Mesoblast Participation at Piper Sandler Conference
Rhea-AI Summary
Mesoblast (Nasdaq: MESO) will participate at the Piper Sandler 37th Annual Healthcare Conference in New York on December 2–4, 2025. Silviu Itescu, Chief Executive, is scheduled for a fireside chat at 12:00 p.m. ET on Thursday, December 4, 2025. A live webcast will be available at the provided event link, and a replay will be posted for up to 30 days on Mesoblast’s investor events page.
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News Market Reaction
On the day this news was published, MESO gained 2.17%, reflecting a moderate positive market reaction.
Data tracked by StockTitan Argus on the day of publication.
Key Figures
Market Reality Check
Peers on Argus
Peers show mixed moves, with gains in SRPT (+3.2%) and AUPH (+2.78%) but declines in DYN (-3.14%) and IMCR (-1.27%), indicating no unified sector trend around this conference update.
Historical Context
| Date | Event | Sentiment | Move | Catalyst |
|---|---|---|---|---|
| Dec 03 | Conference participation | Neutral | +2.2% | Announcement of fireside chat and webcast at Piper Sandler conference. |
| Nov 24 | Trading update | Positive | +1.6% | Ryoncil revenue expected to exceed US$30M with >37% quarter-on-quarter growth. |
| Nov 20 | Clinical trial plan | Positive | -3.6% | Pivotal Phase 3 trial of Ryoncil in severe acute GVHD with ruxolitinib combo. |
| Nov 17 | Management change | Positive | +2.2% | Appointment of US-based CFO to support commercialization and transactions. |
| Nov 04 | Regulatory meeting | Positive | -0.3% | Planned FDA meeting on Phase 3 data for rexlemestrocel-L in CLBP. |
Recent Mesoblast news has generally been positive, with commercial, clinical, and leadership milestones, yet price reactions have been mixed—three aligned upside moves and two divergences on clinically focused updates.
This announcement continues a series of communications highlighting Mesoblast’s commercialization and development activities. In November 2025, the company reported expected Ryoncil® gross revenue of more than US$30.0 million for the quarter ending Dec 31, 2025, up from US$21.9 million in the prior quarter. It also announced a pivotal Phase 3 trial of Ryoncil in severe acute GVHD and an FDA meeting on rexlemestrocel-L for chronic low back pain. The appointment of a new CFO underscored the shift toward a fully integrated commercial organization. Today’s conference appearance fits this ongoing investor-engagement trajectory.
Market Pulse Summary
This announcement highlights Mesoblast’s participation in the Piper Sandler 37th Annual Healthcare Conference, including a fireside chat and a webcast replay available for 30 days. It fits into a broader period marked by Ryoncil® revenue growth, pivotal trial planning, and engagement with the FDA on rexlemestrocel-L. At the same time, recent filings reported a net loss of $102.1 million and cumulative losses of $1,010.9 million, so ongoing commercial traction and regulatory progress remain key metrics to monitor.
Key Terms
allogeneic cellular medicines medical
AI-generated analysis. Not financial advice.
NEW YORK, Dec. 03, 2025 (GLOBE NEWSWIRE) -- Mesoblast Limited (Nasdaq:MESO; ASX:MSB), global leader in allogeneic cellular medicines for inflammatory diseases, today announced its participation at the Piper Sandler 37th Annual Healthcare Conference in New York on December 2–4, 2025.
Silviu Itescu, Chief Executive of Mesoblast, is scheduled for a fireside chat at 12.00 p.m. ET on Thursday, December 4, 2025. A live webcast of the event will be available using this weblink https://event.webcasts.com/starthere.jsp?ei=1745867&tp_key=270ef917d6.
A replay of the webcast will be available following the completion of the event for up to 30 days on Mesoblast’s website at investorsmedia.mesoblast.com/events.
About Mesoblast
Mesoblast (the Company) is a world leader in developing allogeneic (off-the-shelf) cellular medicines for the treatment of severe and life-threatening inflammatory conditions. The therapies from the Company’s proprietary mesenchymal lineage cell therapy technology platform respond to severe inflammation by releasing anti-inflammatory factors that counter and modulate multiple effector arms of the immune system, resulting in significant reduction of the damaging inflammatory process.
Mesoblast’s Ryoncil® (remestemcel-L-rknd) for the treatment of steroid-refractory acute graft versus host disease (SR-aGvHD) in pediatric patients 2 months and older is the first FDA-approved mesenchymal stromal cell (MSC) therapy. Please see the full Prescribing Information at www.ryoncil.com.
Mesoblast is committed to developing additional cell therapies for distinct indications based on its remestemcel-L and rexlemestrocel-L allogeneic stromal cell technology platforms. Ryoncil® is being developed for additional inflammatory diseases including SR-aGvHD in adults and biologic-resistant inflammatory bowel disease. Rexlemestrocel-L is being developed for heart failure and chronic low back pain. The Company has established commercial partnerships in Japan, Europe and China.
About Mesoblast intellectual property: Mesoblast has a strong and extensive global intellectual property portfolio, with over 1,000 granted patents or patent applications covering mesenchymal stromal cell compositions of matter, methods of manufacturing and indications. These granted patents and patent applications provide commercial protection extending through to at least 2044 in all major markets.
About Mesoblast manufacturing: The Company’s proprietary manufacturing processes yield industrial-scale, cryopreserved, off-the-shelf, cellular medicines. These cell therapies, with defined pharmaceutical release criteria, are planned to be readily available to patients worldwide.
Mesoblast has locations in Australia, the United States and Singapore and is listed on the Australian Securities Exchange (MSB) and on the Nasdaq (MESO). For more information, please see www.mesoblast.com, LinkedIn: Mesoblast Limited and X: @Mesoblast
Forward-Looking Statements
This press release includes forward-looking statements and forecasts that relate to future events or our future financial performance and involve known and unknown risks, uncertainties and other factors that may cause our actual results, levels of activity, performance or achievements to differ materially from any future results, levels of activity, performance or achievements expressed or implied by these forward-looking statements. We make such forward-looking statements pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995 and other federal securities laws. Forward-looking statements should not be read as a guarantee of future performance or results, and actual results may differ from the results anticipated in these forward-looking statements, and the differences may be material and adverse. Forward-looking statements include, but are not limited to, statements about: the initiation, timing, progress and results of Mesoblast’s preclinical and clinical studies, and Mesoblast’s research and development programs; Mesoblast’s ability to advance product candidates into, enroll and successfully complete, clinical studies, including multi-national clinical trials; Mesoblast’s ability to advance its manufacturing capabilities; the timing or likelihood of regulatory filings and approvals, manufacturing activities and product marketing activities, if any; the commercialization of Mesoblast’s RYONCIL for pediatric SR-aGVHD and any other product candidates, if approved; regulatory or public perceptions and market acceptance surrounding the use of stem-cell based therapies; the potential for Mesoblast’s product candidates, if any are approved, to be withdrawn from the market due to patient adverse events or deaths; the potential benefits of strategic collaboration agreements and Mesoblast’s ability to enter into and maintain established strategic collaborations; Mesoblast’s ability to establish and maintain intellectual property on its product candidates and Mesoblast’s ability to successfully defend these in cases of alleged infringement; the scope of protection Mesoblast is able to establish and maintain for intellectual property rights covering its product candidates and technology; estimates of Mesoblast’s expenses, future revenues, capital requirements and its needs for additional financing; Mesoblast’s financial performance; developments relating to Mesoblast’s competitors and industry; and the pricing and reimbursement of Mesoblast’s product candidates, if approved. You should read this press release together with our risk factors, in our most recently filed reports with the SEC or on our website. Uncertainties and risks that may cause Mesoblast’s actual results, performance or achievements to be materially different from those which may be expressed or implied by such statements, and accordingly, you should not place undue reliance on these forward-looking statements. We do not undertake any obligations to publicly update or revise any forward-looking statements, whether as a result of new information, future developments or otherwise, except where required by law or the ASX Listing Rules. Past performance given in this announcement is given for illustrative purposes only and should not be relied on as (and is not) an indication of future performance.
Not financial product advice
This announcement does not constitute financial product advice or investment advice (nor tax, accounting or legal advice) and has been prepared without taking into account the objectives, financial situation or needs of individuals. Before making an investment decision, prospective investors should consider the appropriateness of the information having regard to their own objectives, financial situation and needs and seek appropriate professional advice.
Disclaimer
To the maximum extent permitted by law, Mesoblast and its directors, officers, employees, advisers and agents disclaim any obligation or undertaking to release any updates or revisions to the information to reflect any change in expectations or assumptions, and disclaim all responsibility and liability for these forward-looking statements (including, without limitation, any liability for negligence).
Release authorized by the Chief Executive.
For more information, please contact:
| Corporate Communications / Investors |
| Paul Hughes |
| T: +61 3 9639 6036 |
| Media – Global |
| Allison Worldwide |
| Emma Neal |
| T: +1 603 545 4843 |
| E: emma.neal@allisonworldwide.com |
| Media – Australia |
| BlueDot Media |
| Steve Dabkowski |
| T: +61 419 880 486 |
| E: steve@bluedot.net.au |
FAQ
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