BioLineRx Reports Second Quarter 2026 Financial Results and Provides Corporate Update
Rhea-AI Summary
BioLineRx (NASDAQ/TASE: BLRX) reported unaudited Q2 2026 results and pipeline progress. Royalty revenues were $0.3 million, broadly flat year over year, mainly from APHEXDA sales of $1.6 million, generating $0.3 million in royalty income. Research and development expenses rose to $2.9 million and general and administrative expenses to $0.9 million, driving a net loss of $4.3 million versus $3.9 million in Q2 2025.
Cash, cash equivalents and short-term deposits totaled $13.1 million as of June 30, 2026, with cash runway guided into the first half of 2027. According to BioLineRx, a $3.75 million equity offering signed on August 27, 2026 is expected to close around August 31, 2026.
Clinically, the second of five planned cohorts is dosing in the Phase 1/2a GLIX1 glioblastoma study, with a third cohort expected to start in September, supported by new preclinical GBM and ovarian cancer data and multiple upcoming conference presentations.
Positive
- Royalty revenues $0.3m in Q2 2026, stable year over year
- APHEXDA Q2 2026 sales $1.6m generating $0.3m royalty revenue
- GLIX1 Phase 1/2a second cohort dosing; third cohort expected September 2026
- Preclinical GLIX1 data showed robust antitumor activity in TMZ-resistant GBM models
- GLIX1 + PARP inhibitor synergy seen in HR-proficient ovarian cancer PDX model
- Cash & deposits $13.1m at June 30, 2026; runway into 1H 2027
- Signed equity offering for $3.75m expected to close around August 31, 2026
- CheMo4METPANC Phase 2b motixafortide PDAC trial enrollment ongoing
Negative
- Net loss widened to $4.3m in Q2 2026 from $3.9m in Q2 2025
- R&D expenses rose 26.5% year over year to $2.9m in Q2 2026
- G&A expenses increased to $0.9m in Q2 2026 from $0.2m
- Operating loss expanded to $3.6m in Q2 2026 from $2.3m
- Operating cash outflow $5.5m in first half 2026
- Total equity decreased to $16.6m at June 30, 2026 from $23.3m at December 31, 2025
News Explained
The
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Key Figures
Previous Earnings Reports
| Date | Event | Sentiment | 24h Move | Catalyst |
|---|---|---|---|---|
| May 27 | Q1 earnings report | Positive | +6.7% | GLIX1 trial initiation and encouraging preclinical data accompanied quarterly results. |
| Mar 23 | Annual earnings report | Positive | -12.4% | Lower annual loss and GLIX1 patent progress contrasted with the negative reaction. |
| Nov 24 | Q3 earnings report | Positive | +7.7% | GLIX1 joint venture formation and continued clinical development accompanied quarterly results. |
| Aug 14 | Q2 earnings report | Negative | -4.3% | Quarterly net loss and limited revenue accompanied ongoing clinical development updates. |
| May 27 | Q1 earnings report | Positive | +0.6% | Net income, financing completion, and continued pipeline development accompanied quarterly results. |
24h Move is the share-price change in the day after each event; other market factors may also have contributed.
Tag-specific earnings history included both aligned positive and negative reactions, with an average move of -0.37% across five events.
Key Terms
patient-derived xenograft medical
maximum tolerated dose medical
synthetic lethality medical
PARP inhibitor medical
AI-generated analysis. How Rhea-AI works. Not financial advice.
- Second of five planned cohorts ongoing in Phase 1/2a trial of GLIX1 in GBM; third patient cohort expected to commence dosing in September -
- Announced new data showing GLIX1 achieved potent antitumor activity in TMZ-resistant patient-derived xenograft (PDX) GBM in vivo model -
- Announced additional data demonstrating strong synergistic effect between GLIX1 and PARP inhibitor in patient-derived HR-proficient ovarian cancer xenograft model -
- Management to host conference call today, August 31, at 8:30 am EDT -
"During the second quarter and subsequent period, we advanced GLIX1 across multiple fronts," stated Philip Serlin, Chief Executive Officer of BioLineRx. "Our Phase 1/2a study in glioblastoma is advancing as planned, with the second cohort in the Phase 1 part now being dosed, and the third cohort expected to commence dosing in September. To date, a little more than four months into the study, we have been very pleased with the drug's safety and tolerability.
"Also, during the quarter, we were excited to demonstrate the potential of GLIX1 to address unmet needs for GBM as well as ovarian cancer in a number of pre-clinical models. In this regard, we announced new data in a temozolomide-resistant patient-derived xenograft (PDX) GBM in-vivo model, in which GLIX1 demonstrated a robust anti-tumor effect while TMZ showed no effect. These results further support GLIX1's potential to treat a broad range of patients with GBM. We also generated data showing strong synergy between GLIX1 and PARP inhibitors in an HR-proficient patient-derived ovarian cancer in-vivo model, and based upon these excellent findings, we are planning to add an ovarian cancer arm to the Phase 2a expansion phase of the trial. Together, these developments keep GLIX1 on track in glioblastoma while extending its reach into additional tumor types where new treatment options are desperately needed."
Financial Updates
- With
$13.1 million - On August 27, 2026, the Company entered into a definitive agreement for an offering with gross proceeds of
$3.75 million
Development Updates
GLIX1 in GBM
- In July, dosing commenced in the second of five planned cohorts in the Phase 1 dose escalation part of the Phase 1/2a study.
- Three leading cancer centers are enrolling patients in the Phase 1 part of the study: NYU Langone Health, led by Dr. Alexandra Miller; Northwestern University, led by Dr. Roger Stupp and Dr. Ditte Primdahl; and Moffit Cancer Center, led by Dr. Patrick Grogan.
- The Phase 1 part of the trial is expected to recruit up to 30 patients with recurrent and progressive GBM and other high-grade gliomas. The objective is to establish a maximum tolerated dose (MTD) and/or a recommended dose based on safety, PK/PD and preliminary efficacy.
- The Phase 2a expansion part of the trial is planned to include various population cohorts, including GBM (newly diagnosed and/or recurrent), as well as additional cancers with/without standard of care (e.g., PARP inhibitors), including an ovarian cancer arm. These cohorts are expected to identify preliminary efficacy, PD assessments and dose optimization data, serving as the basis for rapid and effective advanced clinical development.
- New data demonstrated potent anti-tumor effect of GLIX1 in GBM across multiple in-vivo studies, including a temozolomide (TMZ)-resistant patient-derived xenograft model. In the three orthotopic CDX studies, significant tumor growth inhibition and survival benefit were observed following treatment with GLIX1 across all doses tested, with greater benefit at higher dose levels. Most notably, in the subcutaneous PDX model, GLIX1 demonstrated a robust anti-tumor effect while TMZ showed no effect.
- Clinical and pre-clinical data have been accepted for publication at the European Association of Neuro-Oncology (EANO) 2026 Conference and at the Society for Neuro-Oncology (SNO) 2026 Annual Meeting.
GLIX1 in combination with PARPi
- New data demonstrated strong synergy between GLIX1 and PARP inhibitors, reinforcing synthetic lethality between GLIX1 and PARP inhibitors.
- Synergy was demonstrated in a patient-derived xenograft (PDX) in-vivo model of HR-proficient ovarian cancer, where PARP inhibitors have historically had limited efficacy. Results show substantially better efficacy in the combination arm versus the control arm and versus the monotherapy arms, despite using lower doses in the combination arm. Notably, the low-dose GLIX1/olaparib combination tumor reduction was similar to cisplatin, the current chemotherapy benchmark.
- An abstract featuring new GLIX1 data, demonstrating synergy with PARP inhibitors in HR-proficient ovarian cancer, was accepted for publication at the 2026 European Society for Medical Oncology Annual Congress (ESMO 2026) in October.
- BioLineRx has initiated discussions with leading PARP inhibitor companies to explore potential development collaborations.
Motixafortide
Pancreatic Ductal Adenocarcinoma (mPDAC)
- Enrollment is continuing in the CheMo4METPANC Phase 2b clinical trial, which is being led by Columbia University, and supported by both Regeneron and BioLineRx. The trial is evaluating motixafortide in combination with the PD-1 inhibitor cemiplimab and standard chemotherapy (gemcitabine and nab-paclitaxel).
- A prespecified interim/futility analysis is planned when
40% of progression-free survival (PFS) events are observed, which the Company continues to anticipate will occur in 2026.
- A prespecified interim/futility analysis is planned when
APHEXDA Performance Update
- For the second quarter of 2026, APHEXDA sales were
$1.6 million $0.3 million
Financial Results for the Quarter ended June 30, 2026
- Revenues for the three months ended June 30, 2026 were
$0.3 million - Research and development expenses for the three months ended June 30, 2026 were
$2.9 million $0.6 million 26.5% , compared to$2.3 million - General and administrative expenses for the three months ended June 30, 2026 were
$0.9 million $0.7 million 313.9% , compared to$0.2 million $0.8 million - Non-operating expenses amounted to
$0.7 million $1.9 million - Net financial expenses for the three months ended June 30, 2026 were
$0.1 million $0.2 million - Net loss for the three months ended June 30, 2026 was
$4.3 million $3.9 million - As of June 30, 2026, the Company had cash, cash equivalents, and short-term bank deposits of
$13.1 million
Conference Call and Webcast Information
To access the conference call, please dial +1-888-407-2553 from the U.S. or +972-3-918-0685 internationally. A live webcast and a replay of the call can be accessed through the event page on the Company's website. Please allow extra time prior to the call to visit the site and download any necessary software to listen to the live broadcast. The call replay will be available approximately two hours after completion of the live conference call. A dial-in replay of the call will be available until September 1, 2026; please dial +1-888-295-2634 from the US or +972-3-925-5904 internationally.
About BioLineRx
BioLineRx Ltd. (NASDAQ/TASE: BLRX) is a biopharmaceutical company pursuing life-changing therapies in oncology and rare diseases. The Company's lead development asset is GLIX1, a first-in-class, oral, small molecule targeting DNA damage response in glioblastoma and other solid tumors, for which a Phase 1/2a clinical trial was initiated in the first quarter of 2026. GLIX1 is being developed under a collaboration with Hemispherian AS.
The Company's first approved product, APHEXDA® (motixafortide), is indicated in the U.S. for stem cell mobilization for autologous transplantation in multiple myeloma, and is being commercialized by Ayrmid Ltd. (globally, except Asia) and by Gloria Biosciences (in Asia). BioLineRx has retained the rights to develop motixafortide in metastatic pancreatic cancer (PDAC) and has a Phase 2b PDAC trial currently ongoing under a collaboration with Columbia University.
Learn more about who we are, what we do, and how we do it at www.biolinerx.com, or on LinkedIn.
Forward Looking Statement
Various statements in this release concerning BioLineRx's future expectations constitute "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995. These statements include words such as "anticipates," "believes," "could," "estimates," "expects," "intends," "may," "plans," "potential," "predicts," "projects," "should," "will," and "would," and describe opinions about future events. These include statements regarding management's expectations, beliefs and intentions regarding, among other things, the expectations with regard to the Phase 1/2a GLIX1 clinical trial, expected timing of a clinical dosing, and BioLineRx's business strategy. These forward-looking statements involve known and unknown risks, uncertainties and other factors that may cause the actual results, performance or achievements of BioLineRx to be materially different from any future results, performance or achievements expressed or implied by such forward-looking statements. Factors that could cause BioLineRx's actual results to differ materially from those expressed or implied in such forward-looking statements include, but are not limited to: the clinical development, commercialization and market acceptance of GLIX1 and motixafortide including the degree and pace of market uptake of APHEXDA for the mobilization of hematopoietic stem cells for autologous transplantation in multiple myeloma patients; the initiation, timing, progress and results of BioLineRx's preclinical studies, clinical trials and other therapeutic candidate development efforts; BioLineRx's ability to advance GLIX1 and motixafortide into clinical trials or to successfully complete its preclinical studies or clinical trials; whether the clinical trial results for GLIX1 and motixafortide will be predictive of real-world results; BioLineRx's receipt of regulatory approvals for GLIX1 and motixafortide and the timing of other regulatory filings and approvals; whether access to GLIX1 and motixafortide is achieved in a commercially viable manner and whether GLIX1 and motixafortide receives adequate reimbursement from third.-party payors; BioLineRx's ability to establish, manage, and maintain corporate collaborations, as well as the ability of BioLineRx's collaborators to execute on their development and commercialization plans; BioLineRx's ability to integrate new therapeutic candidates and new personnel, as well as new collaborations; the interpretation of the properties and characteristics of BioLineRx's therapeutic candidates and of the results obtained with its therapeutic candidates in preclinical studies or clinical trials; the implementation of BioLineRx's business model and strategic plans for its business and therapeutic candidates; the scope of protection that BioLineRx's is able to establish and maintain for intellectual property rights covering its therapeutic candidates and its ability to operate its business without infringing the intellectual property rights of others; estimates of BioLineRx's expenses, future revenues, capital requirements and its need for and ability to access sufficient additional financing; risks related to changes in healthcare laws, rules and regulations in the United States or elsewhere; competitive companies, technologies and BioLineRx's industry; BioLineRx's ability to maintain the listing of its ADSs on Nasdaq; statements as to the impact of the political and security situation in Israel on BioLineRx's business which may exacerbate the magnitude of the factors discussed above. These and other factors are more fully discussed in the "Risk Factors" section of BioLineRx's most recent annual report on Form 20-F filed with the Securities and Exchange Commission on March 23, 2026. In addition, any forward-looking statements represent BioLineRx's views only as of the date of this release and should not be relied upon as representing its views as of any subsequent date. BioLineRx does not assume any obligation to update any forward-looking statements unless required by law.
Contacts:
United States
Chuck Padala
LifeSci Advisors, LLC
IR@biolinerx.com
Israel
Moran Meir
LifeSci Advisors, LLC
moran@lifesciadvisors.com
BioLineRx Ltd. CONDENSED CONSOLIDATED INTERIM STATEMENTS OF FINANCIAL POSITION (UNAUDITED) | ||
December 31, | June 30, | |
2025 | 2026 | |
in USD thousands | ||
Assets | ||
CURRENT ASSETS | ||
Cash and cash equivalents | 3,250 | 4,627 |
Short-term bank deposits | 17,626 | 8,451 |
Prepaid expenses | 201 | 376 |
Other receivables | 456 | 728 |
Inventory | 2,148 | 2,167 |
Total current assets | 23,681 | 16,349 |
NON-CURRENT ASSETS | ||
Property and equipment, net | 160 | 130 |
Right-of-use assets, net | 696 | 673 |
Intangible assets, net | 16,368 | 16,328 |
Total non-current assets | 17,224 | 17,131 |
Total assets | 40,905 | 33,480 |
Liabilities and equity | ||
CURRENT LIABILITIES | ||
Current maturities of long-term loan | 4,479 | 4,479 |
Accounts payable and accruals: | ||
Trade | 3,493 | 4,294 |
Other | 1,743 | 2,206 |
Current maturities of lease liabilities | 234 | 280 |
Warrants | 2,174 | 2,420 |
Total current liabilities | 12,123 | 13,679 |
NON-CURRENT LIABILITIES | ||
Long-term loan, net of current maturities | 4,460 | 2,220 |
Lease liabilities | 977 | 962 |
Total non-current liabilities | 5,437 | 3,182 |
COMMITMENTS AND CONTINGENT LIABILITIES | ||
Total liabilities | 17,560 | 16,861 |
EQUITY | ||
Equity attributable to owners of the Company: | ||
Ordinary shares | 73,428 | 73,776 |
Share premium | 327,584 | 327,928 |
Warrants | 3,686 | 3,686 |
Capital reserve | 15,916 | 15,425 |
Other comprehensive loss | (1,416) | (1,416) |
Accumulated deficit | (401,002) | (405,629) |
Total equity attributable to owners of the Company | 18,196 | 13,770 |
Non-controlling interest | 5,149 | 2,849 |
Total equity | 23,345 | 16,619 |
Total liabilities and equity | 40,905 | 33,480 |
BioLineRx Ltd. CONDENSED CONSOLIDATED INTERIM STATEMENTS OF COMPREHENSIVE INCOME (LOSS) (UNAUDITED) | ||||
Three months ended June 30, | Six months ended June 30, | |||
2025 | 2026 | 2025 | 2026 | |
in USD thousands | in USD thousands | |||
ROYALTY REVENUES | 304 | 294 | 559 | 771 |
COST OF REVENUES | (72) | (59) | (106) | (154) |
GROSS PROFIT | 232 | 235 | 453 | 617 |
RESEARCH AND DEVELOPMENT EXPENSES | (2,326) | (2,943) | (3,949) | (5,471) |
GENERAL AND ADMINISTRATIVE EXPENSES | (209) | (865) | (1,198) | (1,723) |
OPERATING LOSS | (2,303) | (3,573) | (4,694) | (6,577) |
NON-OPERATING INCOME (EXPENSES), NET | (1,851) | (690) | 5,793 | (232) |
FINANCIAL INCOME | 490 | 132 | 784 | 340 |
FINANCIAL EXPENSES | (276) | (208) | (696) | (458) |
NET INCOME (LOSS) AND COMPREHENSIVE INCOME (LOSS) | (3,940) | (4,339) | 1,187 | (6,927) |
ATTRIBUTION OF NET INCOME (LOSS) AND | ||||
To owners of the Company | (3,940) | (3,026) | 1,187 | (4,627) |
To non-controlling interests | - | (1,313) | - | (2,300) |
(3,940) | (4,339) | 1,187 | (6,927) | |
in USD | in USD | |||
EARNINGS (LOSS) PER ORDINARY SHARE – BASIC AND | (0.00) | (0.00) | 0.00 | (0.00) |
WEIGHTED AVERAGE NUMBER OF SHARES USED IN | 2,369,687,536 | 2,664,807,584 | 2,294,127,662 | 2,662,530,811 |
BioLineRx Ltd. CONDENSED CONSOLIDATED INTERIM STATEMENTS OF CHANGES IN EQUITY (UNAUDITED) | ||||||||||
Equity attributable to owners of the Company | ||||||||||
Ordinary shares | Share | Warrants | Capital | Other | Accumulated | Non- | Total | |||
in shares 000's | in USD thousands | |||||||||
BALANCE AT JANUARY 1, 2025 | 1,336,670 | 38,097 | 353,693 | 5,367 | 17,547 | (1,416) | (399,827) | - | 13,461 | |
CHANGES FOR SIX MONTHS | ||||||||||
Issuance of share capital, pre-funded | 925,137 | 25,664 | (20,988) | 501 | - | - | - | - | 5,177 | |
Pre-funded warrants exercised | 295,804 | 8,058 | (5,876) | (2,182) | - | - | - | - | - | |
Employee stock options expired | - | - | 646 | - | (646) | - | - | - | - | |
Share-based compensation | - | - | - | - | 247 | - | - | - | 247 | |
Comprehensive income for the period | - | - | - | - | - | - | 1,187 | - | 1,187 | |
BALANCE AT JUNE 30, 2025 | 2,557,611 | 71,819 | 327,475 | 3,686 | 17,148 | (1,416) | (398,640) | - | 20,072 | |
Equity attributable to owners of the Company | |||||||||
Ordinary shares | Share | Warrants | Capital | Other | Accumulated | Non- | Total | ||
in shares 000's | in USD thousands | ||||||||
BALANCE AT JANUARY 1, 2026 | 2,610,814 | 73,428 | 327,584 | 3,686 | 15,916 | (1,416) | (401,002) | 5,149 | 23,345 |
CHANGES FOR SIX MONTHS | |||||||||
Issuance of share capital | 10,163 | 348 | (304) | - | - | - | - | - | 44 |
Employee stock options expired | - | - | 648 | - | (648) | - | - | - | - |
Share-based compensation | - | - | - | - | 157 | - | - | - | 157 |
Comprehensive loss for the period | - | - | - | - | - | - | (4,627) | (2,300) | (6,927) |
BALANCE AT JUNE 30, 2026 | 2,620,977 | 73,776 | 327,928 | 3,686 | 15,425 | (1,416) | (405,629) | 2,849 | 16,619 |
BioLineRx Ltd. CONDENSED CONSOLIDATED INTERIM STATEMENTS OF CASH FLOWS (UNAUDITED) | ||
Six months ended June 30, | ||
2025 | 2026 | |
in USD thousands | ||
CASH FLOWS - OPERATING ACTIVITIES | ||
Comprehensive income (loss) for the period | 1,187 | (6,927) |
Adjustments required to reflect net cash used in operating activities (see appendix below) | (3,955) | 1,430 |
Net cash used in operating activities | (2,768) | (5,497) |
CASH FLOWS - INVESTING ACTIVITIES | ||
Investments in short-term deposits | (24,818) | (7,663) |
Maturities of short-term deposits | 12,926 | 16,714 |
Proceeds from sale of property and equipment | 11 | - |
Net cash provided by (used in) investing activities | (11,881) | 9,051 |
CASH FLOWS - FINANCING ACTIVITIES | ||
Issuance of share capital and warrants, net of issuance costs | 13,554 | 44 |
Repayments of loan | (2,240) | (2,240) |
Repayments of lease liabilities | (262) | (124) |
Net cash provided by (used in) financing activities | 11,052 | (2,320) |
INCREASE )DECREASE( IN CASH AND CASH EQUIVALENTS | (3,597) | 1,234 |
CASH AND CASH EQUIVALENTS - BEGINNING OF PERIOD | 10,436 | 3,250 |
EXCHANGE DIFFERENCES ON CASH AND CASH EQUIVALENTS | 350 | 143 |
CASH AND CASH EQUIVALENTS - END OF PERIOD | 7,189 | 4,627 |
BioLineRx Ltd. APPENDIX TO CONDENSED CONSOLIDATED INTERIM STATEMENTS OF CASH FLOWS (UNAUDITED) | ||
Six months ended June 30, | ||
2025 | 2026 | |
in USD thousands | ||
APPENDIX | ||
Adjustments required to reflect net cash used in operating | ||
Income and expenses not involving cash flows: | ||
Depreciation and amortization | 341 | 166 |
Exchange differences on cash and cash equivalents | (350) | (143) |
Fair value adjustments of warrants | (6,410) | 246 |
Share-based compensation | 247 | 157 |
Interest and exchange differences on short-term deposits | 48 | 124 |
Warrant issuance costs | 702 | - |
Exchange differences on lease liabilities | 110 | 82 |
(5,312) | 632 | |
Changes in operating asset and liability items: | ||
Decrease in trade receivables | 2,398 | - |
Decrease (increase) in prepaid expenses and other receivables | 1,146 | (447) |
Decrease (increase) in inventory | 295 | (19) |
Increase (decrease) in accounts payable and accruals | (2,482) | 1,264 |
1,357 | 798 | |
(3,955) | 1,430 | |
Supplemental information on interest received in cash | 583 | 463 |
Supplemental information on interest paid in cash | 694 | 467 |
Supplemental information on non-cash transactions: | ||
Changes in right-of-use asset and lease liabilities | 45 | 73 |
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SOURCE BioLineRx Ltd.