Caris Life Sciences Reports Fourth Quarter and Full Year 2025 Financial Results and Provides 2026 Outlook
Rhea-AI Summary
Caris Life Sciences (NASDAQ: CAI) reported strong 2025 results with $812.0M revenue, up 97% year-over-year, and Q4 revenue of $292.9M (+125%). Gross margin improved to 66% for FY 2025. The company reported positive Adjusted EBITDA $137.7M and positive free cash flow $66.9M. Caris expects 2026 revenue of $1.0B–$1.02B and reiterated plans to launch Caris Detect in H1 2026.
Positive
- Revenue +97% year-over-year to $812.0M
- Q4 revenue +125% to $292.9M
- Gross margin improved to 66% (FY 2025)
- Positive Adjusted EBITDA of $137.7M and FCF $66.9M
- 2026 revenue guide of $1.00B–$1.02B (+23%–26%)
Negative
- FY net loss of $68.1M despite Q4 profitability
- Operating expenses increased to $494.1M in 2025
- Revenue concentration — molecular profiling $766.7M of $812.0M
- 2026 GAAP Opex guide rising to $590M–$595M
Market Reaction – CAI
Following this news, CAI has gained 16.42%, reflecting a significant positive market reaction. Argus tracked a peak move of +16.0% during the session. Our momentum scanner has triggered 8 alerts so far, indicating moderate trading interest and price volatility. The stock is currently trading at $22.40. This price movement has added approximately $766M to the company's valuation.
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Key Figures
Market Reality Check
Peers on Argus
CAI is up 0.6% while peers show mixed moves (e.g., MRNA +1.23%, MDGL -1.13%). No evidence of a coordinated sector move.
Previous Earnings Reports
| Date | Event | Sentiment | Move | Catalyst |
|---|---|---|---|---|
| Jan 12 | Prelim 2025 results | Positive | -10.2% | Preliminary Q4 and 2025 results showing strong molecular profiling growth. |
| Nov 05 | Q3 2025 earnings | Positive | -15.8% | Q3 revenue more than doubled and 2025 revenue guidance raised sharply. |
| Aug 12 | Q2 2025 earnings | Positive | +5.6% | Q2 revenue up strongly with higher margins and positive adjusted EBITDA. |
Earnings releases have generally been strong fundamentally, but shares have often sold off, with two of the last three earnings events showing negative next-day moves despite positive trends.
Across recent earnings events on Aug 12, 2025, Nov 5, 2025, and the preliminary Q4 release on Jan 12, 2026, Caris highlighted rapid revenue growth, rising gross margins, and improving cash generation, largely driven by molecular profiling. Despite this, the stock reacted negatively to two of these three earnings updates. Today’s full Q4 and 2025 results and 2026 outlook build directly on that trajectory, confirming strong growth and profitability trends previously flagged in preliminary and quarterly updates.
Historical Comparison
Past 3 earnings headlines led to an average move of -6.78%, even as revenue and margins expanded. The latest Q4 and 2025 report continues this high-growth pattern with 2026 revenue guided to $1.0–$1.02B.
Earnings updates have shown accelerating revenue growth, margin expansion, and rising cash generation through 2025, with guidance repeatedly increased and preliminary Q4 figures now confirmed in the full-year release.
Market Pulse Summary
The stock is surging +16.4% following this news. A strong positive reaction aligns with the report’s combination of rapid revenue growth, margin expansion, and a clear 2026 outlook. Q4 revenue reached $292.9M with 75% gross margin, and full-year revenue hit $812.0M. Historically, earnings headlines averaged a -6.78% move, so sustained strength would contrast with past selloffs and could be tested by any shifts in growth, expenses, or cash generation.
Key Terms
adjusted ebitda financial
free cash flow financial
whole transcriptome medical
gaap financial
AI-generated analysis. Not financial advice.
Full year revenue growth of
Expects full year 2026 revenue to be in the range of
Fourth Quarter 2025 Financial Highlights
- Reported total revenue of
$292.9 million 125% over the corresponding prior year period. - Completed approximately 52,700 clinical therapy selection cases, an increase of approximately
20% over the corresponding prior year period, and consisting of approximately 44,150 MI Profile cases and approximately 8,550 Caris Assure cases. - Reported gross margin of
75% , an approximate 2,000 bps improvement over the corresponding prior year period. - Reported net income of
$82.0 million - Reported positive Adjusted EBITDA of
$106.1 million - Reported positive net cash provided by operating activities of
$44.8 million $39.7 million
Full Year 2025 Financial Highlights
- Reported total revenue of
$812.0 million 97% over the corresponding prior year. - Completed approximately 199,300 clinical therapy selection cases, an increase of approximately
22% over the corresponding prior year, and consisting of approximately 170,300 MI Profile cases and approximately 29,000 Caris Assure cases. - Reported gross margin of
66% , an approximate 2,300 bps improvement over the corresponding prior year period. - Reported net loss of
$68.1 million - Reported positive Adjusted EBITDA of
$137.7 million - Reported positive net cash provided by operating activities of
$83.2 million $66.9 million
"Demand for our platform continued to accelerate in 2025, driving strong growth in volume and revenue and expanding adoption across our solutions. We are focused on building on this momentum, advancing our pipeline, and are particularly excited about the planned launch of our Caris Detect solution in the first half of 2026, which we believe represents a significant growth opportunity for Caris and an important step forward for precision medicine," said David Dean Halbert, Founder, Chairman and CEO of Caris Life Sciences.
Recent Operating Highlights
- Surpassed 1,016,000 total profiles and 740,000 total matched profiles through December 31, 2025.
- More than 627,000 Whole Exome and 678,000 Whole Transcriptome profiles through December 31, 2025.
- Announced partnership with Everlywell to launch Caris' forthcoming MCED assay, Caris Detect.
- Announced collaboration with Genentech to discover novel therapeutic targets in cancers with high unmet clinical need.
Fourth Quarter 2025 Financial Results
Total revenue was
The increase in total revenue was driven primarily by a
Gross profit, calculated as total revenue less cost of services, for the three months ended December 31, 2025 and 2024, was
Operating expenses were
Net income was
Net cash provided by operating activities was
Full Year 2025 Financial Results
Total revenue was
The increase in total revenue was driven primarily by a
Gross profit, calculated as total revenue less cost of services, for the years ended December 31, 2025 and 2024 was
Operating expenses were
Net loss was
Net cash provided by operating activities was
2026 Financial Outlook and Guidance
Caris Life Sciences expects full year 2026 revenue to be in the range of
Within this revenue range:
- Molecular profiling revenue is expected to grow approximately
21% to22% year over year in 2026. Excluding out-of-year revenue from over collections recorded in 2025, this range implies growth of approximately26% to28% . - Pharma & research revenue is expected to be in the range of
$75 million $85 million
Caris Life Sciences expects GAAP operating expenses to be in the range of
Conference Call Information
Event: | Caris Fourth Quarter 2025 Financial Results Conference Call | |
Date: | Thursday, February 26, 2026 | |
Time: | 3:30 p.m. CT (4:30 p.m. ET) | |
Webcast Link: |
Accompanying materials will be posted on our investor relations website at https://investor.carislifesciences.com prior to the conference call. A replay of the conference call will be available on our investor relations website shortly after the conclusion of the call.
About Caris Life Sciences
Caris Life Sciences® (Caris) is a leading, patient-centric, next-generation AI TechBio company and precision medicine pioneer actively developing and commercializing innovative solutions to transform healthcare. Through comprehensive molecular profiling (Whole Genome, Whole Exome and Whole Transcriptome Sequencing), advanced AI and machine learning, Caris has created the large-scale, multimodal clinico-genomic database and computing capability needed to analyze and further unravel the molecular complexity of disease. This convergence of next-generation sequencing, AI and machine learning technologies and high-performance computing provides a differentiated platform for developing the latest generation of advanced precision medicine diagnostic solutions for early detection, diagnosis, monitoring, therapy selection and drug development.
Caris was founded with a vision to realize the potential of precision medicine to improve the human condition. Headquartered in
We intend to use the investor page of our website, https://investor.carislifesciences.com, as a distribution channel of material information about the Company and for complying with our disclosure obligations under Regulation FD. The information we post on our investor webpage may be deemed material. Accordingly, investors should subscribe to our investor alerts, in addition to following our press releases, SEC filings, public conference calls and webcasts.
Forward-Looking Statements
This press release contains forward-looking statements, within the meaning of the Private Securities Litigation Reform Act of 1995 and other federal securities laws. All statements other than statements of historical facts contained in this press release are forward-looking statements, including statements regarding our business, solutions, plans, objectives, goals, industry trends, financial outlook and guidance. In some cases forward-looking statements can be identified by words such as "may," "will," "should," "would," "expect," "plan," "anticipate," "could," "intend," "target," "project," "potential," "contemplate," "believe," "estimate," "predict," "potential" or "continue" or similar expressions.
You should not rely upon forward-looking statements as predictions of future events. Although we believe that the expectations reflected in these forward-looking statements are reasonable based on information currently available to us, we cannot guarantee that the future results, discoveries, levels of activity, performance or events and circumstances reflected in forward-looking statements will be achieved or occur. Forward-looking statements involve known and unknown risks and uncertainties, some of which are beyond our control. Risks and uncertainties that could cause our actual results to differ materially from those indicated or implied by the forward-looking statements in this press release include, among other things: developments in the precision medicine industry; our future financial performance, results of operations or other operational results or metrics; development, analytical and clinical validation, timing and performance of future solutions by us and our competitors; commercial market acceptance for our solutions, including acceptance of preventive as well as diagnostic testing paradigms, and our ability to meet resulting demand; the rapidly evolving competitive environment in which we operate; third-party payer reimbursement and coverage decisions related to our solutions; risks related to data management, storage, and processing capabilities and our ability to integrate and deploy artificial intelligence and advanced data analytics technologies; our ability to protect and enhance our intellectual property; regulatory requirements, decisions or approvals (including the timing and conditions thereof) related to our solutions; reliance on third-party suppliers; risks related to data security, patient privacy, and compliance with healthcare data protection regulations as well as potential cybersecurity threats to our data platforms; our compliance with laws and regulations; the outcome of government investigations and litigation; risks related to our indebtedness; and our ability to hire and retain key personnel as well as risks, uncertainties, and other factors described in the section titled "Risk Factors" and elsewhere in our Annual Report on Form 10-K filed on or about March 3, 2026, and in our other filings we make with the SEC from time to time. We undertake no obligation to update any forward-looking statements to reflect changes in events, circumstances or our beliefs after the date of this press release, except as required by law.
Non-GAAP Measures
We use Adjusted EBITDA and free cash flow, financial measures not calculated in accordance with generally accepted accounting principles in
We define Adjusted EBITDA as net loss, adjusted to exclude interest income, interest expense, changes in fair value of financial instruments, other expense, net, the provision for (benefit from) income taxes, depreciation and amortization, and stock-based compensation expense. We use Adjusted EBITDA in conjunction with GAAP measures as part of our overall assessment of our performance, including the preparation of our annual operating budget and quarterly forecasts, to evaluate the effectiveness of our business strategies, and to communicate with our board of directors concerning our financial performance. We believe Adjusted EBITDA provides useful information to investors and others in understanding and evaluating our operating results in the same manner as our management team and board of directors. Adjusted EBITDA provides a useful measure for period-to-period comparisons of our business, as it removes the effect of certain non-cash expenses and certain variable charges.
We define free cash flow as net cash provided by (used in) operating activities less purchases of property and equipment. We believe free cash flow is a useful measure of liquidity that provides an additional basis for assessing our ability to generate cash.
A reconciliation of the historical non-GAAP financial measures used in this press release to the respective comparable GAAP financial measures, can be found below.
Caris Life Sciences Media:
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Investor Relations:
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Caris Life Sciences, Inc. Condensed Consolidated Statements of Operations and Comprehensive Loss (unaudited)
| |||||||
(amounts in thousands, except share and per share data) | Three Months Ended | Years Ended December 31, | |||||
2025 | 2024 | 2025 | 2024 | ||||
Revenue: | |||||||
Molecular profiling services | $ 282,126 | $ 94,423 | $ 766,719 | $ 349,115 | |||
Pharma research and development services | 10,760 | 35,492 | 45,314 | 63,145 | |||
Total revenue | 292,886 | 129,915 | 812,033 | 412,260 | |||
Costs and operating expenses: | |||||||
Cost of Services - Molecular profiling services | 69,158 | 55,941 | 262,353 | 223,075 | |||
Cost of Services - Pharma research and development services | 2,814 | 3,273 | 10,512 | 10,403 | |||
Selling and marketing expense | 44,151 | 37,525 | 167,506 | 152,602 | |||
General and administrative expense | 56,507 | 43,113 | 224,965 | 169,386 | |||
Research and development expense | 31,845 | 27,109 | 101,584 | 113,916 | |||
Total costs and operating expenses | 204,475 | 166,961 | 766,920 | 669,382 | |||
Income (Loss) from operations | 88,411 | (37,046) | 45,113 | (257,122) | |||
Other expense, net: | |||||||
Interest income | 7,015 | 970 | 16,497 | 7,122 | |||
Interest expense | (11,356) | (13,262) | (56,853) | (50,025) | |||
Changes in fair value of financial instruments | — | 12,417 | (52,285) | 18,484 | |||
Other expense, net | (2,113) | (26) | (20,560) | (349) | |||
Total other expense, net | (6,454) | 99 | (113,201) | (24,768) | |||
Income (Loss) before income taxes and provision for income taxes | 81,957 | (36,947) | (68,088) | (281,890) | |||
Provision for income taxes | — | — | — | — | |||
Net income (loss) | 81,957 | (36,947) | (68,088) | (281,890) | |||
Other comprehensive income, net of tax: | |||||||
Unrealized gain on available-for-sale securities | — | — | — | 7 | |||
Foreign currency translation adjustments | 188 | 5 | 726 | (15) | |||
Comprehensive income (loss) | 82,145 | (36,942) | (67,362) | (281,898) | |||
Net income (loss) attributable to common shareholders: | |||||||
Net income (loss) | 81,957 | (36,947) | (68,088) | (281,890) | |||
Deemed dividend from Series D redeemable convertible preferred stock | — | — | (384,436) | — | |||
Adjustments of redeemable convertible preferred stock to redemption value | — | (24,999) | (85,433) | (96,367) | |||
Net income (loss) attributable to common shareholders | $ 81,957 | $ (61,946) | $ (537,957) | $ (378,257) | |||
Net income (loss) per share attributable to common shareholders: | |||||||
Basic | $ 0.29 | $ (1.73) | $ (3.22) | $ (10.66) | |||
Diluted | $ 0.28 | $ (1.73) | $ (3.22) | $ (10.66) | |||
Weighted-average shares used in computing net income (loss) per share | |||||||
Basic | 282,215,465 | 35,828,916 | 167,205,616 | 35,496,832 | |||
Diluted | 296,089,041 | 35,828,916 | 167,205,616 | 35,496,832 | |||
Caris Life Sciences, Inc. Condensed Consolidated Balance Sheets (unaudited)
| |||
(amounts in thousands, except share data) | As of December 31, | ||
2025 | 2024 | ||
Assets | |||
Current assets: | |||
Cash, cash equivalents, and restricted cash | $ 797,799 | $ 65,442 | |
Short-term marketable securities | 2,295 | 2,201 | |
Accounts receivable | 112,140 | 88,244 | |
Supplies | 63,625 | 39,572 | |
Prepaid expenses and other current assets | 21,941 | 20,270 | |
Total current assets | 997,800 | 215,729 | |
Property and equipment, net | 63,170 | 67,817 | |
Goodwill | 19,344 | 19,344 | |
Other assets | 45,349 | 40,844 | |
Total assets | $ 1,125,663 | $ 343,734 | |
Liabilities, Redeemable Convertible Preferred Stock, and Shareholders' Equity (Deficit) | |||
Current liabilities: | |||
Accounts payable | $ 39,206 | $ 27,791 | |
Accrued expenses and other current liabilities | 87,770 | 77,542 | |
Current portion of indebtedness | 169 | 60,090 | |
Total current liabilities | 127,145 | 165,423 | |
Long-term indebtedness, net of debt discounts | 378,823 | 319,438 | |
Warrant liabilities | — | 91,642 | |
Other long-term liabilities | 42,388 | 44,418 | |
Total liabilities | 548,356 | 620,921 | |
Commitments and contingencies | |||
Redeemable convertible preferred stock: | |||
Series A preferred stock, par value | — | 709,261 | |
Series B preferred stock, par value | — | 42,963 | |
Series C preferred stock, par value | — | 408,715 | |
Series D preferred stock, par value | — | 1,060,712 | |
Redeemable convertible preferred stock | — | 2,221,651 | |
Shareholders' equity (deficit): | |||
Preferred stock, | — | — | |
Common stock | 283 | 38 | |
Treasury stock at cost, 1,611,713 and 182,500 shares of common stock as of December 31, 2025 | (16,896) | (330) | |
Additional paid-in capital | 3,141,720 | — | |
Related party promissory note receivable | — | (26,456) | |
Accumulated deficit | (2,548,736) | (2,472,300) | |
Accumulated other comprehensive income | 936 | 210 | |
Total shareholders' equity (deficit) | 577,307 | (2,498,838) | |
Total liabilities, redeemable convertible preferred stock, and shareholders' equity (deficit) | $ 1,125,663 | $ 343,734 | |
Caris Life Sciences, Inc. Condensed Consolidated Statement of Cash Flows (unaudited)
| |||
(amounts in thousands) | Years Ended December 31, | ||
2025 | 2024 | ||
Cash flows from operating activities | |||
Net loss | $ (68,088) | $ (281,890) | |
Adjustments to reconcile net loss to net cash used in operating activities: | |||
Depreciation and amortization | 22,615 | 48,913 | |
Stock-based compensation expense | 70,006 | 18,643 | |
Non-cash operating lease expense | 5,585 | 5,601 | |
Amortization of debt discounts | 12,768 | 7,054 | |
Changes in fair value of financial instruments | 52,285 | (18,484) | |
Loss on debt extinguishment | 19,895 | — | |
Other | 1,216 | 4,031 | |
Changes in operating assets and liabilities: | |||
Accounts receivable | (29,789) | (33,816) | |
Supplies | (20,750) | 5,459 | |
Prepaid expenses and other current assets | (5,150) | (1,408) | |
Other assets | 48 | 121 | |
Accounts payable | 11,035 | (226) | |
Accrued expenses and other liabilities | 11,479 | 803 | |
Net cash provided by (used in) operating activities | 83,155 | (245,199) | |
Cash flows from investing activities | |||
Maturities of marketable securities | — | 61,376 | |
Purchases of property and equipment | (16,260) | (8,444) | |
Net cash provided by (used in) investing activities | (16,260) | 52,932 | |
Cash flows from financing activities | |||
Payments made on finance lease obligations | (106) | (157) | |
Proceeds from exercise of stock options | 7,637 | 1,530 | |
Payment of taxes withheld from net settlement of exercised options and vested | (18,551) | — | |
Payment of deferred offering costs | (7,710) | (1,059) | |
Proceeds from the 2023 term loan, net of issuance costs | — | 199,978 | |
Repurchase of common stock | (113) | — | |
Issuance of Series E Preferred Stock, net of issuance costs | 87,637 | — | |
Issuance of Series F Preferred Stock, net of issuance costs | 33,601 | — | |
Issuance of the 2025 Convertible Notes, net of issuance costs | 27,865 | — | |
Issuance of the 2025 Warrants | 10,270 | — | |
Payments of 2023 term loan amendment fee | (4,000) | — | |
Proceeds from initial public offering, net of underwriting discounts and commissions | 528,459 | — | |
Net cash provided by financing activities | 664,989 | 200,292 | |
Effect of exchange rate changes on cash, cash equivalents, and restricted cash | 130 | (4) | |
Net increase in cash, cash equivalents, and restricted cash | 732,014 | 8,021 | |
Cash, cash equivalents, and restricted cash at beginning of period | 68,028 | 60,007 | |
Cash, cash equivalents, and restricted cash at end of period | $ 800,042 | $ 68,028 | |
Reconciliation of GAAP Net Loss to Adjusted EBITDA (unaudited)
| |||||||
(amounts in thousands) | Three Months Ended | Years Ended December 31, | |||||
2025 | 2024 | 2025 | 2024 | ||||
Net loss | $ 81,957 | $ (36,947) | $ (68,088) | $ (281,890) | |||
Interest income | (7,015) | (970) | (16,497) | (7,122) | |||
Interest expense | 11,356 | 13,262 | 56,853 | 50,025 | |||
Changes in fair value of financial instruments | — | (12,417) | 52,285 | (18,484) | |||
Other expense, net | 2,113 | 26 | 20,560 | 349 | |||
Provision for income taxes | — | — | — | — | |||
Depreciation and amortization expense | 4,291 | 9,066 | 22,615 | 48,913 | |||
Stock-based compensation expense | 13,367 | 4,977 | 70,006 | 18,643 | |||
Adjusted EBITDA | $ 106,069 | $ (23,003) | $ 137,734 | $ (189,566) | |||
Reconciliation of Net Cash Provided by (Used in) Operating Activities to Free Cash Flow (unaudited)
| |||||||
(amounts in thousands) | Three Months Ended | Twelve Months Ended | |||||
2025 | 2024 | 2025 | 2024 | ||||
Net cash provided by (used in) operating activities | $ 44,780 | $ (38,922) | $ 83,155 | $ (245,199) | |||
Less: purchases of property and equipment | (5,090) | (2,290) | (16,260) | (8,444) | |||
Free cash flow | $ 39,690 | $ (41,212) | $ 66,895 | $ (253,643) | |||
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SOURCE Caris Life Sciences
FAQ
What were Caris Life Sciences (CAI) full-year 2025 revenue and growth?
How did Caris (CAI) perform financially in Q4 2025?
What is Caris (CAI) guidance for full-year 2026 revenue and growth?
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