Spyre Therapeutics Financials

SYRE

Source SEC Filings (10-K/10-Q) Updated Dec 31, 2025 Currency USD FYE December

This page shows Spyre Therapeutics (SYRE) financial statements, including the income statement, balance sheet, cash flow statement, and key financial ratios. View 12 years of annual fundamentals and quarterly data, with year-over-year growth rates and compound annual growth rates (CAGR). All figures are derived from SEC filings (10-K and 10-Q reports).

Financial Health Signals

Piotroski F-Score Weak

2/9

Spyre Therapeutics passes 2 of 9 financial strength tests. 1 of 4 profitability signals pass, 1 of 3 leverage/liquidity signals pass, neither operating efficiency signal passes.

Earnings Quality Low Quality

1.09x

For every $1 of reported earnings, Spyre Therapeutics generates $1.09 in operating cash flow (-$169.3M OCF vs -$155.2M net income). This low ratio suggests earnings are primarily driven by accounting accruals rather than cash generation, which may not be sustainable.

Key Financial Metrics

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Earnings & Revenue

Revenue

Spyre Therapeutics generated $0 in revenue in fiscal year 2025.

EBITDA

-$209.6M

YoY-0.5%

Spyre Therapeutics's EBITDA was -$209.6M in fiscal year 2025, measuring earnings before interest, taxes, depreciation, and amortization. This represents a decrease of 0.5% from the prior year.

Net Income

-$155.2M

YoY+25.4%

Spyre Therapeutics reported -$155.2M in net income in fiscal year 2025. This represents an increase of 25.4% from the prior year.

EPS (Diluted)

N/A

Cash & Balance Sheet

Free Cash Flow

N/A

Cash & Debt

$85.7M

YoY-4.1%

5Y CAGR-1.0%

10Y CAGR+11.3%

Spyre Therapeutics held $85.7M in cash against $0 in long-term debt as of fiscal year 2025.

Dividends Per Share

N/A

Shares Outstanding

79M

YoY+30.3%

Spyre Therapeutics had 79M shares outstanding in fiscal year 2025. This represents an increase of 30.3% from the prior year.

Margins & Returns

Gross Margin

N/A

Operating Margin

N/A

Net Margin

N/A

Return on Equity

-21.7%

YoY+18.5pp

5Y CAGR+36.2pp

Spyre Therapeutics's ROE was -21.7% in fiscal year 2025, measuring profit generated per dollar of shareholder equity. This is up 18.5 percentage points from the prior year.

Capital Allocation

R&D Spending

$171.7M

YoY+5.4%

5Y CAGR+23.5%

10Y CAGR+31.1%

Spyre Therapeutics invested $171.7M in research and development in fiscal year 2025. This represents an increase of 5.4% from the prior year.

Share Buybacks

N/A

Capital Expenditures

N/A

SYRE Income Statement

Metric	FY25	FY24	FY23	FY22	FY21	FY20
Revenue	$0	$0-100.0%	$886K-62.0%	$2.3M-87.6%	$18.7M	$0
Cost of Revenue	N/A	N/A	N/A	N/A	N/A	N/A
Gross Profit	N/A	N/A	N/A	N/A	N/A	N/A
R&D Expenses	$171.7M+5.4%	$162.8M+81.9%	$89.5M+52.8%	$58.6M+2.6%	$57.1M-4.3%	$59.6M
SG&A Expenses	$47.9M+4.7%	$45.8M+14.6%	$39.9M+40.0%	$28.5M+4.4%	$27.3M+25.1%	$21.8M
Operating Income	-$209.6M-0.5%	-$208.6M+13.9%	-$242.3M-185.8%	-$84.8M-29.1%	-$65.6M+19.4%	-$81.5M
Interest Expense	N/A	N/A	N/A	N/A	N/A	N/A
Income Tax	-$15K-129.4%	$51K+296.2%	-$26K+80.9%	-$136K-196.5%	$141K	$0
Net Income	-$155.2M+25.4%	-$208.0M+38.6%	-$338.8M-304.2%	-$83.8M-27.4%	-$65.8M+18.7%	-$80.9M
EPS (Diluted)	N/A	N/A	$13.76	$-24.86+0.6%	$-25.02-1546.1%	$-1.52

Metric	Q4'25	Q3'25	Q2'25	Q1'25	Q4'24	Q3'24	Q2'24	Q1'24
Revenue	N/A	N/A	N/A	N/A	N/A	$0	$0	$0
Cost of Revenue	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Gross Profit	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
R&D Expenses	N/A	$45.2M+12.7%	$40.1M-3.6%	$41.6M	N/A	$44.7M+37.1%	$32.6M-6.6%	$34.9M
SG&A Expenses	N/A	$11.6M-1.3%	$11.8M-1.3%	$11.9M	N/A	$10.6M-7.5%	$11.5M-10.4%	$12.8M
Operating Income	N/A	-$56.9M-35.7%	-$41.9M+21.7%	-$53.6M	N/A	-$55.4M-25.5%	-$44.1M+7.6%	-$47.8M
Interest Expense	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Income Tax	N/A	$0	$0+100.0%	-$15K	N/A	$18K	$0-100.0%	$32K
Net Income	N/A	-$11.2M+69.5%	-$36.7M+18.0%	-$44.8M	N/A	-$69.0M-77.7%	-$38.8M+11.4%	-$43.9M
EPS (Diluted)	N/A	N/A	N/A	N/A	N/A	$1.06+79.7%	$0.59-18.1%	$0.72

SYRE Balance Sheet

Metric	FY25	FY24	FY23	FY22	FY21	FY20
Total Assets	$777.8M+27.8%	$608.5M+78.0%	$341.9M+380.5%	$71.1M-35.3%	$109.9M-32.0%	$161.6M
Current Assets	$777.8M+27.8%	$608.5M+78.2%	$341.5M+448.6%	$62.3M-37.0%	$98.9M-34.0%	$149.8M
Cash & Equivalents	$85.7M-4.1%	$89.4M-52.7%	$188.9M+441.8%	$34.9M+130.2%	$15.1M-83.2%	$90.1M
Inventory	N/A	N/A	N/A	N/A	N/A	N/A
Accounts Receivable	N/A	N/A	N/A	N/A	N/A	N/A
Goodwill	N/A	N/A	N/A	N/A	N/A	N/A
Total Liabilities	$62.5M-31.0%	$90.7M-42.6%	$157.8M+657.4%	$20.8M-19.8%	$26.0M+19.3%	$21.8M
Current Liabilities	$58.7M+8.6%	$54.1M+69.1%	$32.0M+118.2%	$14.7M-27.2%	$20.1M+22.5%	$16.4M
Long-Term Debt	N/A	N/A	N/A	N/A	N/A	N/A
Total Equity	$715.2M+38.1%	$517.8M+181.4%	$184.0M+265.8%	$50.3M-40.1%	$83.9M-40.0%	$139.8M
Retained Earnings	-$1.1B-16.0%	-$972.4M-27.2%	-$764.4M-79.6%	-$425.6M-24.5%	-$341.8M-23.8%	-$276.0M

Metric	Q4'25	Q3'25	Q2'25	Q1'25	Q4'24	Q3'24	Q2'24	Q1'24
Total Assets	$777.8M+54.1%	$504.6M-6.4%	$538.8M-5.4%	$569.8M-6.4%	$608.5M+44.5%	$421.1M-3.4%	$436.1M-10.6%	$487.6M
Current Assets	$777.8M+54.1%	$504.6M-6.4%	$538.8M-5.4%	$569.8M-6.4%	$608.5M+44.5%	$421.1M-3.4%	$435.7M-10.6%	$487.3M
Cash & Equivalents	$85.7M+32.1%	$64.9M-20.5%	$81.7M+68.4%	$48.5M-45.8%	$89.4M+24.9%	$71.6M+58.6%	$45.1M-80.2%	$227.6M
Inventory	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Accounts Receivable	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Goodwill	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Total Liabilities	$62.5M+26.3%	$49.5M-40.4%	$83.1M-4.7%	$87.2M-3.9%	$90.7M-3.2%	$93.7M+51.9%	$61.7M-81.6%	$335.3M
Current Liabilities	$58.7M+26.8%	$46.3M-44.3%	$83.1M+17.5%	$70.7M+30.7%	$54.1M-6.0%	$57.5M+160.1%	$22.1M-48.3%	$42.8M
Long-Term Debt	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Total Equity	$715.2M+57.2%	$455.1M-0.1%	$455.8M-5.6%	$482.6M-6.8%	$517.8M+58.2%	$327.4M-12.6%	$374.4M+145.9%	$152.3M
Retained Earnings	-$1.1B-5.9%	-$1.1B-1.1%	-$1.1B-3.6%	-$1.0B-4.6%	-$972.4M-6.1%	-$916.1M-8.1%	-$847.1M-4.8%	-$808.3M

SYRE Cash Flow Statement

Metric	FY25	FY24	FY23	FY22	FY21	FY20
Operating Cash Flow	-$169.3M-7.5%	-$157.4M-57.6%	-$99.9M-24.7%	-$80.1M-49.2%	-$53.7M+29.1%	-$75.8M
Capital Expenditures	N/A	$0	$0-100.0%	$38K-93.4%	$573K-86.6%	$4.3M
Free Cash Flow	N/A	-$157.4M-57.6%	-$99.9M-24.6%	-$80.2M-47.7%	-$54.3M+32.2%	-$80.1M
Investing Cash Flow	-$143.5M+59.4%	-$353.3M-225.9%	-$108.4M-290.1%	$57.0M+352.0%	-$22.6M-197.5%	-$7.6M
Financing Cash Flow	$309.0M-24.8%	$410.9M+13.8%	$361.1M+746.0%	$42.7M+2963.7%	$1.4M-99.1%	$154.5M
Dividends Paid	N/A	N/A	N/A	N/A	N/A	N/A
Share Buybacks	N/A	N/A	N/A	N/A	N/A	N/A

Metric	Q4'25	Q3'25	Q2'25	Q1'25	Q4'24	Q3'24	Q2'24	Q1'24
Operating Cash Flow	-$44.6M-20.1%	-$37.1M+20.3%	-$46.6M-13.6%	-$41.0M-10.2%	-$37.2M-26.4%	-$29.4M+52.7%	-$62.2M-118.1%	-$28.5M
Capital Expenditures	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Free Cash Flow	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Investing Cash Flow	-$247.4M-1089.7%	$25.0M-68.4%	$79.0M+129604.9%	-$61K+100.0%	-$170.5M-499.0%	$42.7M+135.5%	-$120.5M-14.8%	-$105.0M
Financing Cash Flow	$312.8M+6837.3%	-$4.6M-735.2%	$731K+484.8%	$125K-99.9%	$225.6M+1665.3%	$12.8M+3450.0%	$360K-99.8%	$172.2M
Dividends Paid	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Share Buybacks	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A

SYRE Financial Ratios

Metric	FY25	FY24	FY23	FY22	FY21	FY20
Gross Margin	N/A	N/A	N/A	N/A	N/A	N/A
Operating Margin	N/A	N/A	-27348.0%-23707.7pp	-3640.2%-3289.9pp	-350.3%	N/A
Net Margin	N/A	N/A	-38238.2%-34639.4pp	-3598.7%-3247.6pp	-351.1%	N/A
Return on Equity	-21.7%+18.5pp	-40.2%+143.9pp	-184.1%-17.5pp	-166.6%-88.2pp	-78.4%-20.5pp	-57.9%
Return on Assets	-20.0%+14.2pp	-34.2%+64.9pp	-99.1%+18.7pp	-117.8%-57.9pp	-59.9%-9.8pp	-50.0%
Current Ratio	13.25+2.0	11.26+0.6	10.68+6.4	4.25-0.7	4.91-4.2	9.11
Debt-to-Equity	0.09-0.1	0.18-0.7	0.86+0.4	0.41+0.1	0.31+0.2	0.16
FCF Margin	N/A	N/A	-11276.5%-7833.7pp	-3442.8%-3153.1pp	-289.7%	N/A

Metric	Q4'25	Q3'25	Q2'25	Q1'25	Q4'24	Q3'24	Q2'24	Q1'24
Gross Margin	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Operating Margin	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Net Margin	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Return on Equity	N/A	-2.5%+5.6pp	-8.1%+1.2pp	-9.3%	N/A	-21.1%-10.7pp	-10.4%+18.4pp	-28.8%
Return on Assets	N/A	-2.2%+4.6pp	-6.8%+1.1pp	-7.9%	N/A	-16.4%-7.5pp	-8.9%+0.1pp	-9.0%
Current Ratio	13.25+2.3	10.90+4.4	6.49-1.6	8.06-3.2	11.26+3.9	7.32-12.4	19.70+8.3	11.38
Debt-to-Equity	0.09-0.0	0.11-0.1	0.180.0	0.180.0	0.18-0.1	0.29+0.1	0.16-2.0	2.20
FCF Margin	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A

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Frequently Asked Questions

What is Spyre Therapeutics's annual revenue?

Spyre Therapeutics (SYRE) reported $0 in total revenue for fiscal year 2025. Revenue measures the total income earned from the company's primary business operations before any expenses are deducted.

Is Spyre Therapeutics profitable?

No, Spyre Therapeutics (SYRE) reported a net income of -$155.2M in fiscal year 2025.

What is Spyre Therapeutics's EBITDA?

Spyre Therapeutics (SYRE) had EBITDA of -$209.6M in fiscal year 2025, measuring earnings before interest, taxes, depreciation, and amortization.

What is Spyre Therapeutics's return on equity (ROE)?

Spyre Therapeutics (SYRE) has a return on equity of -21.7% for fiscal year 2025, measuring how efficiently the company generates profit from shareholder equity.

What is Spyre Therapeutics's operating cash flow?

Spyre Therapeutics (SYRE) generated -$169.3M in operating cash flow during fiscal year 2025, representing cash generated from core business activities.

What are Spyre Therapeutics's total assets?

Spyre Therapeutics (SYRE) had $777.8M in total assets as of fiscal year 2025, including both current and long-term assets.

How much does Spyre Therapeutics spend on research and development?

Spyre Therapeutics (SYRE) invested $171.7M in research and development during fiscal year 2025.

How many shares does Spyre Therapeutics have outstanding?

Spyre Therapeutics (SYRE) had 79M shares outstanding as of fiscal year 2025.

What is Spyre Therapeutics's current ratio?

Spyre Therapeutics (SYRE) had a current ratio of 13.25 as of fiscal year 2025, which is generally considered healthy.

What is Spyre Therapeutics's debt-to-equity ratio?

Spyre Therapeutics (SYRE) had a debt-to-equity ratio of 0.09 as of fiscal year 2025, measuring the company's financial leverage by comparing total debt to shareholder equity.

What is Spyre Therapeutics's return on assets (ROA)?

Spyre Therapeutics (SYRE) had a return on assets of -20.0% for fiscal year 2025, measuring how efficiently the company uses its assets to generate profit.

What is Spyre Therapeutics's cash runway?

Based on fiscal year 2025 data, Spyre Therapeutics (SYRE) had $85.7M in cash against an annual operating cash burn of $169.3M. This gives an estimated cash runway of approximately 6 months at the current burn rate. Cash runway measures how long a company can continue operating before running out of cash, assuming no additional funding.

What is Spyre Therapeutics's Piotroski F-Score?

Spyre Therapeutics (SYRE) has a Piotroski F-Score of 2 out of 9, indicating weak financial health. The F-Score evaluates nine binary signals across profitability (positive ROA, positive cash flow, improving ROA, earnings quality), leverage (decreasing debt, improving liquidity, no share dilution), and operating efficiency (improving gross margin, improving asset turnover). Scores of 7–9 indicate strong and improving fundamentals. Learn more in our complete guide to financial health indicators.

Are Spyre Therapeutics's earnings high quality?

Spyre Therapeutics (SYRE) has an earnings quality ratio of 1.09x, considered low quality (accrual-driven). This ratio compares operating cash flow to net income. A ratio above 1.0x means the company generates more cash than its reported earnings, indicating sustainable, cash-backed profits. Ratios below 1.0x suggest earnings rely on accounting accruals rather than actual cash generation. Learn more in our complete guide to financial health indicators.