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Recursion Reports First Quarter Financial Results and Provides Business Update

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Recursion (Nasdaq: RXRX) reported Q1 2026 results and business progress on May 6, 2026. Key clinical highlights include REC-1245 early Phase 1 safety/PK with no DLTs (n=16), REC-4881 Phase 2 polyp reductions (median 43% at Week 13, 53% at Week 25), and first patient dosed in REC-4539. Financials: cash $665.2M (Mar 31, 2026), revenue $6.5M, net loss $117.5M. Company reiterates 2026 operational cash burn <$390M and expects runway into early 2028 without additional financing.

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Positive

  • REC-1245 Phase 1: well-tolerated with no DLTs in 16 patients and dose-dependent PK
  • REC-4881 Phase 2: median polyp burden reduction 43% at Week 13, 53% at Week 25
  • First patient dosed in REC-4539 Phase 1, CNS-penetrant LSD1 inhibitor designed to limit platelet toxicity
  • Cash runway into early 2028 with $665.2M cash and reiterated <$390M 2026 operational cash burn

Negative

  • Total revenue fell to $6.5M in Q1 2026 from $14.7M in Q1 2025
  • Cash balance declined to $665.2M from $753.9M at year-end 2025 (Mar 31, 2026)
  • Net loss of $117.5M in Q1 2026 and Q1 operating cash use of $81.1M

News Market Reaction – RXRX

+1.78%
14 alerts
+1.78% News Effect
-2.5% Trough in 2 hr 25 min
+$31M Valuation Impact
$1.79B Market Cap
0.1x Rel. Volume

On the day this news was published, RXRX gained 1.78%, reflecting a mild positive market reaction. Argus tracked a trough of -2.5% from its starting point during tracking. Our momentum scanner triggered 14 alerts that day, indicating notable trading interest and price volatility. This price movement added approximately $31M to the company's valuation, bringing the market cap to $1.79B at that time.

Data tracked by StockTitan Argus on the day of publication.

Key Figures

Cash balance: $665.2 million Prior cash balance: $753.9 million Q1 2026 revenue: $6.5 million +5 more
8 metrics
Cash balance $665.2 million Cash, cash equivalents and restricted cash as of March 31, 2026
Prior cash balance $753.9 million Cash, cash equivalents and restricted cash as of December 31, 2025
Q1 2026 revenue $6.5 million Total revenue for first quarter 2026 vs $14.7 million in Q1 2025
R&D expense Q1 2026 $87.9 million Research and development expenses vs $129.6 million in Q1 2025
G&A expense Q1 2026 $34.6 million General and administrative expenses vs $54.7 million in Q1 2025
Net loss Q1 2026 $117.5 million Net loss for first quarter 2026 vs $202.5 million in Q1 2025
Operating cash burn guidance <$390 million Reiterated 2026 operational cash burn guidance
Cash operating expense Q1 2026 $85.1 million Cash operating expense vs $120.2 million in Q1 2025

Market Reality Check

Price: $3.44 Vol: Volume 13,313,028 is 17% ...
normal vol
$3.44 Last Close
Volume Volume 13,313,028 is 17% above the 20-day average of 11,418,916 heading into this report. normal
Technical Price at $3.37 is trading below the 200-day MA of $4.51 before the release.

Peers on Argus

RXRX was down 4.26% pre‑release while momentum-screened peers like ARQT and ADPT...
2 Up

RXRX was down 4.26% pre‑release while momentum-screened peers like ARQT and ADPT were up 9.78% and 11.76%. Broader biotech moves do not match RXRX’s direction, suggesting a more stock‑specific setup.

Previous Earnings Reports

5 past events · Latest: Feb 25 (Positive)
Same Type Pattern 5 events
Date Event Sentiment Move Catalyst
Feb 25 Q4/FY 2025 results Positive +6.8% Full-year 2025 results with AI OS validation, milestones, and strong cash.
Nov 05 Q3 2025 results Negative -0.8% Q3 2025 results with lower revenue, high R&D spend, and large net loss.
Aug 05 Q2 2025 results Mixed -4.7% Q2 2025 update with higher revenue, wider net loss, and restructuring plan.
May 05 Q1 2025 results Mixed -16.6% Q1 2025 results with Sanofi milestones, pipeline progress, and high cash burn.
Feb 28 Q4/FY 2024 results Mixed -2.1% FY 2024 results showing revenue growth but larger net loss and big spend.
Pattern Detected

Earnings and results updates have often triggered sizable moves, with most past earnings reactions aligning directionally with the tone of the updates.

Recent Company History

Over the past year, Recursion has repeatedly paired earnings with major pipeline and platform milestones. Prior updates such as Q4/FY 2025 on Feb 25, 2026 emphasized AI OS validation, strong cash of $754M, and runway into 2028. Earlier quarters in 2025 highlighted partner milestones, growing collaboration revenue, and large but narrowing net losses. Today’s Q1 2026 report continues that trajectory with detailed clinical progress, reduced R&D and G&A expenses, and reiterated guidance on keeping 2026 operational cash burn under $390M to support runway into early 2028.

Historical Comparison

-3.5% avg move · Across 5 prior earnings updates, RXRX moved an average of -3.47%. Today’s pre‑report move of -4.26% ...
earnings
-3.5%
Average Historical Move earnings

Across 5 prior earnings updates, RXRX moved an average of -3.47%. Today’s pre‑report move of -4.26% is directionally consistent and only slightly larger than typical.

Earnings releases have charted a path of substantial R&D investment offset by partner milestones and a strong cash position, with recurring emphasis on extending runway into 2027–2028 while advancing multiple AI-enabled oncology and rare disease programs.

Market Pulse Summary

This announcement combines detailed Q1 2026 financials with notable clinical and platform milestones...
Analysis

This announcement combines detailed Q1 2026 financials with notable clinical and platform milestones. Recursion reports cash of $665.2M, revenue of $6.5M, and a narrowed net loss of $117.5M, alongside sizable reductions in R&D and G&A expenses. Management reiterates 2026 operational cash burn guidance of under $390M, supporting runway into early 2028. Investors may track future partnered revenues, execution on REC‑1245 and REC‑4881, and whether efficiency gains persist in subsequent quarters.

Key Terms

pharmacokinetic, dose-limiting toxicities, treatment-related adverse event, MEK1/2, +4 more
8 terms
pharmacokinetic medical
"demonstrate a well-tolerated safety profile and predictable, dose-dependent pharmacokinetics;"
Pharmacokinetic describes how a drug moves through and leaves the body — how it is absorbed, spread to tissues, broken down and excreted — like tracking a package from pickup to delivery and disposal. For investors, these properties determine effective dose, safety risks, how often a medicine must be taken, and how reliably it works, which in turn influence clinical trial success, regulatory approval chances, production complexity and a drug’s commercial value.
dose-limiting toxicities medical
"no DLTs observed to date, supporting ongoing dose escalationREC-4881"
Dose-limiting toxicities are the harmful side effects seen in early clinical trials that are severe enough to stop researchers from raising a drug’s dose. Like a car’s speed limiter marking the safe top speed, DLTs define the maximum tolerable dose, and they matter to investors because they determine whether a medicine can reach effective levels, influence development timelines, costs, and regulatory chances, and thus affect a drug’s commercial prospects.
MEK1/2 medical
"REC-4881 (FAP / MEK1/2): Strong Phase 2 efficacy signals"
MEK1/2 are two closely related enzymes that act like relay switches in a cell’s growth-control wiring, passing signals that tell cells to divide, survive or change. They matter to investors because drugs that block these switches can slow or stop cancer and other diseases, so MEK1/2 are common targets in drug development; trial results or regulatory news about MEK1/2-targeting therapies can significantly affect a company’s prospects and stock value.
LSD1 inhibitor medical
"REC-4539 (LSD1 inhibitor): First patient dosed in Phase 1;"
An LSD1 inhibitor is a drug that blocks the LSD1 enzyme, a protein that helps control which genes are turned on or off in cells. By changing that gene control, these drugs aim to slow or stop the growth of certain cancers and other diseases; for investors, clinical trial results, safety findings, and regulatory decisions on these compounds can quickly shift a developer’s valuation and future revenue prospects—like cutting a key wire in a machine to disable a malfunctioning part.
iPSC-derived medical
"Neuron map generated from a subset of 1 trillion internally manufactured iPSC-derived neuronal cells"
Cells labeled “iPSC-derived” started as ordinary adult cells that scientists rewound into a flexible, stem-cell state and then nudged to become a specific cell type (for example heart, nerve, or liver cells). For investors, this flags a technology platform used in drug development, disease modeling, and regenerative therapies — like turning one tool into many — which can offer scalable new products but also carries clinical, manufacturing and regulatory risk.
transcriptomics medical
"combining our phenomics dataset with Roche and Genentech’s proprietary transcriptomics data"
Analysis of all the RNA molecules a cell produces, showing which genes are actively being used at a given time—like reading which recipes are being pulled from a cookbook to see what’s actually being cooked. For investors, transcriptomics helps reveal how diseases work, whether a drug is hitting its target, and which patient groups are most likely to benefit, making it a tool for valuing therapies, guiding clinical trials, and spotting diagnostic or therapeutic opportunities.
Phase 1/2 medical
"Early data from the ongoing Phase 1/2 DAHLIA study show:"
Phase 1/2 is a combined early-stage clinical trial that first tests a new drug or treatment for safety and the right dose, then quickly expands to check if it shows any signs of working in patients. For investors, results from a Phase 1/2 study offer an early read on both risk and potential reward—like a prototype test that both confirms a product won’t harm users and suggests whether it could sell—helping guide valuation and development decisions.

AI-generated analysis. Not financial advice.

  • Multiple milestones achieved or on track across wholly owned and partnered programs 
  • REC-1245 (RBM39 degrader): Early clinical data in solid tumors demonstrate a well-tolerated safety profile and predictable, dose-dependent pharmacokinetics; no DLTs observed to date, supporting ongoing dose escalation
  • REC-4881 (FAP / MEK1/2): Strong Phase 2 efficacy signals with FDA engagement initiated to define potential registrational pathway; update expected in 2H26
  • REC-4539 (LSD1 inhibitor): First patient dosed in Phase 1; platform-derived, selective, brain-penetrant profile, designed to have a reversible mechanism to reduce on-target platelet toxicity, supporting differentiation in solid tumors and AML
  • Disciplined capital execution: Reiterate 2026 guidance of <$390 million operational cash burn, supporting runway into early 2028 without additional financing

SALT LAKE CITY, May 06, 2026 (GLOBE NEWSWIRE) -- Recursion (Nasdaq: RXRX) a leading clinical stage TechBio company decoding biology to radically improve lives, today reported business updates highlighting strong continued pipeline execution, clinical progress and platform advancement, as well as financial results for its first quarter ended March 31, 2026.

Recursion will host an Earnings Call on May 6, 2026 at 8:00 am ET / 6:00 am MT / 1:00 pm BST from Recursion’s X, LinkedIn, and YouTube accounts giving analysts, investors, and the public the opportunity to ask questions of the Company by submitting questions here: https://forms.gle/TQ4vgUTLKsFmikcu6.

“We are seeing strong momentum and execution across our portfolio, with increasing evidence that our full stack platform can translate biological and chemical insights into differentiated clinical programs,” said Najat Khan, Ph.D., Chief Executive Officer and President of Recursion. “Recent progress, including encouraging initial safety and PK data in REC-1245 and the first patient dosed in REC-4539, represents a growing set of proof points that demonstrate our ability to translate platform insights into clinical programs. This momentum reflects the strength of our end-to-end AI platform, with multiple differentiated internal and partnered programs advancing into and through the clinic.”

Business Highlights

Wholly Owned Pipeline Updates

earnings_pipeline

Favorable Safety and PK Data for REC-1245 (RBM39):

Preliminary safety and pharmacokinetic (PK) data from REC-1245, a potential first-in-class RBM39 degrader discovered and developed using Recursion’s platform, highlight early clinical progress for a novel approach to targeting cancer vulnerabilities linked to replication stress and DNA repair.

REC-1245 advanced from biological discovery to development candidate in 18 months, more than twice as fast as the industry average, demonstrating Recursion’s ability to identify novel targets and design differentiated molecules using its integrated AI-enabled platform.

Early data from the ongoing Phase 1/2 DAHLIA study show:

  • REC-1245 was well-tolerated across select solid tumors (n=16)
  • No dose-limiting toxicities (DLTs) have been observed to date, and the maximum tolerated dose has not yet been reached
  • The majority of TRAEs were Grade 1 or 2, most common GI-related events were constipation, nausea, and vomiting
  • Pharmacokinetic analysis demonstrates predictable, dose-dependent exposure across evaluated patients
  • Pharmacodynamic assessments demonstrate target engagement
  • Dose escalation is ongoing to determine the recommended Phase 2 dose for monotherapy expansion cohorts
Treatment-Related Adverse Event (TRAE)
 Patients (n=16)
Patients with any TRAE10 (62.5%)
Grade 1-29 (56.3%)
Grade 31 (6.2%)
Grade 4-50 (0.0%)
  

Continued Momentum for REC-4881 (MEK1/2):

REC-4881 is an allosteric MEK1/2 inhibitor being developed for familial adenomatous polyposis (FAP), a genetically defined disease driven by APC loss. Based on platform insights into MAPK pathway modulation in APC-deficient systems, REC-4881 represents a targeted approach to addressing the underlying biology of disease progression:

  • Phase 2 positive proof-of-concept clinical data showed a median 43% reduction in polyp burden at Week 13, deepening to 53% at Week 25 following a treatment break, with 40% of patients demonstrating improvement in Spigelman stage, supporting a differentiated and durable profile in FAP.
  • Safety was consistent with MEK1/2 inhibition, with mostly Grade 1-2 TRAEs, Grade 3 events in 15.8% of patients, no Grade ≥4 TRAEs, and commonly including dermatitis acneiform/rash and increased CPK.

Recursion has initiated FDA engagement to align on a potential registrational study design, with an update expected in the second half of 2026. Expansion of TUPELO to include patients aged 18+ to support a broader development strategy is also ongoing.

First Patient Dosed in REC-4539 (LSD1 inhibitor):

REC-4539, an AI-designed, LSD1 inhibitor, highlights early progress for a differentiated approach to targeting epigenetic drivers in cancer. In April, the first patient was dosed in the ENLYGHT Phase 1 clinical study for solid tumors, including small cell lung cancer (SCLC).

REC-4539 was precision designed to have a reversible mechanism and shorter predicted human half-life to address treatment-limiting platelet toxicity observed with other LSD1 inhibitors, enabling a potentially differentiated profile across solid tumors and hematologic malignancies.

The differentiated, CNS-penetrant development candidate was delivered in approximately 20 months through Recursion’s AI-native design platform, demonstrating the Company’s ability to rapidly translate platform insights into optimized clinical candidates.

For the rest of the portfolio, programs continue to progress as planned.

Expected upcoming milestones across Recursion’s wholly-owned pipeline:

  • REC-4881 (MEK1/2):
    • Regulatory update expected in 2H26
    • Additional Phase 1b/2 clinical data expected in 1H27
  • REC-1245 (RBM39): Additional Phase 1 dose escalation data expected in 2H26
  • REC-7735 (PI3Kα H1047R) and REC-102 (ENPP1): IND-enabling studies ongoing; data-driven go/no-go decision on Phase 1 initiation expected in 2H26
  • REC-617 (CDK7): Early Phase 1 safety and PK combination data expected in 1H27
  • REC-3565 (MALT1): Early Phase 1 safety and PK monotherapy data expected in 1H27
  • REC-4539 (LSD1): Early Phase 1 safety and PK monotherapy data expected in 2H27

Advancing partnered discovery, with over $500 million in milestone and upfront payments achieved to date:

earnings_partners

Meaningful upcoming milestones across partnered discovery:

Recursion continues to advance partnered programs that leverage complementary strengths of the Recursion OS.

In AI-enabled chemistry, Sanofi and Recursion joint programs continue progressing toward development candidate designation and earlier-stage milestones over the next 12 months, including programs designed against challenging targets in immunology and oncology.

In AI-enabled biology, Recursion expects to continue jointly translating insights from its large-scale maps of biology delivered to Roche and Genentech into potential target validation milestones over the next 12 months. The maps, jointly built by Recursion, Roche and Genentech are disease-relevant high-content maps built at large scale, including a Neuron map generated from a subset of 1 trillion internally manufactured iPSC-derived neuronal cells and a Microglia map generated from more than 100 billion internally manufactured iPSC-derived microglial cells. Additionally, we are combining our phenomics dataset with Roche and Genentech’s proprietary transcriptomics data to build multi-modal maps designed to explore potential novel targets and pathways by systematically linking gene perturbations to cellular phenotypes.

Recursion OS Advances: Driving platform innovations, grounded in impact

Full Stack AI-powered Platform: The Recursion Operating System (OS) is continuing to drive program development by integrating AI across multimodal biology, precision design, and next-generation clinical development—enabling faster, more efficient, and more innovative drug discovery and development from biology to insight, insight to molecule, and molecule to patient.

State of the Art Transcriptomics Models: Built to better connect Recursion’s proprietary perturbational biology with patient biology to find novel insights and medicines, the integration of these models help bridge the translation gap between what we see in the lab and what matters in disease:

  • TxPert, recently featured in Nature Biotechnology, is a proof-of-principle model for predicting transcriptomic responses to perturbations. The model can generalize beyond its training data, including predicting responses to unseen single-gene perturbations, novel combinations, and known perturbations in new cell types—enabling more efficient hypothesis generation and experimental prioritization, and laying the foundation for Recursion's Virtual Cell.
  • TxFM, presented at the ICLR Workshop on Foundation Models for Science, is a transcriptomics foundation model designed to connect lab perturbations with patient biology within the Recursion OS. Trained on a large, curated dataset of public and proprietary data, it outperforms 16 leading foundation models and baselines, including models trained on datasets 10–100x larger. Beyond enabling target identification, mechanistic understanding, and patient stratification, TxFM's superior batch correction and denoising drive operational efficiency—reducing experimental re-runs, enabling cross-experiment comparisons, and increasing the value of every sequencing dollar spent.

First Quarter 2026 Financial Results

  • Cash Position: Cash, cash equivalents and restricted cash were $665.2 million as of March 31, 2026 compared to $753.9 million as of December 31, 2025. Based on current operating plans and with no additional financing, the Company continues to expect its cash runway to extend into early 2028.
  • Revenue: Total revenue, consisting primarily of revenue from collaboration agreements, was $6.5 million for the first quarter of 2026, compared to $14.7 million for the first quarter of 2025. Roche revenue recognized was less in the current period due to the successful completion of certain project phases in the prior period.
  • Research and Development Expenses: Research and development expenses decreased to $87.9 million for the first quarter of 2026, from $129.6 million for the first quarter of 2025. The decrease was primarily due to lower platform costs resulting from the timing of Tempus record purchases as well as lower costs due to improved operating efficiency. Specifically, the first quarter of 2025 included $27.1 million in non-cash expenses for the use of patient-centric multimodal oncology data within the Company’s R&D pipeline.
  • General and Administrative Expenses: General and administrative expenses were $34.6 million for the first quarter of 2026 compared to $54.7 million for the first quarter of 2025. The decrease of $20.1 million relative to the three months ended March 31, 2025, was primarily driven by a decrease in salaries and one-time transaction costs incurred in the prior year.
  • Net Loss: Net loss was $117.5 million for the first quarter of 2026, compared to a net loss of $202.5 million for the first quarter of 2025.
  • Operational Cash Flows: Net cash used in operating activities was $81.1 million for the three months ended March 31, 2026, compared to net cash used in operating activities of $132.0 million for the three months ended March 31, 2025. The decrease in cash used in operating activities was primarily driven by operating efficiencies across the company and the strategic reprioritization of our clinical portfolio.
  • Cash Operating Expense: Cash operating expense, excluding partnership inflows and transaction costs, for the three months ended March 31, 2026 was $85.1 million compared to $120.2 million for the three months ended March 31, 2025.

About Recursion
Recursion (NASDAQ: RXRX) is a clinical stage TechBio company decoding biology to radically improve lives. Recursion is advancing a portfolio of differentiated investigational medicines across its wholly owned and partnered pipeline in oncology, rare disease, neuroscience, immunology, and other therapeutic areas with significant unmet need. Enabling its mission is the Recursion OS, an AI-native, end-to-end drug discovery and development platform integrating biology, chemistry, and clinical development into a unified intelligence system. Powered by proprietary multimodal data, purpose-built AI models, and bilingual teams fluent in both science and AI, the Recursion OS is designed to translate complex science into medicines that matter — faster, better, and at scale — for patients who are waiting.

Recursion’s platform infrastructure is anchored in Salt Lake City, Utah and Milton Park, Oxfordshire, where its automated biology and chemistry laboratories generate proprietary data at industrial scale. Recursion also maintains offices in New York, Montréal, and London, three global hubs for talent and leadership at the intersection of AI and scientific innovation. Learn more at www.recursion.com, or connect on X and LinkedIn.

Media Contact
media@recursion.com

Investor Contact
investor@recursion.com

Recursion Pharmaceuticals Inc
Consolidated Statements of Operations (unaudited)
(in thousands, except share and per share amounts)

 Three months ended March 31,
 2026
2025
Revenue  
Operating revenue$6,301 $14,818 
Grant revenue 171  (73)
Total revenue 6,472  14,745 
   
Operating costs and expenses  
Cost of revenue 12,490  21,829 
Research and development 87,896  129,634 
General and administrative 34,591  54,650 
Total operating costs and expenses 134,977  206,113 
   
Loss from operations (128,505) (191,368)
Other income (loss), net 6,397  (11,277)
Loss before income tax benefit (122,108) (202,645)
Income tax benefit 4,604  158 
Net loss$(117,504)$(202,487)
   
Per share data  
Net loss per share of Class A, B and Exchangeable common stock, basic and diluted$(0.22)$(0.50)
Weighted-average shares (Class A, B and Exchangeable) outstanding, basic and diluted 529,303,984  402,771,972 
       

Recursion Pharmaceuticals Inc
Consolidated Balance Sheets (unaudited)
(in thousands)

 March 31,December 31,
 2026
2025
Assets  
Current assets  
Cash and cash equivalents$654,473 $743,294 
Restricted cash 5,511  4,594 
Other receivables 13,585  24,649 
Prepaid data assets 11,742  11,742 
Other current assets 24,246  28,566 
Total current assets 709,557  812,845 
   
Restricted cash, non-current 5,196  6,033 
Property and equipment, net 95,811  103,931 
Operating lease right-of-use assets 42,816  45,339 
Financing lease right-of-use assets 18,694  20,210 
Intangible assets, net 294,073  309,903 
Goodwill 160,170  162,158 
Deferred tax assets 957  957 
Other assets, non-current 12,248  12,754 
Total assets$1,339,522 $1,474,130 
   
Liabilities and stockholders’ equity  
Current liabilities  
Accounts payable$20,348 $18,118 
Accrued expenses and other liabilities 54,205  70,230 
Unearned revenue 32,794  37,605 
Operating lease liabilities 13,087  12,663 
Notes payable and financing lease liabilities 9,265  9,091 
Total current liabilities 129,699  147,707 
   
Unearned revenue, non-current 114,723  114,012 
Operating lease liabilities, non-current 42,842  46,647 
Notes payable and financing lease liabilities, non-current 7,181  9,564 
Deferred tax liabilities 18,283  23,255 
Other liabilities, non-current 2,025  2,080 
Total liabilities 314,753  343,265 
   
Stockholders’ equity  
Common stock (Class A, B and Exchangeable) 5  5 
Additional paid-in capital 3,191,608  3,170,145 
Accumulated deficit (2,193,506) (2,076,002)
Accumulated other comprehensive income (loss) 26,662  36,717 
Total stockholders’ equity 1,024,769  1,130,865 
   
Total liabilities and stockholders’ equity$1,339,522 $1,474,130 
       

Recursion Pharmaceuticals Inc
Selected Cash Flow Information (unaudited)
(in thousands)

 Three months ended March 31,
 2026
2025
Net cash used in operating activities$(81,101)$(131,957)
Net cash used in investing activities (338) (7,270)
Net cash provided by (used in) financing activities (3,470) 40,527 
Effect of exchange rate changes on cash, cash equivalents and restricted cash (3,832) 4,833 
Cash, cash equivalents and restricted cash, beginning of period 753,921  603,024 
Cash, cash equivalents and restricted cash, end of period$665,180 $509,157 

Non-GAAP Financial Measure

The reconciliation of operating cash expense to net cash used in operating activities is provided in the following tables:

Cash Operating Expense - Q1 2026(in millions) 
Net cash used in operating activities$81.1*
Add: partnership inflows 4.0 
Cash Operating Expense - Q1 2026$85.1 

*This is from the Recursion Inc Consolidated Statement of Cash Flows for the three months ended March 31, 2026 (see above)

Cash Operating Expense - Q1 2025(in millions)
Net cash used in operating activities$132.0 *
Subtract: transaction costs (11.8)
Cash Operating Expense - Q1 2025$120.2 

*This is from the Recursion Inc Consolidated Statement of Cash Flows for the three months ended March 31, 2025 (see above)

To supplement our financial statements prepared in accordance with U.S. GAAP, we monitor and consider operating cash expense, which is a non-GAAP financial measure. We define operating cash expense as the net cash used in operating activities, excluding non-ordinary course transaction costs and partnership cash inflows. This non-GAAP financial measure is not based on any standardized methodology prescribed by U.S. GAAP and is not necessarily comparable to similarly-titled measures presented by other companies. We believe operating cash expense to be a liquidity measure that provides useful information to management and investors about the amount of cash consumed by the operations of the business. A limitation of using this non-U.S. GAAP measure is that operating cash expense does not represent the total change in cash and cash equivalents for the period because it excludes cash provided by or used for other investing and financing activities. We account for this limitation by providing information about our capital expenditures and other investing and financing activities in the statements of cash flows in our financial statements. Additionally, we reconciled operating cash expense above to net cash used in operating activities, the most directly comparable U.S. GAAP financial measure. In addition, it is important to note that other companies, including companies in our industry, may not use operating cash expense, may calculate operating cash expense in a different manner than we do or may use other financial measures to evaluate their performance, all of which could reduce the usefulness of operating cash expense as a comparative measure. Because of these limitations, operating cash expense should not be considered in isolation from, or as a substitute for, financial information prepared in accordance with U.S. GAAP.

Forward-Looking Statements
This document contains information that includes or is based upon “forward-looking statements” within the meaning of the Securities Litigation Reform Act of 1995, including, without limitation, those regarding the occurrence or realization of potential milestones; the timing of data readouts and other milestones; the impact of initial safety and PK data from the REC-1245 trial on the future success of the trial; the timing and outcome of anticipated engagement with the FDA; financial position, cash runway, and cash burn; Recursion’s ability to translate platform insights into tangible proof; the impact of preclinical data on trial outcomes; Recursion's future as a leader in TechBio and ability to deliver better treatments to patients faster; expectations relating to early and late stage discovery, preclinical, and clinical programs, including timelines for commencement of and enrollment in studies, data readouts, meetings with regulators, and progression toward IND-enabling studies; expectations and developments with respect to licenses and collaborations, including option exercises by partners and the amount and timing of potential milestone payments, and the acceleration of progress across multiple partnered programs; prospective products and their potential future indications and market opportunities; developments with Recursion OS, including achieving future returns on investment in the platform and the ability to discover and develop new medicines and provide insights into patient populations; and all other statements that are not historical facts. Forward-looking statements may or may not include identifying words such as “plan,” “will,” “expect,” “anticipate,” “intend,” “believe,” “potential,” “continue,” and similar terms. These statements are subject to known or unknown risks and uncertainties that could cause actual results to differ materially from those expressed or implied in such statements, including but not limited to: challenges inherent in pharmaceutical research and development, including the timing and results of preclinical and clinical programs, where the risk of failure is high and failure can occur at any stage prior to or after regulatory approval due to lack of sufficient efficacy, safety considerations, or other factors; our ability to leverage and enhance our drug discovery platform; our ability to obtain financing for development activities and other corporate purposes; the success of our collaboration activities; our ability to obtain regulatory approval of, and ultimately commercialize, drug candidates; our ability to obtain, maintain, and enforce intellectual property protections; cyberattacks or other disruptions to our technology systems; our ability to attract, motivate, and retain key employees and manage our growth; inflation and other macroeconomic issues; and other risks and uncertainties such as those described under the heading “Risk Factors” in our filings with the U.S. Securities and Exchange Commission, including our Annual Report on Form 10-K. All forward-looking statements are based on management’s current estimates, projections, and assumptions, and Recursion undertakes no obligation to correct or update any such statements, whether as a result of new information, future developments, or otherwise, except to the extent required by applicable law.

Photos accompanying this announcement are available at:
https://www.globenewswire.com/NewsRoom/AttachmentNg/d2751ce2-f602-4ebf-b6b6-8acff83456f5
https://www.globenewswire.com/NewsRoom/AttachmentNg/4ce21071-12a0-4234-b8c1-b5c0fd1d0e99


FAQ

What did Recursion (RXRX) report for cash and runway on May 6, 2026?

Recursion reported $665.2 million in cash, cash equivalents and restricted cash as of March 31, 2026. According to the company, this cash and an expected 2026 operating burn below $390 million support runway into early 2028 without additional financing.

What were the key safety and PK findings for REC-1245 (RBM39) in Q1 2026?

REC-1245 showed tolerability with no dose-limiting toxicities observed to date in 16 patients and predictable, dose-dependent PK. According to the company, the majority of treatment-related adverse events were Grade 1–2, and dose escalation is ongoing to define a Phase 2 dose.

What efficacy data did Recursion disclose for REC-4881 (MEK1/2) in FAP?

REC-4881 demonstrated a median 43% polyp burden reduction at Week 13, deepening to 53% at Week 25 after a treatment break. According to the company, 40% of patients improved Spigelman stage and FDA engagement has been initiated toward a potential registrational pathway.

How did Recursion (RXRX) perform financially in Q1 2026 versus Q1 2025?

Total revenue was $6.5 million in Q1 2026 versus $14.7 million in Q1 2025, and net loss was $117.5 million. According to the company, decreases reflect completion of prior project phases and timing-related platform cost reductions.

What upcoming milestones did Recursion outline for its pipelines in 2H26 and 1H27?

Recursion expects a regulatory update for REC-4881 in 2H26 and additional REC-1245 dose-escalation data in 2H26, with multiple Phase 1 safety/PK readouts across programs into 1H27. According to the company, IND-enabling and go/no-go decisions for other programs target 2H26 timing.