Gyre Therapeutics Reports Second Quarter 2025 and Year-to-Date Financial Results and Provides Business and Leadership Update
Gyre Therapeutics (NASDAQ:GYRE) reported Q2 2025 financial results with revenue of $26.8 million and net income of $1.6 million. The company announced a leadership change as Ping Zhang, Executive Chairman, was appointed interim CEO while Dr. Han Ying transitions to SVP of Science.
Key highlights include positive Phase 3 results for Hydronidone in CHB-associated liver fibrosis, successful launch of Etorel for SSc-ILD and PF-ILD treatments, and NMPA approval for pirfenidone clinical trials. The company reaffirmed its full-year 2025 revenue guidance of $118-128 million.
Financial position remains strong with $75.9 million in total cash and investments, bolstered by a $23 million public offering completed in May 2025.
Gyre Therapeutics (NASDAQ:GYRE) ha comunicato i risultati finanziari del secondo trimestre 2025 con ricavi per $26.8 milioni e utile netto di $1.6 milioni. L'azienda ha annunciato un cambiamento nella leadership: Ping Zhang, Presidente Esecutivo, è stato nominato CEO ad interim mentre il Dr. Han Ying passa a SVP della Scienza.
I principali punti salienti includono risultati positivi di Fase 3 per Hydronidone nella fibrosi epatica associata a CHB, il lancio riuscito di Etorel per i trattamenti di SSc-ILD e PF-ILD e l'approvazione da parte della NMPA per gli studi clinici sul pirfenidone. L'azienda ha confermato la guidance sui ricavi per l'intero 2025 di $118-128 milioni.
La posizione finanziaria resta solida con $75.9 milioni in liquidità e investimenti, rafforzata da un'offerta pubblica da $23 milioni completata a maggio 2025.
Gyre Therapeutics (NASDAQ:GYRE) presentó los resultados financieros del segundo trimestre de 2025 con ingresos de $26.8 millones y beneficio neto de $1.6 millones. La compañía anunció un cambio en la dirección: Ping Zhang, Presidente Ejecutivo, fue nombrado CEO interino mientras la Dra. Han Ying pasa a SVP de Ciencia.
Entre los principales hitos se incluyen resultados positivos de Fase 3 para Hydronidone en fibrosis hepática asociada a CHB, el exitoso lanzamiento de Etorel para los tratamientos de SSc-ILD y PF-ILD, y la aprobación de la NMPA para ensayos clínicos de pirfenidona. La compañía reafirmó su guía de ingresos para todo 2025 de $118-128 millones.
La posición financiera sigue sólida con $75.9 millones en efectivo e inversiones, reforzada por una oferta pública de $23 millones completada en mayo de 2025.
Gyre Therapeutics (NASDAQ:GYRE)는 2025년 2분기 실적을 발표하며 매출 $26.8 million과 순이익 $1.6 million을 기록했습니다. 회사는 경영진 변경을 발표했으며 핑 장(Ping Zhang) 이그제큐티브 의장이 임시 CEO로 임명되고 한잉 박사(Dr. Han Ying)는 과학 부문 SVP로 이동합니다.
핵심 내용으로는 CHB 관련 간 섬유증에 대한 Hydronidone의 3상 긍정적 결과, SSc-ILD 및 PF-ILD 치료를 위한 Etorel의 성공적 출시, 그리고 피르페니돈 임상시험에 대한 NMPA 승인 등이 있으며, 회사는 2025년 전체 매출 가이던스 $118-128 million을 재확인했습니다.
재무 상태는 총 현금 및 투자 $75.9 million으로 견조하며, 2025년 5월 완료된 $23 million 규모의 공모가 이를 뒷받침하고 있습니다.
Gyre Therapeutics (NASDAQ:GYRE) a publié ses résultats financiers du 2e trimestre 2025 avec des revenus de $26.8 millions et un bénéfice net de $1.6 million. La société a annoncé un changement de direction : Ping Zhang, président exécutif, a été nommé CEO par intérim tandis que le Dr Han Ying devient SVP en charge de la science.
Parmi les points marquants figurent des résultats positifs de Phase 3 pour Hydronidone dans la fibrose hépatique associée à la CHB, le lancement réussi de Etorel pour les traitements SSc-ILD et PF-ILD, et l'approbation par la NMPA des essais cliniques du pirfénidone. La société a réaffirmé ses prévisions de revenus pour l'année 2025 de $118-128 millions.
La position financière reste solide avec $75.9 millions en liquidités et investissements, renforcée par une augmentation de capital publique de $23 millions réalisée en mai 2025.
Gyre Therapeutics (NASDAQ:GYRE) meldete die Finanzergebnisse für Q2 2025 mit Umsätzen von $26.8 Millionen und Nettoeinnahmen von $1.6 Millionen. Das Unternehmen gab einen Führungswechsel bekannt: Ping Zhang, Executive Chairman, wurde zum Interim-CEO ernannt, während Dr. Han Ying in die Rolle des SVP of Science wechselt.
Wesentliche Highlights sind positive Phase‑3‑Ergebnisse für Hydronidone bei CHB-assoziierter Leberfibrose, die erfolgreiche Markteinführung von Etorel zur Behandlung von SSc-ILD und PF-ILD sowie die Zulassung durch die NMPA für klinische Studien mit Pirfenidon. Das Unternehmen bestätigte seine Umsatzprognose für das Gesamtjahr 2025 von $118-128 Millionen.
Die finanzielle Lage bleibt solide mit $75.9 Millionen an liquiden Mitteln und Investitionen, gestützt durch ein im Mai 2025 abgeschlossenes öffentliches Angebot über $23 Millionen.
- Positive Phase 3 trial results for Hydronidone showing statistically significant liver fibrosis regression
- Strong cash position of $75.9 million including recent $23 million public offering
- Successful commercial launch of Etorel generating $1.6 million in first partial quarter
- Increased ownership stake in Gyre Pharmaceuticals from 65.2% to 69.7%
- Q2 revenue growth to $26.8 million, up from $25.2 million year-over-year
- ETUARY sales declined by $6.8 million in first half 2025 compared to 2024
- Operating income decreased to $2.2 million from $3.2 million in Q2 2024
- Net income declined to $1.6 million from $4.5 million in Q2 2024
- General and administrative expenses increased by $1.4 million year-over-year
- Stock dilution from 2.56 million share public offering at $9.00 per share
Insights
Gyre's Q2 shows mixed results with leadership changes, pipeline progress, and maintained guidance despite decreasing profitability year-over-year.
Gyre Therapeutics posted
First-half results show more concerning trends, with six-month revenue declining
Despite these challenges, management maintained full-year 2025 guidance of
The company's cash position remains solid at
A significant leadership transition sees Executive Chairman Ping Zhang stepping in as interim CEO while Dr. Han Ying shifts to leading R&D activities. This restructuring prioritizes commercial expansion over scientific leadership at the executive level.
On the pipeline front, Hydronidone showed statistically significant liver fibrosis regression in a pivotal Phase 3 trial for CHB-associated liver fibrosis, positioning it for potential NMPA filing in Q3 2025. The company is also advancing multiple clinical programs, including a planned Phase 2 trial for Hydronidone in MASH-associated liver fibrosis in the US and a Phase 2/3 trial for pirfenidone in oncology-related pulmonary complications.
Net income of
Ping Zhang, Executive Chairman, appointed interim CEO as Dr. Han Ying transitions to scientific leadership role
- Revenue of
$26.8 million and$48.8 million for the three and six months ended June 30, 2025, respectively - GAAP basic EPS:
$0.00 and$0.04 for the three and six months ended June 30, 2025, respectively - Pivotal Phase 3 trial of Hydronidone (F351) in CHB-associated liver fibrosis demonstrated statistically significant fibrosis regression after 52 weeks of treatment; Phase 2 trial in the United States evaluating Hydronidone for the treatment of MASH-associated liver fibrosis expected to initiate in 2H 2025, pending regulatory approval
- Successfully launched Etorel (nintedanib ethanesulfonate soft capsules) in the PRC for the treatment of SSc-ILD and PF-ILD
- Announced NMPA approval for clinical trial evaluating pirfenidone capsules in oncology-related pulmonary complications with Phase 2/3 trial anticipated in 2H 2025
- First volunteer dosed in Phase 1 clinical trial of F230 for treatment of PAH
SAN DIEGO, Aug. 11, 2025 (GLOBE NEWSWIRE) -- Gyre Therapeutics (“Gyre”) (Nasdaq: GYRE), an innovative, commercial-stage biopharmaceutical company dedicated to advancing fibrosis-first therapies across organ systems affected by chronic disease, today announced financial results for the second quarter ended June 30, 2025 and provided a business and leadership update.
Dr. Han Ying has stepped down as Chief Executive Officer and will transition into the role of Senior Vice President, Science and will oversee research and discovery activities to support Gyre’s fibrosis focused pipeline. Ping Zhang, Executive Chairman, has been appointed Interim Chief Executive Officer, and will lead the company’s day-to-day operations and strategic global expansion.
“I want to thank Dr. Ying for his contributions and dedication during his tenure as CEO. His deep background in research and discovery will be invaluable to advance our science and continued innovation,” said Mr. Zhang. “As interim CEO, I am excited to work closely with our leadership team to strengthen Gyre’s global footprint and accelerate our progress toward delivering transformative therapies to patients.”
“Looking ahead, we are thrilled with the rapid progress we have made towards expanding our commercial footprint and advancing our pipeline of fibrosis-first therapies. Our lead compound, Hydronidone, demonstrated statistically significant fibrosis regression in patients with CHB-associated liver fibrosis in a pivotal Phase 3 trial in the PRC, a critical step that not only underscores the potential of Hydronidone, but also lays the foundation to expand into additional fibrotic indications,” continued Mr. Zhang. “In the second half of 2025 we are well-positioned to grow our footprint in the United States with our planned Phase 2 trial evaluating Hydronidone in MASH-associated liver fibrosis, while continuing to advance our robust pipeline in the PRC, highlighted by a new Phase 2/3 trial of pirfenidone in oncology-related pulmonary complications expected to initiate later this year. In addition, Gyre Pharmaceuticals remains on track to file an NDA for Hydronidone with the NMPA in the third quarter of 2025 to potentially support our growing commercial portfolio.”
Second Quarter Business Highlights and Upcoming Milestones
Commercial Portfolio Expansion
ETUARY® (pirfenidone): Generated
Etorel (nintedanib ethanesulfonate soft capsules): In June 2025, Gyre launched Etorel in the PRC for the treatment of systemic sclerosis-associated ILD, and progressive fibrosing ILD, and generated sales of
Contiva (avatrombopag maleate tablets): In March 2025, Gyre initiated commercialization of Contiva in the PRC for thrombocytopenia in adults with chronic liver disease and immune thrombocytopenic purpura, and generated sales for
Pipeline Development Updates
Hydronidone:
- In May 2025, Gyre reported positive results from its pivotal Phase 3 trial of Hydronidone for chronic hepatitis B (“CHB”)-associated liver fibrosis in the PRC, which demonstrated statistically significant regression in liver fibrosis after 52 weeks compared to placebo. In addition, Hydronidone met a key secondary endpoint with statistically significant inflammation improvement without fibrosis progression at Week 52 versus the placebo arm. Hydronidone was well tolerated with a comparable incidence of serious adverse events (
4.88% vs.6.45% in the placebo group) and no discontinuations due to adverse events in either group. Gyre plans to submit primary results for publication in a peer-reviewed journal and present full trial results at a future medical conference. Based on these results, Gyre intends to file a New Drug Application (“NDA”) with the PRC’s National Medical Products Administration (“NMPA”) in the third quarter of 2025. - Gyre previously submitted an investigational new drug application (“IND”) for the treatment of liver fibrosis associated with a broad spectrum of chronic liver diseases with the U.S. Food and Drug Administration and conducted a Phase 1 trial of Hydronidone in healthy volunteers for the treatment of metabolic dysfunction-associated steatohepatitis (“MASH”)-associated liver fibrosis. The Company is currently conducting an internal review to determine whether a new IND will be required for a Phase 2 trial in MASH-associated liver fibrosis. The Phase 2 trial is expected to start in the second half of 2025, subject to regulatory feedback.
ETUARY® (Pirfenidone):
- Gyre plans to initiate an adaptive Phase 2/3 trial of pirfenidone for radiation-induced lung injury (“RILI”), including cases complicated by immune-related pneumonitis across top oncology centers in the PRC in the second half of 2025.
F573:
- F573 is a caspase inhibitor and potential Category 1 new drug for the treatment of acute/acute on-chronic liver failure (“ALF/ACLF”). Completion of the Phase 2 clinical trial of F573 for ALF/ACLF is expected by the end of 2026.
F230:
- In June 2025, the first volunteer was successfully dosed in a Phase 1 clinical trial evaluating F230, a novel endothelin A receptor agonist, for the treatment of pulmonary arterial hypertension (“PAH”) in the PRC.
F528:
- F528, a novel anti-inflammation agent with the potential to modify the progression of chronic obstructive pulmonary disease (“COPD”), is undergoing preclinical studies as a potential first-line therapy for the treatment of COPD. Gyre plans to submit an IND application in 2026.
Corporate Updates
- In August 2025, Ping Zhang was appointed interim CEO as Dr. Han Ying transitions to a scientific leadership role. Mr. Zhang, who was appointed Executive Chairman in March 2025, has served on Gyre’s Board of Directors since January 2025.
- In May 2025, Gyre completed an underwritten public offering of 2,555,555 shares of its common stock at a public offering price of
$9.00 per share. The gross proceeds of the offering, before deducting underwriting discounts and commissions and other offering expenses, were approximately$23.0 million . - In the third quarter of 2025, BJContinent Pharmaceuticals Limited increased its capital contribution in Gyre Pharmaceuticals (also known as Beijing Continent Pharmaceuticals Co., Ltd.) by
$1.28 million in exchange for 9,184,910 additional shares. As a result, the Company’s indirect interest in Gyre Pharmaceuticals increased from65.2% to69.7% .
Financial Results
Cash Position
As of June 30, 2025, Gyre held
Financial Results for the Three Months Ended June 30, 2025
- Revenues: Revenues for the three months ended June 30, 2025 were
$26.8 million , compared to$25.2 million for the same period in 2024. The$1.6 million increase was primarily driven by a$1.6 million increase in revenue as a result of Etorel’s commercial launch in June 2025 and a$1.5 million increase in revenue from the sales of Contiva. These increases were offset by a$1.5 million decline in ETUARY® sales.
Gyre anticipates revenue growth over the remainder of the year, driven by the commercial launch of Etorel in June 2025 and the continued expansion of Contiva.
- Cost of Revenues: For the three months ended June 30, 2025, cost of revenues was
$1.2 million , compared to$0.8 million for the same period in 2024. The$0.4 million increase was primarily driven by a$0.2 million increase in the costs associated with Contiva and Etorel, in line with the corresponding increase in their sales, and a$0.2 million increase in ETUARY®’s cost due to the higher plant, property and equipment depreciation from a plant renovation. - Selling and Marketing Expense: For the three months ended June 30, 2025, selling and marketing expense was
$15.2 million , compared to$14.4 million for the same period in 2024. The$0.8 million increase was primarily attributable to a$0.9 million increase in payroll costs, driven by higher headcount and increase of sales in the three months ended June 30, 2025, partially offset by$0.1 million decrease in promotion and conference expenses. - Research and Development Expense: For the three months ended June 30, 2025, research and development expense was
$3.4 million , compared to$3.3 million for the same period in 2024. The$0.1 million increase was primarily attributable to a$0.1 million increase in clinical trial costs, primarily related to data analysis costs for Hydronidone, and a$0.1 million increase in staff costs. These increases were partially offset by a$0.1 million decrease in materials and utilities expenses. - General and Administrative Expense: For the three months ended June 30, 2025, general and administrative expense was
$4.8 million , compared to$3.4 million for the same period in 2024. The$1.4 million increase was primarily driven a$0.5 million increase in professional fees, and a$0.9 million increase in functional and administrative department’s personnel and stock compensation costs. - Income from Operations: For the three months ended June 30, 2025, income from operations was
$2.2 million , compared to$3.2 million income from operation for the same period in 2024. The$1.0 million decrease was primarily driven by$2.6 million increase in total operating expenses, partially offset by a$1.6 million increase in revenue. - Net Income: For the three months ended June 30, 2025, net income was
$1.6 million , compared to$4.5 million net income for the same period in 2024. - Non-GAAP Adjusted Net Income: For the three months ended June 30, 2025, non-GAAP adjusted net income was
$2.9 million , compared to$3.1 million non-GAAP adjusted net income for the same period in 2024. The decrease was primarily driven by the increase in operating expenses of$1.7 million , partially offset by an increase in revenue of$1.6 million .
Financial Results for the Six Months Ended June 30, 2025
- Revenues: Revenues for the six months ended June 30, 2025 were
$48.8 million , compared to$52.4 million for the same period in 2024. The$3.6 million decrease was primarily driven by a$6.8 million decline in ETUARY® sales, partially offset by the increase in new product sales of Contiva by$1.8 million and Etorel by$1.6 million . The decrease in ETUARY® sales was mainly due to lower sales volume compared to the first half of 2024, when revenues were elevated by a one-time rural marketing campaign that was not repeated in 2025. Additionally, weaker economic conditions in China and increased competition in the IPF treatment market also contributed to the decline. During the first half of 2025, marketing funds were intentionally shifted to support the launches of Etorel and Contiva.
Gyre anticipates revenue growth over the remainder of the year, driven by the continued expansion of Contiva in March 2025 and the commercial launch of Etorel in June 2025.
- Cost of Revenues: For the six months ended June 30, 2025, cost of revenues was
$2.0 million , compared to$1.7 million for the same period in 2024. The$0.3 million increase was primarily driven by a$0.1 million increase in stock-based compensation and a$0.2 million increase in the costs of Etorel and Contiva, in line with the corresponding increase in their sales. - Selling and Marketing Expense: For the six months ended June 30, 2025, selling and marketing expense was
$26.0 million , compared to$26.9 million for the same period in 2024. The$0.9 million decrease was primarily driven by a reduction in commission costs due to the decrease of sales. - Research and Development Expense: For the six months ended June 30, 2025, research and development expense was
$6.5 million , compared to$5.5 million for the same period in 2024. The$1.0 million increase was primarily attributable to a$1.5 million increase in clinical trial costs, primarily as a result of data analysis costs for Hydronidone. This increase was offset by a$0.3 million decrease in materials and utilities expenses and a$0.1 million decrease in facilities, depreciation and other. - General and Administrative Expense: For the six months ended June 30, 2025, general and administrative expense was
$9.8 million , compared to$6.8 million for the same period in 2024. The$3.0 million increase was primarily driven a$0.6 million increase in professional fees, a$1.6 million increase in functional and administrative department’s personnel and stock compensation costs, and a$0.8 million increase in miscellaneous expense, mainly due to the increase for the annual meeting expense. - Income from Operations: For the six months ended June 30, 2025, income from operations was
$4.4 million , compared to$11.3 million income from operation for the same period in 2024. The$6.9 million decrease was primarily driven by a$3.6 million decrease in revenue and$3.3 million increase in total operating expenses. - Net Income: For the six months ended June 30, 2025, net income was
$5.3 million , compared to$14.5 million net income for the same period in 2024. - Non-GAAP Adjusted Net Income: For the six months ended June 30, 2025, non-GAAP adjusted net income was
$5.8 million , compared to$11.3 million non-GAAP adjusted net income for the same period in 2024. The decrease was primarily driven by the decline in revenue of$3.6 million and increase in operating expenses of$1.9 million .
Full Year 2025 Financial Guidance
For the full year 2025, the Company expects to generate revenues of
| Guidance Range | |
| Total Revenue | |
Please note that total revenue guidance assumes a constant foreign currency exchange rate and no significant economic disruption or downturn.
Use of Non-GAAP Financial Measures by Gyre Therapeutics, Inc.
Gyre reports financial results in accordance with accounting principles generally accepted in the United States (“GAAP”). This release presents the financial measure “adjusted net income,” which is not calculated in accordance with GAAP. The most directly comparable GAAP measure for this non-GAAP financial measure is “net income.” Adjusted net income presents Gyre’s results of operations after excluding gain from change in fair value of warrants, stock-based compensation, and provision for income taxes. This is meant to supplement, and not substitute, Gyre’s financial information presented in accordance with GAAP. Adjusted net income as defined by Gyre may not be comparable to similar non-GAAP measures presented by other companies. Management believes that presenting adjusted net income provides investors with additional useful information in evaluating the Gyre’s performance and valuation. See the reconciliation of adjusted net income to net income in the section titled “Reconciliation of GAAP to Non-GAAP Financial Measures” below.
About Gyre Pharmaceuticals
Gyre Pharmaceuticals is a commercial-stage biopharmaceutical company committed to the research, development, manufacturing and commercialization of innovative drugs for organ fibrosis. Its flagship product, ETUARY® (pirfenidone capsule), was the first approved treatment for IPF in the PRC in 2011 and has maintained a prominent market share (2024 net sales of
About Gyre Therapeutics
Gyre Therapeutics is a biopharmaceutical company headquartered in San Diego, CA, primarily focused on the development and commercialization of Hydronidone for liver fibrosis, including MASH, in the United States Gyre’s strategy builds on its experience in mechanistic studies using MASH rodent models and clinical studies in CHB-induced liver fibrosis. In the People’s Republic of China, Gyre is advancing a broad pipeline through its indirect controlling interest in Gyre Pharmaceuticals, including therapeutic expansions of ETUARY®, and development programs for F573, F528, and F230.
Forward-Looking Statements
This press release contains “forward-looking statements” within the meaning of the “safe harbor” provisions of the Private Securities Litigation Reform Act of 1995, which statements are subject to substantial risks and uncertainties and are based on estimates and assumptions. All statements, other than statements of historical facts included in this press release, are forward-looking statements, including statements concerning: the expectations regarding Gyre’s research and development efforts, timing of expected clinical readouts, including timing of the initiation of Gyre’s Phase 2 trial in the U.S. for Hydronidone for the treatment of MASH-associated liver fibrosis, the initiation of Gyre’s Phase 2/3 trial in the PRC for pirfenidone capsules for the treatment of RILI, including cases complicated by immune-related pneumonitis, the filing of an NDA with the NMPA for Hydronidone for the treatment of CHB-related liver fibrosis, timing of completion of Gyre’s Phase 2 clinical trial in the PRC of F573 for ALF/ACLF, and IND submission of F528 in COPD, the expectations regarding commercial revenues from the sales of Etorel and Contiva maleate tablets, interactions with regulators, expectations regarding future product sales, and Gyre’s financial position and cash resources. In some cases, you can identify forward-looking statements by terms such as “may,” “might,” “will,” “objective,” “intend,” “should,” “could,” “can,” “would,” “expect,” “believe,” “design,” “estimate,” “predict,” “potential,” “plan” or the negative of these terms, and similar expressions intended to identify forward-looking statements. These statements reflect our plans, estimates, and expectations, as of the date of this press release. These statements involve known and unknown risks, uncertainties and other factors that could cause our actual results to differ materially from the forward-looking statements expressed or implied in this press release. Actual results and the timing of events could differ materially from those anticipated in such forward-looking statements as a result of these risks and uncertainties, which include, without limitation: Gyre’s ability to execute on its clinical development strategies; positive results from a clinical trial may not necessarily be predictive of the results of future or ongoing clinical trials; the timing or likelihood of regulatory filings and approvals; competition from competing products; the impact of general economic, health, industrial or political conditions in the United States or internationally; the sufficiency of Gyre’s capital resources and its ability to raise additional capital. Additional risks and factors are identified under “Risk Factors” in Gyre’s Annual Report on Form 10-K for the year ended December 31, 2024 filed on March 17, 2025 and in other filings with the Securities and Exchange Commission.
Gyre expressly disclaims any obligation to update any forward-looking statements whether as a result of new information, future events or otherwise, except as required by law.
For Investors:
David Zhang
Gyre Therapeutics
david.zhang@gyretx.com
| Gyre Therapeutics, Inc. Condensed Consolidated Statements of Operations (In thousands, except share and per share amounts) (Unaudited) | |||||||||||||||
| Three Months Ended June 30, | Six Months Ended June 30, | ||||||||||||||
| 2025 | 2024 | 2025 | 2024 | ||||||||||||
| Revenues | $ | 26,771 | $ | 25,225 | $ | 48,829 | $ | 52,397 | |||||||
| Operating expenses: | |||||||||||||||
| Cost of revenues | 1,151 | 770 | 2,045 | 1,749 | |||||||||||
| Selling and marketing | 15,194 | 14,414 | 26,035 | 26,956 | |||||||||||
| Research and development | 3,425 | 3,355 | 6,520 | 5,537 | |||||||||||
| General and administrative | 4,829 | 3,424 | 9,784 | 6,822 | |||||||||||
| Loss on disposal of assets, net | 1 | 68 | 1 | 68 | |||||||||||
| Total operating expenses | 24,600 | 22,031 | 44,385 | 41,132 | |||||||||||
| Income from operations | 2,171 | 3,194 | 4,444 | 11,265 | |||||||||||
| Other income, net: | |||||||||||||||
| Change in fair value of warrant liability | 212 | 2,913 | 2,467 | 7,201 | |||||||||||
| Other (expense) income, net | (145 | ) | (72 | ) | (38 | ) | 50 | ||||||||
| Income before income taxes | 2,238 | 6,035 | 6,873 | 18,516 | |||||||||||
| Provision for income taxes | (662 | ) | (1,497 | ) | (1,563 | ) | (4,043 | ) | |||||||
| Net income | 1,576 | 4,538 | 5,310 | 14,473 | |||||||||||
| Net income attributable to noncontrolling interest | 1,134 | 1,010 | 2,170 | 3,413 | |||||||||||
| Net income attributable to common stockholders | $ | 442 | $ | 3,528 | $ | 3,140 | $ | 11,060 | |||||||
| Net income per share attributable to common stockholders: | |||||||||||||||
| Basic | $ | 0.00 | $ | 0.04 | $ | 0.04 | $ | 0.13 | |||||||
| Diluted | $ | 0.00 | $ | 0.01 | $ | 0.01 | $ | 0.04 | |||||||
| Weighted average shares used in calculating net income per share attributable to common stockholders: | |||||||||||||||
| Basic | 89,119,344 | 85,502,403 | 87,295,099 | 84,384,141 | |||||||||||
| Diluted | 102,701,707 | 102,205,888 | 101,868,781 | 102,421,084 | |||||||||||
| Gyre Therapeutics, Inc. Condensed Consolidated Balance Sheets (In thousands, except share and per share amounts) (Unaudited) | |||||||
| June 30, 2025 | December 31, 2024 | ||||||
| (Unaudited) | |||||||
| Assets | |||||||
| Current assets: | |||||||
| Cash and cash equivalents | $ | 36,491 | $ | 11,813 | |||
| Short-term bank deposits | 17,874 | 14,858 | |||||
| Notes receivable | 499 | 4,373 | |||||
| Accounts receivables, net | 24,629 | 19,589 | |||||
| Other receivables from GNI | 230 | 230 | |||||
| Inventories, net | 8,861 | 6,337 | |||||
| Receivable from GCBP | — | 4,961 | |||||
| Prepaid assets and other current assets | 2,701 | 2,625 | |||||
| Total current assets | 91,285 | 64,786 | |||||
| Property and equipment, net | 23,401 | 23,880 | |||||
| Intangible assets, net | 4,962 | 273 | |||||
| Deferred tax assets | 6,134 | 5,619 | |||||
| Long-term certificates of deposit | 21,528 | 24,568 | |||||
| Other assets, noncurrent | 5,336 | 6,280 | |||||
| Total assets | $ | 152,646 | $ | 125,406 | |||
| Liabilities and stockholders’ equity | |||||||
| Current liabilities: | |||||||
| Accounts payable | $ | 71 | $ | 108 | |||
| Contract liabilities | — | 61 | |||||
| Due to related parties | 219 | 227 | |||||
| Accrued expenses and other current liabilities | 14,924 | 10,615 | |||||
| Income tax payable | 1,084 | 2,831 | |||||
| Operating lease liabilities, current | 622 | 713 | |||||
| CVR derivative liability | — | 4,961 | |||||
| Total current liabilities | 16,920 | 19,516 | |||||
| Operating lease liabilities, noncurrent | 771 | 885 | |||||
| Deferred government grants | 884 | 928 | |||||
| Warrant liability, noncurrent | 3,201 | 5,668 | |||||
| Other noncurrent liabilities | 1,427 | 7 | |||||
| Total liabilities | 23,203 | 27,004 | |||||
| Stockholders’ equity: | |||||||
| Common stock, | 91 | 86 | |||||
| Additional paid-in capital | 161,437 | 136,185 | |||||
| Statutory reserve | 3,098 | 3,098 | |||||
| Accumulated deficit | (70,313 | ) | (73,453 | ) | |||
| Accumulated other comprehensive loss | (2,287 | ) | (2,597 | ) | |||
| Total Gyre stockholders’ equity | 92,026 | 63,319 | |||||
| Noncontrolling interest | 37,417 | 35,083 | |||||
| Total equity | 129,443 | 98,402 | |||||
| Total liabilities and stockholders’ equity | $ | 152,646 | $ | 125,406 | |||
| Gyre Therapeutics, Inc. Reconciliation of GAAP to Non-GAAP Financial Measures (In thousands) (Unaudited) | |||||||||||||||
| Three Months Ended June 30, | Six Months Ended June 30, | ||||||||||||||
| 2025 | 2024 | 2025 | 2024 | ||||||||||||
| Net income | $ | 1,576 | $ | 4,538 | $ | 5,310 | $ | 14,473 | |||||||
| Gain from change in fair value of warrant liability (1) | (212 | ) | (2,913 | ) | (2,467 | ) | (7,201 | ) | |||||||
| Stock-based compensation | 906 | 16 | 1,413 | 27 | |||||||||||
| Provision for income taxes | 662 | 1,497 | 1,563 | 4,043 | |||||||||||
| Non-GAAP adjusted net income | $ | 2,932 | $ | 3,138 | $ | 5,819 | $ | 11,342 | |||||||
(1) Reflects adjustments for fair value of warrant liability based on the Black-Scholes option pricing model.
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