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ENDRA Life Sciences Bolsters TAEUS® System Intellectual Property with New Patents in U.S., China and Europe

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ENDRA Life Sciences Inc. (NDRA) expands its intellectual property portfolio with the issuance of three new patents in the U.S., China, and Europe, bringing the total to 74 worldwide. These patents protect the TAEUS system, enhancing radiofrequency energy absorption, reducing signal noise, and enabling precise temperature monitoring during surgical procedures and thermal ablation. The innovative technology aims to optimize treatment parameters, minimize damage to healthy tissue, and effectively target cancerous cells for improved therapeutic outcomes with reduced side effects.
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The expansion of ENDRA Life Sciences Inc.'s intellectual property portfolio is a strategic move that solidifies the company's competitive edge in the medical imaging and therapy sector. The issuance of patents in the U.S., China and Europe for the Thermo Acoustic Enhanced UltraSound (TAEUS®) technology suggests a robust approach to protecting their innovations on a global scale. This can be a critical factor for investors, as patents provide a form of legal monopoly, allowing ENDRA to potentially generate higher revenues through exclusivity of their technology.

The thermoacoustic technology covered by these patents is designed to enhance the precision of surgical procedures and thermal ablation therapies. The ability to monitor temperature changes accurately is crucial in treatments such as cancer therapy, where the margin between effective treatment and damage to healthy tissue is narrow. By optimizing treatment parameters, the TAEUS system could lead to improved patient outcomes and potentially reduce costs associated with post-procedure complications.

From an investment perspective, this expansion of the patent portfolio may increase ENDRA's valuation due to the potential for licensing deals, strategic partnerships, or even acquisition interest from larger companies seeking to enhance their own offerings with ENDRA's technology. Additionally, the mention of a 'novel sleeve-type structural configuration' and 'signal polarization' indicates that ENDRA is not only expanding their patent quantity but also the quality and specificity of their intellectual property, which could further deter competition and foster innovation.

The granting of new patents in major markets like the U.S., China and Europe indicates ENDRA's commitment to international expansion and market penetration. For stakeholders, this suggests a proactive approach to capturing market share in the rapidly growing field of medical imaging and therapeutic technology. Given the prevalence of cancer and the ongoing need for advancements in its treatment, the TAEUS system's focus on thermal therapies could address a significant portion of the healthcare market.

Understanding the market dynamics, the protection of the TAEUS system in these regions could disrupt the existing market by providing a differentiated product that enhances the precision of thermal therapies. As the healthcare industry continues to emphasize personalized medicine and outcome-based treatments, technologies that can offer precise monitoring and control during procedures are likely to be in high demand.

Furthermore, the protection of intellectual property in China is particularly noteworthy, as it represents a large and growing healthcare market. The ability to enforce patents in China can be challenging, but it is critical for companies looking to capitalize on the opportunities in this region. The successful issuance of a patent here may signal ENDRA's preparedness to navigate the complex regulatory and business landscape in China, which could be a strong indicator of the company's long-term growth strategy and its potential impact on the market.

The strategic expansion of ENDRA's patent portfolio is a testament to the company's foresight in safeguarding its technological advancements. Patents serve as a barrier to entry for competitors and with 74 issued patents worldwide, ENDRA has created a substantial moat around its TAEUS technology. The legal protection these patents afford can prevent other companies from replicating the technology, thus maintaining ENDRA's market exclusivity.

The specifics of the patents, such as the 'sleeve-type structural configuration' and the ability to enable 'signal polarization,' highlight the company's focus on innovation and detail in their intellectual property strategy. These patents not only cover the broad use of the technology but also its intricate design elements, which can be crucial in defending against infringement claims or in pursuing litigation if necessary.

For investors, the legal strength of a company's patent portfolio can significantly influence its market value and attractiveness for partnerships or mergers. A robust patent estate can also be leveraged during fundraising activities or public offerings, as it underscores the company's commitment to innovation and its potential for long-term commercial success. The international scope of these patents further emphasizes ENDRA's intention to compete in the global market, protecting its interests across different legal jurisdictions with varying intellectual property laws and enforcement practices.

Global Intellectual Property Portfolio Expands to 74 Issued Patents

ANN ARBOR, Mich.--(BUSINESS WIRE)-- ENDRA Life Sciences Inc. (NASDAQ: NDRA), a pioneer of Thermo Acoustic Enhanced UltraSound (TAEUS®), announces the issuance of three new patents, including one in the U.S., one in China and one in Europe. ENDRA’s intellectual property portfolio now includes 74 issued patents worldwide providing protection for the TAEUS system with its novel thermoacoustic technology.

These patents protect novel innovations integral to the TAEUS system, ensuring maximum radiofrequency energy absorption, minimized signal noise and precise temperature monitoring during surgical procedures and thermal ablation. With the ability to accurately monitor temperature changes during thermal therapies, clinicians can, for example, optimize treatment parameters to minimize damage to healthy tissue while effectively targeting cancerous cells, leading to better therapeutic outcomes and reduced side effects.

“We are proud of our growing patent estate, which is particularly impressive for a company of our size. These newly issued patents reinforce ENDRA's commitment to advancing state-of-the-art thermoacoustic systems, and expand the horizons for our novel TAEUS® technology to address unmet clinical needs," commented ENDRA's Chief Technology Officer Michael Thornton. "We remain committed to fortifying our intellectual property to safeguard our technology in key global markets, deploying a robust portfolio that now encompasses 74 granted patents."

The following three patents were issued:

  • U.S. Patent No. 11844650 (the ‘650 patent), titled “Thermoacoustic Measurement Probe,” protects a novel sleeve-type structural configuration for TAEUS that maximizes radiofrequency energy absorption and the corresponding thermoacoustic signal strength. The sleeve-type configuration also minimizes signal noise to provide a clearer thermoacoustic signal. Embodiments cited in the ‘650 patent utilize a plurality of radiofrequency feeds that enable signal polarization and lead to a clearer thermoacoustic measurement.
  • Chinese Patent No. ZL2021800757024 (the ‘024 patent), titled “Thermal Ablation System with Integrated Thermoacoustic Temperature Measurement,” relates to the TAEUS system determining temperature at a specific location in the human body. For example, the ‘024 patent protects a system designed to monitor temperature during thermal ablation for overheating to avoid destroying healthy tissue and underheating to mitigate not destroying targeted cancerous tumor cells.
  • European Patent No. EP3902490, titled “Method and System for Monitoring Tissue Temperature,” relates to a novel method with the TAEUS system for monitoring tissue temperature during surgical procedures, such as thermotherapy and cryotherapy.

About ENDRA Life Sciences Inc.

ENDRA Life Sciences is the pioneer of Thermo Acoustic Enhanced UltraSound (TAEUS®), a ground-breaking technology, which characterizes tissue like MRI, but at 1/50th the cost and at the point of patient care. TAEUS® is designed to work in concert with over 700,000 ultrasound systems in use globally today. TAEUS® is initially focused on the measurement of fat in the liver as a means to assess and monitor Steatotic Liver Disease (SLD) (formerly known as NAFLD-NASH), a chronic liver spectrum that affects over two billion people globally, and for which there are no practical diagnostic tools. Beyond the liver, ENDRA is exploring several other clinical applications of TAEUS®, including visualization of tissue temperature during energy-based surgical procedures. For more information, please visit www.endrainc.com.

Forward-Looking Statements

All statements in this press release that are not based on historical fact are “forward-looking statements” within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. Forward-looking statements, which are based on certain assumptions and describe our future plans, strategies and expectations, can generally be identified by the use of terms such as “approximate,” “anticipate,” “attempt,” “believe,” “could,” “estimate,” “expect,” “forecast,” “future,” “goal,” “hope,” “intend,” “may,” “plan,” “possible,” “potential,” “project,” “seek,” “should,” “will,” “would,” or other comparable terms (including the negative of any of the foregoing), although some forward-looking statements are expressed differently. Examples of forward-looking statements for ENDRA include, among others: estimates of the timing of future events and anticipated results of our development efforts, including the timing of submission for and receipt of required regulatory approvals and product launches; statements relating to future financial position and projected costs and revenue; expectations concerning ENDRA’s business strategy; and statements regarding ENDRA’s ability to find and maintain development partners. Forward-looking statements involve inherent risks and uncertainties that could cause actual results to differ materially from those in the forward-looking statements as a result of various factors including, among others: the ability to raise additional capital in order to continue as a going concern; the ability to obtain regulatory approvals necessary to sell ENDRA medical devices in certain markets in a timely manner, or at all; the ability to develop a commercially feasible technology and its dependence on third parties to design and manufacture its products; the impact of COVID-19 on ENDRA’s business plans; the ability to find and maintain development partners; market acceptance of ENDRA’s technology and the amount and nature of competition in its industry; ENDRA’s ability to protect its intellectual property; and the other risks and uncertainties described in the Risk Factors and Management’s Discussion and Analysis of Financial Condition and Results of Operations sections of the Company’s most recent Annual Report on Form 10-K and in subsequent Quarterly Reports on Form 10-Q filed with the SEC. You should not rely upon forward-looking statements as predictions of future events. The forward-looking statements made in this press release speak only as of the date of issuance, and ENDRA assumes no obligation to update any such forward-looking statements to reflect actual results or changes in expectations, except as otherwise required by law.

Company:

Irina Pestrikova

Senior Director, Finance

investors@endrainc.com

www.endrainc.com



Investor Relations:

Yvonne Briggs

LHA Investor Relations

(310) 691-7100

ybriggs@lhai.com

Source: ENDRA Life Sciences Inc.

The ticker symbol of ENDRA Life Sciences Inc. is NDRA.

ENDRA's intellectual property portfolio now includes 74 issued patents worldwide.

The U.S. Patent No. 11844650 protects a novel sleeve-type structural configuration for TAEUS that enhances radiofrequency energy absorption and reduces signal noise.

The Chinese Patent No. ZL2021800757024 relates to the TAEUS system determining temperature at a specific location in the human body during thermal ablation.

The European Patent No. EP3902490 covers a novel method with the TAEUS system for monitoring tissue temperature during surgical procedures.
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Electromedical and Electrotherapeutic Apparatus Manufacturing
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Health Technology, Biotechnology, Manufacturing, Surgical and Medical Instrument Manufacturing

About NDRA

endra life sciences is bringing new capabilities to ultrasound. our photo-acoustic solutions help medical researchers screen and modify disease models with unparalleled quality and speed. we’re proud to have a global installed base of leading institutions using our nexus-128 system, the only 3d imaging solution for imaging anatomy, physiology and labeled molecular targets. the nexus 128 is a preclinical photoacoustic computed tomography (ct) scanner for small animal imaging. the system is used for simple, fast, non-invasive quantification of physiological parameters such as tumor vasculature without ionizing radiation. the fully-3d imaging technology used by the nexus 128 provides increased sensitivity compared to slice-based scanners, and dynamic (4-d) photoacoustic ct scans allow for applications such as quantification of probe uptake. the nexus 128 is currently being used by top imaging laboratories around the globe.