Cabaletta Bio Announces Multiple Upcoming Presentations, Including Data on Rese-cel without Preconditioning and Rese-cel with Automated Manufacturing, at the ASGCT 2026 Annual Meeting
Rhea-AI Summary
Cabaletta Bio (Nasdaq: CABA) will present multiple manufacturing, translational and clinical updates on resecabtagene autoleucel (rese-cel) at the ASGCT 2026 Annual Meeting in Boston, May 11–15, 2026. Sessions include data on rese-cel without preconditioning, automated Cellares Cell Shuttle manufacturing, donor vs patient product comparability, and single-cell profiling across RESET Phase 1/2 cohorts.
Selected poster dates: May 12 and May 14; presentation materials and accepted abstracts will be posted after presentation.
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Key Figures
Market Reality Check
Peers on Argus
CABA was down 3.28% with below‑average volume as at least 2 biotech peers (e.g., SGMO, AARD) also moved down (median around -3.5%), pointing to broader sector pressure rather than company‑specific trading.
Historical Context
| Date | Event | Sentiment | Move | Catalyst |
|---|---|---|---|---|
| Apr 14 | Manufacturing update | Positive | +4.3% | First two Cell Shuttle–manufactured rese-cel doses met specs and were infused. |
| Mar 23 | Earnings and update | Positive | -4.1% | Q4/FY25 results, cash runway into Q4 2026, and 2027 BLA plans for myositis. |
| Feb 24 | Conference participation | Neutral | +13.4% | Announcement of TD Cowen health care conference fireside chat participation. |
| Feb 05 | Conference participation | Neutral | -7.2% | Planned fireside chat at Guggenheim Emerging Outlook: Biotech Summit 2026. |
| Jan 12 | Strategic priorities | Positive | +5.2% | Outlined 2026 priorities for rese-cel development, registrational cohorts and automation. |
News tied to core RESET/Cell Shuttle execution has sometimes seen positive alignment, while conference and strategy updates have produced mixed, often divergent, price reactions.
Over the last few months, CABA has highlighted advancing rese‑cel across multiple autoimmune RESET trials, automation with Cellares’ Cell Shuttle, and a planned myositis registrational cohort and potential 2027 BLA. Strategic priorities and manufacturing/clinical updates on Jan 12 and Apr 14 coincided with gains, while the Mar 23 earnings and several conference participation announcements saw declines. Today’s ASGCT presentation notice extends this ongoing data and manufacturing‑focused communication cadence.
Regulatory & Risk Context
The company has an active S-3 shelf filed on 2025-08-07 that remains within its stated effectiveness window, with 0 recorded usage events and not yet effective as of the latest data.
Market Pulse Summary
This announcement details multiple ASGCT 2026 presentations covering rese-cel across no‑preconditioning, automated manufacturing, and single‑cell profiling in several RESET Phase 1/2 cohorts. It continues the company’s emphasis on execution around clinical data generation and scalable production. Investors tracking the story may focus on the depth of new clinical and translational data, manufacturing robustness, and how these results intersect with previously disclosed regulatory and strategic plans.
Key Terms
car t medical
autologous medical
4-1bb medical
pbmc medical
phase 1/2 medical
AI-generated analysis. Not financial advice.
PHILADELPHIA, April 27, 2026 (GLOBE NEWSWIRE) -- Cabaletta Bio, Inc. (Nasdaq: CABA), a late-stage clinical biotechnology company focused on developing and launching targeted cell therapies designed specifically for patients with autoimmune diseases, today announced multiple upcoming presentations including manufacturing, translational and clinical data on rese-cel (resecabtagene autoleucel) at the American Society of Gene & Cell Therapy (ASGCT) 2026 Annual Meeting, being held from May 11-15, 2026, in Boston, MA.
The presentations will feature clinical and translational data from the lowest dose cohort of rese-cel without preconditioning in RESET-PV® (pemphigus vulgaris), and initial translational data from the first two autoimmune patients treated with rese-cel manufactured using the automated Cellares Cell Shuttle™ platform in the RESET™ clinical development program. In addition, manufacturing comparability data between healthy donor and patient starting material as well as single-cell profiling across multiple RESET Phase 1/2 trial cohorts will be presented.
Presentation Details:
Title: CAR T therapy without preconditioning in pemphigus vulgaris: Early clinical and translational data with resecabtagene autoleucel, an autologous 4-1BB CD19-CAR T
Presentation ID: 3368
Session: Poster Reception
Date and Time: Thursday, May 14, 2026, 5:00 p.m. – 6:30 p.m. ET
Presenter: Jenell Volkov, Ph.D., Senior Director, Translational Medicine, Cabaletta Bio
Title: End-to-end fully automated CAR T manufacturing using the Cellares Cell Shuttle Platform: Initial translational data from autoimmune patients treated in RESET trials with rese-cel (Resecabtagene Autoleucel), an autologous 4-1BB CD19-CAR T cell therapy
Presentation ID: 3379
Session: Poster Reception
Date and Time: Thursday, May 14, 2026, 5:00 p.m. – 6:30 p.m. ET
Presenter: Daniel Nunez, Ph.D., Senior Director, Computational Biology, Cabaletta Bio
Title: Product quality for Resecabtagene autoleucel between healthy donors and autoimmune patients in the RESET clinical trial program starting material is consistent and platform agnostic demonstrating manufacturing robustness in the session Enabling the next generation of manufacturing ex-vivo cell therapies
Session: Enabling the next generation of manufacturing ex-vivo cell therapies
Date and Time: Tuesday, May 12, 2026, 11:00 a.m. ET
Presenter: Sagar Sharma, Scientist, Cabaletta Bio
Title: Single-cell profiling of PBMC subsets following rese-cel (Resecabtagene Autoleucel) treatment across the RESET-Myositis, RESET-SSc, and RESET-SLE trials Phase 1/2 Cohorts
Session: Emerging clinical evidence in cell and gene therapy: Long-term outcomes, biomarkers, and first-in-human insights
Date and Time: Wednesday, May 13, 2026, 8:45 a.m. ET
Presenter: Daniel Nunez, Ph.D., Senior Director, Computational Biology, Cabaletta Bio
Additional information, including the accepted abstracts, can be accessed on the website of the ASGCT 2026 Annual Meeting. Presentation materials will be made available on the Posters & Publications section of the Company’s website following their presentation.
About rese-cel
Rese-cel (resecabtagene autoleucel) is an investigational, autologous CAR T cell therapy engineered with a fully human CD19 binder and a 4-1BB co-stimulatory domain, designed specifically for the treatment of autoimmune diseases. Administered as a single, weight-based infusion, rese-cel has demonstrated the ability to transiently, reliably and deeply deplete CD19-positive cells, with the goal of resetting the immune system and achieving durable clinical responses without the need for chronic therapy. Cabaletta is evaluating rese-cel in the RESET™ (REstoring SElf-Tolerance) clinical development program, which includes multiple ongoing company-sponsored trials across a broad range of autoimmune diseases in rheumatology, neurology and dermatology.
About Cabaletta Bio
Cabaletta Bio (Nasdaq: CABA) is a late-stage clinical biotechnology company focused on developing and launching curative targeted cell therapies designed specifically for patients with autoimmune diseases. The CABA™ platform encompasses two complementary strategies which aim to advance the discovery and development of engineered T cell therapies with the potential to become deep and durable, perhaps curative, treatments for a broad range of autoimmune diseases. The lead CARTA (Chimeric Antigen Receptor T cells for Autoimmunity) strategy is prioritizing the development of rese-cel, a 4-1BB-containing fully human CD19-CAR T cell investigational therapy. Rese-cel is currently being evaluated in the RESET™ (REstoring SElf-Tolerance) clinical development program spanning multiple therapeutic areas, including rheumatology, neurology and dermatology. Cabaletta Bio’s headquarters and labs are located in Philadelphia, PA. For more information, please visit www.cabalettabio.com and connect with us on LinkedIn.
Contacts:
Anup Marda
Chief Financial Officer
investors@cabalettabio.com
