Karyopharm Therapeutics Reports Inducement Grants Under Nasdaq Listing Rule 5635(c)(4)

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Karyopharm Therapeutics (Nasdaq: KPTI) granted inducement awards to seven newly hired employees as of November 30, 2025 under its 2022 Inducement Stock Incentive Plan.

The company issued stock options to purchase an aggregate of 2,800 shares at an exercise price of $5.62 (closing price on the Grant Date) and granted an aggregate of 15,791 restricted stock units (RSUs). Options vest over four years (25% after one year, then monthly 1/48th), and RSUs vest over three years (33 1/3% each year), each subject to continued service.

NEWTON, Mass., Dec. 1, 2025 /PRNewswire/ -- Karyopharm Therapeutics Inc. (Nasdaq: KPTI), a commercial-stage pharmaceutical company pioneering novel cancer therapies, today announced that the Company granted a stock option to purchase an aggregate of 2,800 shares of Karyopharm's common stock and an  aggregate of 15,791 restricted stock units (RSUs) to seven newly-hired employees. These awards were granted as of November 30, 2025 (the "Grant Date") pursuant to the Company's 2022 Inducement Stock Incentive Plan, as amended, as inducements material to the new employees entering into employment with Karyopharm in accordance with Nasdaq Listing Rule 5635(c)(4).

The stock options have an exercise price of $5.62 per share, the closing price of Karyopharm's common stock on the Grant Date and vest over four years, with 25% of the total number of shares underlying the stock options vesting on the one-year anniversary of the employee's commencement date and 1/48th of the total number of shares vesting monthly thereafter, subject to the employee's continued service as an employee of, or other service provider to, Karyopharm through the applicable vesting dates. 

Each RSU award will vest over three years, with 33 1/3% of the shares underlying the RSU award vesting on each of the three consecutive anniversaries of the Grant Date. The vesting of each RSU award is subject to the employee's continued service as an employee of, or other service provider to, Karyopharm through the applicable vesting dates.

About Karyopharm Therapeutics

Karyopharm Therapeutics Inc. (Nasdaq: KPTI) is a commercial-stage pharmaceutical company whose dedication to pioneering novel cancer therapies is fueled by a belief in the extraordinary strength and courage of patients with cancer. Since its founding, Karyopharm has been an industry leader in oral compounds that address nuclear export dysregulation, a fundamental mechanism of oncogenesis. Karyopharm's lead compound and first-in-class, oral exportin 1 (XPO1) inhibitor, XPOVIO^® (selinexor), is approved in the U.S. and marketed by the Company in three oncology indications. It has also received regulatory approvals in various indications in 50 ex-U.S. territories and countries, including the European Union, the United Kingdom (as NEXPOVIO^®) and China. Karyopharm has a focused pipeline targeting indications in multiple high unmet need cancers, including in multiple myeloma, endometrial cancer, myelofibrosis, and diffuse large B-cell lymphoma (DLBCL). For more information about our people, science and pipeline, please visit www.karyopharm.com, and follow us on LinkedIn and on X at @Karyopharm.

XPOVIO^® and NEXPOVIO^® are registered trademarks of Karyopharm Therapeutics Inc.

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SOURCE Karyopharm Therapeutics Inc.

FAQ

What inducement awards did Karyopharm (KPTI) grant on November 30, 2025?

Karyopharm granted options for an aggregate of 2,800 shares and 15,791 RSUs to seven newly hired employees, effective November 30, 2025.

What is the exercise price of the KPTI stock options granted as inducements?

The exercise price is $5.62 per share, equal to Karyopharm's closing price on the Grant Date.

How do the KPTI stock options vest for the November 30, 2025 grants?

Options vest over four years: 25% after one year, then 1/48th monthly thereafter, subject to continued service.

What is the vesting schedule for the RSUs KPTI awarded to new hires?

Each RSU award vests over three years with 33 1/3% vesting each year, subject to continued service.

Why were the inducement awards granted under Nasdaq Listing Rule 5635(c)(4)?

The awards were granted as inducements material to new employees entering employment, in accordance with Nasdaq Listing Rule 5635(c)(4).