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Spyre Therapeutics CFO sells 25,000 shares

The option award represents a right to purchase 404,857 shares, with vesting subject to continued employment.

(Neutral)

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Form Type
4

Rhea-AI Filing Summary

Spyre Therapeutics, Inc. (SYRE) Chief Financial Officer Scott L. Burrows exercised options for 17,500 shares on September 30, 2026, at a $14.50 exercise price, then sold 17,500 common shares at a weighted-average $89.89 per share; prices ranged from $89.00 to $90.62. On October 1, he exercised options for 7,500 shares at $14.50 and reported five sales: 600 shares at a weighted-average $89.07 ($88.63–$89.53 range), 1,500 at $90.27 ($89.96–$90.95), 2,100 at $91.92 ($91.41–$92.26), 3,071 at $92.95 ($92.54–$93.53), and 229 at $93.57 ($93.54–$93.59). Across both dates, his reported sales covered 25,000 shares. The October 1 transactions were pursuant to a Rule 10b5-1 trading plan adopted November 10, 2025. A post-transaction amount includes 33,738 RSUs, each a contingent right to one common share upon vesting; they vest September 1, 2027, subject to continued employment.

Insider Burrows Scott L
Role Chief Financial Officer
Sold 25,000 shs ($2.26M)
Approx. gross sale proceeds $2.26M
Approx. exercise cost $363K
Approx. pre-tax spread $1.90M
Type Security Shares Price Value
Exercise Stock Option (Right to Buy) F2, F9 7,500 $0.00 $0.00
Exercise Common Stock F2 7,500 $14.50 $109K
Sale Common Stock F2, F3 600 $89.07 $53K
Sale Common Stock F2, F4 1,500 $90.27 $135K
Sale Common Stock F2, F5 2,100 $91.92 $193K
Sale Common Stock F2, F6 3,071 $92.95 $285K
Sale Common Stock F2, F7, F8 229 $93.57 $21K
Exercise Stock Option (Right to Buy) F9 17,500 $0.00 $0.00
Exercise Common Stock 17,500 $14.50 $254K
Sale Common Stock F1 17,500 $89.89 $1.57M
Holdings After Transaction: Stock Option (Right to Buy) — 312,357 contracts (Direct); Common Stock — 79,762 shares (Direct)
Footnotes (9)
  1. F1. The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $89.00 to $90.62, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission (the "SEC"), upon request, full information regarding the number of shares sold at each separate price within the range.
  2. F2. This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on November 10, 2025.
  3. F3. The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $88.63 to $89.53, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission (the "SEC"), upon request, full information regarding the number of shares sold at each separate price within the range.
  4. F4. The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $89.96 to $90.95, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.
  5. F5. The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $91.41 to $92.26, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.
  6. F6. The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $92.54 to $93.53, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.
  7. F7. The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $93.54 to $93.59, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.
  8. F8. Includes 33,738 RSUs. Each RSU represents a contingent right to receive, upon vesting, one share of the Issuer's common stock. The RSUs vest on September 1, 2027, subject to the Reporting Person's continued employment with the Issuer.
  9. F9. This option represents a right to purchase 404,857 shares of the Issuer's common stock (which have been adjusted to reflect the Issuer's 1-for-25 reverse stock split on September 8, 2023), one quarter of which vested and became exercisable on September 1, 2024, with the remaining three quarters vesting in monthly installments over the following three years, subject to the Reporting Person's continued employment with the Issuer.
Shares sold 25,000 shares Across September 30 and October 1, 2026
Options exercised 17,500 shares September 30, 2026
Options exercised 7,500 shares October 1, 2026
Exercise price $14.50 per share Options exercised on September 30 and October 1, 2026
Weighted-average sale price $89.89 per share September 30 sale of 17,500 shares
RSUs 33,738 RSUs Vesting September 1, 2027, subject to continued employment
Shares covered by option right 404,857 shares Option described in the footnote
Rule 10b5-1 trading plan regulatory
"pursuant to a Rule 10b5-1 trading plan adopted on November 10, 2025"
A Rule 10b5-1 trading plan is a pre-arranged schedule that allows company insiders to buy or sell stock at specific times, even if they have inside information. It helps prevent accusations of unfair trading by making these transactions look planned and transparent, rather than sneaky or illegal.
weighted average price financial
"The price reported above is a weighted average price"
Weighted average price is the average price of a security where each trade or component is counted according to its size, so bigger trades pull the average more than smaller ones. Think of it like calculating the average cost of a grocery haul where items you bought more of have greater influence on the final per-item cost. Investors use it to understand the true average price paid or received, judge execution quality, and compare trading performance against market movement.
RSUs financial
"Includes 33,738 RSUs"
RSUs, or restricted stock units, are a form of company shares given to employees as part of their compensation. They are typically awarded with certain restrictions, such as a waiting period before they can be fully owned or sold, similar to earning a gift that becomes fully yours over time. For investors, RSUs can impact a company's stock offerings and reflect how much the company relies on stock-based incentives to attract and retain talent.
reverse stock split financial
"1-for-25 reverse stock split on September 8, 2023"
A reverse stock split reduces a company's number of outstanding shares while raising the price per share proportionally, so the total value of each investor's holding is unchanged; a 1-for-10 split turns 100 shares worth $1 each into 10 shares worth $10 each. Companies often do this to regain compliance with an exchange's minimum price rule or to attract investors who avoid very low-priced stocks.

FAQ

AI-generated questions and answers. How Rhea-AI works. Not financial advice.

How many SYRE shares did Scott L. Burrows sell?

Scott L. Burrows sold 25,000 shares across September 30 and October 1, 2026. The September 30 sale covered 17,500 shares at a weighted-average $89.89 per share, while October 1 sales were reported in five blocks. The October 1 transactions were pursuant to a Rule 10b5-1 trading plan adopted November 10, 2025.

What were the prices for Scott L. Burrows's October 1 SYRE sales?

The five reported blocks were 600 shares at a weighted-average $89.07 per share, 1,500 at $90.27, 2,100 at $91.92, 3,071 at $92.95, and 229 at $93.57. Their respective price ranges were $88.63–$89.53, $89.96–$90.95, $91.41–$92.26, $92.54–$93.53, and $93.54–$93.59.

What vesting schedule applied to the option reported by SYRE CFO Scott L. Burrows?

The option described a right to purchase 404,857 shares, adjusted for the issuer's 1-for-25 reverse stock split on September 8, 2023. One quarter vested and became exercisable on September 1, 2024; the remaining three quarters vest in monthly installments over the following three years, subject to continued employment.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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Learn about SEC filing dates
SEC Form 4
FORM 4UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
OMB APPROVAL
OMB Number:3235-0287
Estimated average burden
hours per response:0.5
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
X
Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.
1. Name and Address of Reporting Person*
Burrows Scott L

(Last)(First)(Middle)
221 CRESCENT STREET, BUILDING 23,
SUITE 105

(Street)
WALTHAM MASSACHUSETTS 02453

(City)(State)(Zip)

UNITED STATES

(Country)
2. Issuer Name and Ticker or Trading Symbol
Spyre Therapeutics, Inc. [ SYRE ]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
Director10% Owner
XOfficer (give title below)Other (specify below)
Chief Financial Officer
2a. Foreign Trading Symbol
3. Date of Earliest Transaction (Month/Day/Year)
09/30/2026
6. Individual or Joint/Group Filing (Check Applicable Line)
XForm filed by One Reporting Person
Form filed by More than One Reporting Person
4. If Amendment, Date of Original Filed (Month/Day/Year)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year)2A. Deemed Execution Date, if any (Month/Day/Year)3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeVAmount(A) or (D)Price
Common Stock09/30/2026M17,500A$14.597,262D
Common Stock09/30/2026S17,500D$89.89(1)79,762D
Common Stock10/01/2026M(2)7,500A$14.587,262D
Common Stock10/01/2026S(2)600D$89.07(3)86,662D
Common Stock10/01/2026S(2)1,500D$90.27(4)85,162D
Common Stock10/01/2026S(2)2,100D$91.92(5)83,062D
Common Stock10/01/2026S(2)3,071D$92.95(6)79,991D
Common Stock10/01/2026S(2)229D$93.57(7)79,762(8)D
Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year)3A. Deemed Execution Date, if any (Month/Day/Year)4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 6. Date Exercisable and Expiration Date (Month/Day/Year)7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeV(A)(D)Date ExercisableExpiration DateTitleAmount or Number of Shares
Stock Option (Right to Buy)$14.509/30/2026M17,500 (9)09/01/2033Common Stock17,500$0319,857D
Stock Option (Right to Buy)$14.510/01/2026M(2)7,500 (9)09/01/2033Common Stock7,500$0312,357D
Explanation of Responses:
1. The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $89.00 to $90.62, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission (the "SEC"), upon request, full information regarding the number of shares sold at each separate price within the range.
2. This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on November 10, 2025.
3. The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $88.63 to $89.53, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission (the "SEC"), upon request, full information regarding the number of shares sold at each separate price within the range.
4. The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $89.96 to $90.95, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.
5. The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $91.41 to $92.26, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.
6. The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $92.54 to $93.53, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.
7. The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $93.54 to $93.59, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.
8. Includes 33,738 RSUs. Each RSU represents a contingent right to receive, upon vesting, one share of the Issuer's common stock. The RSUs vest on September 1, 2027, subject to the Reporting Person's continued employment with the Issuer.
9. This option represents a right to purchase 404,857 shares of the Issuer's common stock (which have been adjusted to reflect the Issuer's 1-for-25 reverse stock split on September 8, 2023), one quarter of which vested and became exercisable on September 1, 2024, with the remaining three quarters vesting in monthly installments over the following three years, subject to the Reporting Person's continued employment with the Issuer.
Remarks:
/s/ Heidy King-Jones, as Attorney-in-Fact10/02/2026
** Signature of Reporting PersonDate
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
* Form 4: SEC 1474 (03-26)

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