Lexeo Therapeutics Announces Key Leadership Appointments Strengthening Cardiovascular Expertise Alongside Updates to Strategic Partnership for Novel Cardiac RNA Therapeutics
Rhea-AI Summary
Lexeo Therapeutics (Nasdaq: LXEO) announced multiple senior leadership appointments and an update to its strategic partnership for cardiac RNA therapeutics on January 27, 2026. Key hires include Narinder Bhalla, MD as Chief Medical Officer, José Manuel Otero, PhD as Chief Operating Officer, and new cardiology development leads Hayes Dansky, MD and Greg Aubert, MD, PhD. Eric Adler, MD will become CEO of Myoventive, a cardiac precision medicines company co-founded by Lexeo and partners to develop a novel non-viral RNA platform for genetic cardiac diseases. The appointments are presented as strengthening late-stage clinical and commercial execution while maintaining discovery and early cardiac development.
Positive
- Appointed Narinder Bhalla, MD as Chief Medical Officer to bolster late-stage clinical leadership
- Co-founded Myoventive to advance a novel non-viral RNA platform for genetic cardiac diseases
- Named José Manuel Otero, PhD as Chief Operating Officer after delivering consistent clinical supply and major manufacturing transition
Negative
- Executive reshuffle shifts Head of Research Eric Adler, MD away from day-to-day Lexeo leadership to Myoventive CEO
- No new financial or timing guidance provided for LX2006 or Myoventive programs
Key Figures
Market Reality Check
Peers on Argus
LXEO was up 0.13% with below-average volume, while close peers showed mixed moves (e.g., MNPR -4.22%, MREO -5.37%, CAPR +2.56%), suggesting stock-specific rather than sector-driven trading.
Previous Partnership Reports
| Date | Event | Sentiment | Move | Catalyst |
|---|---|---|---|---|
| Jun 24 | Strategic partnership | Positive | +6.3% | Announced cardiac RNA partnership backed by up to $40M private financing. |
Prior partnership news in Jun 2025 saw a positive price reaction, contrasting with today’s flat pre-announcement trading.
Over the past several months, Lexeo has combined financial strengthening and advancing cardiovascular programs. A Jun 24, 2025 partnership on novel cardiac RNA therapeutics produced a 6.31% gain. Subsequent 2025–2026 updates focused on clinical progress (LX2006, LX2020) and collaborations. Today’s leadership changes and partnership update tie back to that prior RNA venture, emphasizing continued execution around cardiac genetic medicines rather than a new clinical or financing inflection.
Historical Comparison
Past partnership news led to an average 6.31% move. In contrast, LXEO traded nearly flat at +0.13% ahead of these leadership and partnership updates.
The Jun 2025 partnership established the non-viral cardiac RNA venture; today’s appointments and Myoventive update reinforce that strategy by adding late-stage cardiology leadership around the same cardiac genetic medicine focus.
Regulatory & Risk Context
An effective Form S-3 resale registration filed on Nov 5, 2025 covers up to 1,250,015 shares issuable from pre-funded warrants held by a single investor. Lexeo is not selling shares in this registration and would receive only nominal $0.0001 per-share proceeds upon any cash exercises; sales would come from the holder’s existing position.
Market Pulse Summary
This announcement concentrated on reinforcing senior cardiovascular leadership and updating the 2025 cardiac RNA partnership, including Myoventive’s role. It followed earlier milestones such as FDA interactions on LX2006 and positive LX2020 interim data. Investors may track how these hires accelerate late-stage development of LX2006 and other cardiac programs, as well as future milestones from the non-viral RNA collaboration and any use of existing registered securities programs.
Key Terms
phase i/ii medical
preclinical medical
gene therapies medical
cardiometabolic medical
AI-generated analysis. Not financial advice.
NEW YORK, Jan. 27, 2026 (GLOBE NEWSWIRE) -- Lexeo Therapeutics, Inc. (Nasdaq: LXEO), a clinical stage genetic medicine company dedicated to pioneering novel treatments for cardiovascular diseases, today announced a series of key senior leadership appointments that underscore the company’s continued and growing expertise in cardiovascular medicine and late-stage clinical development. The company also provided an update on the strategic partnership announced in June 2025 with Perceptive Xontogeny Venture Funds and venBio Partners to develop therapies for genetic cardiac diseases utilizing a novel non-viral RNA platform.
Narinder Bhalla, MD has been appointed Chief Medical Officer, effective immediately. With more than two decades of experience as an interventional cardiologist and nearly a decade in biopharma leadership, Dr. Bhalla is a seasoned physician-executive who has held senior roles at AstraZeneca and, most recently, at Bristol Myers Squibb, where he served as Senior Vice President and Head of Global Medical, Immunology & Cardiovascular. He is widely recognized for building and scaling high-impact medical and clinical development organizations as well as leading successful global product launches that deliver meaningful outcomes for patients.
In connection with Dr. Bhalla’s appointment, Eric Adler, MD, currently Head of Research at Lexeo Therapeutics, will serve as President and Chief Executive Officer of cardiac precision medicines company, Myoventive, Inc. Lexeo co-founded Myoventive in June 2025 with Perceptive Xontogeny Venture Funds and venBio Partners, with subsequent participation by MRL Ventures Fund (the therapeutics-focused venture group of Merck & Co., Inc.) and Alexandria Venture Investments. Myoventive is utilizing a novel platform designed to enable targeted RNA modulation in the heart, addressing genetic cardiac diseases that existing AAV platforms are unable to treat. Dr. Adler will remain a senior clinical and scientific advisor to Lexeo.
“As we advance LX2006 development and prepare for the next phase of Lexeo’s growth, Dr. Bhalla’s global medical leadership, commercial launch experience, and deep cardiovascular expertise will help us translate our scientific potential into meaningful patient impact,” said R. Nolan Townsend, Chief Executive Officer of Lexeo Therapeutics. “Dr. Adler will continue to drive industry‑leading innovation in the discovery of cardiac genetic medicines, and as a member of Myoventive’s board of directors, I look forward to partnering with him to build a high-impact organization for patients, investors, and Lexeo shareholders. Together, these leadership appointments strengthen our ability to execute on Lexeo’s late-stage clinical and commercial objectives while continuing to invest in high-quality discovery and early cardiac development, both internally and through our involvement with Myoventive.”
“I’m honored to join Lexeo at such a pivotal moment,” added Dr. Bhalla. “The company’s mission to transform care for genetically mediated cardiovascular diseases aligns closely to where I see the greatest unmet medical need, and we share a deep commitment to improving outcomes for those impacted by devastating cardiac conditions. I look forward to working with this talented team to advance LX2006 and the broader pipeline with urgency, rigor, and an unwavering focus on patients.”
In addition to Dr. Bhalla’s appointment, Lexeo announced the following updates:
- José Manuel Otero, PhD has been appointed Chief Operating Officer, transitioning from his role as Chief Technical Officer, effective immediately. Under Dr. Otero’s leadership, Lexeo has achieved industry-leading cost of goods, executed a major manufacturing platform transition under high regulatory standards, and delivered consistent, timely clinical supply across programs. His new role underscores his significant contributions and positions him to further elevate performance across Lexeo’s operations, preclinical R&D and manufacturing functions.
- Hayes Dansky, MD has joined Lexeo as Vice President, Late-Stage Cardiology Development. A cardiologist and physician-scientist with 20 years of research and development experience, Dr. Dansky has led multiple clinical studies across a broad range of cardiovascular assets including Xarelto®, CETP inhibitor anacetrapib, and an ANGPTL3 antagonist antibody for hyperlipidemia. Dr. Dansky has also worked on clinical studies in obesity, pulmonary arterial hypertension and sarcoidosis, and on cellular and gene therapies for sickle cell disease and cystic fibrosis. He most recently served as Vice President of Innovation at Novo Nordisk’s Bio Innovation Hub, supporting cardiometabolic disease initiatives, and previously served as Head of Clinical Development at Roivant and Sumitovant.
- Greg Aubert, MD, PhD has been named Vice President, Early-Stage Cardiology Development and Translational Science. Dr. Aubert is a cardiologist and physician-scientist specializing in cardiovascular genetics, gene therapy, and cardiometabolic research. He previously served as the Director of the Clinical and Translational Research Division at the Loyola University Cardiovascular Research Institute, where he founded the institution’s Cardiovascular Genetics Clinic, and later led late-stage clinical trials at CSL Vifor. Dr. Aubert has been instrumental in advancing Lexeo’s cardiac programs to date and will now oversee the company’s Phase I/II and preclinical programs while continuing to support work in Friedreich ataxia cardiomyopathy.
About Lexeo Therapeutics
Lexeo Therapeutics is a New York City-based, clinical stage genetic medicine company dedicated to reshaping heart health by applying pioneering science to fundamentally change how cardiovascular diseases are treated. The company is advancing a portfolio of therapeutic candidates that take aim at the underlying genetic causes of conditions, including LX2006 in Friedreich ataxia (FA) cardiomyopathy, LX2020 in plakophilin-2 (PKP2) arrhythmogenic cardiomyopathy, and others in devastating diseases with high unmet need.
Cautionary Note Regarding Forward-Looking Statements
Certain statements in this press release may constitute “forward-looking statements” within the meaning of the federal securities laws, including, but not limited to, Lexeo’s expectations and plans regarding its current product candidates and programs and the anticipated benefits of its current product candidates. Words such as “may,” “might,” “will,” “objective,” “intend,” “should,” “could,” “can,” “would,” “expect,” “believe,” “design,” “estimate,” “predict,” “potential,” “develop,” “plan” or the negative of these terms, and similar expressions, or statements regarding intent, belief, or current expectations, are forward-looking statements. While Lexeo believes these forward-looking statements are reasonable, undue reliance should not be placed on any such forward-looking statements. These forward-looking statements are based upon current information available to the company as well as certain estimates and assumptions and are subject to various risks and uncertainties (including, without limitation, those set forth in Lexeo’s filings with the U.S. Securities and Exchange Commission (SEC)), many of which are beyond the company’s control and subject to change. Actual results could be materially different from those indicated by such forward-looking statements as a result of many factors, including but not limited to: expectations regarding the initiation, progress, and expected results of Lexeo’s preclinical studies, clinical trials and research and development programs; the unpredictable relationship between preclinical study results and clinical study results; delays in submission of regulatory filings or failure to receive regulatory approval; liquidity and capital resources; and other risks and uncertainties identified in Lexeo’s Quarterly Report on Form 10-Q for the quarterly period ended September 30, 2025, filed with the SEC on November 5, 2025, and subsequent future filings Lexeo may make with the SEC. New risks and uncertainties may emerge from time to time, and it is not possible to predict all risks and uncertainties. Lexeo claims the protection of the Safe Harbor contained in the Private Securities Litigation Reform Act of 1995 for forward-looking statements. Lexeo expressly disclaims any obligation to update or alter any statements whether as a result of new information, future events or otherwise, except as required by law.
Media Response:
Media@lexeotx.com
Investor Response:
Ashley Kaplowitz
akaplowitz@lexeotx.com
FAQ
Who is Lexeo Therapeutics' new Chief Medical Officer and when did the appointment take effect?
What is Myoventive and what role will Eric Adler, MD play in it after Lexeo's January 2026 update?
How did Lexeo change its operational leadership on January 27, 2026?
Which new clinical development leaders did Lexeo name for late-stage and early-stage cardiology?
What does Lexeo say the leadership changes mean for LX2006 development?
