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Annovis Appoints Cheng Fang, Ph.D., as Chief Scientific Officer

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Annovis (NYSE: ANVS) promoted Cheng Fang, Ph.D., to Chief Scientific Officer. Fang, formerly Senior VP of R&D, will lead scientific strategy and research operations for the company’s Alzheimer’s and Parkinson’s programs.

The move comes as Annovis advances its oral therapy buntanetap toward Phase 3 Alzheimer’s top-line data and a potential NDA submission.

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News Market Reaction – ANVS

+3.23%
1 alert
+3.23% Session close to close
$81.68M Market Cap
1.03K Volume

In the Jul 1 session, ANVS gained 3.23%, reflecting a moderate positive market reaction.

Data tracked by StockTitan Argus on the day of publication.

Market Context

This announcement reinforces scientific leadership as buntanetap nears pivotal Phase 3 Alzheimer’s d...
Analysis

This announcement reinforces scientific leadership as buntanetap nears pivotal Phase 3 Alzheimer’s data and a potential NDA. Prior filings highlight higher R&D spend and liquidity risk, so investors may watch execution and future financing closely.

Key Figures

Phase: Phase 3 Year joined: 2021
2 metrics
Phase Phase 3 Pivotal Alzheimer’s disease study for buntanetap
Year joined 2021 Cheng Fang’s start year at Annovis Bio

Historical Context

5 past events · Latest: May 26 (Positive)
Pattern 5 events
Date Event Sentiment 24h Move Catalyst
May 26 Listing compliance update Positive -7.6% Regained NYSE listing compliance after cure plan raised market cap and equity.
May 20 Dilutive equity offering Negative -0.8% Priced $15M stock and warrant offering at $1.90 to fund Phase 3 work.
May 19 Equity offering launch Negative -0.8% Announced proposed stock and warrant offering to fund buntanetap development.
May 15 Quarterly earnings update Negative -3.3% Reported higher R&D spending, larger net loss and limited cash for late-stage trials.
May 07 Conference presentation Positive -5.8% CEO scheduled to present multi‑protein Alzheimer’s model and highlight buntanetap program.

24h Move is the share-price change in the day after each event; other market factors may also have contributed.

Pattern Detected

Recent history shows ANVS often trading lower after both positive corporate updates and dilutive financing or earnings news.

Key Terms

phase 3, translational science, biomarker, new drug application (nda), +1 more
5 terms
phase 3 clinical
"the pivotal Phase 3 AD study and a subsequent New Drug Application"
Phase 3 is the late-stage clinical testing step for a new drug or medical treatment, where the product is given to large groups of patients to confirm effectiveness, monitor side effects, and compare it to standard care. Successful Phase 3 results are often the final scientific hurdle before regulators decide on approval and market launch—like passing a final exam before graduation—and can sharply change a company's valuation and future revenue prospects.
translational science medical
"including translational science, clinical development, biomarker strategy, and regulatory"
Translational science is the process of turning laboratory discoveries into practical medical tests, therapies, or devices and figuring out how to deliver them safely to patients. For investors, it matters because progress in this area signals a clearer path from research to sellable products—like converting a prototype into a finished product—affecting a company’s potential revenue, regulatory risk, and likelihood of partnerships or buyouts.
biomarker medical
"both traditional cognitive and functional as well as innovative biomarker endpoints"
A biomarker is a measurable indicator found in the body, such as in blood or tissues, that provides information about health, disease, or how the body responds to treatment. For investors, biomarkers can signal the potential success or risk of medical products or therapies, influencing the value of related companies and industry trends. They act like signals or clues that help assess the progress of medical advancements and their market impact.
new drug application (nda) regulatory
"toward top-line data readout from the pivotal Phase 3 AD study and a subsequent New Drug Application (NDA)"
A new drug application (NDA) is a formal request submitted to regulatory authorities to gain approval for a new medication to be sold and used by the public. It is a comprehensive review process that examines the drug’s safety, effectiveness, and manufacturing quality. For investors, an NDA approval can signal a potential breakthrough product and influence a company's stock value.
neurodegenerative diseases medical
"buntanetap, for neurodegenerative diseases such as Alzheimer’s disease"
Neurodegenerative diseases are conditions where brain or nerve cells progressively lose function and die, causing symptoms like memory loss, movement problems, or cognitive decline — think of the brain’s wiring slowly wearing out. Investors care because these illnesses create sustained demand for treatments, diagnostics, and long-term care, drive regulatory decisions and clinical-trial milestones that move stock prices, and concentrate both high development risk and the potential for large financial returns if effective therapies are approved.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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MALVERN, Pa., July 01, 2026 (GLOBE NEWSWIRE) -- Annovis Bio, Inc. (NYSE: ANVS) (“Annovis” or the “Company”), a Phase 3 clinical-stage biotechnology company developing the investigational oral therapy, buntanetap, for neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD), today announced the promotion of Cheng Fang, Ph.D., to Chief Scientific Officer.

Dr. Fang, who joined Annovis in 2021 and most recently served as Senior Vice President, Research and Development, will lead scientific strategy and research operations across the Company's AD and PD programs, including translational science, clinical development, biomarker strategy, and regulatory interactions. Her promotion comes at a pivotal moment, as Annovis advances its lead drug candidate, buntanetap, toward top-line data readout from the pivotal Phase 3 AD study and a subsequent New Drug Application (NDA) submission.

"Cheng has been instrumental in deepening our understanding of buntanetap's therapeutic potential, designing and overseeing rigorous, high-quality clinical trials that integrate both traditional cognitive and functional as well as innovative biomarker endpoints," said Maria Maccecchini, Ph.D., Founder, President and Chief Executive Officer of Annovis Bio. "Her dedication and expertise have brought us to the cusp of a defining moment for our company and for the patient community. As we approach these pivotal scientific and regulatory milestones, there is no one better suited to lead our scientific efforts forward."

"I am honored to take on this role at such a defining moment for Annovis," said Cheng Fang, Ph.D., Chief Scientific Officer. "I am proud of the work our team has put into advancing buntanetap, and I am energized by what lies ahead. I look forward to building on this foundation as we work to bring a meaningful new therapy to the patients and families who are counting on us."

Dr. Fang has held multiple senior leadership and academic roles spanning translational research, clinical development, and regulatory strategy, with a sustained focus on understanding and treating neurodegenerative diseases. She earned her Ph.D. in Neuroscience from The Pennsylvania State University and her B.S. in Biopharmaceutical Sciences from Nanjing University.

About Annovis
Headquartered in Malvern, Pennsylvania, Annovis Bio, Inc. (NYSE: ANVS) is a Phase 3 clinical-stage biotechnology company developing treatments for neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD). The Company's lead drug candidate, buntanetap (formerly posiphen), is an investigational once-daily oral therapy that inhibits the translation of multiple neurotoxic proteins, including APP and amyloid beta, tau, alpha-synuclein, and TDP-43, through a specific RNA-targeting mechanism of action. By addressing the underlying causes of neurodegeneration, Annovis aims to halt disease progression and improve cognitive and motor functions in patients. For more information, visit www.annovisbio.com and follow us on LinkedInYouTube, and X.

Investor Alerts
Interested investors and shareholders are encouraged to sign up for press releases and industry updates by registering for email alerts at https://www.annovisbio.com/email-alerts.

Forward-Looking Statements
This press release contains forward-looking statements under the Securities Act of 1933 and the Securities Exchange Act of 1934, as amended. Actual results may differ due to various risks and uncertainties, including those outlined in the Company’s SEC filings under “Risk Factors” in its Annual Report on Form 10-K and Quarterly Reports on Form 10-Q. The Company undertakes no obligation to update forward-looking statements except as required by law.

Contact Information:
Annovis Bio Inc.
101 Lindenwood Drive
Suite 225
Malvern, PA 19355
www.annovisbio.com

Investor Contact:
Alexander Morin, Ph.D.
Director, Strategic Communications
Annovis Bio
ir@annovisbio.com


FAQ

Who is Cheng Fang, Ph.D., the new Chief Scientific Officer of Annovis (NYSE: ANVS)?

Cheng Fang, Ph.D., is Annovis’ newly promoted Chief Scientific Officer. She joined in 2021 and previously served as Senior Vice President of R&D, focusing on translational research, clinical development, and regulatory strategy for neurodegenerative diseases.

What will Cheng Fang, Ph.D., oversee as Chief Scientific Officer at Annovis (ANVS)?

As Chief Scientific Officer, Cheng Fang will lead scientific strategy and research operations. Her responsibilities include translational science, clinical development, biomarker strategy, and regulatory interactions across Annovis’ Alzheimer’s and Parkinson’s disease programs.

How does the CSO appointment relate to Annovis (ANVS) Phase 3 Alzheimer’s program?

The CSO appointment occurs as Annovis advances buntanetap toward top-line Phase 3 Alzheimer’s data. According to the company, Fang has been central in designing clinical trials that use cognitive, functional, and biomarker endpoints supporting these pivotal milestones.

What is buntanetap in Annovis’ (NYSE: ANVS) clinical pipeline?

Buntanetap is Annovis’ investigational oral therapy for neurodegenerative diseases. According to the company, it is being developed in Phase 3 for Alzheimer’s disease and as a lead candidate in programs that also target Parkinson’s disease.

What are the next regulatory steps Annovis (ANVS) plans for buntanetap?

Annovis plans to move buntanetap toward a potential New Drug Application. According to the company, this would follow the top-line data readout from its pivotal Phase 3 Alzheimer’s disease study, marking a key scientific and regulatory milestone.

What is Cheng Fang’s background before becoming CSO at Annovis (ANVS)?

Cheng Fang has held senior leadership and academic roles in translational research, clinical development, and regulatory strategy. She earned a Ph.D. in Neuroscience from Pennsylvania State University and a B.S. in Biopharmaceutical Sciences from Nanjing University.