/C O R R E C T I O N -- MyOme, Inc/

Rhea-AI Summary

Illumina (NASDAQ: ILMN) announced a collaboration and strategic investment in MyOme, announced Dec. 11, 2025, to support MyOme's Proactive Health (MPH) Trial and commercial product expansion.

The MPH trial aims to begin enrollment in 2026 and will evaluate whole‑genome sequencing (WGS) plus MyOme's AI‑integrated risk models (IRMs) for common chronic disease, cancer and rare disease. Health economic modeling cited in the announcement suggests potential U.S. savings of more than $200 billion per year from broad WGS+IRM adoption; the release notes U.S. annual healthcare spend of about $5 trillion. The financing also lists continued support from Natera, Sequoia Capital and The Duquesne Family Office.

Positive

• Collaboration announced with Illumina on Dec. 11, 2025
• MPH trial enrollment scheduled to begin in 2026
• Modeled > $200 billion/year potential U.S. savings from WGS+IRMs
• Financing supported by Natera, Sequoia Capital and The Duquesne Family Office

Negative

• Projected $200 billion savings are model‑based and not yet clinically validated
• Clinical evidence pending: MPH trial only begins enrollment in 2026
• No transaction financial terms or investment amount disclosed

News Market Reaction

+1.13%

1 alert

+1.13% News Effect

On the day this news was published, ILMN gained 1.13%, reflecting a mild positive market reaction.

Data tracked by StockTitan Argus on the day of publication.

Partnership unites Illumina's leading sequencing technology with cutting-edge clinical genomics analyses and AI to advance precision medicine for early detection and prevention.

SAN DIEGO and MENLO PARK, Calif., Dec. 11, 2025 /PRNewswire/ -- Illumina, Inc. (NASDAQ: ILMN) and MyOme, a leading genomics innovation and risk modeling company, today announced a collaboration and investment by Illumina into MyOme. The collaboration and investment will help advance MyOme's strategic roadmap including MyOme's Proactive Health (MPH) Trial — a large-scale prospective trial that aims to prove enhanced patient outcomes and substantial cost savings resulting from use of whole-genome sequencing (WGS) combined with MyOme's AI-integrated risk models (IRMs) for common, chronic conditions, cancers, and rare disease.

The U.S. spends approximately $5 trillion annually on healthcare. Health economic and outcomes modeling suggests that broad adoption of clinical WGS combined with MyOme's industry-leading IRMs could yield potential savings of more than $200 billion per year. WGS and IRM adoption would enable earlier detection and intervention when treatment costs are lower. Earlier intervention could also prevent or delay the onset of a wide range of chronic and age-related conditions^1,2. The MPH trial will begin enrollment in 2026.

"MyOme's approach represents an important evolution in the use of genomics for preventive care," said Jakob Wedel, chief strategy and corporate development officer of Illumina. "By combining Illumina's next-generation sequencing technologies with MyOme's AI-integrated risk models, we are helping advance science and generate the clinical evidence needed to transform how diseases are detected and managed."

The collaboration will also support MyOme's ability to expand its commercially available products, including a suite of proactive health and rare disease diagnostic tests. By combining Illumina's leadership in large-scale population health with MyOme's IRMs, MyOme aims to help patients gain access to more accurate, ancestry-relevant risk assessments for many of the leading causes of death. Illumina's technology roadmap will accelerate MyOme's innovation in rare disease testing, further increasing diagnostic yield.

 "This collaboration advances fundamental healthcare science," said Matt Rabinowitz, PhD, Executive Chairman of MyOme. "MyOme is using whole genome sequencing, advanced bioinformatics and AI to deliver lifelong clinical benefits across diverse situations and phenotypes. These include pharmacogenomic insights, analysis of over 150 genes with actionable incidental findings and integrated risk models combining polygenic risk scores, rare variants and other analytes for major cancers, cardiometabolic disease, kidney, liver, cognitive and other diseases. With Illumina's sequencing, we aim to demonstrate how next-generation genomics, integrated with AI-driven risk models, can deliver deeper insights into human biology as well as meaningful economic impact for the U.S.A." 

Strategic Backing from Leading Partners
MyOme's latest financing is further strengthened by continued support from Natera, a global leader in genetic testing and diagnostics that brings deep clinical expertise in cancer detection, women's health, organ health and hereditary disease. Sequoia Capital, The Duquesne Family Office, and others also participated in the financing.

About Illumina
Illumina is improving human health by unlocking the power of the genome. Our focus on innovation has established us as a global leader in DNA sequencing and array-based technologies, serving customers in the research, clinical, and applied markets. Our products are used for applications in the life sciences, oncology, reproductive health, agriculture, and other emerging segments. To learn more, visit illumina.com and connect with us on X, Facebook, LinkedIn, Instagram, TikTok, and YouTube.

About MyOme
MyOme is a clinical whole genome analysis platform company helping families understand their risk for inherited diseases. As a leader in genomic plus AI integrated risk modeling, MyOme leverages the power of the whole genome for a lifetime of meaningful and actionable insights. Certified under the Clinical Laboratory Improvement Amendments (CLIA) and certified by the College of American Pathologists (CAP), MyOme is based in Menlo Park, California. For more information, please visit myome.com.

References

1. National Human Genome Research Institute. The Cost of Genome Sequencing and Its Impact on Healthcare. (NIH, 2023).
2. Phillips, K.A., et al. Potential Economic Value of Precision Medicine: Implications for U.S. Healthcare. Health Affairs, 2022.

FAQ

What did Illumina announce about MyOme on Dec. 11, 2025 (ILMN)?

Illumina announced a collaboration and strategic investment to support MyOme's programs, including the MPH trial.

When will MyOme's Proactive Health (MPH) Trial begin enrolling participants?

The announcement states that MPH trial enrollment is expected to begin in 2026.

How much annual U.S. savings does MyOme claim WGS plus IRMs could yield?

The release cites health economic modeling that suggests potential savings of more than $200 billion per year.

Will Illumina's investment speed MyOme's rare disease testing?

The announcement says Illumina's sequencing roadmap will accelerate MyOme's innovation and diagnostic yield for rare disease testing.

Which investors participated in MyOme's latest financing alongside Illumina?

The filing lists continued support from Natera, Sequoia Capital, and The Duquesne Family Office.

Are the claimed cost savings from WGS+IRMs proven?

No; the savings figure is derived from modeling and the announcement frames the MPH trial as needed to generate clinical evidence.