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Karyopharm to Participate at the Piper Sandler 37th Annual Healthcare Conference

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Karyopharm (Nasdaq: KPTI) announced that its senior management team will participate in a fireside chat at the Piper Sandler 37th Annual Healthcare Conference on Thursday, December 4, 2025 at 10:30 a.m. ET in New York.

A live webcast will be available under the company’s Investor "Events & Presentations" page and the presentation will be available for replay following the event.

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News Market Reaction – KPTI

+2.31%
9 alerts
+2.31% News Effect
+18.3% Peak in 2 hr 55 min
+$2M Valuation Impact
$105M Market Cap
0.9x Rel. Volume

On the day this news was published, KPTI gained 2.31%, reflecting a moderate positive market reaction. Argus tracked a peak move of +18.3% during that session. Our momentum scanner triggered 9 alerts that day, indicating moderate trading interest and price volatility. This price movement added approximately $2M to the company's valuation, bringing the market cap to $105M at that time.

Data tracked by StockTitan Argus on the day of publication.

Key Figures

Conference time: 10:30 a.m. ET
1 metrics
Conference time 10:30 a.m. ET Piper Sandler 37th Annual Healthcare Conference fireside chat on Dec 4, 2025

Market Reality Check

Price: $9.41 Vol: Volume 596,389 is 4.28x t...
high vol
$9.41 Last Close
Volume Volume 596,389 is 4.28x the 20-day average, ahead of a neutral conference appearance. high
Technical Price $7.00 is trading above the 200-day MA of $5.48, after a 1.41% daily gain.

Peers on Argus

KPTI gained 1.41% while peers showed mixed moves, with MAIA recently down 4.17% ...
1 Down

KPTI gained 1.41% while peers showed mixed moves, with MAIA recently down 4.17% in momentum data and sector names like CAMP and MAIA in the static list previously up double-digits, suggesting stock-specific factors rather than a unified sector swing.

Historical Context

5 past events · Latest: Dec 08 (Neutral)
Pattern 5 events
Date Event Sentiment Move Catalyst
Dec 08 Conference participation Neutral +2.4% Announcement of Baird virtual fireside chat with external expert.
Dec 01 Inducement grants Neutral -6.8% Stock options and RSUs granted to seven new employees.
Dec 01 Conference participation Neutral +2.3% Piper Sandler fireside chat with webcast and replay access.
Nov 03 Inducement grants Neutral +4.7% RSU award to a new hire under inducement plan.
Nov 03 Earnings and update Neutral +4.7% Q3 2025 results, guidance reaffirmation and trial enrollment update.
Pattern Detected

Recent news has centered on conferences, inducement grants, and Q3 results, with most items followed by positive single-day price reactions despite mixed fundamental disclosures.

Recent Company History

Over the last two months, Karyopharm’s news flow included multiple conference participations, inducement equity grants, and Q3 2025 financial results. The Piper Sandler conference appearance on Dec 4, 2025 and Baird fireside chat were both followed by modest gains. Inducement grants on Nov 3 and Nov 30, 2025 produced mixed reactions, while the Q3 earnings release highlighting $44.0M revenue and continued net loss saw shares rise. Today’s conference notice fits this cadence of largely informational updates.

Regulatory & Risk Context

Active S-3 Shelf
Shelf Active
Active S-3 Shelf Registration 2025-11-03

An effective S-3 resale registration dated Nov 3, 2025 covers up to 2,805,688 existing or warrant-linked shares offered by selling stockholders. The company is not selling securities and would only receive cash if outstanding warrants are exercised at their stated price.

Market Pulse Summary

This announcement highlights Karyopharm’s participation in the Piper Sandler healthcare conference, ...
Analysis

This announcement highlights Karyopharm’s participation in the Piper Sandler healthcare conference, continuing a pattern of investor outreach via fireside chats and webcasts. Recent history includes Q3 2025 results with ongoing net losses, new financings, and registrations for resale of existing shares by stockholders. Investors may focus on any incremental strategic or clinical color shared during the event and monitor future filings, trial milestones, and balance sheet developments.

AI-generated analysis. Not financial advice.

NEWTON, Mass., Dec. 1, 2025 /PRNewswire/ -- Karyopharm Therapeutics Inc. (Nasdaq: KPTI), a commercial-stage pharmaceutical company pioneering novel cancer therapies, today announced that the Company's senior management team will participate at the Piper Sandler 37th Annual Healthcare Conference in a fireside chat on Thursday, December 4, 2025 at 10:30 a.m. ET in New York, NY.

A live webcast of the fireside chat can be accessed under "Events & Presentations" in the Investor section of the Company's website, https://investors.karyopharm.com/events-presentations, and will be available for replay following the event.

About Karyopharm Therapeutics

Karyopharm Therapeutics Inc. (Nasdaq: KPTI) is a commercial-stage pharmaceutical company whose dedication to pioneering novel cancer therapies is fueled by a belief in the extraordinary strength and courage of patients with cancer. Since its founding, Karyopharm has been an industry leader in oral compounds that address nuclear export dysregulation, a fundamental mechanism of oncogenesis. Karyopharm's lead compound and first-in-class, oral exportin 1 (XPO1) inhibitor, XPOVIO® (selinexor), is approved in the U.S. and marketed by the Company in three oncology indications. It has also received regulatory approvals in various indications in 50 ex-U.S. territories and countries, including the European Union, the United Kingdom (as NEXPOVIO®) and China. Karyopharm has a focused pipeline targeting indications in multiple high unmet need cancers, including in multiple myeloma, endometrial cancer, myelofibrosis, and diffuse large B-cell lymphoma (DLBCL). For more information about our people, science and pipeline, please visit www.karyopharm.com, and follow us on LinkedIn and on X at @Karyopharm.

XPOVIO® and NEXPOVIO® are registered trademarks of Karyopharm Therapeutics Inc. Any other trademarks referred to in this release are the property of their respective owners.

(PRNewsfoto/Karyopharm Therapeutics Inc.)

Cision View original content to download multimedia:https://www.prnewswire.com/news-releases/karyopharm-to-participate-at-the-piper-sandler-37th-annual-healthcare-conference-302624649.html

SOURCE Karyopharm Therapeutics Inc.

FAQ

When will Karyopharm (KPTI) present at the Piper Sandler 37th Annual Healthcare Conference?

Karyopharm will present in a fireside chat on Thursday, December 4, 2025 at 10:30 a.m. ET.

How can investors watch the Karyopharm (KPTI) fireside chat on December 4, 2025?

Investors can watch a live webcast via the company’s Investor "Events & Presentations" page and view the replay afterward.

Where will the Piper Sandler conference fireside chat with Karyopharm (KPTI) be held?

The fireside chat will be held in New York, NY as part of the Piper Sandler 37th Annual Healthcare Conference.

Will Karyopharm (KPTI) make the presentation available after the Piper Sandler event?

Yes. The webcast will be available for replay on the company’s Investor "Events & Presentations" page following the event.

Which Karyopharm (KPTI) executives will participate in the December 4, 2025 fireside chat?

The announcement states the company’s senior management team will participate; specific names were not listed in the notice.

Where is the webcast link for Karyopharm (KPTI) events and presentations?

The webcast and replay will be accessible at https://investors.karyopharm.com/events-presentations.
Karyopharm Therapeutics Inc

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171.52M
17.08M
Biotechnology
Pharmaceutical Preparations
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United States
NEWTON