Monopar Announces ALXN1840 Data Selected for Late-Breaker Presentation at EASL Congress 2025
Monopar Therapeutics announced that their ALXN1840 drug candidate for Wilson disease has been selected for a prestigious late-breaker presentation at the EASL International Liver Congress 2025 in Amsterdam.
The presentation will focus on long-term efficacy and safety data of tiomolybdate choline (ALXN1840). The selection as a late-breaker abstract is significant, as these slots are reserved for the most recent and impactful research findings that could substantially influence the field.
The presentation titled "Sustained long-term clinical improvement in Wilson disease patients on tiomolybdate choline" will be delivered by Dr. Karl Heinz Weiss on May 7, 2025. The poster will be made available on Monopar's website the same day.
This selection underscores the potential importance of the research, as late-breaker abstracts must meet strict criteria including presenting latest findings, demonstrating significant potential impact, and featuring prospective clinical studies.
Monopar Therapeutics ha annunciato che il loro candidato farmaco ALXN1840 per la malattia di Wilson è stato selezionato per una prestigiosa presentazione late-breaker al EASL International Liver Congress 2025 ad Amsterdam.
La presentazione si concentrerà sui dati di efficacia e sicurezza a lungo termine del tiomolibdato colina (ALXN1840). La selezione come abstract late-breaker è significativa, poiché questi spazi sono riservati alle ricerche più recenti e rilevanti che potrebbero influenzare in modo sostanziale il settore.
La presentazione intitolata "Miglioramento clinico sostenuto a lungo termine nei pazienti con malattia di Wilson trattati con tiomolibdato colina" sarà tenuta dal Dr. Karl Heinz Weiss il 7 maggio 2025. Il poster sarà disponibile sul sito web di Monopar lo stesso giorno.
Questa selezione evidenzia l'importanza potenziale della ricerca, dato che gli abstract late-breaker devono soddisfare criteri rigorosi, tra cui la presentazione di risultati recenti, dimostrare un impatto significativo e includere studi clinici prospettici.
Monopar Therapeutics anunció que su candidato a medicamento ALXN1840 para la enfermedad de Wilson ha sido seleccionado para una prestigiosa presentación late-breaker en el EASL International Liver Congress 2025 en Ámsterdam.
La presentación se centrará en datos de eficacia y seguridad a largo plazo del tiomolibdato colina (ALXN1840). La selección como resumen late-breaker es significativa, ya que estos espacios están reservados para los hallazgos de investigación más recientes e impactantes que podrían influir sustancialmente en el campo.
La presentación titulada "Mejora clínica sostenida a largo plazo en pacientes con enfermedad de Wilson tratados con tiomolibdato colina" será impartida por el Dr. Karl Heinz Weiss el 7 de mayo de 2025. El póster estará disponible en el sitio web de Monopar ese mismo día.
Esta selección subraya la importancia potencial de la investigación, ya que los resúmenes late-breaker deben cumplir con estrictos criterios, incluyendo la presentación de hallazgos recientes, demostrar un impacto significativo y contar con estudios clínicos prospectivos.
Monopar Therapeutics는 윌슨병 치료제 후보인 ALXN1840이 암스테르담에서 열리는 EASL 국제 간 학술대회 2025에서 권위 있는 레이트 브레이커 발표로 선정되었다고 발표했습니다.
이번 발표는 티오몰리브데이트 콜린(ALXN1840)의 장기 효능 및 안전성 데이터에 초점을 맞출 예정입니다. 레이트 브레이커 초록 선정은 최신의 영향력 있는 연구 결과만이 받을 수 있는 자리로, 이 분야에 중대한 영향을 미칠 수 있는 연구임을 의미합니다.
"티오몰리브데이트 콜린을 투여받은 윌슨병 환자의 지속적인 장기 임상 개선"이라는 제목의 발표는 2025년 5월 7일 Dr. Karl Heinz Weiss가 진행할 예정이며, 같은 날 Monopar 웹사이트에 포스터가 게시됩니다.
이번 선정은 최신 연구 결과를 제시하고, 중대한 잠재적 영향을 입증하며, 전향적 임상 연구를 포함해야 하는 엄격한 기준을 충족해야 하는 레이트 브레이커 초록의 중요성을 강조합니다.
Monopar Therapeutics a annoncé que leur candidat médicament ALXN1840 pour la maladie de Wilson a été sélectionné pour une présentation prestigieuse en late-breaker lors du EASL International Liver Congress 2025 à Amsterdam.
La présentation portera sur les données d'efficacité et de sécurité à long terme du tiomolybdate choline (ALXN1840). La sélection en tant que résumé late-breaker est importante, car ces créneaux sont réservés aux recherches les plus récentes et impactantes susceptibles d'influencer considérablement le domaine.
La présentation intitulée « Amélioration clinique soutenue à long terme chez les patients atteints de la maladie de Wilson sous tiomolybdate choline » sera donnée par le Dr Karl Heinz Weiss le 7 mai 2025. Le poster sera disponible sur le site de Monopar le même jour.
Cette sélection souligne l'importance potentielle de la recherche, les résumés late-breaker devant répondre à des critères stricts, notamment la présentation des dernières découvertes, la démonstration d'un impact significatif et l'inclusion d'études cliniques prospectives.
Monopar Therapeutics gab bekannt, dass ihr Wirkstoffkandidat ALXN1840 für die Wilson-Krankheit für eine prestigeträchtige Late-Breaker-Präsentation auf dem EASL International Liver Congress 2025 in Amsterdam ausgewählt wurde.
Die Präsentation wird sich auf Langzeitdaten zur Wirksamkeit und Sicherheit von Tiomolybdat-Cholin (ALXN1840) konzentrieren. Die Auswahl als Late-Breaker-Abstract ist bedeutsam, da diese Plätze für die neuesten und einflussreichsten Forschungsergebnisse reserviert sind, die das Fachgebiet erheblich beeinflussen könnten.
Die Präsentation mit dem Titel „Anhaltende langfristige klinische Verbesserung bei Patienten mit Wilson-Krankheit unter Tiomolybdat-Cholin“ wird am 7. Mai 2025 von Dr. Karl Heinz Weiss gehalten. Das Poster wird am selben Tag auf der Website von Monopar verfügbar sein.
Diese Auswahl unterstreicht die potenzielle Bedeutung der Forschung, da Late-Breaker-Abstracts strenge Kriterien erfüllen müssen, darunter die Präsentation neuester Erkenntnisse, den Nachweis einer signifikanten potenziellen Wirkung und die Einbeziehung prospektiver klinischer Studien.
- ALXN1840 data selected for prestigious late-breaker presentation at EASL 2025, indicating significant research findings
- Study data met rigorous selection criteria for late-breaker status, suggesting potentially impactful results
- Long-term efficacy and safety data to be presented, showing sustained clinical improvement in Wilson disease patients
- None.
Insights
Monopar's Wilson disease treatment data accepted for prestigious EASL conference validates scientific significance and suggests positive clinical outcomes.
The acceptance of Monopar's ALXN1840 (tiomolybdate choline) data as a late-breaker presentation at the European Association for the Study of the Liver (EASL) Congress 2025 represents a significant scientific endorsement. Per the article, EASL late-breaker spots are reserved for "the most recent and significant findings" with "potential to impact the field in a substantial manner" - making this acceptance particularly noteworthy.
The presentation title "Sustained long-term clinical improvement in Wilson disease patients on tiomolybdate choline" strongly suggests positive durability in treatment outcomes, which is critical for chronic conditions requiring lifelong management. The abstract underwent what EASL describes as a "rigorous review" process with an acceptance rate "lower than regular abstracts" - providing external validation from hepatology experts regarding the data's significance.
For clinical-stage biopharmaceutical companies like Monopar, acceptance at prestigious medical conferences serves multiple strategic purposes: establishing scientific credibility, increasing visibility among potential partners and investors, and building momentum toward potential regulatory submissions. The selection of Dr. Karl Heinz Weiss as presenter adds further credibility, as he is recognized in the Wilson disease research community.
While specific efficacy metrics aren't disclosed in this announcement, the May 7th presentation will likely provide investors with important insights into this candidate's clinical profile and potential competitive positioning in the Wilson disease treatment landscape.
Late-breaker acceptance for tiomolybdate choline data suggests meaningful clinical advancements for Wilson disease patients with unmet needs.
Wilson disease represents a significant unmet medical need despite being a rare genetic disorder. This autosomal recessive condition affects approximately 1 in 30,000 individuals worldwide, causing toxic copper accumulation primarily in the liver and brain. Current standard treatments (chelating agents like penicillamine and zinc therapy) have limitations including serious side effects, adherence challenges, and variable efficacy.
The EASL International Liver Congress acceptance of Monopar's tiomolybdate choline data as a late-breaker abstract is particularly meaningful given the congress's criteria requiring that research "is considered highly significant with the potential to impact the field in a substantial manner." For Wilson disease patients, the presentation title suggesting "sustained long-term clinical improvement" addresses a critical aspect of disease management - these patients require lifelong treatment, making durability of effect and long-term safety essential therapeutic considerations.
The article specifies that qualifying clinical studies must be prospective rather than retrospective analyses, suggesting this data comes from well-designed forward-looking investigations rather than historical case reviews. This methodological rigor strengthens the potential clinical relevance of the findings.
While we must await the actual presentation for specific efficacy and safety metrics, this acceptance signals that independent hepatology experts view these findings as potentially advancing the standard of care for a condition with significant quality-of-life implications and life-threatening complications when inadequately managed.
WILMETTE, Ill., April 29, 2025 (GLOBE NEWSWIRE) -- Monopar Therapeutics Inc. (Nasdaq: MNPR), a clinical-stage biopharmaceutical company focused on developing innovative treatments for patients with unmet medical needs, today announced that data on the long term efficacy and safety of its ALXN1840 (tiomolybdate choline) drug candidate for Wilson disease has been accepted for a late-breaker poster presentation at the European Association for the Study of the Liver (“EASL”) International Liver Congress 2025. EASL is recognized as one of the premier events in the hepatology space and will be held in Amsterdam, Netherlands from May 7 – 10, 2025.
Late-breaker provides an opportunity to present “the most recent and significant findings,” according to EASL. Criteria for late-breaker abstracts include: (1) they present the latest, up-to-date research findings; (2) the research is considered highly significant with the potential to impact the field in a substantial manner; and (3) clinical studies should be prospective. Late-breaker abstracts undergo a rigorous review, and the acceptance rate is lower than regular abstracts with only the most compelling abstracts selected.
Details of the EASL Congress 2025 late-breaker poster presentation are as follows:
Title: Sustained long-term clinical improvement in Wilson disease patients on tiomolybdate choline
Abstract Number: LB25251
Session: Late-breaker Posters
Date and Time: Wednesday, May 7, 8:30 a.m. CET
Presenter: Karl Heinz Weiss, M.D.
Location: Amsterdam, Netherlands
The poster to be presented at EASL 2025 will be available online at www.monopartx.com on May 7, 2025.
About Monopar Therapeutics Inc.
Monopar Therapeutics is a clinical-stage biotechnology company with late-stage ALXN1840 for Wilson disease, and radiopharma programs including Phase 1-stage MNPR-101-Zr for imaging advanced cancers, and Phase 1a-stage MNPR-101-Lu and late preclinical-stage MNPR-101-Ac225 for the treatment of advanced cancers. For more information, visit: www.monopartx.com.
CONTACT:
Monopar Therapeutics Inc.
Investor Relations
Quan Vu
Chief Financial Officer
vu@monopartx.com
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