Spyre officer to sell $4.2M in stock via options

Heidy King-Jones plans to sell up to 46,665 SYRE shares in a Rule 144 trade starting about Sept. 1, 2026, valued at ~$4.17M.

Rhea-AI Filing Summary

Spyre Therapeutics, Inc. (SYRE) received a Rule 144 notice indicating that officer Heidy King-Jones plans to sell up to 46,665 shares of common stock. The shares are to be sold through Morgan Stanley Smith Barney LLC Executive Financial Services, with sales planned beginning on or about 09/01/2026.

The shares were and will be acquired upon the exercise of stock options over the next three months, with the dates of acquisition and payment matching the exercise/sale dates. The filing lists an aggregate market value of approximately $4,168,584.45 for the shares and notes 88,173,762 shares outstanding as of 09/01/2026.

Key Figures

Shares to be sold: 46,665 shares Aggregate market value: $4,168,584.45 Shares outstanding: 88,173,762 shares +2 more

5 metrics

Shares to be sold 46,665 shares Common stock covered by Rule 144 notice

Aggregate market value $4,168,584.45 Market value of 46,665 shares to be sold

Shares outstanding 88,173,762 shares Common shares outstanding as of 09/01/2026

Planned sale start date 09/01/2026 Date listed for securities information and sales

Shares underlying planned option exercises 46,665 shares Options to be exercised over next three months

Key Terms

Rule 144, Form 144, Exercise of Stock Options, aggregate market value, +1 more

5 terms

Rule 144 regulatory

"See the definition of "person" in paragraph (a) of Rule 144."

Rule 144 is a U.S. securities regulation that sets conditions under which restricted or insider-held shares can be legally resold to the public, such as required holding periods, availability of public information, limits on how much can be sold at once, and certain filing requirements. For investors it matters because it determines when previously locked-up shares can enter the market — like a release valve that can increase supply, affect share price, and signal insider intent.

Form 144 regulatory

"144: Filer Information 144: Issuer Information"

Form 144 is a document that investors must file with the government when they plan to sell a large number of shares of a company's stock. It helps ensure transparency so everyone knows how many shares are being sold and when, which can impact the stock's price.

Exercise of Stock Options financial

"Common | 09/01/2026 | Exercise of Stock Options | Issuer"

aggregate market value financial

"Common | Morgan Stanley Smith Barney LLC ... | 46665 | 4168584.45"

Aggregate market value is the combined price you would pay to buy all outstanding shares of a company or all companies in a group at current market prices — essentially the sum of each stock’s market capitalization. It matters to investors because it shows the overall size and weight of an investment or sector (like the total cost to buy every piece of a puzzle), helps compare scale across companies or markets, and influences index composition and risk exposure.

Executive Financial Services financial

"Morgan Stanley Smith Barney LLC Executive Financial Services 1 New York Plaza"

FAQ

AI-generated questions and answers. How Rhea-AI works. Not financial advice.

What does the Form 144 filing disclose for Spyre Therapeutics (SYRE)?

It discloses that officer Heidy King-Jones plans to sell up to 46,665 shares of Spyre Therapeutics common stock under Rule 144, with shares obtained through stock option exercises and sales expected to begin around 09/01/2026.

How many SYRE shares are planned to be sold under this Form 144?

The notice covers up to 46,665 shares of Spyre Therapeutics common stock. The securities are associated with the planned exercise of stock options over a three-month period, with sales reported under Rule 144.

What is the aggregate market value of the SYRE shares in this Form 144?

The Form 144 lists an aggregate market value of approximately $4,168,584.45 for the 46,665 shares of Spyre Therapeutics common stock covered by the planned Rule 144 sales.

How will the Spyre Therapeutics (SYRE) shares be acquired for sale?

The shares will be acquired upon the exercise of stock options. The remarks state that the securities to be sold were and will be received through stock option exercises over the next three months, with acquisition and payment dates matching the exercise/sale dates.

What is the stated shares outstanding figure for SYRE in this filing?

The Form 144 notes that 88,173,762 shares of Spyre Therapeutics common stock were outstanding as of 09/01/2026. This figure serves as context and is separate from the 46,665 shares covered by the notice.

Who is the broker for the planned SYRE share sales under Form 144?

The planned sales will be executed through Morgan Stanley Smith Barney LLC Executive Financial Services, located at 1 New York Plaza, New York, NY, as listed for the common stock in the Form 144 filing.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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Available on EDGAR 09/01/2026 - 04:58 PM EDT Accepted by SEC EDGAR 09/01/2026 - 04:57 PM EDT Learn about SEC filing dates

Form 144 Filer Information	UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 144 NOTICE OF PROPOSED SALE OF SECURITIES PURSUANT TO RULE 144 UNDER THE SECURITIES ACT OF 1933
FORM 144

144: Filer Information

Filer CIK	0001794898
Filer CCC	XXXXXXXX
Is this a LIVE or TEST Filing?	LIVE TEST
Submission Contact Information
Name
Phone
E-Mail Address

144: Issuer Information

Name of Issuer	SPYRE THERAPEUTICS INC
SEC File Number	001-37722
Address of Issuer	221 Crescent Street Building 23 Waltham MASSACHUSETTS 02453
Phone	6176515940
Name of Person for Whose Account the Securities are To Be Sold	HEIDY KING-JONES
See the definition of "person" in paragraph (a) of Rule 144. Information is to be given not only as to the person for whose account the securities are to be sold but also as to all other persons included in that definition. In addition, information shall be given as to sales by all persons whose sales are required by paragraph (e) of Rule 144 to be aggregated with sales for the account of the person filing this notice.
Relationship to Issuer	Officer

144: Securities Information

Title of the Class of Securities To Be Sold	Name and Address of the Broker	Number of Shares or Other Units To Be Sold	Aggregate Market Value	Number of Shares or Other Units Outstanding	Approximate Date of Sale	Name the Securities Exchange
Common	Morgan Stanley Smith Barney LLC Executive Financial Services 1 New York Plaza 8th Floor New York NY 10004	46665	4168584.45	88173762	09/01/2026	NASDAQ

Furnish the following information with respect to the acquisition of the securities to be sold and with respect to the payment of all or any part of the purchase price or other consideration therefor:

144: Securities To Be Sold

Title of the Class	Date you Acquired	Nature of Acquisition Transaction	Name of Person from Whom Acquired	Is this a Gift?	Date Donor Acquired	Amount of Securities Acquired	Date of Payment	Nature of Payment *
Common	09/01/2026	Exercise of Stock Options	Issuer			46665	09/01/2026	Cash

* If the securities were purchased and full payment therefor was not made in cash at the time of purchase, explain in the table or in a note thereto the nature of the consideration given. If the consideration consisted of any note or other obligation, or if payment was made in installments describe the arrangement and state when the note or other obligation was discharged in full or the last installment paid.

Furnish the following information as to all securities of the issuer sold during the past 3 months by the person for whose account the securities are to be sold.

144: Securities Sold During The Past 3 Months

Nothing to Report

144: Remarks and Signature

Remarks	The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale.
Date of Notice	09/01/2026
Date of Plan Adoption or Giving of Instruction, If Relying on Rule 10b5-1	04/16/2026
ATTENTION:
The person for whose account the securities to which this notice relates are to be sold hereby represents by signing this notice that he does not know any material adverse information in regard to the current and prospective operations of the Issuer of the securities to be sold which has not been publicly disclosed. If such person has adopted a written trading plan or given trading instructions to satisfy Rule 10b5-1 under the Exchange Act, by signing the form and indicating the date that the plan was adopted or the instruction given, that person makes such representation as of the plan adoption or instruction date.
Signature	/s/ Heidy King-Jones
ATTENTION: Intentional misstatements or omission of facts constitute Federal Criminal Violations (See 18 U.S.C. 1001)