Nkarta Reports Second Quarter 2025 Financial Results and Corporate Highlights
Nkarta (NASDAQ: NKTX), a clinical-stage biopharmaceutical company developing NK cell therapies, reported its Q2 2025 financial results. The company maintains a strong financial position with $334.0 million in cash and investments as of June 30, 2025, expected to fund operations into 2029.
Key financial metrics include R&D expenses of $20.8 million, G&A expenses of $6.4 million, and a net loss of $23.0 million ($0.31 per share). The company appointed Dr. Shawn Rose as Chief Medical Officer and Head of R&D in June 2025, strengthening its clinical leadership in autoimmune diseases.
Nkarta plans to release preliminary data from Ntrust-1 and Ntrust-2 clinical trials for NKX019 in multiple autoimmune indications in H2 2025.
Nkarta (NASDAQ: NKTX), azienda biofarmaceutica in fase clinica che sviluppa terapie con cellule NK, ha riportato i risultati finanziari del secondo trimestre 2025. La società mantiene una solida posizione finanziaria con $334.0 million in liquidità e investimenti al 30 giugno 2025, che dovrebbero finanziare le operazioni fino al 2029.
I principali indicatori finanziari includono spese di R&S per $20.8 million, spese G&A per $6.4 million e una perdita netta di $23.0 million ($0.31 per azione). A giugno 2025 è stato nominato il Dott. Shawn Rose Direttore Medico e Responsabile della R&S, rafforzando la leadership clinica nelle malattie autoimmuni.
Nkarta prevede di pubblicare i dati preliminari dagli studi clinici Ntrust-1 e Ntrust-2 su NKX019 in più indicazioni autoimmuni nella seconda metà del 2025.
Nkarta (NASDAQ: NKTX), compañía biofarmacéutica en fase clínica que desarrolla terapias con células NK, informó sus resultados financieros del segundo trimestre de 2025. La empresa mantiene una posición financiera sólida con $334.0 million en efectivo e inversiones al 30 de junio de 2025, que se espera financien las operaciones hasta 2029.
Los indicadores clave incluyen gastos de I+D de $20.8 million, gastos G&A de $6.4 million y una pérdida neta de $23.0 million ($0.31 por acción). En junio de 2025 se nombró al Dr. Shawn Rose Director Médico y Jefe de I+D, fortaleciendo el liderazgo clínico en enfermedades autoinmunes.
Nkarta planea publicar los datos preliminares de los ensayos clínicos Ntrust-1 y Ntrust-2 sobre NKX019 en varias indicaciones autoinmunes en la segunda mitad de 2025.
Nkarta (NASDAQ: NKTX), NK 세포 치료제를 개발하는 임상 단계 바이오제약사, 2025년 2분기 재무실적을 발표했습니다. 회사는 2025년 6월 30일 기준 $334.0 million의 현금 및 투자자산을 보유해 2029년까지 운영자금을 확보할 것으로 예상됩니다.
주요 재무 지표는 연구개발 비용(R&D) $20.8 million, 일반관리비(G&A) $6.4 million, 그리고 순손실 $23.0 million ($0.31 주당)입니다. 2025년 6월에 Dr. Shawn Rose를 최고의료책임자(CMO) 겸 연구개발(R&D) 책임자로 임명해 자가면역질환 분야의 임상 리더십을 강화했습니다.
Nkarta는 2025년 하반기에 NKX019의 여러 자가면역 적응증에 대한 Ntrust-1 및 Ntrust-2 임상시험의 예비 데이터를 발표할 계획입니다.
Nkarta (NASDAQ: NKTX), société biopharmaceutique en phase clinique développant des thérapies par cellules NK, a publié ses résultats financiers du deuxième trimestre 2025. L'entreprise conserve une position financière solide avec 334,0 millions de dollars en liquidités et investissements au 30 juin 2025, censés financer les opérations jusqu'en 2029.
Les principaux indicateurs financiers comprennent des dépenses de R&D de 20,8 millions de dollars, des dépenses G&A de 6,4 millions de dollars et une perte nette de 23,0 millions de dollars (0,31 $ par action). En juin 2025, le Dr Shawn Rose a été nommé Chief Medical Officer et responsable R&D, renforçant la direction clinique dans les maladies auto-immunes.
Nkarta prévoit de publier au second semestre 2025 les données préliminaires des essais cliniques Ntrust-1 et Ntrust-2 concernant NKX019 dans plusieurs indications auto-immunes.
Nkarta (NASDAQ: NKTX), ein biopharmazeutisches Unternehmen in der klinischen Phase, das NK-Zelltherapien entwickelt, meldete seine Finanzergebnisse für das 2. Quartal 2025. Das Unternehmen verfügt über eine starke Finanzlage mit $334.0 million an liquiden Mitteln und Investments zum 30. Juni 2025, die voraussichtlich bis 2029 die Geschäftstätigkeit finanzieren.
Wesentliche Finanzkennzahlen umfassen F&E-Aufwendungen von $20.8 million, G&A-Aufwendungen von $6.4 million und einen Nettoverlust von $23.0 million ($0.31 pro Aktie). Im Juni 2025 wurde Dr. Shawn Rose zum Chief Medical Officer und Leiter der Forschung & Entwicklung ernannt, wodurch die klinische Führung im Bereich Autoimmunerkrankungen gestärkt wird.
Nkarta plant, in der zweiten Hälfte 2025 vorläufige Daten aus den klinischen Studien Ntrust-1 und Ntrust-2 zu NKX019 in mehreren Autoimmunindikationen zu veröffentlichen.
- Strong cash position of $334.0 million expected to fund operations into 2029
- Appointment of experienced CMO Dr. Shawn Rose with strong track record in autoimmune drug development
- Multiple ongoing clinical trials for NKX019 with data readout expected in H2 2025
- Net loss of $23.0 million in Q2 2025
- Increased R&D expenses of $20.8 million for the quarter
Insights
Nkarta reports solid $334M cash position funding operations into 2029 while advancing NK cell therapy trials for autoimmune diseases.
Nkarta's Q2 report reveals a strong financial foundation with
The company reported quarterly R&D expenses of
The core value proposition centers on NKX019, Nkarta's engineered natural killer (NK) cell therapy being evaluated across multiple autoimmune indications. While specific diseases weren't named, autoimmune disorders represent a massive market opportunity with significant unmet needs despite recent advances in biologics and JAK inhibitors. The company is executing four parallel clinical studies (Ntrust-1, Ntrust-2, and two investigator-sponsored trials), indicating broad exploration of NKX019's potential applications.
The addition of Dr. Shawn Rose as CMO and Head of R&D brings valuable autoimmune disease expertise from major pharmaceutical companies. His background in bringing forward multiple approved medicines for autoimmune conditions aligns perfectly with Nkarta's strategic focus.
Investors should watch closely for the preliminary clinical data expected in H2 2025, which will provide the first meaningful efficacy signals for NK cell therapy in autoimmune conditions - potentially opening a new treatment paradigm beyond the current standards of care.
- Initial update for NKX019 in multiple autoimmune indications expected in second half of 2025
- Cash balance of
$334.0 million on June 30, 2025, including cash, cash equivalents and investments, expected to fund operations into 2029
SOUTH SAN FRANCISCO, Calif., Aug. 12, 2025 (GLOBE NEWSWIRE) -- Nkarta, Inc. (Nasdaq: NKTX), a clinical-stage biopharmaceutical company developing engineered natural killer (NK) cell therapies, today reported financial results for the second quarter and year ended June 30, 2025.
“We remain focused on the execution of our clinical trials and continue to believe in the differentiated potential of NK cell therapy to address unmet needs in the treatment of autoimmune diseases,” said Paul J. Hastings, CEO of Nkarta. “Welcoming Dr. Rose and other key new members of our clinical team with rheumatology experience has provided us with world-class medical expertise to inform our ongoing enrollment of patients across our clinical studies and investigator-sponsored trials. Dr. Rose’s track record as a seasoned rheumatologist, immunologist and accomplished drug developer in the autoimmune space will be invaluable as we continue to advance our NKX019 clinical trial programs.”
NKX019 Clinical Program Progress and Upcoming Milestones
- NKX019 clinical programs in autoimmune diseases continue to enroll patients. This includes Ntrust-1, Ntrust-2 and two investigator-sponsored trials.
- Preliminary data from the Ntrust-1 and Ntrust-2 clinical trials is planned for release in the second half of 2025.
Other Corporate Updates
- Shawn Rose, M.D. Ph.D, was appointed Chief Medical Officer and Head of Research and Development in June 2025. In previous roles with Johnson & Johnson, BMS and emerging biopharma companies, Dr. Rose brought forward more than a dozen programs from discovery into clinical development, and he has developed multiple pioneering approved medicines for autoimmune conditions.
Second Quarter 2025 and Recent Financial Highlights
- Nkarta had cash, cash equivalents, restricted cash, and investments in marketable securities of
$334.0 million as of June 30, 2025. - Research and development (R&D) expenses were
$20.8 million for the second quarter of 2025. Non-cash stock-based compensation expense included in R&D expense was$0.9 million for the second quarter of 2025. - General and administrative (G&A) expenses were
$6.4 million for the second quarter of 2025. Non-cash stock-based compensation expense included in G&A expense was$1.2 million for the second quarter of 2025. - Net loss was
$23.0 million , or$0.31 per basic and diluted share, for the second quarter of 2025. This net loss includes non-cash charges of$3.4 million that consisted primarily of share-based compensation and depreciation expenses.
Financial Guidance
- Nkarta expects its current cash and cash equivalents will be sufficient to fund its current operating plan into 2029.
About the Ntrust℠ Clinical Trials in Autoimmune Disease
Ntrust-1 (NCT06557265) and Ntrust-2 (NCT06733935) are multi-center, open label, dose escalation clinical trials that build on academic studies of durable, drug-free remissions in patients with autoimmune disease after CD19-targeted cell therapy. Both trials will assess the safety of NKX019 in people living with autoimmune diseases as well as its ability to enable long-term remissions via a “reset” of the immune system through the elimination of pathogenic B cells.
Ntrust-1 is initially enrolling up to 24 patients with lupus nephritis or primary membranous nephropathy. Ntrust-2 is initially enrolling up to 36 patients with systemic sclerosis, idiopathic inflammatory myopathy, or ANCA-associated vasculitis.
In both studies, patients receive a three-dose cycle of NKX019 on Days 0, 3, and 7 following lymphodepleting conditioning with either fludarabine and cyclophosphamide or cyclophosphamide alone. Leveraging the engineering of NKX019, no patients in either trial will receive supplemental cytokines or antibody-based therapeutics. This approach is designed to evaluate the single-agent activity of NKX019 and facilitate a more rapid path to regulatory approval. Patients in Ntrust-1 may also receive additional cycles, if necessary, to restore response.
About the Investigator-Sponsored Clinical Trial of NKX019 for Generalized Myasthenia Gravis
The single-arm, open-label Phase 1 investigator-sponsored clinical trial is designed to enroll patients with generalized myasthenia gravis and will evaluate safety and clinical outcomes. Translational and biomarker studies, including autoantibodies, cytokine profiles and pharmacokinetics are planned. Patients receive 3 doses of NKX019 following lymphodepletion. The clinical trial is being co-led by Ali A. Habib, M.D., Clinical Professor of Neurology at the University of California, Irvine, and other investigators.
About the Investigator-Sponsored Clinical Trial of NKX019 for Systemic Lupus Erythematosus
The single-center, single-arm, open-label Phase 1 investigator-sponsored clinical trial (NCT06518668) is designed to enroll up to 6 patients with systemic lupus erythematosus, regardless of renal involvement, and will evaluate safety and clinical outcomes in a potentially different population than Ntrust-1. Translational and biomarker studies, including autoantibodies, cytokine profiles and pharmacokinetics are planned. Patients receive 3 doses of NKX019 following lymphodepletion. The clinical trial is being led by Anca D. Askanase, M.D., M.P.H., Director, Lupus Center at Columbia University Irving Medical Center and the Director of Rheumatology Clinical Trials.
About NKX019
NKX019 is an allogeneic, cryopreserved, off-the-shelf immunotherapy candidate that uses natural killer (NK) cells derived from the peripheral blood of healthy adult donors. It is engineered with a humanized CD19-directed chimeric antigen receptor (CAR) for enhanced cell targeting and a proprietary, membrane-bound form of interleukin-15 (IL-15) for greater persistence and activity without exogenous cytokine support. CD19 is a biomarker for normal B cells as well as those implicated in autoimmune disease. Nkarta is evaluating NKX019 in multiple autoimmune conditions.
About Nkarta
Nkarta is a clinical-stage biotechnology company advancing the development of allogeneic, off-the-shelf natural killer (NK) cell therapies for autoimmune diseases. By combining its cell expansion and cryopreservation platform with proprietary cell engineering technologies, Nkarta is building a pipeline of future cell therapies engineered for deep therapeutic activity and intended for broad access in the outpatient treatment setting. For more information, please visit the company’s website at www.nkartatx.com.
Cautionary Note on Forward-Looking Statements
Statements contained in this press release regarding matters that are not historical facts are “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995, as amended. Words such as "anticipates," "believes," "expects," "intends," “plans,” “potential,” "projects,” “would” and "future" or similar expressions are intended to identify forward-looking statements. Examples of these forward-looking statements include, but are not limited to, statements concerning Nkarta’s expectations regarding any or all of the following: Nkarta’s position, plans, strategies, and timelines for the continued and future clinical development and commercial potential of NKX019 (including the plans for Nkarta’s investigator-sponsored clinical trials, the future availability and disclosure of clinical data and other updates from Nkarta’s clinical trials, and the regulatory pathway for NKX019); the therapeutic potential, accessibility, tolerability, advantages, and safety profile of NK cell therapies, including NKX019 for the treatment of autoimmune diseases, such as lupus, primary membranous nephropathy, systemic lupus erythematosus, systemic sclerosis, myositis, vasculitis, and myasthenia gravis; and Nkarta’s expected cash runway.
Because such statements are subject to risks and uncertainties, actual results may differ materially from those expressed or implied by such forward-looking statements. These risks and uncertainties include, among others: Nkarta’s limited operating history and historical losses; Nkarta’s lack of any products approved for sale and its ability to achieve profitability; the risk that the results of preclinical studies and early-stage clinical trials may not be predictive of future results; Nkarta’s ability to raise additional funding to complete the development and any commercialization of its product candidates; Nkarta’s dependence on the clinical success of NKX019; that Nkarta may be delayed in initiating, enrolling patients in or completing its clinical trials; competition from third parties that are developing products for similar uses; Nkarta’s ability to obtain, maintain and protect its intellectual property; Nkarta’s dependence on third parties in connection with manufacturing, clinical trials and pre-clinical studies; the complexity of the manufacturing process for CAR NK cell therapies; and the success of Nkarta’s recent (and any future) cost containment measures.
These and other risks and uncertainties are described more fully in Nkarta’s filings with the Securities and Exchange Commission (“SEC”), including the “Risk Factors” section of Nkarta’s Quarterly Report on Form 10-Q for the quarter ended March 31, 2025, filed with the SEC on May 14, 2025, and Nkarta’s other documents subsequently filed with or furnished to the SEC. All forward-looking statements contained in this press release speak only as of the date on which they were made. Except to the extent required by law, Nkarta undertakes no obligation to update such statements to reflect events that occur or circumstances that exist after the date on which they were made.
| Nkarta, Inc. Condensed Statements of Operations (in thousands, except share and per share data) (Unaudited) | |||||||||||||||
| Three Months Ended June 30, | Six Months Ended June 30, | ||||||||||||||
| 2025 | 2024 | 2025 | 2024 | ||||||||||||
| Operating expenses | |||||||||||||||
| Research and development | $ | 20,778 | $ | 23,130 | $ | 44,950 | $ | 48,367 | |||||||
| General and administrative | 6,408 | 7,585 | 18,800 | 15,110 | |||||||||||
| Total operating expenses | 27,186 | 30,715 | 63,750 | 63,477 | |||||||||||
| Loss from operations | (27,186 | ) | (30,715 | ) | (63,750 | ) | (63,477 | ) | |||||||
| Other income, net: | |||||||||||||||
| Interest income | 3,970 | 5,724 | 8,346 | 8,970 | |||||||||||
| Other income (expense), net | 239 | (2 | ) | 444 | (4 | ) | |||||||||
| Total other income, net | 4,209 | 5,722 | 8,790 | 8,966 | |||||||||||
| Net loss | $ | (22,977 | ) | $ | (24,993 | ) | $ | (54,960 | ) | $ | (54,511 | ) | |||
| Net loss per share, basic and diluted | $ | (0.31 | ) | $ | (0.34 | ) | $ | (0.74 | ) | $ | (0.88 | ) | |||
| Weighted average shares used to compute net loss per share, basic and diluted | 73,977,625 | 73,494,523 | 73,947,220 | 62,088,495 | |||||||||||
| Nkarta, Inc. Condensed Balance Sheets (in thousands) (Unaudited) | |||||||
| June 30, 2025 | December 31, 2024 | ||||||
| Assets | |||||||
| Cash, cash equivalents, restricted cash and investments | $ | 334,041 | $ | 380,489 | |||
| Property and equipment, net | 70,341 | 74,658 | |||||
| Operating lease right-of-use assets | 35,076 | 36,014 | |||||
| Other assets | 8,854 | 10,042 | |||||
| Total assets | $ | 448,312 | $ | 501,203 | |||
| Liabilities and stockholders' equity | |||||||
| Accounts payable, accrued and other liabilities | $ | 12,102 | $ | 12,954 | |||
| Operating lease liabilities | 78,542 | 80,273 | |||||
| Total liabilities | 90,644 | 93,227 | |||||
| Stockholders’ equity | 357,668 | 407,976 | |||||
| Total liabilities and stockholders’ equity | $ | 448,312 | $ | 501,203 | |||
Nkarta Media/Investor Contact:
Nadir Mahmood
Nkarta, Inc.
nmahmood@nkartatx.com
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