Spyre Therapeutics officer proposes $1.57M share sale

Burrows also reported a prior sale of 18,232 common shares for $1,629,029.20 on September 2, 2026.

Rhea-AI Filing Summary

Spyre Therapeutics, Inc. officer Scott Burrows reported a proposed sale of 17,500 common shares, with an aggregate market value of $1,573,157.25, scheduled for September 30, 2026. The notice identifies Morgan Stanley Smith Barney LLC Executive Financial Services as broker and Nasdaq as the exchange. It also lists a cash stock-option exercise from the issuer for 17,500 common shares on September 30, 2026.

Key Figures

Proposed shares to be sold: 17,500 common shares Aggregate market value: $1,573,157.25 Shares outstanding: 88,173,762 shares +1 more

4 metrics

Proposed shares to be sold 17,500 common shares Scheduled for September 30, 2026

Aggregate market value $1,573,157.25 Proposed sale of 17,500 common shares

Shares outstanding 88,173,762 shares Reported in the securities-to-be-sold information

Shares acquired through stock-option exercise 17,500 common shares From the issuer for cash on September 30, 2026

Key Terms

Rule 144, Aggregate market value, Stock Option Exercise

3 terms

Rule 144 regulatory

"See the definition of "person" in paragraph (a) of Rule 144"

Rule 144 is a U.S. securities regulation that sets conditions under which restricted or insider-held shares can be legally resold to the public, such as required holding periods, availability of public information, limits on how much can be sold at once, and certain filing requirements. For investors it matters because it determines when previously locked-up shares can enter the market — like a release valve that can increase supply, affect share price, and signal insider intent.

Aggregate market value financial

"Aggregate market value"

Aggregate market value is the combined price you would pay to buy all outstanding shares of a company or all companies in a group at current market prices — essentially the sum of each stock’s market capitalization. It matters to investors because it shows the overall size and weight of an investment or sector (like the total cost to buy every piece of a puzzle), helps compare scale across companies or markets, and influences index composition and risk exposure.

Stock Option Exercise technical

"Stock Option Exercise"

A stock option exercise is the act of using a previously granted right to buy shares of a company's stock at a specific, predetermined price by paying that price and receiving the shares. It matters to investors because exercising changes who owns the shares (which can dilute existing ownership), can trigger taxable events and shift potential gains or losses, and affects voting power and the company’s outstanding share count—like turning a voucher into an actual product that becomes part of circulating supply.

FAQ

AI-generated questions and answers. How Rhea-AI works. Not financial advice.

How many SYRE shares does Scott Burrows plan to sell?

Scott Burrows reported a proposed sale of 17,500 common shares scheduled for September 30, 2026, with an aggregate market value of $1,573,157.25. The notice identifies Morgan Stanley Smith Barney LLC Executive Financial Services as the broker.

What recent SYRE stock sales did Scott Burrows report?

Scott Burrows reported sales of 18,232 common shares for $1,629,029.20 on September 2, 2026; 7,500 shares for $654,783.00 on September 1, 2026; 7,500 shares for $716,761.00 on August 3, 2026; and 7,500 shares for $658,043.00 on July 1, 2026.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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Available on EDGAR 09/30/2026 - 04:03 PM Accepted by SEC EDGAR 09/30/2026 - 04:03 PM Learn about SEC filing dates

Form 144 Filer Information	UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 144 NOTICE OF PROPOSED SALE OF SECURITIES PURSUANT TO RULE 144 UNDER THE SECURITIES ACT OF 1933
FORM 144

144: Filer Information

Filer CIK	0001853327
Filer CCC	XXXXXXXX
Is this a LIVE or TEST Filing?	LIVE TEST
Submission Contact Information
Name
Phone
E-Mail Address

144: Issuer Information

Name of Issuer	SPYRE THERAPEUTICS, INC.
SEC File Number	001-37722
Address of Issuer	221 Crescent Street Building 23, Suite 105 Waltham MASSACHUSETTS 02453
Phone	(617) 651-5940
Name of Person for Whose Account the Securities are To Be Sold	SCOTT BURROWS
See the definition of "person" in paragraph (a) of Rule 144. Information is to be given not only as to the person for whose account the securities are to be sold but also as to all other persons included in that definition. In addition, information shall be given as to sales by all persons whose sales are required by paragraph (e) of Rule 144 to be aggregated with sales for the account of the person filing this notice.
Relationship to Issuer	Officer

144: Securities Information

Title of the Class of Securities To Be Sold	Name and Address of the Broker	Number of Shares or Other Units To Be Sold	Aggregate Market Value	Number of Shares or Other Units Outstanding	Approximate Date of Sale	Name the Securities Exchange
Common	Morgan Stanley Smith Barney LLC Executive Financial Services 1 New York Plaza 8th Floor New York NY 10004	17500	1573157.25	88173762	09/30/2026	NASDAQ

Furnish the following information with respect to the acquisition of the securities to be sold and with respect to the payment of all or any part of the purchase price or other consideration therefor:

144: Securities To Be Sold

Title of the Class	Date you Acquired	Nature of Acquisition Transaction	Name of Person from Whom Acquired	Is this a Gift?	Date Donor Acquired	Amount of Securities Acquired	Date of Payment	Nature of Payment *
Common	09/30/2026	Stock Option Exercise	Issuer			17500	09/30/2026	Cash

* If the securities were purchased and full payment therefor was not made in cash at the time of purchase, explain in the table or in a note thereto the nature of the consideration given. If the consideration consisted of any note or other obligation, or if payment was made in installments describe the arrangement and state when the note or other obligation was discharged in full or the last installment paid.

Furnish the following information as to all securities of the issuer sold during the past 3 months by the person for whose account the securities are to be sold.

144: Securities Sold During The Past 3 Months

Name and Address of Seller	Title of Securities Sold	Date of Sale	Amount of Securities Sold	Gross Proceeds
SCOTT BURROWS 221 Crescent Street Building 23, Suite 105 Waltham MA 02453	Common	09/02/2026	18232	1629029.20
SCOTT BURROWS 221 Crescent Street Building 23, Suite 105 Waltham MA 02453	Common	09/01/2026	7500	654783.00
SCOTT BURROWS 221 Crescent Street Building 23, Suite 105 Waltham MA 02453	Common	08/03/2026	7500	716761.00
SCOTT BURROWS 221 Crescent Street Building 23, Suite 105 Waltham MA 02453	Common	07/01/2026	7500	658043.00

144: Remarks and Signature

Remarks
Date of Notice	09/30/2026
ATTENTION:
The person for whose account the securities to which this notice relates are to be sold hereby represents by signing this notice that he does not know any material adverse information in regard to the current and prospective operations of the Issuer of the securities to be sold which has not been publicly disclosed. If such person has adopted a written trading plan or given trading instructions to satisfy Rule 10b5-1 under the Exchange Act, by signing the form and indicating the date that the plan was adopted or the instruction given, that person makes such representation as of the plan adoption or instruction date.
Signature	/s/ Scott Burrows
ATTENTION: Intentional misstatements or omission of facts constitute Federal Criminal Violations (See 18 U.S.C. 1001)