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Ascentage Pharma Reports 2026 Interim Unaudited Financial Results and Provides Business Updates

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Ascentage Pharma (NASDAQ: AAPG) reported unaudited results for the six months ended June 30, 2026, with revenue rising 29% year-over-year on a constant currency basis to US$44.5 million (RMB302.2 million), driven by a 32.6% increase in product sales to US$41.6 million. Gross profit reached RMB290.5 million (US$42.8 million).

Operating expenses expanded significantly: selling and distribution expenses grew 64.3% to US$33.4 million, research and development expenses increased 32.0% to US$102.8 million, and administrative expenses rose 19.3% to US$17.5 million. Loss for the period widened to US$120.4 million, or US$0.32 per share. Cash and bank balances were US$279.4 million, down from US$353.2 million at year-end 2025, mainly due to higher R&D spending.

The company highlighted commercial expansion of Olverembatinib and Lisaftoclax in China and progress across nine registrational Phase III trials, plus FDA and China CDE IND clearances for BTK degrader APG-3288. New Chief Business and Chief Commercial Officers were appointed, and the “B” marker was removed from its HKEX short name.

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Positive

  • Revenue +29.3% YoY to US$44.5 million for H1 2026, driven by product sales growth
  • Product sales +32.6% YoY on a constant currency basis to US$41.6 million in H1 2026
  • Olverembatinib formulary reach expanded to 879 DTP pharmacies and hospitals, including 394 hospitals, up 34% YoY
  • Lisaftoclax market presence at 415 DTP pharmacies and hospitals, including 60 hospitals, as of June 30, 2026
  • Nine registrational Phase III trials in progress globally, including FDA- and EMA-cleared POLARIS and GLORA programs
  • APG-3288 IND clearances obtained from FDA and China CDE in early 2026, enabling a global Phase I study
  • Cash and bank balances of US$279.4 million as of June 30, 2026, providing funding for ongoing trials

Negative

  • Net loss widened to US$120.4 million for H1 2026 from US$82.5 million a year earlier
  • Loss per share increased to US$0.32 from US$0.24 for the comparable 2025 period
  • R&D expenses +32.0% YoY to US$102.8 million, reflecting higher global clinical trial costs
  • Selling and distribution expenses +64.3% YoY to US$33.4 million, mainly from increased Lisaftoclax marketing
  • Other expenses +71.9% YoY to US$10.2 million, primarily due to higher foreign exchange loss and donations
  • Cash and bank balances decreased by US$73.8 million since December 31, 2025, mainly due to accelerated clinical spending

Market Context

Comparable earnings events recorded reactions of -4.84%, +1.05%, and +9.96%, providing a mixed histo...
Analysis

Comparable earnings events recorded reactions of -4.84%, +1.05%, and +9.96%, providing a mixed historical benchmark. This interim report balanced revenue expansion with a larger loss; cash usage remains a risk to monitor.

Key Figures

Revenue: US$44.5 million Revenue growth: 29% year-over-year Product sales: US$41.6 million +5 more
8 metrics
Revenue US$44.5 million First half of 2026
Revenue growth 29% year-over-year First half of 2026
Product sales US$41.6 million First half of 2026; up 32.6% on a constant currency basis
Selling and distribution expenses US$33.4 million First half of 2026; up 64.3% on a constant currency basis
Research and development expenses US$102.8 million First half of 2026; up 32.0% on a constant currency basis
Net loss US$120.4 million First half of 2026
Loss per share US$0.32 per ordinary share First half of 2026
Cash and bank balances US$279.4 million As of June 30, 2026

Previous Earnings Reports

3 past events · Latest: Mar 25 (Negative)
Same Type Pattern 3 events
Date Event Sentiment 24h Move Catalyst
Mar 25 Full-year earnings Negative -4.8% Revenue declined while annual losses and operating investment increased.
Aug 20 Interim earnings Positive +1.1% Product sales growth and Lisaftoclax approval supported the interim update.
Mar 27 Full-year earnings Positive +10.0% Revenue growth, reduced losses, and Nasdaq IPO proceeds strengthened results.

24h Move is the share-price change in the day after each event; other market factors may also have contributed.

Pattern Detected

Comparable earnings disclosures produced mixed reactions, ranging from a negative response to strong positive gains.

Key Terms

tki, bcr-abl1, pharmacokinetics, protac, +1 more
5 terms
tki medical
"Olverembatinib is a novel, third-generation TKI"
A TKI (tyrosine kinase inhibitor) is a type of drug that blocks specific enzymes cells use to send growth signals, effectively slowing or stopping the proliferation of certain cancer and disease cells. For investors, TKIs matter because they are often central to a biotech company's product pipeline and revenue potential: successful TKIs can win regulatory approval, command premium pricing, and shift competitive dynamics in treatment markets, much like a key component that can make or break a new technology's commercial success.
bcr-abl1 medical
"the first third-generation BCR-ABL1 TKI approved in China"
bcr-abl1 is an abnormal gene created when two separate genes join together, producing a protein that acts like a stuck accelerator in a cell and drives uncontrolled blood-cell growth. It matters to investors because it is a clear diagnostic marker and the direct target of several important cancer therapies; changes in testing, treatment approvals, or trial results for drugs aimed at bcr-abl1 can significantly affect clinical use, sales forecasts, and company valuations.
pharmacokinetics medical
"evaluating APG-3288’s pharmacokinetics, safety, tolerability"
Pharmacokinetics is the study of how a substance, such as a drug or chemical, moves through and is processed by the body over time. It tracks how it is absorbed, distributed, broken down, and eventually eliminated. For investors, understanding pharmacokinetics helps gauge the effectiveness, safety, and potential risks of new medications or treatments, which can influence a company’s success and valuation in the healthcare industry.
protac technical
"our proprietary proteolysis-targeting chimera (PROTAC) technology platform"
A PROTAC (proteolysis targeting chimera) is a small engineered molecule that tags a specific protein inside cells and brings it to the cell’s disposal machinery so the protein is destroyed rather than just blocked. Think of it as a targeted cleanup crew that removes a problematic part instead of temporarily turning it off. Investors care because PROTACs can tackle disease targets that traditional drugs cannot, creating potential for breakthrough therapies, larger markets, and binary clinical readouts that can sharply affect company value.
ind clearance regulatory
"Received IND clearance from the FDA in January 2026"
IND clearance is regulatory authorization that allows a company to begin testing an experimental drug in human clinical trials. Think of it as a safety-passport from regulators confirming enough preclinical evidence exists to move from lab work to people; for investors it marks a major development milestone that de-risks the program’s path to approval, unlocks value-driving data milestones, and often influences funding, partnerships, and stock value.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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  • Revenue for the first half of 2026 increased 29% year-over-year to US$44.5 million (RMB302.2 million), primarily attributable to increased product sales.
  • Expanded executive leadership with appointments of Dr. Faical Miyara as Chief Business Officer and Mr. James Ziegler as Chief Commercial Officer
  • Nine registrational Phase III clinical trials are in progress worldwide, including four cleared by FDA and EMA
  • Chinese (Mandarin) investor webcast at 9:00 am HKT on August 20, 2026 / 9:00 pm EDT on August 19, 2026; and English language investor webcast at 8:00 am EDT / 8:00 pm HKT on August 20, 2026

ROCKVILLE, Md., Aug. 19, 2026 (GLOBE NEWSWIRE) -- Ascentage Pharma Group International (Ascentage Pharma) (NASDAQ: AAPG; HKEX: 6855) (referred hereinto as “Ascentage Pharma,” the “Company,” “we,” “us” or “our”), a global, commercial stage, integrated biopharmaceutical company engaged in the discovery, development and commercialization of novel, differentiated therapies to address unmet medical needs in cancer, today reported its unaudited financial results for the six months ended June 30, 2026, and provided updates on key ongoing clinical programs and commercial activities.

Dr. Dajun Yang, Chairman and Chief Executive Officer of Ascentage Pharma, said, "During the first half of 2026, we continued to execute on our key strategic priorities while expanding our global footprint. The appointments of Dr. Faiçal Miyara as Chief Business Officer and Mr. Jim Ziegler as Chief Commercial Officer further strengthen our strategic capabilities and commercial leadership as we continue building a global commercial-stage oncology company."

Key Commercial Product and Pipeline Updates

Olverembatinib (HQP1351) is a novel, third-generation TKI and the first third-generation BCR-ABL1 TKI approved in China for treatment of patients with chronic myeloid leukemia (CML) in chronic-phase (-CP) or CML in accelerated phase (-AP) with T315I mutations, and in CML-CP that is resistant and/or intolerant to first and second-generation TKIs.

Commercial progress

  • The number of Direct-to-Patient (DTP) pharmacies and hospitals where Olverembatinib is on the formulary reached 879 as of June 30, 2026, a 12% increase compared to 782 as of June 30, 2025. In particular, the number of hospitals where Olverembatinib is on the formulary increased by 34% over the same period, to 394 hospitals as of June 30, 2026, from 295 hospitals as of June 30, 2025.

Clinical progress

  • Enrollment continues in an FDA and EMA-cleared global registrational Phase III clinical trial of Olverembatinib in combination with chemotherapy versus investigator-choice TKI in combination with chemotherapy in patients with newly diagnosed Philadelphia chromosome positive ALL (Ph+ ALL) (POLARIS-1).

  • Enrollment continues in an FDA and EMA-cleared global registrational Phase III clinical trial of Olverembatinib for previously treated CML-CP patients, both with and without the T315I mutation (POLARIS-2).

  • Enrollment continues in a multinational registrational Phase III clinical trial of Olverembatinib for the treatment of patients with succinate dehydrogenase (SDH)-deficient gastrointestinal stromal tumor (GIST) who have not responded to prior systemic treatment (POLARIS-3).

  • Continue to evaluate Olverembatinib in combination with the Bcl-2 inhibitor Lisaftoclax in early-phase clinical trials.

Upcoming milestones

  • Continue to advance enrollment in the POLARIS-1, POLARIS-2, and POLARIS-3 trials.

Lisaftoclax (APG-2575) is a novel, oral B-cell lymphoma 2 (Bcl-2) inhibitor developed to treat a variety of hematologic malignancies and solid tumors by selectively blocking Bcl-2 to restore the normal apoptosis process in cancer cells.

Commercial progress

  • As of June 30, 2026, the number of DTP pharmacies and hospitals where Lisaftoclax is on the formulary reached 415, including 60 hospitals where Lisaftoclax is on the formulary.

Clinical progress

  • Enrollment continues in an FDA and EMA-cleared global, registrational Phase III clinical trial of Lisaftoclax in combination with AZA for the treatment of patients with newly diagnosed HR-MDS (GLORA-4).

  • Enrollment continues in a multinational registrational Phase III clinical trial of Lisaftoclax in combination with AZA for the treatment of elderly or unfit patients with newly diagnosed AML (GLORA-3).

  • Enrollment continues in a registrational Phase III clinical trial to evaluate Lisaftoclax in combination with the BTK inhibitor acalabrutinib, versus immunochemotherapy in patients with previously untreated CLL/SLL, to investigate a fixed duration of combination regimen as a first-line treatment (GLORA-2).

  • Enrollment continues in an FDA and EMA-cleared global registrational Phase III clinical trial of Lisaftoclax in combination with BTK inhibitors in patients with CLL/SLL previously treated sub-optimally with BTK inhibitors (GLORA).

  • Enrollment continues in Phase Ib/II clinical trials of Lisaftoclax in combination with other therapies for the treatment of patients with multiple myeloma (MM) in the United States.

  • Enrollment continues in a Phase Ib/II study of Lisaftoclax as a single agent or in combination with other therapies for the treatment of patients with AML/MDS, including patients resistant to venetoclax, in China.

  • Enrollment continues in Phase Ib/II studies of Lisaftoclax in combination with other therapies for the treatment of patients with AML/MDS in the United States.

Upcoming milestones

  • Plan to initiate clinical studies to confirm Lisaftoclax’s potential to overcome venetoclax resistance in patients who have failed venetoclax treatment.

  • Continue to advance enrollment in the GLORA, GLORA-2, GLORA-3, and GLORA-4 trials.

  • Plan to actively advance the inclusion of Lisaftoclax in China’s NRDL in 2026.

APG-3288 is a novel, highly potent, and selective BTK degrader and first clinical candidate developed utilizing our proprietary proteolysis-targeting chimera (PROTAC) technology platform. 

Clinical progress

  • Received IND clearance from the FDA in January 2026 and received IND application clearance from the China CDE in February 2026.

  • Continue to advance the global Phase I study evaluating APG-3288’s pharmacokinetics, safety, tolerability and efficacy data in patients with relapsed/refractory B-cell malignancies, including in the U.S. and China.

Business Updates

  • Appointment of Dr. Faiçal Miyara as Chief Business Officer and Jim Ziegler as Chief Commercial Officer

  • Removal of the “B” marker from the HKEX stock short name

Half Year 2026 Unaudited Financial Results

Revenue for the six months ended June 30, 2026 was US$44.5 million, compared to US$32.6 million for the six months ended June 30, 2025, which represented an increase of US$11.9 million, or 29.3% on a constant currency basis. The increase in revenue was primarily due to product sales, which increased by US$11.9 million, or 32.6% on a constant currency basis, to US$41.6 million for the first half of 2026 from US$29.7 million for the six months ended June 30, 2025.

Selling and distribution expenses for the six months ended June 30, 2026 were US$33.4 million, compared to US$19.2 million for the six months ended June 30, 2025, which represented an increase of US$14.2 million, or 64.3% on a constant currency basis. The increase was mainly attributable to increased marketing and promotion investment for Lisaftoclax.

Research and development expenses for the six months ended June 30, 2026 were US$102.8 million, compared to US$73.8 million for the six months ended June 30, 2025, which represented an increase of US$29.0 million, or 32.0% on a constant currency basis. The increase was attributable to increased internal research and development expenses related to our ongoing global clinical trials.

Administrative expenses for the six months ended June 30, 2026 were US$17.5 million, compared to US$13.9 million for the six months ended June 30, 2025, which represented an increase of US$3.6 million, or 19.3% on a constant currency basis. The increase was due to an increase in Share Option and RSU expenses.

Other expenses for the six months ended June 30, 2026 were US$10.2 million, compared to US$5.6 million for the six months ended June 30, 2025, which represented an increase of US$4.6 million, or 71.9% on a constant currency basis. The increase was primarily attributable to the increase in foreign exchange loss and donation expenditure.

Loss for the six months ended June 30, 2026 was US$120.4 million, compared to the loss of US$82.5 million for the six months ended June 30, 2025. The loss per share attributable to ordinary equity holders was US$0.32 per ordinary share for the six months ended June 30, 2026, compared to the loss per share of US$0.24 per ordinary share for the six months ended June 30, 2025.

Cash and bank balances as of June 30, 2026, were US$279.4 million, compared to US$353.2 million as of December 31, 2025, which represented a decrease of US$73.8 million, or 23.3% on a constant currency basis. The decrease was primarily due to the acceleration of global clinical progress, leading to a significant increase in research and development expenses.

Investor Conference Call and Webcast

Ascentage Pharma will be holding investor webcasts to discuss its six months 2026 unaudited interim results.

Ascentage Pharma will host the Chinese (Mandarin) investor webcast at 9:00 am HKT on August 20, 2026 / 9:00 pm EDT on August 19, 2026. To access the Chinese language investor event or conference call, please register in advance here.

The English language investor webcast will be held at 8:00 am EDT / 8:00 pm HKT on August 20, 2026. To access the English language webcast, please register in advance here. The webcast replay for English language conference call and presentation will also be available on the News & Events page of the Ascentage Pharma website.

Currency and Exchange Rate Information

Unless otherwise indicated, translations from RMB to U.S. dollars for the six months ended June 30, 2026 and 2025 and as at December 31, 2025 are made at RMB6.7851 to US$1.00, RMB7.1636 to US$1.00 and RMB6.9931 to US$1.00, respectively, representing the noon buying rate in the City of New York, as certified by the Federal Reserve Bank of New York, on June 30, 2026, June 30, 2025 and December 31, 2025. Ascentage Pharma makes no representation that the RMB or U.S. dollar amounts referred to in this press release could have been or could be converted into U.S. dollars or RMB, as the case may be, at any particular rate or at all.

About Ascentage Pharma

Ascentage Pharma Group International (NASDAQ: AAPG; HKEX: 6855) (“Ascentage Pharma” or the “Company”) is a global, commercial stage, integrated biopharmaceutical company engaged in the discovery, development and commercialization of novel, differentiated therapies to address unmet medical needs in cancer. The Company has built a rich pipeline of innovative drug products and candidates that include inhibitors targeting key proteins in the apoptotic pathway, such as Bcl-2 and MDM2-p53, next-generation kinase inhibitors, and protein degraders.

The Company’s first approved product, Olverembatinib, is the first novel third-generation BCR-ABL1 inhibitor approved in China for the treatment of patients with CML in chronic phase (CML-CP) with T315I mutations, CML in accelerated phase (CML-AP) with T315I mutations, and CML-CP that is resistant or intolerant to first and second-generation TKIs. It is covered by the China National Reimbursement Drug List (NRDL). Ascentage Pharma is currently conducting an FDA- and EMA-cleared registrational Phase III trial, called POLARIS-2, of Olverembatinib for CML, as well as FDA- and EMA-cleared registrational Phase III trials for patients with newly diagnosed Ph+ ALL, called POLARIS-1, and SDH-deficient GIST patients, called POLARIS-3.

The Company’s second approved product, Lisaftoclax, is a novel Bcl-2 inhibitor for the treatment of various hematologic malignancies. Lisaftoclax has been approved by China’s National Medical Products Administration (NMPA) for the treatment of adult patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) who have previously received at least one systemic therapy including Bruton’s tyrosine kinase (BTK) inhibitors. The Company is currently conducting four global registrational Phase III trials: the FDA- and EMA-cleared GLORA study of Lisaftoclax in combination with BTK inhibitors in patients with CLL/SLL previously treated with BTK inhibitors for more than 12 months with suboptimal response; the GLORA-2 study in patients with newly diagnosed CLL/SLL; the GLORA-3 study in newly diagnosed, elderly and unfit patients with AML; and the FDA- and EMA-cleared GLORA-4 study in patients with newly diagnosed higher risk MDS.

Leveraging its robust R&D capabilities, Ascentage Pharma has built a portfolio of global intellectual property rights and entered into global partnerships and other relationships with numerous leading biotechnology and pharmaceutical companies, such as Takeda, AstraZeneca, Merck, Pfizer, and Innovent, in addition to research and development relationships with leading research institutions, such as Dana-Farber Cancer Institute, Mayo Clinic, National Cancer Institute and the University of Michigan. For more information, visit https://ascentage.com/

Cautionary Note Regarding Forward-Looking Statements

This press release includes forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 and Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. All statements, other than statements of historical facts, contained in this press release may be forward-looking statements, including statements that express Ascentage Pharma’s opinions, expectations, beliefs, plans, objectives, assumptions or projections regarding future events or future results of operations or financial condition. These forward-looking statements are subject to a number of risks and uncertainties as discussed in Ascentage Pharma’s filings with the SEC, including those set forth in the sections titled “Risk factors” and “Cautionary note regarding forward-looking statements” in its Annual Report on Form 20-F for the year ended December 31, 2025, filed with the SEC on April 29, 2026, the sections headed “Forward-looking Statements” and “Risk Factors” in the prospectus of the Company for its Hong Kong initial public offering dated October 16, 2019, and other filings with the SEC and/or The Stock Exchange of Hong Kong Limited where the Company’s ordinary shares are listed it has made or it makes from time to time that may cause actual results, levels of activity, performance or achievements to be materially different from the information expressed or implied by these forward-looking statements. The forward-looking statements contained in this press release do not constitute profit forecast by the Company’s management.

As a result of these factors, you should not rely on these forward-looking statements as predictions of future events. The forward-looking statements contained in this press release are based on Ascentage Pharma’s current expectations and beliefs concerning future developments and their potential effects and speak only as of the date of such statements. Ascentage Pharma does not undertake any obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise.

Contact Information

Investor Relations:

Ascentage Pharma
IR@ascentage.com
+1 (301) 792-6286

astr partners
brian.korb@astrpartners.com
+1 (917) 653-5122

Ascentage Pharma Group International         
UNAUDITED INTERIM CONDENSED CONSOLIDATED STATEMENT OF PROFIT OR LOSS
(Amounts in thousands of Renminbi (“RMB”) and U.S. dollar (“US$”), except for number of shares and per share data)
             
             
  For the Six Months Ended June 30,
  2024  2025  2026  2026 
  RMB RMB RMB US$
  (Unaudited) (Unaudited) (Unaudited) (Unaudited)
REVENUE        
Intellectual property  678,416   -   -   - 
Products    124,823   212,874   282,367   41,616 
Others  20,507   20,825   19,847   2,925 
Total revenue  823,746   233,699   302,214   44,541 
             
Cost of sales            
Products  (14,158)  (20,659)  (10,788)  (1,590)
Others  (901)  (991)  (935)  (138)
Total cost of sales  (15,059)  (21,650)  (11,723)  (1,728)
             
Gross profit  808,687   212,049   290,491   42,813 
             
Other income and gains  17,346   36,661   44,827   6,607 
Selling and distribution expenses  (89,637)  (137,787)  (226,355)  (33,361)
Administrative expenses  (86,988)  (99,685)  (118,930)  (17,528)
Research and development expenses  (444,079)  (528,561)  (697,460)  (102,793)
Other expenses  (7,106)  (40,192)  (69,110)  (10,186)
Finance costs  (34,076)  (27,798)  (26,814)  (3,952)
Share of (loss)/profit of a joint venture  (1,252)  1   (22)  (3)
             
PROFIT/(LOSS) BEFORE TAX  162,895   (585,312)  (803,373)  (118,403)
             
Income tax expense  (69)  (5,512)  (13,625)  (2,008)
             
PROFIT/(LOSS) FOR
THE PERIOD
  162,826   (590,824)  (816,998)  (120,411)
             
Attributable to:            
Ordinary equity holders of the Company  163,001   (590,768)  (816,694)  (120,366)
Non-controlling interests  (175)  (56)  (304)  (45)
             
   162,826   (590,824)  (816,998)  (120,411)
EARNINGS/(LOSS) PER SHARE ATTRIBUTABLE TO ORDINARY EQUITY HOLDERS OF THE COMPANY 
Basic  0.56   (1.73)  (2.19)  (0.32)
Diluted  0.55   (1.73)  (2.19)  (0.32)
                 


Ascentage Pharma Group International      
UNAUDITED INTERIM CONDENSED CONSOLIDATED STATEMENT OF COMPREHENSIVE LOSS
(Amounts in thousands of Renminbi (“RMB”) and U.S. dollar (“US$”), except for number of shares and per share data)
            
            
 For the Six Months Ended June 30,
 2024  2025  2026  2026 
 RMB RMB RMB US$
 (Unaudited) (Unaudited) (Unaudited) (Unaudited)
PROFIT/(LOSS) FOR THE PERIOD 162,826   (590,824)  (816,998)  (120,411)
            
OTHER COMPREHENSIVE INCOME/(LOSS)           
Other comprehensive income that may be reclassified to profit or loss in subsequent periods:           
Exchange differences on translation of foreign operations 40   1,095   29,078   4,285 
Other comprehensive income that will not be reclassified to profit or loss in subsequent periods, net of tax:           
Exchange differences on translation of the Company 2,229   (2,035)  (57,207)  (8,431)
OTHER COMPREHENSIVE INCOME/(LOSS) FOR THE PERIOD, NET OF TAX 2,269   (940)  (28,129)  (4,146)
TOTAL COMPREHENSIVE INCOME/(LOSS) FOR THE PERIOD 165,095   (591,764)  (845,127)  (124,557)
            
Attributable to:           
Ordinary equity holders of the Company 165,270   (591,708)  (844,823)  (124,512)
Non-controlling interests (175)  (56)  (304)  (45)
            
  165,095   (591,764)  (845,127)  (124,557)
                


Ascentage Pharma Group International        
UNAUDITED INTERIM CONDENSED CONSOLIDATED STATEMENT OF FINANCIAL POSITION
(Amounts in thousands of Renminbi (“RMB”) and U.S. dollar (“US$”), except for number of shares and per share data)
          
          
  As at
  December 31, 2025 June 30,
2026
 June 30,
2026
  RMB RMB US$
    (Unaudited) (Unaudited)
NON-CURRENT ASSETS      
Property, plant and equipment  781,235  751,518  110,760
Right-of-use assets  47,827  48,915  7,209
Goodwill  24,694  24,694  3,639
Other intangible assets  65,936  37,566  5,537
Investment in a joint venture  33,030  33,009  4,865
Financial assets at fair value through profit or loss (“FVTPL”)4,000  7,000  1,032
Deferred tax assets  31,957  18,375  2,708
Other non-current assets  30,725  26,361  3,885
          
Total non-current assets  1,019,404  947,438  139,635
          
CURRENT ASSETS         
Inventories  28,618  64,300  9,477
Trade receivables, net  252,938  156,396  23,050
Prepayments, other receivables and other assets192,532  176,985  26,084
Cash and bank balances  2,470,085  1,895,583  279,374
          
Total current assets  2,944,173  2,293,264  337,985
          
CURRENT LIABILITIES         
Trade payables  106,740  106,912  15,756
Other payables and accruals  276,666  231,932  34,183
Contract liabilities  37,485  69,539  10,249
Interest-bearing bank and other borrowings 1,222,481  1,475,122  217,406
          
Total current liabilities  1,643,372  1,883,505  277,594
          
NET CURRENT ASSETS  1,300,801  409,759  60,391
          
TOTAL ASSETS LESS CURRENT LIABILITIES 2,320,205  1,357,197  200,026
          


       
Ascentage Pharma Group International       
UNAUDITED INTERIM CONDENSED CONSOLIDATED STATEMENT OF FINANCIAL POSITION
(Amounts in thousands of Renminbi (“RMB”) and U.S. dollar (“US$”), except for number of shares and per share data)
         
         
  As at
  December 31, 2025 June 30,
2026
 June 30,
2026
  RMB RMB US$
    (Unaudited) (Unaudited)
NON-CURRENT LIABILITIES      
Contract liabilities  210,224   158,453   23,353
 
Interest-bearing bank and other borrowings 757,238   619,449   91,295 
Deferred income  6,500   6,300   929 
Other non-current liabilities  12,031   7,162   1,056 
          
Total non-current liabilities  985,993   791,364   116,633 
          
TOTAL LIABILITIES  2,629,365   2,674,869   394,227 
          
EQUITY         
Equity attributable to ordinary equity holders of the Company     
Ordinary shares (par value of US$0.0001 per share as of December 31, 2025 and June 30, 2026; 373,321,692 and 373,555,768 shares authorized, issued and outstanding as of December 31, 2025 and June 30, 2026, respectively)256   256   38 
Treasury shares  (2,961)  (16,362)  (2,411)
Share premium  8,916,853   8,926,700   1,315,632 
Capital and reserves  (397,276)  (316,974)  (46,716)
Exchange fluctuation reserve  (179,086)  (207,215)  (30,540)
Accumulated losses  (7,013,324)  (7,830,018)  (1,154,002)
   1,324,462   556,387   82,001 
          
Non-controlling interests  9,750   9,446   1,392 
          
Total equity
  1,334,212
   565,833   83,393 



FAQ

How did Ascentage Pharma (NASDAQ: AAPG) perform financially in the first half of 2026?

Ascentage Pharma reported H1 2026 revenue of US$44.5 million, up 29.3% year-over-year on a constant currency basis. According to the company, this growth was mainly driven by product sales, but the net loss widened to US$120.4 million with loss per share of US$0.32.

What drove Ascentage Pharma’s revenue growth in H1 2026 (AAPG)?

Revenue growth was primarily driven by higher product sales, which rose to US$41.6 million, a 32.6% increase on a constant currency basis. According to Ascentage Pharma, expanding commercialization of Olverembatinib and Lisaftoclax in China contributed to the 29.3% year-over-year increase in total revenue.

Why did Ascentage Pharma’s net loss increase in the first half of 2026?

Net loss increased to US$120.4 million from US$82.5 million a year earlier, mainly due to higher operating expenses. According to Ascentage Pharma, R&D expenses rose to US$102.8 million and selling and distribution expenses to US$33.4 million, reflecting intensified global clinical and commercial activities.

What is Ascentage Pharma’s cash position as of June 30, 2026?

As of June 30, 2026, Ascentage Pharma held US$279.4 million in cash and bank balances, down from US$353.2 million at year-end 2025. According to the company, the US$73.8 million decrease mainly reflected accelerated global clinical progress and related increases in research and development spending.

How advanced is Ascentage Pharma’s clinical pipeline in 2026?

Ascentage Pharma reported nine registrational Phase III trials ongoing worldwide across Olverembatinib and Lisaftoclax programs. According to the company, several trials, including POLARIS-1, POLARIS-2, POLARIS-3 and GLORA studies, have FDA and EMA clearance, underpinning its late-stage oncology pipeline in hematologic malignancies and solid tumors.

What are the key commercial updates for Olverembatinib and Lisaftoclax in 2026?

Olverembatinib reached 879 DTP pharmacies and hospitals, including 394 hospitals, while Lisaftoclax reached 415 sites, including 60 hospitals. According to Ascentage Pharma, these expansions in formulary coverage support growing product sales and broader clinical use across China’s oncology market.

When will Ascentage Pharma hold its investor webcasts for the 2026 interim results?

Ascentage Pharma scheduled a Chinese-language webcast at 9:00 am HKT on August 20, 2026 (9:00 pm EDT August 19) and an English-language webcast at 8:00 am EDT / 8:00 pm HKT on August 20, 2026. According to the company, investors must register in advance to access both events.