideration given. If the consideration consisted of any note or other obligation, or if payment was made in installments describe the arrangement and state when the note or other obligation was discharged in full or the last installment paid.

Furnish the following information as to all securities of the issuer sold during the past 3 months by the person for whose account the securities are to be sold.

144: Securities Sold During The Past 3 Months

Name and Address of Seller	Title of Securities Sold	Date of Sale	Amount of Securities Sold	Gross Proceeds
10b5-1 Sales for CAMERON W TURTLE 221 Crescent Street Building 23 Waltham MA 02453	Common	06/01/2026	15000	1056508.50
10b5-1 Sales for CAMERON W TURTLE 221 Crescent Street Building 23 Waltham MA 02453	Common	05/01/2026	15000	1070506.50

144: Remarks and Signature

Remarks
Date of Notice	07/01/2026
Date of Plan Adoption or Giving of Instruction, If Relying on Rule 10b5-1	06/20/2025
ATTENTION:
The person for whose account the securities to which this notice relates are to be sold hereby represents by signing this notice that he does not know any material adverse information in regard to the current and prospective operations of the Issuer of the securities to be sold which has not been publicly disclosed. If such person has adopted a written trading plan or given trading instructions to satisfy Rule 10b5-1 under the Exchange Act, by signing the form and indicating the date that the plan was adopted or the instruction given, that person makes such representation as of the plan adoption or instruction date.
Signature	/s/ Cameron Turtle
ATTENTION: Intentional misstatements or omission of facts constitute Federal Criminal Violations (See 18 U.S.C. 1001)