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#1 DNA leads with +4,550% September 2021

DNA (Ginkgo Bioworks Holdings, Inc.) is the best performing stock in September 2021. Following are IVT (+1,457%) and BKSY (+725%). Top performing sectors: Healthcare (+1530% avg, 1 in top 10), Real Estate (+494% avg, 1 in top 10), Industrials (+91% avg, 1 in top 10).

Top Stock Gainers September 2021 - Monthly Performance Ranked

Discover the best stocks of September 2021 ranked by monthly performance. Find out which public companies delivered the highest returns this month, with market caps over $100 million on Nasdaq and NYSE.
2021

This ranking shows the best performing stocks during September 2021, calculated from the first to the last trading day of the month. Using split-adjusted data ensures accurate performance calculations.

Monthly performance rankings help identify short-term momentum and sector rotation patterns that may not be visible in longer timeframes. These rapid movers often present opportunities for traders and momentum investors.

Looking for a specific Symbol?

Data as of March 16, 2026 at 7:46 PM EDT

Rank
Symbol
Company Name
Sep Gain
Market Cap
Price
Country
Sector
1
4549.95%
411.18 M
$ 6.64
United States
Healthcare
2
1456.67%
2.48 B
$ 31.97
United States
Real Estate
3
724.7%
848.30 M
$ 23.5688
United States
Industrials
4
65.87%
6.16 B
$ 20.96
United States
Energy
5
60.59%
3.12 B
$ 4.065
Canada
Energy
6
50.38%
648.56 M
$ 16.76
United States
Energy
7
50.23%
1.84 B
$ 11.9314
Canada
Energy
8
45.91%
10.40 B
$ 43.9
United States
Energy
9
43.44%
613.39 M
$ 16.68
United States
Energy
10
43.01%
260.38 M
$ 6.31
United States
Energy
11
41.92%
1.41 B
$ 11.375
United States
Energy
12
39.95%
6.33 B
$ 26.575
United States
Energy
13
34.37%
1.67 B
$ 7.03
United States
Technology
14
33.85%
5.11 B
$ 43.7
United States
Energy
15
33.83%
24.67 B
$ 32.49
United States
Energy
16
33.43%
7.03 B
$ 56.565
United States
Energy
17
32.94%
16.44 B
$ 19.4
United States
Energy
18
31.33%
2.53 B
$ 41.555
United States
Consumer Defensive
19
31.27%
4.15 B
$ 211.06
United States
Energy
20
30.59%
4.74 B
$ 20.38
United States
Consumer Cyclical
21
28.61%
621.64 M
$ 6.075
Monaco
Industrials
22
28.13%
12.77 B
$ 41.4
United States
Energy
23
27.23%
2.68 B
$ 27.47
United States
Energy
24
26.88%
1.23 B
$ 93.32
Canada
Energy
25
26.86%
354.35 M
$ 17.44
United States
Industrials
26
26.44%
350.04 M
$ 10.575
United States
Industrials
27
25.98%
3.67 B
$ 109.94
United States
Industrials
28
25.95%
2.39 B
$ 185.92
United States
Basic Materials
29
25.91%
1.46 B
$ 6.58
United States
Energy
30
25.74%
28.95 B
$ 46.68
United States
Energy
31
25.28%
1.07 B
$ 14.93
United States
Basic Materials
32
25.25%
2.16 B
$ 17.655
United States
Energy
33
24.9%
339.94 M
$ 3.045
United States
Healthcare
34
24.89%
1.16 B
$ 2.415
United States
Energy
35
24.1%
19.02 B
$ 121.912
United States
Basic Materials
36
24.01%
148.44 B
$ 121.44
United States
Energy
37
23.66%
398.81 M
$ 16.89
United States
Energy
38
23.33%
864.61 M
$ 24.03
United States
Industrials
39
23.01%
6.73 B
$ 73.12
United States
Technology
40
22.97%
6.88 B
$ 30.89
Cyprus
Energy
41
22.54%
2.34 B
$ 27.38
United States
Energy
42
22.34%
7.44 B
$ 11.675
South Africa
Basic Materials
43
22.22%
2.09 B
$ 38.76
Canada
Communication Services
44
22.06%
1.72 B
$ 73.94
United States
Consumer Defensive
45
21.59%
963.54 M
$ 11.3
Bermuda
Energy
46
21.46%
1.34 B
$ 56.49
United States
Financial Services
47
21.08%
2.58 B
$ 65.86
Bermuda
Energy
48
21%
3.92 B
$ 202.71
United States
Energy
49
20.99%
2.53 B
$ 20.78
Canada
Energy
50
20.96%
73.14 B
$ 134.79
United States
Energy
51
20.94%
298.71 M
$ 8.71
United States
Consumer Cyclical
52
20.91%
44.11 B
$ 23.38
Canada
Energy
53
20.74%
5.17 B
$ 36.2176
United States
Energy
54
20.55%
2.82 B
$ 28.05
United States
Energy
55
20.26%
15.63 B
$ 55.15
United States
Energy
56
20.24%
1.55 B
$ 28.64
Bermuda
Energy
57
20.15%
1.60 B
$ 14.71
United States
Energy
58
19.6%
384.37 M
$ 51.525
United States
Energy
59
19.44%
89.56 B
$ 35.905
Norway
Energy
60
19.39%
4.87 B
$ 30.06
United States
Energy
61
18.73%
120.56 M
$ 0.6839
United States
Financial Services
62
18.64%
6.33 B
$ 91.41
Bermuda
Energy
63
18.63%
42.03 B
$ 22.11
Australia
Energy
64
17.94%
56.62 B
$ 57.405
United States
Energy
65
17.89%
1.08 B
$ 6.78
United States
Basic Materials
66
17.7%
1.41 B
$ 133.255
United States
Basic Materials
67
17.6%
571.86 M
$ 5.485
United States
Energy
68
17.1%
3.28 B
$ 15.425
United States
Energy
69
16.25%
470.66 M
$ 3.1635
United States
Energy
70
16.06%
1.31 B
$ 9.495
Ireland
Healthcare
71
15.85%
5.53 B
$ 62.39
United States
Energy
72
15.45%
296.25 M
$ 5.865
United States
Financial Services
73
15.3%
1.12 B
$ 76.365
Bermuda
Energy
74
15.09%
264.34 M
$ 2.2829
Greece
Industrials
75
14.97%
1.56 B
$ 117.445
United States
Energy
76
14.83%
209.38 M
$ 13.055
United States
Basic Materials
77
14.44%
25.66 B
$ 63.43
United Kingdom
Energy
78
14.41%
5.56 B
$ 29.48
United States
Energy
79
14.36%
639.30 M
$ 56.1875
United States
Energy
80
14.35%
621.42 M
$ 24.81
United States
Industrials
81
14.33%
565.35 M
$ 13.88
Bermuda
Industrials
82
13.98%
206.21 M
$ 44.18
United States
Financial Services
83
13.85%
3.77 B
$ 298.7
United States
Consumer Cyclical
84
13.77%
341.43 M
$ 39.52
United States
Real Estate
85
13.52%
46.07 B
$ 148.97
United States
Energy
86
13.41%
47.58 B
$ 109.165
Canada
Energy
87
13.17%
2.74 B
$ 17.025
Bermuda
Energy
88
12.93%
3.08 B
$ 26.2
United States
Communication Services
89
12.83%
1.45 B
$ 5.88
United States
Technology
90
12.65%
7.49 B
$ 68.07
United States
Financial Services
91
12.59%
4.61 B
$ 39.24
United States
Industrials
92
12.55%
254.96 B
$ 90.635
United Kingdom
Energy
93
12.52%
6.39 B
$ 184.05
United States
Consumer Cyclical
94
12.42%
110.20 B
$ 43.02
United Kingdom
Energy
95
12.38%
1.30 B
$ 4.295
Canada
Basic Materials
96
12.38%
51.74 B
$ 240.69
United States
Energy
97
12.35%
71.74 B
$ 60.25
Canada
Energy
98
12.32%
1.72 B
$ 31.59
United States
Consumer Cyclical
99
12.32%
2.33 B
$ 13.69
United States
Energy
100
12.31%
239.37 M
$ 14.82
United States
Real Estate
For the most accurate results, consider cross-referencing our data with other sources.

Frequently Asked Questions

Q What is the best stock of September 2021?
A

DNA (Ginkgo Bioworks Holdings, Inc.) was the best performing stock in September 2021 with a gain of 4,550%. Top performers this month include DNA, IVT, BKSY.

Q What stocks gained the most in September 2021?
A

The biggest gainers in September 2021 were: DNA (+4,550%), IVT (+1,457%), BKSY (+725%), CRK (+66%), BTE (+61%). These monthly rankings show which stocks had the strongest short-term momentum.

Q Which sectors performed best in September 2021?
A

The top performing sectors in September 2021 included Healthcare, Real Estate, Industrials, based on the stocks with highest monthly gains. DNA led the Healthcare sector.

Q How is monthly stock performance calculated?
A

Monthly stock performance is calculated by comparing the closing price on the last trading day of the month to the opening price on the first trading day. Split-adjusted prices ensure accuracy.

Understanding Monthly Stock Performance

Monthly performance rankings reveal short-term momentum patterns and help identify stocks experiencing rapid price movements:

  • Momentum Trading: Stocks showing strong monthly performance often continue their trend into subsequent months, making this data valuable for momentum-based strategies.
  • Sector Rotation: Monthly rankings can reveal which sectors are gaining favor with investors, signaling potential rotation opportunities.
  • Event-Driven Moves: Earnings releases, product launches, and regulatory approvals often create significant monthly price movements.

Using Monthly Data Effectively

  • Combine Timeframes: Compare monthly gainers with 52-week and YTD performance to identify stocks with both short and long-term momentum.
  • Research the Catalyst: Investigate why top monthly performers moved significantly - understanding the cause helps assess sustainability.
  • Watch for Reversals: Extreme monthly gains sometimes precede corrections, so consider risk management when chasing recent performers.