Indicate by check mark whether the registrant files or will file annual
reports under cover of Form 20-F or Form 40-F.
On
July 19, 2026, Ascentage Pharma Group International (“Ascentage Pharma” or the “Company”) issued a Voluntary
Announcement and Overseas Regulatory Announcement entitled, “Proposed At-The-Market Offering Program Pursuant to a Registration
Statement on Form F-3 Filed with The U.S. Securities And Exchange Commission and Application for Waivers from the Listing Rules”.
A copy of the announcement is furnished as Exhibit 99.1 to this Report.
Pursuant to the requirements
of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto
duly authorized.
Exhibit 99.1
Hong Kong Exchanges and Clearing Limited and
The Stock Exchange of Hong Kong Limited take no responsibility for the contents of this announcement, make no representation as to its
accuracy or completeness and expressly disclaim any liability whatsoever for any loss howsoever arising from or in reliance upon the
whole or any part of the contents of this announcement.
This
announcement appears for information purposes only and does not constitute any invitation or offer to acquire, purchase or subscribe
for any securities in Hong Kong or elsewhere, nor shall it (or any part of it) or the fact of its distribution, form the basis of, or
be relied on in connection with, any contract or invitation to subscribe for securities, and is provided for information only. The distribution
of this announcement may be restricted by law in certain jurisdictions and persons into whose possession the information referred to
herein comes should inform themselves about and observe any such restriction. Any failure to comply with these restrictions may constitute
a violation of the laws of any such jurisdictions. Securities referred to in this announcement have not been issued, registered in accordance
with any securities laws and regulations or allowed to be offered to public or to circulate in Hong Kong or elsewhere. No representation
is made that any such securities will be issued or so registered or allowed to be offered to the public or circulated in Hong Kong or
elsewhere.

ASCENTAGE
PHARMA GROUP INTERNATIONAL
亞盛醫藥集團
(Incorporated
in the Cayman Islands with limited liability)
(Stock
Code: 6855)
VOLUNTARY
ANNOUNCEMENT AND
OVERSEAS
REGULATORY ANNOUNCEMENT
PROPOSED
AT-THE-MARKET OFFERING PROGRAM PURSUANT TO A REGISTRATION STATEMENT ON FORM F-3 FILED WITH THE U.S. SECURITIES AND EXCHANGE COMMISSION
AND APPLICATION FOR WAIVERS FROM THE LISTING RULES
This
announcement is made voluntarily by Ascentage Pharma Group International (the “Company”, together with its subsidiaries,
the “Group”) to keep the shareholders of the Company (“Shareholders”) and potential investors informed
of the latest developments of the Group, and is also made pursuant to Rule 13.09 and Rule 13.10B of the Rules Governing the Listing of
Securities on The Stock Exchange of Hong Kong Limited (the “Listing Rules”) and the Inside Information Provisions (as
defined in the Listing Rules) under Part XIVA of the Securities and Futures Ordinance (Chapter 571, Laws of Hong Kong) (the “SFO”).
The
board (the “Board”) of directors (the “Directors”) of the Company is pleased to announce that, on July
20, 2026 (U.S. Eastern time), the Company, which qualifies as a “well-known seasoned issuer”, submitted with the U.S. Securities
and Exchange Commission (the “SEC”) for filing an automatic shelf registration statement on Form F-3 (Registration No.
333-297559) (the “Registration Statement”). The Registration Statement contains two prospectuses: (i) a base prospectus
which covers the offering, issuance and sale by the Company of American depositary shares (“ADSs”), each representing
four ordinary shares of the Company, par value US$0.0001 each (the “Ordinary Shares”), from time to time in one or more offerings;
and (ii) a sales agreement prospectus (the “ATM Prospectus”) covering an at-the-market offering of up to $200 million
of the Company’s ADSs (the “Proposed ATM Program”) as described below.
Sales
of ADSs under the Proposed ATM Program, if any, would be conducted in the United States only and will not constitute a public offering
in Hong Kong. No application for the securities offered under the Proposed ATM Program will be accepted in Hong Kong and the Company
will not issue any prospectus under the Companies (Winding Up and Miscellaneous Provisions) Ordinance (Chapter 32 of the Laws of Hong
Kong) or application form in respect of the Proposed ATM Program in Hong Kong.
Any
sales of ADSs under the Proposed ATM Program, if and when conducted, will be subject to certain conditions and restrictions as described
below.
No
sales of ADSs will be made under the Proposed ATM Program:
(i)
during the period commencing on July 17, 2026 and ending immediately prior to the filing with, or furnishing to, the SEC of a Form 6-K
containing the Company’s financial results for the six months ended June 30, 2026,
(ii)
during any period in which the Company is, or could be deemed to be, in possession of material non-public information;
(iii)
at any time when the Company has imposed a trading blackout; or
(iv)
prior to the Stock Exchange granting the Listing Rules Waivers (as described below).
Features
of the Proposed ATM Program
The
Proposed ATM Program is an at-the-market equity offering program as defined in Rule 415(a)(4) under the U.S. Securities Act of 1933,
as amended (the “Securities Act”), that will be conducted on Nasdaq through the Sales Agents, acting as the Company’s
agents, including through ordinary brokers’ transactions on or through Nasdaq or any other market on which the ADSs may be traded,
in the over-the-counter market, in negotiated transactions, or through a combination of such methods.
In
the Proposed ATM Program, ADSs may be sold at market prices prevailing at the time of sale, at prices related to such prevailing market
prices, or at negotiated prices. During potential execution periods of the Proposed ATM Program, if any, the Company will designate
a certain dollar amount of ADSs to be sold under condition of minimum price per ADS at which such ADSs may be sold. The Sales Agents
will use their commercially reasonable efforts, consistent with their normal sales and trading practices, to sell ADSs designated by
the Company. The Company may instruct a Sales Agent not to sell any ADSs if such sales cannot be effected at or above the price designated
by the Company. The volume of ADSs to be issued under the Proposed ATM Program will be determined by the Company from time to time
based on prevailing market conditions and trading volumes.
There
will be no marketing or bookbuilding process for the Proposed ATM Program. Price discovery in the Proposed ATM Program is through the
automatic matching of buy and sell orders in the open market or via reverse inquiry bid on Nasdaq by the trading system of the said stock
exchange.
The
Proposed ATM Program is subject to certain customary conditions precedent set out in the Sales Agreement (as defined below), including
(in summarised terms) the Registration Statement having been filed with the SEC; there being no material adverse change affecting the
business, operations or financials of the Group or the ability of the Company to perform its obligations in connection with the Proposed
ATM Program; the ADSs to be sold at each settlement date shall have been listed on Nasdaq; and the grant by the Stock Exchange of the
listing of, and permission to deal in, the Ordinary Shares underlying the ADSs to be sold under the Proposed ATM Program having been
effective and not been subsequently withdrawn.
The
Company will suspend the Proposed ATM Program (i) during the blackout periods within the meaning under Rule A3 of Appendix C3 (Model
Code for Securities Transactions by Directors of Listed Issuers) of the Listing Rules or (ii) when the Company is in possession of any
undisclosed inside information.
THE
PROPOSED ATM PROGRAM
In
connection with the Proposed ATM Program, the Company has entered into a sales agreement dated July 17, 2026 (the “Sales Agreement”)
with Citigroup Global Markets Inc. (“Citigroup”), Deutsche Bank AG, Hong Kong Branch (“Deutsche Bank”)
and BTIG, LLC (“BTIG”, together with Citigroup and Deutsche Bank, the “Sales Agents”), pursuant to
which the Company may offer and sell ADSs having an aggregate offering price of up to US$200,000,000 (the “Maximum Amount”)
from time to time through the Sales Agents. The Sales Agents may act as agents on the Company’s behalf or purchase ADSs as principal.
Sales
of ADSs, if any, under the Sales Agreement will be effected by any method that is deemed to be an “at-the-market offering”
as defined in Rule 415(a)(4) under the U.S. Securities Act of 1933, as amended (the “Securities Act”), including ordinary
brokers’ transactions on or through Nasdaq or any other market on which the ADSs may be traded, in the over-the-counter market,
in negotiated transactions, or through a combination of such methods. ADSs may be sold at market prices prevailing at the time of sale,
at prices related to such prevailing market prices, or at negotiated prices. The Sales Agents will use their commercially reasonable
efforts, consistent with their normal sales and trading practices, to sell ADSs designated by the Company from time to time on the terms
and subject to the conditions set out in the Sales Agreement.
Pricing
Mechanism
Under
the Proposed ATM Program, ADSs may be sold through two execution strategies: (i) dribble-out trades, where ADSs are sold incrementally
into the open market at prevailing market prices through ordinary broker’s transactions on Nasdaq; and (ii) agency block transactions,
where institutional investors may approach a Sales Agent with a reverse inquiry bid to purchase a block of ADSs, and the Sales Agent
will negotiate the size and price of the block on behalf of the Company. For agency block transactions, the negotiated price will be
at or related to prevailing market prices.
No
Sales During Blackout Periods
For
the avoidance of doubt, the Company will not effect, and will not permit any Sales Agent to effect, any sales of ADSs under the Sales
Agreement (i) at any time during which a trading blackout period imposed by the Company is in effect, or (ii) during any period in which
the Company is, or could be deemed to be, in possession of material non-public information. This restriction applies at all times during
the term of the Sales Agreement, and sales under the Proposed ATM Program will resume only after the applicable blackout period has ended
or, as the case may be, the material non-public information has ceased to be non-public.
Settlement
of sales of ADSs under the Sales Agreement will generally occur on the first trading day following the date on which such sales are made,
through the facilities of The Depository Trust Company or by such other means as the Company and the relevant Sales Agent may agree,
and there is no arrangement for funds to be received in escrow, trust or other similar arrangement. In connection with such sales, the
Sales Agents may be deemed to be “underwriters” within the meaning of the Securities Act, and the Company has agreed to provide
indemnification and contribution to the Sales Agents in respect of certain liabilities, including civil liabilities under the Securities
Act.
The
Company will report at least quarterly the number of ADSs sold through the Sales Agents under the Sales Agreement, the net proceeds to
the Company (before expenses), and the aggregate compensation paid by the Company to the Sales Agents in connection with such sales.
The
Company’s ADSs are listed on Nasdaq under the symbol “AAPG”, with each ADS representing four Ordinary Shares, and JPMorgan
Chase Bank, N.A. acts as depositary for the ADSs. The Company’s Ordinary Shares remain listed on The Stock Exchange of Hong Kong
Limited (the “Stock Exchange”) under stock code 6855.
General
Mandate
Any
ADSs and Ordinary Shares issued and allotted pursuant to the Proposed ATM Program will be issued and allotted pursuant to the general
mandate granted to the Directors by the Shareholders at the annual general meeting of the Company held on May 20, 2026 to allot, issue
and deal with up to 74,666,950 Ordinary Shares (the “General Mandate”). As at the date of this announcement, no Ordinary
Shares have been issued under the General Mandate. As an estimate, based on the maximum offering amount of US$200,000,000, the Company
expects that the Ordinary Shares underlying the ADSs issued pursuant to the Proposed ATM Program will not exceed 20% of the total number
of issued Ordinary Shares (excluding Treasury Shares, if any) as at the date of the annual general meeting. The allotment and issue of
the relevant Ordinary Shares is not subject to additional approval of the Company’s shareholders.
Use
of Proceeds
The
Company currently intends to use the net proceeds from the Proposed ATM Program to fund the commercialization of Olverembatinib and Lisaftoclax,
the ongoing clinical trials for its drug candidates, working capital and general corporate purposes. The Company may also use a portion
of the net proceeds to invest in or acquire businesses or technologies that it believes to be complementary to its own, although it has
no current plans, commitments or agreements with respect to any such acquisitions as at the date of this announcement. Pending such uses,
the Company intends to invest the net proceeds in investment-grade, interest-bearing securities. The Company will retain broad discretion
over the use of the net proceeds.
PRC
Filing Requirements
Pursuant
to the Trial Administrative Measures of Overseas Securities Offering and Listing by Domestic Companies (the “Trial Measures”)
promulgated by the China Securities Regulatory Commission (the “CSRC”), any offering of ADSs under the ATM Prospectus
is expected to constitute an indirect overseas offering and listing by the Company and will be subject to the filing requirements of
the CSRC. The Company will be required to submit a filing to the CSRC within three business days after completion of any offering of
ADSs under the ATM Prospectus.
APPLICATION
FOR WAIVERS FROM THE LISTING RULES
Sales
of ADSs under the ATM Prospectus are subject to the Stock Exchange granting waivers from strict compliance with certain requirements
of the Listing Rules (the “Listing Rules Waivers”). The Company has applied to the Stock Exchange for the following
Listing Rules Waivers:
| (a) | a
waiver from strict compliance with Note 1 to Rule 13.36(2)(b) and Chapter 14A of the Listing
Rules in respect of “dribble-out” trades under the Proposed ATM Program. This waiver
is sought because, under the dribble-out strategy, sales are conducted through anonymous,
electronically matched broker transactions on Nasdaq, and neither the Company nor the Sales
Agents are able to identify or exclude connected persons from purchasing ADSs in the open
market. Requiring the Company to comply strictly with Chapter 14A and Note 1 to Rule 13.36(2)(b)
of the Listing Rules in respect of such anonymous open market transactions would be unduly
burdensome and impractical, and would not achieve the regulatory purpose for which these
rules were made; and |
| (b) | a
waiver from strict compliance with Rules 13.28(2) to 13.28(5) of the Listing Rules, both
at the time of filing the Registration Statement and in respect of dribble-out trades under
the Proposed ATM Program. This waiver is sought because the fundamental nature of an at-the-market
offering program is that securities are sold incrementally over time at prevailing market
prices, and the precise terms of each sale (including the number of ADSs, the price and the
aggregate proceeds) are inherently not determinable until the relevant sale is actually effected.
Requiring the Company to provide such information at the time of filing the Registration
Statement would not be achievable. The Company will publish a separate announcement pursuant
to Rule 13.28 of the Listing Rules in respect of each agency block transaction and will disclose
the information required under Rules 13.28(2) to 13.28(5) in next-day disclosure returns
in respect of dribble-out trades. |
No
sales of ADSs will be made under the ATM Prospectus unless and until the Listing Rules Waivers have been granted by the Stock Exchange.
As at the date of this announcement, the application for the Listing Rules Waivers remains pending and there is no assurance as to whether
or when the Listing Rules Waivers will be granted, or as to the terms on which they may be granted. Shareholders and potential investors
of the Company are advised to exercise caution when dealing in the securities of the Company.
The
Company will make further announcement(s) in relation to the Proposed ATM Program and the Listing Rules Waivers as and when appropriate
in compliance with the requirements under the Listing Rules to keep the Shareholders and potential investors of the Company informed.
REASONS
FOR THE PROPOSED ATM PROGRAM
The
Board has determined that an at-the-market offering program in the United States is the most suitable financing method for the Company
at this time for the following reasons:
(a)
Flexibility and control: Unlike a traditional underwritten public offering, an ATM program allows the Company to sell ADSs incrementally
over time at prevailing market prices, providing the Company with flexibility to raise capital when market conditions are favorable and
to control the timing and volume of sales. The Company is not obligated to sell any minimum amount of ADSs and may suspend or terminate
sales at any time.
(b)
Minimal market impact: Because ADSs are sold in defined amounts over a specified period of time through ordinary market transactions,
an ATM program is designed to have minimal impact on daily trading price of the ADSs.
(c)
Cost efficiency: An ATM program does not require underwriting, roadshows, or extensive marketing activities that are typically associated
with traditional equity offerings, resulting in lower transaction costs for the Company.
(d)
Preservation of general mandate: The Proposed ATM Program will utilize the General Mandate granted by Shareholders at the annual general
meeting, and the Company is not required to seek additional shareholder approval for the issuance of Ordinary Shares underlying the ADSs
sold pursuant to the Proposed ATM Program.
The
maximum gross proceeds that can be raised, if any, from the Proposed ATM Program is US$200,000,000. As it is not mandatory for the Company
to reach the said maximum gross proceeds under the Proposed ATM Program, the precise gross and net proceeds is not determinable as at
the date of this announcement. The Company will disclose the total gross and net proceeds received and an update on the use of net proceeds
from the Proposed ATM Program in its annual report, interim report and quarterly reports.
The
Company intends to use the net proceeds from the Proposed ATM Program for (i) research and development activities, (ii) commercialization
infrastructure build-up in the United States for the coming commercial launch of its drug candidates, and (iii) working capital needs
and general corporate purposes. Besides, the Company intends to improve trading liquidity of the ADSs on the U.S. market.
To
the extent that the net proceeds of the Proposed ATM Program are not immediately required for the above purposes, the Company may hold
such funds in bank deposits at authorized financial institutions and/or licensed banks.
The
foregoing represents the Company’s current intentions to use and allocate the net proceeds of the Proposed ATM Program based upon
its present plans and business conditions. The management of the Company, however, will have significant flexibility and discretion to
apply the net proceeds of the Proposed ATM Program. If an unforeseen event occurs or business conditions change, the Company may use
the proceeds of the Proposed ATM Program differently than as described herein.
SAFE
HARBOUR STATEMENT
This
announcement shall not constitute an offer to sell, or the solicitation of an offer to subscribe or buy, any shares or securities, nor
are they part of an offer or invitation to subscribe for any shares or securities, nor do they form or are intended to form the basis
of any commitment or investment decision.
Statements
about the Company’s future expectations and all other statements in this announcement other than historical facts, are “forward-looking
statements” within the meaning of Section 27A of the Securities Act, Section 21E of the Securities Exchange Act of 1934, and as
that term is defined in the Private Securities Litigation Reform Act of 1995. The Company intends that such forward-looking statements
be subject to the safe harbors created thereby.
The
information set out in this announcement contains information relating to the Company that is based on the beliefs of the Company and/or
its management, as well as assumptions made by any information currently available to the Company or its management. When used in this
announcement, the words “anticipate”, “estimate”, “expect”, “intend”, “plans”, “projects”,
and similar expressions, as they relate to the Company or its management, are intended to identify forward-looking statements. Such statements
reflect the current view of the Company regarding future events and are subject to certain risks, uncertainties and assumptions, including
the risks and uncertainties noted. Should one or more of these risks or uncertainties materialize, or should underlying assumptions prove
to be incorrect, actual results may vary materially from those described herein as anticipated, believed, estimated, expected, intended
or projected. In each instance, forward-looking information should be considered in light of the accompanying meaningful cautionary statements
herein. Factors that could cause results to differ include, but are not limited to, successful performance of internal plans, the impact
of competitive services and pricing and general economic risks and uncertainties.
Information
from third party sources identified in this announcement are based on published reports for such information and we have assumed the
accuracy of such reports without independent investigation or inquiry.
This
announcement is for informational purposes only and is neither an offer to sell nor a solicitation of an offer to subscribe or purchase
any shares or securities of the Company, including but not limited to its ADSs.
Information
made available on the Company’s website is not a part of any disclosure made or to be made by the Company with respect to any offer
to sell or solicitation of an offer to purchase any securities of the Company and are not part of any filings by the Company with the
SEC.
WARNING
As
the Proposed ATM Program and the related Listing Rules Waivers may or may not be completed or granted, respectively, and the Registration
Statement has not yet become, and may not become, effective, shareholders and potential investors of the Company are advised to exercise
caution when dealing in the securities of the Company.
By
order of the Board
Ascentage
Pharma Group International
Dr.
Yang Dajun
Chairman
and Executive Director
Suzhou,
People’s Republic of China, July 19, 2026
As
at the date of this announcement, the Board comprises Dr. Yang Dajun as Chairman and executive Director, Dr. Wang Shaomeng and Dr. Lu
Simon DazhongNote 1 as non-executive Directors, and Mr. Ye Changqing, Mr. Ren Wei, Dr. David SidranskyNote 2, Ms.
Marina S. Bozilenko, Dr. Debra Yu and Dr. Marc E. Lippman, MD as independent non-executive Directors.
Notes:
1.
Dr. Lu Simon Dazhong satisfy the independence requirements of the U.S. Securities and Exchange Commission and Nasdaq corporate governance
requirements.
2.
Dr. David Sidransky is the Lead Independent Non-Executive Director of the Company