Spyre CEO sells 15,000 shares under 10b5-1 plan

Spyre Therapeutics’ CEO and director sold 15,000 SYRE shares under a Rule 10b5-1 plan at weighted average prices in the mid-to-high $80s.

Rhea-AI Filing Summary

Spyre Therapeutics, Inc. (SYRE) reports that Chief Executive Officer and director Turtle Cameron sold 15,000 shares of common stock on September 1, 2026 in four open-market transactions at weighted average prices of $86.36, $87.15, $88.06, and $89.07.

The sales were executed pursuant to a Rule 10b5-1 trading plan adopted on June 20, 2025, with each price reflecting multiple trades within stated ranges. A footnote also states that Cameron has 43,593 shares scheduled to vest in monthly installments through November 2026, subject to continued service.

Insider Trade Summary 10b5-1

Net Seller: 15,000 shares

Net Sell 4 txns

Insider Turtle Cameron

Role Chief Executive Officer

Sold 15,000 shs ($1.31M)

Type	Security	Shares	Price	Value
Sale	Common Stock F1, F2, F3	2,500	$86.36	$216K
Sale	Common Stock F1, F4, F3	8,400	$87.15	$732K
Sale	Common Stock F1, F5, F3	3,700	$88.06	$326K
Sale	Common Stock F1, F6, F3	400	$89.07	$36K

Holdings After Transaction: Common Stock — 552,540 shares (Direct)

Footnotes (6)

1. F1. This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on June 20, 2025.
2. F2. The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $85.67 to $86.66, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission (the "SEC"), upon request, full information regarding the number of shares sold at each separate price within the range.
3. F3. Includes 43,593 shares of common stock that vest in monthly installments through November 2026, subject to the continuing service of the Reporting Person on each vesting date.
4. F4. The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $86.67 to $87.65, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.
5. F5. The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $87.68 to $88.67, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.
6. F6. The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $88.69 to $89.38, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

Key Figures

Total shares sold: 15,000 shares Shares sold at $86.36: 2,500 shares Shares sold at $87.15: 8,400 shares +3 more

6 metrics

Total shares sold 15,000 shares Common stock sales on September 1, 2026 by the CEO

Shares sold at $86.36 2,500 shares Weighted average sale price of $86.36 on September 1, 2026

Shares sold at $87.15 8,400 shares Weighted average sale price of $87.15 on September 1, 2026

Shares sold at $88.06 3,700 shares Weighted average sale price of $88.06 on September 1, 2026

Shares sold at $89.07 400 shares Weighted average sale price of $89.07 on September 1, 2026

Unvested shares vesting monthly 43,593 shares Common stock scheduled to vest monthly through November 2026

Key Terms

Rule 10b5-1 trading plan, weighted average price, monthly installments, vesting

4 terms

Rule 10b5-1 trading plan regulatory

"This transaction was executed pursuant to a Rule 10b5-1 trading plan"

A Rule 10b5-1 trading plan is a pre-arranged schedule that allows company insiders to buy or sell stock at specific times, even if they have inside information. It helps prevent accusations of unfair trading by making these transactions look planned and transparent, rather than sneaky or illegal.

weighted average price financial

"The price reported above is a weighted average price"

Weighted average price is the average price of a security where each trade or component is counted according to its size, so bigger trades pull the average more than smaller ones. Think of it like calculating the average cost of a grocery haul where items you bought more of have greater influence on the final per-item cost. Investors use it to understand the true average price paid or received, judge execution quality, and compare trading performance against market movement.

monthly installments financial

"shares of common stock that vest in monthly installments through November 2026"

Monthly installments are regular, fixed payments made each month to gradually pay off a larger amount, such as a loan or purchase. Think of it like paying for a big item in small, manageable parts instead of all at once. For investors, understanding installment payments helps gauge how debts are structured and how they might affect financial stability or cash flow over time.

vesting financial

"shares of common stock that vest in monthly installments through November 2026"

Vesting is the process by which you earn full ownership of something, like company stock or a retirement benefit, over time. It’s like earning the right to keep a gift piece by piece the longer you stay with a company, making sure employees stay committed before they receive all the benefits.

FAQ

How many SYRE shares did the CEO sell in this Form 4 filing?

Chief Executive Officer Turtle Cameron sold a total of 15,000 shares of Spyre Therapeutics, Inc. common stock on September 1, 2026, across four separate open-market transactions reported in this Form 4.

At what prices were the SYRE shares sold by the CEO?

The reported weighted average sale prices were $86.36 for 2,500 shares, $87.15 for 8,400 shares, $88.06 for 3,700 shares, and $89.07 for 400 shares. Each reflects multiple trades within specified price ranges.

Was the SYRE CEO’s share sale made under a Rule 10b5-1 plan?

Yes. A footnote states the transactions were executed pursuant to a Rule 10b5-1 trading plan adopted on June 20, 2025, indicating they followed a pre-arranged trading schedule.

When was the Rule 10b5-1 trading plan for SYRE’s CEO adopted?

The Rule 10b5-1 trading plan covering these sales was adopted on June 20, 2025, according to the footnote describing the plan applicable to the reported September 1, 2026 transactions.

Does the SYRE CEO have additional shares scheduled to vest?

A footnote states that Turtle Cameron has 43,593 shares of common stock that vest in monthly installments through November 2026, subject to continued service on each vesting date.

What role does Turtle Cameron hold at Spyre Therapeutics (SYRE)?

Turtle Cameron is reported as both a director and the Chief Executive Officer of Spyre Therapeutics, Inc. in this Form 4 insider transaction report.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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Available on EDGAR 09/03/2026 - 09:33 PM Accepted by SEC EDGAR 09/03/2026 - 09:33 PM Learn about SEC filing dates

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:			3235-0287
Estimated average burden
hours per response:			0.5

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

X

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

Turtle Cameron

(Last) (First) (Middle)

221 CRESCENT STREET, BUILDING 23,

SUITE 105

(Street)

WALTHAM MASSACHUSETTS 02453

(City) (State) (Zip)

UNITED STATES

(Country)

2. Issuer Name and Ticker or Trading Symbol
Spyre Therapeutics, Inc. [ SYRE ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

X	Director		10% Owner
X	Officer (give title below)		Other (specify below)
	Chief Executive Officer

2a. Foreign Trading Symbol

3. Date of Earliest Transaction (Month/Day/Year)
09/01/2026

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

4. If Amendment, Date of Original Filed (Month/Day/Year)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock	09/01/2026		S(1)		2,500	D	$86.36(2)	565,040(3)	D
Common Stock	09/01/2026		S(1)		8,400	D	$87.15(4)	556,640(3)	D
Common Stock	09/01/2026		S(1)		3,700	D	$88.06(5)	552,940(3)	D
Common Stock	09/01/2026		S(1)		400	D	$89.07(6)	552,540(3)	D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares

Explanation of Responses:

1. This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on June 20, 2025.

2. The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $85.67 to $86.66, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission (the "SEC"), upon request, full information regarding the number of shares sold at each separate price within the range.

3. Includes 43,593 shares of common stock that vest in monthly installments through November 2026, subject to the continuing service of the Reporting Person on each vesting date.

4. The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $86.67 to $87.65, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

5. The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $87.68 to $88.67, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

6. The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $88.69 to $89.38, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

Remarks:

	/s/ Heidy King-Jones, as Attorney-in-Fact	09/03/2026
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
* Form 4: SEC 1474 (03-26)