Cytokinetics Announces Nine Upcoming Presentations at the European Society of Cardiology Heart Failure 2026 Congress
Rhea-AI Summary
Cytokinetics (Nasdaq: CYTK) will present nine abstracts at the European Society of Cardiology Heart Failure 2026 Congress in Barcelona, May 9–12, 2026. Eight presentations focus on MYQORZO (aficamten), including a late‑breaking oral MAPLE‑HCM presentation; one presentation covers omecamtiv mecarbil and several moderated and ePoster sessions report clinical and real‑world HCM findings.
Positive
- None.
Negative
- None.
News Market Reaction – CYTK
In the Apr 28 session, CYTK declined 1.48%, reflecting a mild negative market reaction.
Data tracked by StockTitan Argus on the day of publication.
Key Figures
Historical Context
| Date | Event | Sentiment | 24h Move | Catalyst |
|---|---|---|---|---|
| Apr 21 | Earnings date notice | Neutral | +0.8% | Announcement of Q1 2026 results date and conference call logistics. |
| Apr 20 | Equity inducement grants | Neutral | -0.5% | Inducement stock options and RSUs granted to new employees under Nasdaq rules. |
| Apr 06 | Conference participation | Neutral | +0.8% | Needham 2026 virtual healthcare conference fireside chat announcement. |
| Mar 18 | Equity inducement grants | Neutral | +1.2% | Inducement stock options and RSUs for recent hires under equity plan. |
| Mar 16 | Scientific presentations | Positive | +0.9% | Four ACC 2026 presentations highlighting MYQORZO data and regulatory approvals. |
24h Move is the share-price change in the day after each event; other market factors may also have contributed.
Recent CYTK headlines, including scientific conference appearances and corporate updates, have typically produced modest single-day moves, often slightly positive, suggesting the current larger decline against constructive scientific news is atypical versus this short history.
Over the last few months, Cytokinetics has mainly issued routine corporate and scientific updates. On Mar 16, four ACC 2026 presentations on MYQORZO, including pooled analyses (pooled n=371; washout n=182), coincided with a 0.87% gain. Subsequent news on inducement grants and conference participation (Mar 18, Apr 6, Apr 20) produced modest moves between roughly -0.51% and +1.22%. The upcoming Q1 2026 earnings date announced on Apr 21 saw a 0.79% rise, framing today’s larger downside move versus another set of MYQORZO-focused presentations as a departure from these generally muted reactions.
Key Terms
allosteric medical
cardiac myosin medical
left ventricular outflow tract (LVOT) medical
hypertrophic cardiomyopathy medical
heart failure with reduced ejection fraction (HFrEF) medical
qrs duration medical
resynchronization medical
nyha class medical
AI-generated analysis. How Rhea-AI works. Not financial advice.
SOUTH SAN FRANCISCO, Calif., April 28, 2026 (GLOBE NEWSWIRE) -- Cytokinetics, Incorporated (Nasdaq: CYTK) today announced nine presentations at the European Society of Cardiology Heart Failure 2026 Congress taking place in Barcelona, Spain, from May 9–12, 2026. Eight presentations, including a late-breaking science oral presentation, are related to MYQORZO® (aficamten). Recently approved for the treatment of adults with symptomatic obstructive hypertrophic cardiomyopathy (oHCM) by the U.S. Food and Drug Administration, European Commission, and the China National Medical Products Administration, MYQORZO is an allosteric and reversible inhibitor of cardiac myosin motor activity. In patients with oHCM, myosin inhibition with MYQORZO reduces cardiac contractility and consequently, left ventricular outflow tract (LVOT) obstruction.
Late Breaking Science Oral Presentation
Title: Dose-dependent effects of aficamten compared with metoprolol in obstructive HCM: the MAPLE-HCM study
Presenter: Pablo Garcia-Pavia, M.D., Ph.D., Head of the Inherited Cardiac Diseases and Heart Failure Unit, Department of Cardiology, Hospital Universitario Puerta de Hierro and Full Professor at Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain
Date: May 11, 2026
Session Title: Advances in Cardiomyopathies
Session Time: 3:30 PM – 4:30 PM CEST
Presentation Time: 4:06 PM – 4:18 PM CEST
Location: Room 3
Rapid Fire Presentations
Title: Favorable Effect of Aficamten on Left Atrial Mechanics in Obstructive Hypertrophic Cardiomyopathy: Insights From the SEQUOIA-HCM Trial
Presenter: Yasuhiro Hamatani, M.D., Ph.D., Postdoctoral Fellow, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
Date: May 9, 2026
Session Title: Advanced Phenotyping and Risk Stratification in Cardiomyopathies and Myocarditis
Session Time: 3:30 PM – 4:30 PM CEST
Presentation Time: 3:47 PM – 3:55 PM CEST
Location: Agora 2
Title: Effect of Aficamten Compared with Metoprolol in Women Versus Men: Analysis of MAPLE-HCM
Presenter: Xiaowen Wang, MD, MPH, Associate Director, Cardiac Imaging Core Lab, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
Date: May 10, 2026
Session Title: Novel and Targeted Therapies: Precision Pharmacology in Heart Failure
Session Time: 2:30 PM – 3:15 PM CEST
Presentation Time: 2:57 PM – 3:06 PM CEST
Location: Agora 2
In addition to the rapid fire presentations related to MYQORZO® (aficamten), one presentation will offer further insights into the treatment effect of omecamtiv mecarbil in heart failure with reduced ejection fraction (HFrEF).
Title: The Influence of QRS Duration and Resynchronization Status on the Efficacy and Safety of Omecamtiv Mecarbil in Heart Failure with Reduced Ejection Fraction: The GALACTIC-HF Trial
Presenter: Mihály Ruppert, MD, PhD, Researh Fellow, Brigham and Women's Hospital, Boston, MA, USA
Date: May 10, 2026
Session Title: Novel and Targeted Therapies: Precision Pharmacology in Heart Failure
Session Time: 2:30 PM – 3:15 PM CEST
Presentation Time: 2:39 PM – 2:48 PM CEST
Location: Agora 2
Moderated Posters
Title: No Increase in Arrhythmia Burden Following Aficamten Treatment in Obstructive Hypertrophic Cardiomyopathy: Extended Ambulatory Electrocardiogram Analysis From FOREST-HCM
Presenter: Ethan J. Rowin, M.D., Associate Professor of Medicine at UMass Chan-Lahey, UMass Chan Medical School, Lahey Hospital & Medical Center, Burlington, MA
Date: May 11, 2026
Session Title: Hypertrophic Obstructive Cardiomyopathy: Treatment, Monitoring, and Outcomes
Session Time: 1:30 PM – 2:15 PM CEST
Location: Moderated ePosters 3
Title: Clinical and Economic Burden in NYHA Class I Versus II-IV Hypertrophic Cardiomyopathy: Real-World Survey Data From the United States of America
Presenter: Paulos Gebrehiwet, PhD, Senior Manager, Health Economics and Outcomes Research, Europe, Cytokinetics
Date: May 10, 2026
Session Title: Comprehensive phenotyping and real-world impact in hypertrophic cardiomyopathy
Session Time: 10:30 AM – 11:15 AM CEST
Location: Moderated ePosters 3
Title: Impact of Guideline-Directed Medical Therapies on Clinical and Economic Outcomes in Nonobstructive Hypertrophic Cardiomyopathy: Analysis of Data from a Multinational Cross-Sectional Survey
Presenter: Paulos Gebrehiwet, PhD, Senior Manager, Health Economics and Outcomes Research, Europe, Cytokinetics, South San Francisco, CA
Date: May 10, 2026
Session Title: Comprehensive phenotyping and real-world impact in hypertrophic cardiomyopathy
Session Time: 10:30 AM – 11:15 AM CEST
Location: Moderated ePosters 3
ePoster Presentations
Title: Impact of Hypertrophic Cardiomyopathy on Work Productivity and Activity Impairment in Patients with HCM: Analysis of a Real-World Cross-Sectional Survey
Presenter: Paulos Gebrehiwet, PhD, Senior Manager, Health Economics and Outcomes Research, Europe, Cytokinetics, South San Francisco, CA
Date: May 9, 2026
Session Title: ePosters in myocardial disease - hypertrophic cardiomyopathy (2)
Session Time: 8:30 AM – 5:30 PM CEST
Presentation Time: 8:30 AM – 9:30 AM CEST
Location: ePosters screen 22
Title: Phenotypic Distribution and Clinical Burden of Pediatric Hypertrophic Cardiomyopathy: Insights From a Longitudinal US Claims Database
Presenter: Jennifer Conway, MD, FRCPC, MSc, Professor of Pediatrics, Director of the Heart Function and Cardiomyopathy Program, Stollery Children’s Hospital, Edmonton, Canada
Date: May 10, 2026
Session Title: ePosters in myocardial disease - hypertrophic cardiomyopathy (2)
Session Time: 8:30 AM – 5:30 PM CEST
Presentation Time: 4:30 PM – 5:30 PM CEST
Location: ePosters screen 22
About MYQORZO® (aficamten)
MYQORZO® (aficamten) is a cardiac myosin inhibitor approved in the U.S., China and European Union for the treatment of symptomatic obstructive hypertrophic cardiomyopathy (oHCM). In patients with oHCM, myosin inhibition with MYQORZO reduces cardiac contractility and consequently, left ventricular outflow tract (LVOT) obstruction. MYQORZO was engineered to achieve a predictable exposure response, rapid onset of action and reversibility.1
Aficamten is also under clinical investigation in ACACIA-HCM, a Phase 3 trial in patients with non-obstructive HCM (nHCM) and CEDAR-HCM, in a pediatric population with oHCM. Aficamten has not been deemed safe or effective for use in either of these patient populations. In addition, aficamten is being studied in FOREST-HCM, an open-label extension clinical study.
INDICATIONS AND USAGE
MYQORZO is indicated for the treatment of adults with symptomatic oHCM to improve functional capacity and symptoms.
IMPORTANT SAFETY INFORMATION
| WARNING: RISK OF HEART FAILURE MYQORZO reduces left ventricular ejection fraction (LVEF) and can cause heart failure due to systolic dysfunction. Echocardiogram assessments are required prior to and during treatment with MYQORZO to monitor for systolic dysfunction. Initiation of MYQORZO in patients with LVEF < Because of the risk of heart failure due to systolic dysfunction, MYQORZO is available only through a restricted program under a Risk Evaluation and Mitigation Strategy (REMS) called the MYQORZO REMS Program. |
CONTRAINDICATIONS
MYQORZO is contraindicated with concomitant use of rifampin.
WARNING AND PRECAUTIONS
Heart Failure
MYQORZO reduces cardiac contractility, which can reduce LVEF and cause heart failure.
Patients who experience a serious intercurrent illness (eg, serious infection) or arrhythmia (eg, new or uncontrolled atrial fibrillation) may be at greater risk of developing systolic dysfunction and heart failure.
Assess patients’ clinical status and LVEF prior to and during treatment and adjust the MYQORZO dose accordingly. New or worsening arrhythmia, dyspnea, chest pain, fatigue, leg edema, or elevations in N-terminal pro-B-type natriuretic peptide may be signs and symptoms of heart failure.
Initiation of MYQORZO in patients with LVEF <
MYQORZO REMS Program
MYQORZO is available only through a restricted program called the MYQORZO REMS Program, because of the risk of heart failure due to systolic dysfunction.
Notable requirements of the MYQORZO REMS Program include:
- Prescribers must be certified by enrolling in the MYQORZO REMS Program
- Patients must enroll in the MYQORZO REMS Program and comply with ongoing monitoring requirements
- Pharmacies must be certified by enrolling in the MYQORZO REMS Program and must only dispense to patients who are authorized to receive MYQORZO
- Wholesalers and distributors must only distribute to certified pharmacies
Further information is available at www.MYQORZOREMS.com, or at 1-844-285-7367.
Cytochrome P450 Interactions Leading to Heart Failure or Loss of Effectiveness
MYQORZO is metabolized primarily by CYP2C9, and to a lesser extent by CYP3A, CYP2D6, and CYP2C19 enzymes. Initiation of medications that inhibit multiple P450 pathways of MYQORZO elimination (eg, fluconazole, voriconazole, or fluvoxamine) or strong CYP2C9 inhibitors, and discontinuation of moderate-to-strong CYP3A inducers may lead to increased blood concentrations of aficamten and increase the risk of heart failure due to systolic dysfunction. Conversely, initiation of medications that induce P450 pathways of MYQORZO (eg, rifampin, moderate-to-strong CYP3A inducers) may lead to decreased blood concentrations of aficamten and potential loss of effectiveness. Assess LVEF 2 to 8 weeks after initiation of such inhibitors or after discontinuation of such inducers and adjust the dose of MYQORZO accordingly.
Advise patients of the potential for drug interactions. Advise patients to inform their healthcare provider of all concomitant medications prior to and during MYQORZO treatment.
ADVERSE REACTIONS
Hypertension (
Please see full Prescribing Information, including Boxed WARNING and Medication Guide.
About Hypertrophic Cardiomyopathy
Hypertrophic cardiomyopathy (HCM) is a disease in which the heart muscle becomes abnormally thick. HCM can be obstructive, when thickened muscle blocks blood flow, or non-obstructive, when blood flow is not blocked but heart function is still affected. In obstructive HCM, the thickening of cardiac muscle leads to the inside of the left ventricle becoming smaller, stiffer and less able to relax and fill with blood. Ultimately, HCM limits the heart’s pumping function, leading to reduced exercise capacity and a variety of symptoms.
HCM is the most common monogenic inherited cardiovascular disorder, with well over 300,000 patients diagnosed in the U.S.2 However, there are an estimated 400,000-800,000 additional patients who remain undiagnosed.3,4,5 Approximately half of patients with HCM have obstructive HCM (oHCM) and half have non-obstructive HCM (nHCM).2
People with HCM are at high risk of also developing cardiovascular complications including atrial fibrillation, stroke and mitral valve disease.6 People with HCM are at risk for potentially fatal ventricular arrhythmias and it is one of the leading causes of sudden cardiac death in younger people or athletes.7 A subset of patients with HCM are at high risk of progressive disease leading to dilated cardiomyopathy and heart failure necessitating cardiac transplantation.
About Cytokinetics
Cytokinetics is a specialty cardiovascular biopharmaceutical company, building on its over 25 years of pioneering scientific innovations in muscle biology, and advancing a pipeline of potential new medicines for patients suffering from diseases of cardiac muscle dysfunction. Cytokinetics’ MYQORZO® (aficamten) is a cardiac myosin inhibitor approved in the U.S., Europe and China for the treatment of adults with symptomatic obstructive hypertrophic cardiomyopathy (oHCM). Aficamten is also being studied for the potential treatment of non-obstructive HCM. Cytokinetics is also developing omecamtiv mecarbil, an investigational cardiac myosin activator for the potential treatment of patients with heart failure with severely reduced ejection fraction and ulacamten, an investigational cardiac myosin inhibitor for the potential treatment of heart failure with preserved ejection fraction, while continuing pre-clinical research and development in muscle biology.
For additional information about Cytokinetics, visit www.cytokinetics.com and follow us on X, LinkedIn, Facebook and YouTube.
Forward-Looking Statements
This press release contains forward-looking statements for purposes of the Private Securities Litigation Reform Act of 1995 (the “Act”). Cytokinetics disclaims any intent or obligation to update these forward-looking statements and claims the protection of the Act's safe harbor for forward-looking statements. Examples of such statements include, but are not limited to, statements, express or implied, related to Cytokinetics’ research and development activities; clinical trial initiation, design, enrollment, conduct, progress, continuation, completion, timing and results; regulatory submissions, review processes, approval timing and outcomes, including with respect to supplemental applications and approvals in jurisdictions outside the United States; the scope, expansion, modification, durability or continuation of labeling and promotional claims; commercial readiness, launch timing, market access and reimbursement; anticipated patient, prescriber and payer adoption; expectations regarding market opportunity, growth and market share; pipeline development and expansion into additional indications or geographies; access to and use of capital; and Cytokinetics’ business strategy, objectives and future plans. Such statements are based on management's current expectations and assumptions; however, actual results may differ materially due to various risks and uncertainties, including, but not limited to, uncertainties inherent in drug development and commercialization; the timing, conduct and outcomes of clinical trials; regulatory review and approval processes in the United States and other jurisdictions; differences in regulatory requirements, labeling, market access or promotional restrictions across jurisdictions; the ability to obtain, expand, maintain or continue desired labeling, promotional claims or commercial positioning for approved products; potential legal, intellectual property or regulatory constraints affecting commercialization and marketing claims; patient and prescriber acceptance of MYQORZO as compared to alternative therapies; the availability and terms of reimbursement from commercial and government payers; manufacturing, supply and distribution risks; competition; and the availability of sufficient capital to execute Cytokinetics’ business plans. These forward-looking statements speak only as of the date they are made, and Cytokinetics undertakes no obligation to subsequently update any such statement, except as required by law. For further information regarding these and other risks related to Cytokinetics’ business, investors should consult Cytokinetics’ filings with the Securities and Exchange Commission (the “SEC”).
CYTOKINETICS® and the CYTOKINETICS C-shaped logo are registered trademarks of Cytokinetics in the U.S. and certain other countries.
MYQORZO® is a registered trademark of Cytokinetics in the U.S. and the European Union.
Contact:
Cytokinetics
Diane Weiser
Senior Vice President, Corporate Affairs
(415) 290-7757
References
- Hartman JJ, Hwee DT, Roebrt-Paganin J, et al. Aficamten is a small-molecule cardiac myosin inhibitor designed to treat hypertrophic cardiomyopathy. Nat Cardiovasc Res. 2024;3(8) :1003-1016. doi:10.1038/s44161-024-00505-0
- Butzner M, et al. Epidemiology of Hypertrophic Cardiomyopathy in the United States From 2016 to 2023. JACC Adv. 2026. 2026;5(2):102552. doi:10.1016/j.jacadv.2025.102552
- CVrg: Heart Failure 2020-2029, p 44; Maron et al. 2013 doi:10.1016/S0140-6736(12)60397-3; Maron et al 2018 10.1056/NEJMra1710575
- Symphony Health 2016-2021 Patient Claims Data DoF;
- Maron MS, Hellawell JL, Lucove JC, Farzaneh-Far R, Olivotto I. Occurrence of Clinically Diagnosed Hypertrophic Cardiomyopathy in the United States. Am J Cardiol. 2016; 15;117(10):1651-1654.
- Gersh, B.J., Maron, B.J., Bonow, R.O., Dearani, J.A., Fifer, M.A., Link, M.S., et al. 2011 ACCF/AHA guidelines for the diagnosis and treatment of hypertrophic cardiomyopathy. A report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines. Journal of the American College of Cardiology and Circulation, 58, e212-260.
- Hong Y, Su WW, Li X. Risk factors of sudden cardiac death in hypertrophic cardiomyopathy. Current Opinion in Cardiology. 2022 Jan 1;37(1):15-21
