STOCK TITAN

Opaleye boosts Alpha Cognition (ACOG) stake with open-market share buys

Filing Impact
(Moderate)
Filing Sentiment
(Positive)
Form Type
4

Rhea-AI Filing Summary

Opaleye Management Inc., a 10% owner of Alpha Cognition Inc., reported a series of indirect open-market purchases of common stock. Through Opaleye, L.P., it bought a total of 73,738 shares on May 27–29, 2026 at prices around $5.73–$5.90 per share.

After these trades, indirect holdings by Opaleye, L.P. increased to 2,604,107 shares of common stock, while a separately managed account holds 90,000 shares. Opaleye Management may be deemed to beneficially own these securities to the extent of its pecuniary interest and expressly disclaims broader beneficial ownership.

Positive

  • None.

Negative

  • None.
Insider Opaleye Management Inc.
Role null
Bought 73,738 shs ($435K)
Type Security Shares Price Value
Purchase Common Stock, no par value 70,577 $5.8999 $416K
Purchase Common Stock, no par value 2,000 $5.832 $12K
Purchase Common Stock, no par value 1,161 $5.73 $7K
holding Common Stock, no par value -- -- --
Holdings After Transaction: Common Stock, no par value — 2,604,107 shares (Indirect, By Opaleye, L.P.)
Footnotes (1)
  1. Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund. Securities owned by a separately managed account (the "Managed Account"). As the portfolio manager of the Managed Account, Opaleye may be deemed to beneficially own the securities owned directly by the Managed Account. The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $5.82 to $5.85. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range. The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $5.88 to $5.90. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range. Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose.
Total shares bought 73,738 shares Net open-market purchases disclosed in Form 4
May 29 purchase 70,577 shares at $5.8999/share Common stock, open-market purchase on May 29, 2026
May 28 purchase 2,000 shares at $5.8320/share Common stock, open-market purchase on May 28, 2026
May 27 purchase 1,161 shares at $5.7300/share Common stock, open-market purchase on May 27, 2026
Holdings via Opaleye, L.P. 2,604,107 shares Indirect common stock ownership following May 29, 2026 trade
Managed account holdings 90,000 shares Indirect common stock holdings by a separately managed account
open-market purchase financial
"transaction_action: "open-market purchase" for common stock transactions"
An open-market purchase is when an investor or a company buys shares on a public stock exchange at the going market price, rather than through a private deal. It matters to investors because these purchases change how many shares are available, can push the stock price up or signal confidence from large buyers, and often affect per-share metrics like earnings—think of it like someone buying lots of apples off a grocery shelf, reducing supply and potentially raising the price.
beneficially own financial
"may be deemed to beneficially own the securities owned directly by the Fund"
Beneficially own means having the economic rights and risks of a security—such as the right to receive dividends, sell the shares, or profit from price changes—whether or not your name appears on the official share register. Think of it like renting a car: you use it and reap the benefits even if the title lists someone else. Investors care because beneficial ownership determines who truly controls value, must be disclosed under securities rules, and can signal potential influence or trading activity that affects a stock’s price.
separately managed account financial
"Securities owned by a separately managed account (the "Managed Account")."
A separately managed account (SMA) is a personalized investment portfolio owned by a single investor and run by a professional manager who buys and sells securities on that investor’s behalf. It matters to investors because an SMA offers tailored asset selection, tax handling, and transparency—like hiring a personal chef who prepares meals to your dietary needs rather than sharing a set menu—so you can align holdings with your goals and see exactly what you own.
weighted average price financial
"The price reported is a weighted average price. These shares were purchased in multiple transactions"
Weighted average price is the average price of a security where each trade or component is counted according to its size, so bigger trades pull the average more than smaller ones. Think of it like calculating the average cost of a grocery haul where items you bought more of have greater influence on the final per-item cost. Investors use it to understand the true average price paid or received, judge execution quality, and compare trading performance against market movement.
pecuniary interest financial
"disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein"
SEC Form 4
FORM 4UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
OMB APPROVAL
OMB Number:3235-0287
Estimated average burden
hours per response:0.5
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.
1. Name and Address of Reporting Person*
Opaleye Management Inc.

(Last)(First)(Middle)
ONE BOSTON PLACE, 26TH FLOOR

(Street)
BOSTON MASSACHUSETTS 02108

(City)(State)(Zip)

UNITED STATES

(Country)
2. Issuer Name and Ticker or Trading Symbol
Alpha Cognition Inc. [ ACOG ]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
DirectorX10% Owner
Officer (give title below)Other (specify below)
2a. Foreign Trading Symbol
3. Date of Earliest Transaction (Month/Day/Year)
05/27/2026
6. Individual or Joint/Group Filing (Check Applicable Line)
XForm filed by One Reporting Person
Form filed by More than One Reporting Person
4. If Amendment, Date of Original Filed (Month/Day/Year)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year)2A. Deemed Execution Date, if any (Month/Day/Year)3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeVAmount(A) or (D)Price
Common Stock, no par value05/27/2026P1,161A$5.732,531,530IBy Opaleye, L.P.(1)(5)
Common Stock, no par value05/28/2026P2,000A$5.832(3)2,533,530IBy Opaleye, L.P.(1)(5)
Common Stock, no par value05/29/2026P70,577A$5.8999(4)2,604,107IBy Opaleye, L.P.(1)(5)
Common Stock, no par value90,000IBy Managed Account(2)(5)
Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year)3A. Deemed Execution Date, if any (Month/Day/Year)4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 6. Date Exercisable and Expiration Date (Month/Day/Year)7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeV(A)(D)Date ExercisableExpiration DateTitleAmount or Number of Shares
Explanation of Responses:
1. Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund.
2. Securities owned by a separately managed account (the "Managed Account"). As the portfolio manager of the Managed Account, Opaleye may be deemed to beneficially own the securities owned directly by the Managed Account.
3. The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $5.82 to $5.85. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range.
4. The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $5.88 to $5.90. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range.
5. Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose.
Opaleye Management Inc., By: /s/ James Silverman, President05/29/2026
** Signature of Reporting PersonDate
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
* Form 4: SEC 1474 (03-26)

FAQ

How many Alpha Cognition (ACOG) shares did Opaleye buy in this Form 4?

Opaleye-related entities bought a total of 73,738 Alpha Cognition shares in open-market transactions. These purchases occurred over several days and increased their indirect ownership position disclosed in the filing.

What prices did Opaleye pay for Alpha Cognition (ACOG) shares?

Reported transaction prices ranged from about $5.73 to $5.90 per share. Footnotes state weighted average prices, with individual trades occurring within ranges of $5.82–$5.85 and $5.88–$5.90 across multiple executions.

What is Opaleye’s Alpha Cognition (ACOG) stake after these trades?

After the reported purchases, Opaleye, L.P. holds 2,604,107 Alpha Cognition shares indirectly. A separately managed account associated with Opaleye holds an additional 90,000 shares, as disclosed in the Form 4 holding entry.

Who actually owns the Alpha Cognition (ACOG) shares reported by Opaleye?

Shares are owned directly by Opaleye, L.P. and a separately managed account. Opaleye Management Inc. is investment manager or portfolio manager and may be deemed to beneficially own them only to the extent of its pecuniary interest, which it carefully limits in a disclaimer.

Were Opaleye’s Alpha Cognition (ACOG) trades open-market purchases?

Yes. The Form 4 classifies the transactions with code P, described as open-market or private purchases of common stock. These are non-derivative trades, not option exercises or conversions, according to the transaction details provided.