STOCK TITAN

NovaBridge Reports First Half 2026 Financial Results and Highlights Pipeline Momentum and Strategic Execution

(Moderate)
(Very Positive)
Tags

NovaBridge (Nasdaq: NBP) reported first half 2026 results, highlighting pipeline progress in oncology and ophthalmology and leadership changes. As of June 30, 2026, cash, cash equivalents, short-term investments and equity investments at fair value totaled $215.9 million, which the company believes can fund multiple milestones, including a planned Phase 3 interim read-out for givastomig in 2028.

Givastomig delivered positive Phase 1b data in first-line metastatic gastric cancer and is in a global Phase 2 study, with potential Phase 3 initiation as early as year-end 2026 under an Accelerated Approval Pathway. VIS-101 showed positive Phase 2a data in nAMD, with Phase 2b initiation in 2H 2026 and a global Phase 3 in 2027. R&D expenses rose to $14.3 million and administrative expenses to $26.4 million, driving a $37.9 million net loss for the period.

Loading...
Loading translation...

Positive

  • $215.9 million in cash, investments and equity at fair value as of June 30, 2026
  • Givastomig Phase 1b ORR of 77% at 8 mg/kg and 73% at 12 mg/kg in 1L gastric cancer
  • Givastomig median progression-free survival of 16.9 months at 8 mg/kg in evaluable patients
  • FDA Fast Track Designation granted to givastomig for untreated HER2-negative advanced or metastatic GEA in June 2026
  • VIS-101 reported positive Phase 2a data in March 2026 with favorable safety and durability in nAMD
  • R&D investment increased to $14.3 million in H1 2026 to advance clinical programs

Negative

  • Net loss increased to $37.9 million for H1 2026 from $8.7 million a year earlier
  • Net loss per share widened to $0.14 from $0.05 in the prior-year period
  • Research and development expenses rose to $14.3 million from $4.1 million year over year
  • Administrative expenses increased to $26.4 million from $8.3 million, including a one-time write-off of deferred offering costs
  • Total shareholders’ equity declined to $201.1 million as of June 30, 2026 from $230.9 million at December 31, 2025

News Explained

At June 30, 2026, NovaBridge’s $215.9 million liquidity included $25,057 thousand of equity investments; clinical phases remained planned.

The release adds balance-sheet detail to NovaBridge’s first-half update: its reported $215.9 million of liquidity at June 30, 2026 included cash, investments and equity securities, while the next clinical phases remained planned future steps.

Using the December 31, 2025 cash balance and that quarter’s operating cash outflow, cash equaled 1298.8 days of the last reported operating cash use.

The June 30, 2026 balance sheet also reported 266,798,199 ordinary shares outstanding and 270,740,388 issued, establishing the current ownership baseline.

Sources and calculations
  • Cash and equivalents vs quarterly operating cash outflow, in days of cash use $210,632,000 / ($14,596,000 / 90) = [object Object]

Market reaction after 1H26 earnings report: NBP -3.54% in the Aug 20 session

-3.54% 14.1x vol
12 alerts
-3.54% Session close to close
-4.8% Trough in 8 min
$216.26M Market Cap
14.1x Rel. Volume

In the Aug 20 session, NBP declined 3.54%, reflecting a moderate negative market reaction. Argus tracked a trough of -4.8% from its starting point during tracking. Our momentum scanner triggered 12 alerts that day, indicating notable trading interest and price volatility. Trading volume was exceptionally heavy at 14.1x the daily average, suggesting significant selling pressure.

Data tracked by StockTitan Argus on the day of publication.

Market Context

The comparable earnings record included a -1.21% 24-hour move, providing limited tag-specific histor...
Analysis

The comparable earnings record included a -1.21% 24-hour move, providing limited tag-specific history. Investors could weigh the clinical milestones against rising losses and Net Selling, while monitoring Phase 3 and Phase 2b execution.

Key Figures

Cash and investments: $215.9 million Objective response rate: 77% at 8 mg/kg; 73% at 12 mg/kg Median progression-free survival: 16.9 months +5 more
8 metrics
Cash and investments $215.9 million As of June 30, 2026
Objective response rate 77% at 8 mg/kg; 73% at 12 mg/kg Givastomig Phase 1b dose expansion; 52 evaluable subjects
Median progression-free survival 16.9 months Givastomig at 8 mg/kg; 27 evaluable subjects
R&D expenses $14.3 million vs. $4.1 million Six months ended June 30, 2026 vs. 2025
Administrative expenses $26.4 million vs. $8.3 million Six months ended June 30, 2026 vs. 2025
Net loss $37.9 million vs. $8.7 million Six months ended June 30, 2026 vs. prior-year period
Net loss per share $0.14 vs. $0.05 Six months ended June 30, 2026 vs. prior-year period
Target patient population Approximately 105,000 cases HER2-negative and Claudin 18.2-positive first-line GEA cases across seven markets

Previous Earnings Reports

1 past event · Latest: Apr 07 (Positive)
Same Type Pattern 1 events
Date Event Sentiment 24h Move Catalyst
Apr 07 Full-year earnings Positive -1.2% Pipeline advances, cash runway, and clinical efficacy highlights accompanied full-year results.

24h Move is the share-price change in the day after each event; other market factors may also have contributed.

Pattern Detected

The tag-matched earnings history showed a negative 24-hour reaction despite pipeline and cash positives, indicating divergence in the available comparable event.

Key Terms

orr, accelerated approval pathway, fast track designation, bispecific antibody
4 terms
orr medical
"The data showed that givastomig produced a 77% ORR at 8 mg/kg"
Objective Response Rate (ORR) is the percentage of patients in a clinical trial whose tumors shrink or disappear by a predefined amount after treatment. For investors, ORR is a quick, measurable signal of a therapy’s effectiveness—like early sales numbers for a new product—and strong ORR data can boost a drug’s commercial prospects and company valuation, while weak ORR can temper expectations.
accelerated approval pathway regulatory
"potential eligibility for the U.S. Food and Drug Administration’s (FDA) Accelerated Approval Pathway"
The accelerated approval pathway is a process that allows new medicines to be approved more quickly based on early evidence that they may be effective, rather than waiting for full proof. This can help patients access promising treatments faster, but it also means ongoing studies are needed to confirm the benefits. For investors, it highlights potential faster market entry and earlier revenue opportunities, along with some uncertainty about long-term outcomes.
fast track designation regulatory
"the FDA granted Fast Track Designation to givastomig"
Fast track designation is a status the U.S. Food and Drug Administration grants to drugs intended to treat serious conditions and address an unmet medical need. It gives the developer more frequent communication with the FDA and can allow parts of the application to be reviewed on a rolling basis, and it may pave the way to priority review or accelerated approval. It can shorten development timelines, though it does not guarantee approval.
bispecific antibody medical
"It is a bispecific Claudin 18.2 × 4-1BB antibody"
A bispecific antibody is a specially designed protein that can attach to two different targets at the same time. Think of it as a custom-made connector that brings two things together—such as a disease cell and an immune system component—helping the body fight illnesses more effectively. For investors, understanding bispecific antibodies is important because they represent innovative therapies that could lead to new treatments and potentially lucrative market opportunities.

AI-generated analysis. How Rhea-AI works. Not financial advice.

See more from StockTitan in Google Search and AI answers. Adds StockTitan as a preferred source · opens Google
Add on Google
  • Executing NovaBridge’s strategy to identify differentiated science, develop it efficiently and create long-term value for patients and shareholders
  • Appointed Srishti Gupta, MD, MPP, as Chief Executive Officer, to strengthen strategic oversight, governance, and capital allocation across the Company
  • Advancing givastomig toward initiating a registrational Phase 3 study as early as YE 2026, under a potential Accelerated Approval Pathway
  • Progressing VIS-101 toward Phase 2b initiation in 2H 2026, following positive Phase 2a results supporting potential best-in-class durability
  • Maintained a strong balance sheet with $215.9 million in cash, cash equivalents, short-term investments, and equity investment at fair value as of June 30, 2026, providing runway through several important clinical and strategic inflection points, including givastomig’s planned Phase 3 interim data read-out in 2028

ROCKVILLE, Md., Aug. 20, 2026 (GLOBE NEWSWIRE) -- NovaBridge Biosciences (Nasdaq: NBP) (“NovaBridge” or the “Company”), a global biotechnology company that identifies differentiated innovation and applies disciplined development, financing, and partnering strategies to create value, today reported financial results for the six months ended June 30, 2026, and provided a business update. During the first half of 2026, the Company continued executing its strategic priorities by progressing key clinical milestones for its lead programs. The Company also strengthened leadership, governance, and capital allocation to support long-term value creation.

“Significant innovation exists across geographies and organizations, yet many promising therapies never reach their full potential,” said Srishti Gupta, MD, MPP, Chief Executive Officer of NovaBridge. “NovaBridge was built to identify those opportunities, advance them efficiently and create value through the path best suited to each asset. The progress of givastomig and VIS-101 reflects our ability to both identify differentiated science and to achieve meaningful development milestones, positioning NovaBridge to continue creating value for patients and shareholders.”

“NovaBridge is building the capabilities required to succeed over the long term. The progress of givastomig and VIS-101, together with the continued strengthening of the organization, reflects deliberate execution against that objective,” said Fu Wei, Chairman of the Board of NovaBridge.

Pipeline Overview and Potential Upcoming Milestones

NovaBridge’s two lead programs illustrate the complementary capabilities at the core of its strategy. Givastomig, a potential first-in-class Claudin 18.2-Targeted Immuno Amplifier (“CTIA”), reflects NovaBridge’s ability to efficiently execute differentiated science toward registrational development. VIS-101, a purpose-designed tetravalent VEGF-A × ANG-2 peptibody for retinal vascular diseases, developed through NovaBridge’s majority-owned subsidiary leading its ophthalmology platform, Visara, Inc. (“Visara”), reflects NovaBridge’s ability to identify and acquire differentiated therapeutic assets that others have overlooked.

Givastomig

Givastomig is a potential first-in-class CTIA. It is a bispecific Claudin 18.2 × 4-1BB antibody targeting Claudin 18.2-positive tumor cells being developed for the treatment of first-line metastatic gastric cancer.

In January 2026, NovaBridge reported positive data from the givastomig Phase 1b dose expansion combination study in patients with first-line (“1L”) gastric cancer. The data showed that givastomig produced a 77% ORR at 8 mg/kg and 73% ORR at 12 mg/kg (among 52 evaluable subjects), and a 16.9-month median progression-free survival at 8 mg/kg (among 27 evaluable subjects), with responses observed across a range of PD-L1 and Claudin 18.2 expression levels. Givastomig demonstrated favorable overall tolerability in combination with immunochemotherapy without dose-dependent toxicity.

In February 2026, NovaBridge initiated a global, randomized Phase 2 study of givastomig combined with immunochemotherapy in patients with HER2-negative, 1L metastatic gastric cancer.

In March 2026, NovaBridge reported givastomig’s potential eligibility for the U.S. Food and Drug Administration’s (FDA) Accelerated Approval Pathway in first-line HER2-negative, Claudin 18.2-positive, PD-L1-positive patients with gastroesophageal adenocarcinoma (“GEA”).

In June 2026, the FDA granted Fast Track Designation to givastomig for the treatment of previously untreated HER2-negative advanced or metastatic GEA in combination with nivolumab and chemotherapy.

NovaBridge estimates that approximately 180,0001 patients are diagnosed with first-line GEA in the U.S., France, Germany, Italy, Spain, the United Kingdom and Japan, of which approximately 105,0002,3 cases are HER2-negative and Claudin 18.2-positive, the population givastomig targets. The Company also believes givastomig has broad potential across other Claudin 18.2-positive gastrointestinal malignancies, including biliary tract cancer and pancreatic ductal adenocarcinoma.

Upcoming Givastomig Milestones:

  • October 25, 2026: Poster presentation of Phase 1b combination dose expansion data at the European Society for Medical Oncology (ESMO) Congress 2026
  • As early as YE 2026: Initiate Phase 3 registrational study under a potential Accelerated Approval Pathway

VIS-101

VIS-101 is a potential best-in-class VEGF-A × ANG-2. It is a purpose-designed tetravalent peptibody being developed for neovascular retinal diseases. Positive Phase 2a data reported in March 2026 demonstrated favorable safety and tolerability results, meaningful visual acuity improvements, and encouraging durability in neovascular (wet) age-related macular degeneration (“nAMD”) patients. VIS-101 is being developed for nAMD, diabetic macular edema (“DME”), and retinal vein occlusion (“RVO”), which together affect more than 57 million people globally.4

VIS-101 is being advanced through Visara. Consistent with NovaBridge’s operating model, Visara combines specialized ophthalmology expertise with NovaBridge’s strategic oversight, capital allocation, and business development capabilities to support focused execution and future growth of the ophthalmology franchise.

Upcoming VIS-101 Milestones:

  • H2 2026: Initiate Phase 2b program in nAMD
  • 2027: Initiate global Phase 3 program in nAMD

1H Execution Highlights

During the first half of 2026 and subsequent period, NovaBridge continued to strengthen its leadership team to support the Company's next phase of growth. NovaBridge appointed Srishti Gupta, MD, MPP, as Chief Executive Officer to lead corporate strategy, capital allocation, business development, and operational execution. The Company also appointed Mark Hagler as Chief Commercial Officer, adding commercial and portfolio planning expertise to support future development and partnership opportunities. At Visara, Jeffrey Nau, PhD, MMS, was appointed President and Chief Executive Officer to lead the advancement of VIS-101 and the continued build-out of the ophthalmology franchise. With these additions, NovaBridge continued executing its strategy to identify, develop, and create value from differentiated therapeutic assets. During the period, the Company advanced key pipeline programs toward important development milestones while continuing to evaluate opportunities to expand its portfolio and create long-term value for patients and shareholders.

In addition, NovaBridge is implementing enhancements to its segment disclosure and half-year reporting structure, expected to provide shareholders with clearer visibility into the performance of the Company and its operating subsidiaries.

First Half 2026 Financial Results

Cash Position

As of June 30, 2026, the Company had cash, cash equivalents, short-term investments, and equity investment at fair value of $215.9 million. Based on its current operating plan, the Company believes its cash position is sufficient to support the advancement of its portfolio through multiple anticipated clinical and strategic milestones, including givastomig’s planned Phase 3 interim data read-out in 2028.

Research & Development Expenses

Research and development expenses were $14.3 million for the six months ended June 30, 2026, compared to $4.1 million for the six months ended June 30, 2025. The increase was primarily driven by investment in clinical development activities for givastomig and the continued build-out of NovaBridge’s development capabilities to support current and future portfolio programs.

Administrative Expenses

Administrative expenses were $26.4 million for the six months ended June 30, 2026, compared to $8.3 million for the six months ended June 30, 2025. The increase was primarily driven by higher share-based compensation expense associated with equity awards granted in 2025, increased personnel-related costs as the Company expanded its organizational capabilities, and a one-time write-off of deferred offering costs related to the previously proposed HKEx dual primary listing.

Net Loss

Net loss was $37.9 million for the six months ended June 30, 2026, compared to $8.7 million for the prior-year period. Net loss per share attributable to ordinary shareholders was $0.14 compared to $0.05 in the prior-year period.

About Givastomig

Givastomig (TJ033721 / ABL111), a potential first-in-class CTIA, is a Claudin 18.2 × 4-1BB bispecific antibody. Givastomig conditionally activates T cells via the 4-1BB signaling pathway in the tumor microenvironment where Claudin 18.2 is expressed. Givastomig is being developed for potential treatment of gastric cancer, its current lead indication. Givastomig also has potential applicability across other Claudin 18.2+ gastrointestinal malignancies including biliary tract cancer and pancreatic ductal adenocarcinoma. Givastomig is being evaluated in a global, randomized Phase 2 study (NCT07432295), following positive topline results from a Phase 1b, multicenter, open-label study in first-line gastric cancer. NovaBridge expects to initiate a Phase 3 registrational study under a potential Accelerated Approval Pathway as early as year end 2026.

Givastomig is being jointly developed through a global partnership with ABL Bio, Inc. (“ABL Bio”). NovaBridge is the lead party and shares worldwide rights equally with ABL Bio, excluding Greater China and South Korea.

About VIS-101

VIS-101 (ASKG712/AM712) is a tetravalent VEGF-A × ANG-2 peptibody purpose-designed to be best-in-class. It targets retinal vascular diseases, including nAMD, DME, and RVO, which together affect more than 57 million people globally.⁴ VIS-101 is the only intravitreal therapeutic with two binding sites for each of VEGF-A and ANG-2, and carries the molecular weight of a full-length monoclonal antibody, a structural design intended to deliver a rapid, robust, and durable treatment response for patients with neovascular retinal diseases.

VIS-101 has completed initial safety and dose-escalation studies in both the U.S. and China, along with a randomized, dose-ranging Phase 2a study in China (NCT05456828). It is expected to advance to a randomized, controlled, dose-determining Phase 2b study in the second half of 2026, with anticipated initiation of a global Phase 3 program in 2027.

NovaBridge is the majority shareholder of Visara, which controls global rights to VIS-101 outside of Greater China and certain countries in Asia.

References:

  1. Markets include U.S., France, Germany, Italy, Spain, the United Kingdom, and Japan in 2025 based on Data Monitor Biomed Tracker, based on 1L treatment
  2. HER2-negative status of 78%. Van Cutsem E, Bang YJ, Feng-Yi F, et al. HER-2 screening data from ToGA: targeting HER2 in gastric and gastroesophageal junction cancer. Gastric Cancer 2015;18(3):476-84
  3. CLDN18.2 positive status of ~70%. Kohei Shitara, et al, 2023 ASCO Annual Meeting (June 2-6), poster #4035
  4. Invest Ophthalmol Vis Sci. 2021 Nov 24; 62 (14): 26. doi: 10.1167/iovs.62.14.26

Webcast/Conference Call Details:

NovaBridge will hold a webcast on Thursday, August 20, 2026 at 9:00 AM ET/9:00 PM China Standard Time to discuss recent corporate progress and financial results for the six months ended June 30, 2026.

Webcast Information:

  • Date: Thursday, August 20, 2026
  • Time: 9:00 AM ET/9:00 PM China Standard Time
  • Web Access - China: Click here
  • Webcast Access – All other locations: Click here

The live and archived webcast can also be accessed by visiting the NovaBridge Biosciences website on the Upcoming Events section of the Investors page. A replay of the webcast will be archived for at least 30 days after the event.

About NovaBridge

NovaBridge Biosciences (Nasdaq: NBP) is a global biotechnology company advancing a portfolio of therapeutic programs in oncology and ophthalmology. The Company identifies differentiated therapeutic opportunities, generates value-defining clinical evidence, and applies the development, financing, and partnering strategy best suited to each program.

NovaBridge’s portfolio is led by givastomig and VIS-101. The Company's objective is to build a sustainable biotechnology company by repeatedly identifying differentiated innovation, advancing it efficiently, and bringing novel therapies to patients through the path best suited to each opportunity.

For more information, please visit www.novabridge.com and follow us on LinkedIn.

Forward Looking Statements

This announcement contains forward-looking statements. These statements are made under the “safe harbor” provisions of the U.S. Private Securities Litigation Reform Act of 1995. These forward-looking statements can be identified by terminology such as “will,” “expects,” “believes,” “designed to,” “anticipates,” “future,” “intends,” “plans,” “potential,” “estimates,” “confident,” and similar terms or the negative thereof. NovaBridge may also make written or oral forward-looking statements in its periodic reports to the U.S. Securities and Exchange Commission (the SEC), in its annual report to shareholders, in press releases and other written materials and in oral statements made by its officers, directors or employees to third parties. Statements that are not historical facts, including statements about the Company’s beliefs and expectations, are forward-looking statements. Forward-looking statements in this press release include, without limitation, statements regarding: the strategy, clinical development, plans, timing, results, safety and efficacy of the Company's drug candidates, including givastomig, VIS-101, ragistomig and uliledlimab; the Company’s anticipated cash runway; anticipated clinical milestones, potential regulatory interactions and results, and related timing. Forward-looking statements involve inherent risks and uncertainties that may cause actual results to differ materially from those contained in these forward-looking statements, including but not limited to the following: the Company’s ability to demonstrate the safety and efficacy of its drug candidates; the clinical results for its drug candidates, which may or may not support further development or New Drug Application/Biologics License Application approval or eligibility for accelerated approval pathway or receipt of accelerated approval; the content and timing of decisions made by the relevant regulatory authorities, including the FDA, regarding regulatory approval of the Company’s drug candidates; the Company’s ability to achieve commercial success for its drug candidates, if approved; the Company’s ability to obtain and maintain protection of intellectual property for its technology and drugs; the Company’s reliance on third parties to conduct drug development, manufacturing and other services; the Company’s limited operating history and the Company’s ability to obtain additional funding for operations and to complete the development and commercialization of its drug candidates; the impact of macroeconomic conditions, including inflation, tariffs, volatile interest rates, regulatory uncertainty, potential government shutdowns, volatility in the capital markets, and regional and other global events, including ongoing armed conflicts in different regions of the world; and those risks more fully discussed in the “Risk Factors” section in the Company’s annual report on Form 20-F filed with the SEC on April 7, 2026, and amended on June 16, 2026, as well as the discussions of potential risks, uncertainties, and other important factors in the Company’s subsequent filings with the SEC. All forward-looking statements are based on information currently available to the Company. The Company undertakes no obligation to publicly update or revise any forward-looking statements, whether as a result of new information, future events, or otherwise, except as may be required by law.

NovaBridge Investor & Media Contacts

NovaBridge Biosciences
+1-240-745-6330
IR@novabridge.com

Bill Begien, VP, Investor Relations
bill.begien@novabridge.com

Jessica Zhang, Director, Public Relations
jessica.zhang@novabridge.com


NovaBridge Biosciences
Condensed Consolidated Balance Sheets
As of June 30, 2026 and December 31, 2025
(Unaudited)
(All amounts in thousands, except for share data, unless otherwise noted)

  As of 
  June 30,
2026
  December 31, 2025 
Assets      
Current assets      
Cash and cash equivalents $190,637  $210,632 
Short-term investments  210   210 
Prepayments and other receivables  7,156   6,678 
Total current assets  198,003   217,520 
Property, equipment and software  1,266   140 
Operating lease right-of-use assets  4,344   2,809 
Investments at fair value, equity securities  25,057   37,241 
Other non-current assets  2,872   2,812 
Total assets $231,542  $260,522 
       
Liabilities and shareholders’ equity      
Current liabilities      
Accruals and other payables (including amounts with related parties of $120 and $1,131, as of June 30, 2026 and December 31, 2025, respectively) $15,768  $16,823 
Operating lease liabilities, current  1,276   891 
Other current liabilities  8,878   9,180 
Total current liabilities  25,922   26,894 
Operating lease liabilities, non-current  3,182   2,176 
Other non-current liabilities  1,334   511 
Total liabilities  30,438   29,581 
       
Redeemable noncontrolling interest      
Shareholders’ equity      
Ordinary shares ($0.0001 par value, 800,000,000 shares authorized as of
June 30, 2026 and December 31, 2025; 270,740,388 shares
issued as of June 30, 2026 and December 31, 2025 ; 266,798,199 and 265,377,891
outstanding as of June 30, 2026 and December 31, 2025, respectively)
 $27  $27 
Treasury Stock (3,942,189 and 5,362,497 shares
as of June 30, 2026 and December 31, 2025, respectively)
  (3,706)  (5,042)
Additional paid-in capital  1,532,920   1,526,718 
Accumulated other comprehensive income  42,039   41,546 
Accumulated deficit  (1,370,176)  (1,332,308)
Total shareholders’ equity  201,104   230,941 
Total liabilities and shareholders’ equity $231,542  $260,522 
         

The accompanying notes are an integral part of these condensed consolidated financial statements.

NovaBridge Biosciences
Condensed Consolidated Statements of Comprehensive Loss
For the Six Months Ended June 30, 2026 and 2025
(Unaudited)
(All amounts in thousands, except for share and per share data, unless otherwise noted)

  Six Months Ended June 30, 
  2026  2025 
     
Expenses      
Research and development expenses $(14,329) $(4,071)
Administrative expenses (including amounts with related parties of
$576 and $55, for the six months ended June 30, 2026 and 2025 respectively)
  (26,416)  (8,309)
Total expenses  (40,745)  (12,380)
Loss from operations  (40,745)  (12,380)
Interest income, net  2,349   3,672 
Other income, net  528   54 
Loss before income tax expense  (37,868)  (8,654)
Income tax expense      
Net loss  (37,868)  (8,654)
Net loss attributable to noncontrolling interests      
Net loss attributable to shareholders of NovaBridge $(37,868) $(8,654)
       
Other comprehensive income:      
Unrealized gain on available-for-sale debt securities, net of tax $  $3,644 
Foreign currency translation adjustments, net of tax  493   11 
Total other comprehensive income  493   3,655 
Comprehensive loss  (37,375)  (4,999)
Comprehensive loss attributable to redeemable noncontrolling interests      
Comprehensive loss attributable to shareholders of NovaBridge $(37,375) $(4,999)
       
Weighted-average number of ordinary shares used in calculating net
loss per share - basic and diluted
  266,157,063   187,794,543 
Net loss per share - basic and diluted $(0.14) $(0.05)
Net loss per ADS* - basic and diluted $(0.33) $(0.11)
         

*10 American depositary shares (“ADS”) represents 23 ordinary shares

The accompanying notes are an integral part of these condensed consolidated financial statements.

NovaBridge Biosciences
Condensed Consolidated Statements of Changes in Shareholders’ Equity
For the Six Months Ended June 30, 2026 and 2025
(Unaudited)
(All amounts in thousands, except for share data, unless otherwise noted)

  Ordinary share          Accumulated      
  ($0.0001 par value) Treasury stock  Additional  other    Total 
  Number of   Number of     paid-in  comprehensive Accumulated  shareholders’ 
  shares Amount shares  Amount  capital  income deficit  equity 
Balance as of December 31, 2024 194,073,729 $19 (6,621,234) $(6,225) $1,460,021  $33,384 $(1,286,039) $201,160 
Foreign currency translation adjustments             11     11 
Net loss               (8,654)  (8,654)
Unrealized gain on available-
for-sale debt securities
             3,644     3,644 
Share-based compensation          572        572 
Issuance of ordinary shares for
restricted share units
    655,683   616   (616)        
Balance as of June 30, 2025 194,073,729 $19 (5,965,551) $(5,609) $1,459,977  $37,039 $(1,294,693) $196,733 
                      
Balance as of December 31, 2025 270,740,388 $27 (5,362,497) $(5,042) $1,526,718  $41,546 $(1,332,308) $230,941 
Foreign currency translation adjustments             493     493 
Net loss               (37,868)  (37,868)
Share-based compensation          6,796        6,796 
Exercise of stock options    1,191,073   1,120   (378)       742 
Issuance of ordinary shares for
restricted share units
    229,235   216   (216)        
Balance as of June 30, 2026 270,740,388 $27 (3,942,189) $(3,706) $1,532,920  $42,039 $(1,370,176) $201,104 
                            

The accompanying notes are an integral part of these condensed consolidated financial statements.

NovaBridge Biosciences
Condensed Consolidated Statements of Cash Flows
For the Six Months Ended June 30, 2026 and 2025
(Unaudited)
(All amounts in thousands, unless otherwise noted)

  Six Months Ended June 30, 
  2026  2025 
Cash flows from operating activities      
Net loss $(37,868) $(8,654)
Adjustments to reconcile net loss to net cash used in operating activities      
Share-based compensation  6,796   572 
Depreciation of property, equipment and software  75   36 
Amortization of right-of use assets  527   388 
Loss from disposal of property and equipment and software  28   16 
Write-off of deferred cost for planned dual listing  3,796    
Gain on disposal of investments, equity securities  (328)   
Foreign exchange gain  (173)   
Changes in operating assets and liabilities      
Prepayments and other receivables  (4,274)  1,321 
Other non-current assets  (60)  145 
Accruals and other payables  (1,388)  (1,262)
Other non-current liabilities  615    
Operating lease liability, net  (672)  (402)
Net cash used in operating activities  (32,926)  (7,840)
Cash flows from investing activities      
Proceeds from disposal of short-term and other investments  210   154,885 
Purchase of short-term and other investments  (210)  (49,960)
Purchase of property, equipment and software  (990)  (7)
Proceeds from disposal of property and equipment     47 
Proceeds from disposal of investments, equity securities  13,233    
Net cash generated from investing activities  12,243   104,965 
Cash flows from financing activities      
Proceeds from exercise of stock options  742    
Net cash generated from financing activities  742    
Effect of exchange rate changes on cash and cash equivalents  (54)  16 
Net (decrease) increase in cash and cash equivalents  (19,995)  97,141 
       
Cash and cash equivalents, beginning of period  210,632   68,263 
Cash and cash equivalents, end of period $190,637  $165,404 
       
Additional ASC 842 supplemental disclosures      
Cash paid for fixed operating lease costs included in the measurement of lease obligations
in operating activities
 $632  $505 
Non-cash activities      
Payables for purchase of property, equipment and software $31  $ 
Unrealized gain on available-for-sale debt securities $  $3,644 
         

The accompanying notes are an integral part of these condensed consolidated financial statements.


FAQ

What were NovaBridge (NBP) key financial results for the first half of 2026?

NovaBridge reported a net loss of $37.9 million for the six months ended June 30, 2026. According to NovaBridge, research and development expenses were $14.3 million and administrative expenses were $26.4 million, with net loss per share of $0.14 compared to $0.05 a year earlier.

How much cash runway does NovaBridge (NBP) report as of June 30, 2026?

NovaBridge reported $215.9 million in cash, cash equivalents, short-term investments and equity investment at fair value as of June 30, 2026. According to NovaBridge, this cash position is expected to support its portfolio through multiple milestones, including givastomig’s planned Phase 3 interim data read-out in 2028.

What is the status of NovaBridge’s givastomig program as of August 2026?

Givastomig has positive Phase 1b data and is in a global randomized Phase 2 trial for first-line HER2-negative metastatic gastric cancer. According to NovaBridge, FDA granted Fast Track Designation in June 2026, and a Phase 3 registrational study could start as early as year-end 2026.

What are the next clinical milestones for VIS-101 in the NovaBridge (NBP) pipeline?

VIS-101 is advancing toward a randomized, controlled, dose-determining Phase 2b study in nAMD in the second half of 2026. According to NovaBridge, initiation of a global Phase 3 program in nAMD is anticipated in 2027, following positive Phase 2a safety and efficacy data reported in March 2026.

How did operating expenses change for NovaBridge (NBP) in the first half of 2026?

Operating expenses increased significantly, with research and development expenses rising to $14.3 million and administrative expenses to $26.4 million. According to NovaBridge, higher spending reflected clinical development of givastomig, expanded organizational capabilities, share-based compensation, and a one-time write-off of deferred offering costs.

What leadership changes did NovaBridge (NBP) announce in 2026 and why are they important?

NovaBridge appointed Srishti Gupta, MD, MPP, as Chief Executive Officer and Mark Hagler as Chief Commercial Officer in 2026. According to NovaBridge, these appointments strengthen strategic oversight, capital allocation, commercial planning, and support execution of its oncology and ophthalmology pipeline, including VIS-101 at subsidiary Visara.

When is NovaBridge’s webcast to discuss first half 2026 results and how can investors access it?

NovaBridge scheduled a webcast on Thursday, August 20, 2026 at 9:00 AM ET (9:00 PM China Standard Time). According to NovaBridge, investors can access live and archived webcasts via region-specific links and through the Upcoming Events section on the company’s investor relations webpage.