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Karyopharm to Report Fourth Quarter and Full Year 2025 Financial Results on February 12, 2026

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Karyopharm (Nasdaq: KPTI) will report its fourth quarter and full year 2025 financial results on Thursday, February 12, 2026. Management will host a conference call and live audio webcast at 8:00 a.m. ET to discuss results and company updates.

Dial-in numbers are provided for domestic and international callers, and accompanying slides plus an archived webcast will be available on the company’s Investor "Events & Presentations" webpage about two hours after the call.

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News Market Reaction – KPTI

-3.33%
1 alert
-3.33% Session close to close
$115.35M Market Cap
1.4x Rel. Volume

In the Feb 5 session, KPTI declined 3.33%, reflecting a moderate negative market reaction.

Data tracked by StockTitan Argus on the day of publication.

Market Context

This announcement sets the timing for Karyopharm’s fourth quarter and full year 2025 results, with a...
Analysis

This announcement sets the timing for Karyopharm’s fourth quarter and full year 2025 results, with a conference call and webcast on Feb 12, 2026. It follows a recent 8‑K previewing about $145M in 2025 revenue and key 2026 Phase 3 milestones. Investors may focus on how the formal release compares with those preliminary figures, recent insider Form 4 activity, and the existing resale registration covering 2,805,688 shares when evaluating the broader context.

Key Figures

Share price: $6.30 Market cap: $119,932,354 Resale registration shares: 2,805,688 shares +5 more
8 metrics
Share price $6.30 Prior close before earnings date announcement
Market cap $119,932,354 Equity value prior to Feb 12, 2026 earnings call
Resale registration shares 2,805,688 shares Resale S-3 filed Nov 3, 2025
Outstanding shares 17,050,876 shares As of Oct 30, 2025 per shelf filing
Affinity ownership 1,713,092 shares (8.6%) Schedule 13G/A as of Jan 22, 2026
2025 total revenue (prelim) $145 million Preliminary 2025 result per 8-K on Jan 12, 2026
Q4 2025 revenue (prelim) $33 million Quarter ended Dec 31, 2025 per 8-K
Cash & investments $64 million As of Dec 31, 2025 per 8-K

Historical Context

5 past events · Latest: Feb 02 (Neutral)
Pattern 5 events
Date Event Sentiment 24h Move Catalyst
Feb 02 Inducement RSU grants Neutral -3.2% Reported 1,799 RSUs granted to new hires under inducement plan.
Jan 12 Prelim 2025 revenue Positive -5.6% Preliminary 2025 revenue ≈ $145M and key 2026 Phase 3 data objectives.
Jan 02 Inducement RSU grants Neutral +2.9% Two new hires received 1,533 RSUs under 2022 Inducement Plan.
Dec 08 Investor event Neutral +2.4% Announced virtual fireside chat participation in Baird’s Biotech Discovery Series.
Dec 01 Inducement equity awards Neutral -6.8% Issued options on 2,800 shares and 15,791 RSUs to new employees.

24h Move is the share-price change in the day after each event; other market factors may also have contributed.

Pattern Detected

Routine corporate updates and inducement grant filings have generally seen modest, mixed reactions, while the positive preliminary 2025 revenue and Phase 3 outlook on Jan 12, 2026 coincided with a notably negative price move.

Recent Company History

Over the past few months, Karyopharm’s news flow has centered on inducement equity grants, investor outreach, and 2025 performance visibility. On Dec 1, 2025 and multiple later dates, the company reported stock option and RSU inducement awards to new hires, with varied share price reactions. On Jan 12, 2026, Karyopharm released preliminary 2025 revenue of about $145M and highlighted key 2026 Phase 3 readouts, yet shares fell. Today’s announcement simply schedules the formal Q4 and full‑year 2025 earnings release and conference call on Feb 12, 2026.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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-- Conference Call Scheduled for Thursday, February 12, 2026, at 8:00 a.m. ET --

NEWTON, Mass., Feb. 5, 2026 /PRNewswire/ -- Karyopharm Therapeutics Inc. (Nasdaq: KPTI), a commercial-stage pharmaceutical company pioneering novel cancer therapies, today announced it will report fourth quarter and full year 2025 financial results on Thursday, February 12, 2026. Karyopharm's management team will host a conference call and audio webcast at 8:00 a.m. ET on Thursday, February 12, 2026, to discuss the financial results and other company updates.

To access the conference call, please dial (800) 836-8184 (local) or (646) 357-8785 (international) at least 10 minutes prior to the start time and ask to be joined into the Karyopharm Therapeutics call. A live audio webcast of the call, along with accompanying slides, will be available under "Events & Presentations" in the Investor section of the Company's website, http://investors.karyopharm.com/events-presentations. An archived webcast will be available on the Company's website approximately two hours after the event.

About Karyopharm Therapeutics

Karyopharm Therapeutics Inc. (Nasdaq: KPTI) is a commercial-stage pharmaceutical company whose dedication to pioneering novel cancer therapies is fueled by a belief in the extraordinary strength and courage of patients with cancer. Since its founding, Karyopharm has been an industry leader in oral compounds that address nuclear export dysregulation, a fundamental mechanism of oncogenesis. Karyopharm's lead compound and first-in-class, oral exportin 1 (XPO1) inhibitor, XPOVIO® (selinexor), is approved in the U.S. and marketed by the Company in three oncology indications. It has also received regulatory approvals in various indications in more than 50 ex-U.S. territories and countries, including the European Union, the United Kingdom (as NEXPOVIO®) and China. Karyopharm has a focused pipeline targeting indications in multiple high unmet need cancers, including in multiple myeloma, endometrial cancer, myelofibrosis, and diffuse large B-cell lymphoma (DLBCL). For more information about our people, science and pipeline, please visit www.karyopharm.com, and follow us on LinkedIn and on X at @Karyopharm.

XPOVIO® and NEXPOVIO® are registered trademarks of Karyopharm Therapeutics Inc.

(PRNewsfoto/Karyopharm Therapeutics Inc.)

Cision View original content to download multimedia:https://www.prnewswire.com/news-releases/karyopharm-to-report-fourth-quarter-and-full-year-2025-financial-results-on-february-12-2026-302679676.html

SOURCE Karyopharm Therapeutics Inc.

FAQ

When will Karyopharm (KPTI) report Q4 and full year 2025 results and when is the conference call?

Karyopharm will report results on Thursday, February 12, 2026, with a conference call at 8:00 a.m. ET. According to the company, management will discuss financial results and company updates during the webcast and call.

How can investors join the Karyopharm (KPTI) earnings call on February 12, 2026?

Investors can join by dialing (800) 836-8184 (U.S.) or (646) 357-8785 (international) at least 10 minutes early. According to the company, callers should ask to be joined into the Karyopharm Therapeutics call.

Where will the Karyopharm (KPTI) earnings webcast and slides be available?

A live audio webcast and accompanying slides will be available under Investor > Events & Presentations on the company website. According to the company, an archived webcast will be posted about two hours after the event.

Will Karyopharm (KPTI) provide an archived recording of the February 12, 2026 call?

Yes, an archived webcast will be available approximately two hours after the live call. According to the company, the archived audio and slides will remain accessible on the Investor Events & Presentations webpage.

What topics will Karyopharm (KPTI) management cover during the February 12, 2026 call?

Management will discuss the fourth quarter and full year 2025 financial results and other company updates. According to the company, the call and webcast are intended to review financial performance and recent corporate developments.