As
filed with the Securities and Exchange Commission on July 8, 2026
Registration
No. 333-297257
UNITED
STATES
SECURITIES
AND EXCHANGE COMMISSION
Washington,
D.C. 20549
Amendment
No. 1
To
FORM
S-3
REGISTRATION
STATEMENT
UNDER
THE
SECURITIES ACT OF 1933
AKARI
THERAPEUTICS, PLC
(Exact
name of registrant as specified in its charter)
| England
and Wales |
|
2834
|
|
98-1034922 |
(State
or other jurisdiction of
incorporation
or organization) |
|
(Primary
Standard Industrial
Classification Code) |
|
(I.R.S.
Employer
Identification
No.) |
401
East Jackson Street, Suite 3300
Tampa,
FL 33602
(929)
274-7510
(Address,
including zip code, and telephone number, including area code, of registrant’s principal executive offices)
Abizer
Gaslightwala
President
and Chief Executive Officer
401
East Jackson Street, Suite 3300
Tampa,
FL 33602
(929)
274-7510
(Name,
address, including zip code, and telephone number, including area code, of agent for service)
Copies
to:
Gary
Emmanuel, Esq.
Win
Rutherfurd, Esq.
Greenberg
Traurig, LLP
One
Vanderbilt Avenue
New
York, NY 10017
Tel:
(212) 801-9200
Approximate
date of commencement of proposed sale to the public: From time to time after the effective date of this Registration Statement.
If
the only securities being registered on this Form are being offered pursuant to dividend or interest reinvestment plans, please check
the following box. ☐
If
any of the securities being registered on this Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the
Securities Act of 1933, other than securities offered only in connection with dividend or interest reinvestment plans, check the following
box. ☒
If
this Form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act, please check the
following box and list the Securities Act registration statement number of the earlier effective registration statement for the same
offering. ☐
If
this Form is a post-effective amendment filed pursuant to Rule 462(c) under the Securities Act, check the following box and list the
Securities Act registration statement number of the earlier effective registration statement for the same offering. ☐
If
this Form is a registration statement pursuant to General Instruction I.D. or a post-effective amendment thereto that shall become effective
upon filing with the Commission pursuant to Rule 462(e) under the Securities Act, check the following box. ☐
If
this Form is a post-effective amendment to a registration statement filed pursuant to General Instruction I.D. filed to register additional
securities or additional classes of securities pursuant to Rule 413(b) under the Securities Act, check the following box. ☐
Indicate
by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, smaller reporting company,
or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller
reporting company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act.
| Large
accelerated filer |
☐ |
Accelerated
filer |
☐ |
| Non-accelerated
filer |
☒ |
Smaller
Reporting Company |
☒ |
| |
|
Emerging
Growth Company |
☐ |
If
an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying
with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐
The
registrant hereby amends this registration statement on such date or dates as may be necessary to delay its effective date until the
registrant shall file a further amendment which specifically states that this registration statement shall thereafter become effective
in accordance with Section 8(a) of the Securities Act of 1933 or until the registration statement shall become effective on such date
as the Securities and Exchange Commission, acting pursuant to said Section 8(a), may determine.
EXPLANATORY
NOTE
This
Amendment No. 1 to the Registration Statement on Form S-3 (File No. 333-297257) is being filed solely for the purpose of filing
certain exhibits. Accordingly, this Amendment No. 1 consists only of the facing page, this explanatory note, Item 16 of Part II of the
Registration Statement, the signature page to the Registration Statement, and the filed exhibits. The remainder of the Registration Statement
is unchanged and has therefore been omitted.
PART
II
INFORMATION
NOT REQUIRED IN PROSPECTUS
Item
16. Exhibits
The
following exhibits are attached hereto:
| Exhibit
No. |
|
Description |
| 3.1 |
|
Amended Articles of Association of Akari Therapeutics, Plc (incorporated by reference to the Exhibit 3.1 to Registrant’s Current Report on Form 6-K, as filed with the SEC on July 8, 2023). |
| 4.1 |
|
Form of Deposit Agreement among the Registrant, Deutsche Bank Trust Company Americas, as Depositary, and all Owners and Holders from time to time of American Depositary Shares issued thereunder (incorporated by reference to the exhibit 99.(A) previously filed with the Registrant’s Registration Statement on Form F-6 (No. 333-185197) filed on November 30, 2012). |
| 4.2 |
|
Amendment to Deposit Agreement among the Registrant, Deutsche Bank Trust Company Americas, as Depositary, and all Owners and Holders from time to time of American Depositary Shares issued thereunder (incorporated by reference to the registrant’s Post-Effective Amendment No. 1 to Registration Statement on Form F-6 (No. 333-185197) filed on December 24, 2013). |
| 4.3 |
|
Form of American Depositary Receipt; the Form is Exhibit A of Amendment No. 1 to the Deposit Agreement (incorporated by reference to the exhibit previously filed with the Registrant’s Registration Statement on Form F-6 (No. 333-185197) filed on November 30, 2012). |
| 4.4 |
|
Form of Amendment No. 2 to Deposit Agreement (incorporated by reference to the exhibit previously filed with the Registrant’s Post-Effective Amendment on Registration Statement Form F-6 (File No. 333-185197) filed on September 9, 2015). |
| 4.5 |
|
Form of Amendment No. 3 to Deposit Agreement (incorporated by reference to the exhibit previously filed with the Registrant’s Post-Effective Amendment on Registration Statement Form F-6 (File No. 333-185197) filed on August 17, 2023). |
| 4.5 |
|
Form of Amendment No. 4 to Deposit Agreement (incorporated by reference to the exhibit previously filed with the Registrant’s Post-Effective Amendment on Registration Statement Form F-6 (File No. 333-185197) filed on March 31, 2026). |
| 4.6 |
|
Form of American Depositary Receipt; the Form is Exhibit A of Amendment No. 2 to the Deposit Agreement (incorporated by reference to the exhibit previously filed with the Registrant’s Post-Effective Amendment on Registration Statement Form F-6 (File No. 333-185197) filed on September 9, 2015). |
| 4.7** |
|
Form of Pre-Funded Warrant issued by Akari Therapeutics, Plc in connection with the May Private Placement. |
| 4.8* |
|
Form of Series H Warrant issued by Akari Therapeutics, Plc in connection with the May Private Placement. |
| 4.9* |
|
Form of Series I Warrant issued by Akari Therapeutics, Plc in connection with the May Private Placement. |
| 4.10**
|
|
Form of Series J Warrant issued by Akari Therapeutics, Plc in connection with the May Private Placement. |
| 5.1* |
|
Opinion of Greenberg Traurig LLP as to the legality of the securities being registered. |
| 10.1** |
|
Form of Securities Purchase Agreement dated as of May 20, 2026 between Akari Therapeutics, Plc and the purchasers party thereto (incorporated by reference to Exhibit 10.1 previously filed with the Registrant’s Current Report on Form 8-K as filed with the SEC on May 22, 2026). |
| 10.2** |
|
Amendment No.1 to the Securities Purchase Agreement dated as of June 23, 2026 between Akari Therapeutics, Plc and the purchasers party thereto (incorporated by reference to Exhibit 10.1 previously filed with the Registrant’s Current Report on Form 8-K as filed with the SEC on June 26, 2026). |
| 23.1* |
|
Consent of BDO USA, P.C. |
| 23.3* |
|
Consent of Greenberg Traurig LLP (included in Exhibit 5.1) |
| 24.1** |
|
Power of Attorney (included in signature page) |
| 107** |
|
Filing Fee Table |
*
Filed herewith.
**
Previously Filed.
SIGNATURES
Pursuant
to the requirements of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing on Form S-3 and has duly caused this registration statement to be signed on its behalf by the undersigned,
thereunto duly authorized, in Tampa, Florida on this July 8, 2026.
| AKARI
THERAPEUTICS, PLC |
|
| |
|
|
| By: |
/s/
Abizer Gaslightwala |
|
| Name: |
Abizer
Gaslightwala |
|
| Title: |
President
and Chief Executive Officer |
|
| |
(Principal
Executive Officer) |
|
Pursuant
to the requirements of the Securities Act of 1933, as amended, this Registration Statement has been signed by the following persons on
behalf of the registrant and in the capacities and on the dates indicated.
| Name |
|
Title |
|
Date |
| |
|
|
|
|
| * |
|
President,
Chief Executive Officer and Director |
|
July
8, 2026 |
| Abizer
Gaslightwala |
|
(principal
executive officer) |
|
|
| |
|
|
|
|
| * |
|
Interim
Chief Financial Officer |
|
July
8, 2026 |
| Kameel
Farag |
|
(principal
financial and accounting officer) |
|
|
| |
|
|
|
|
| * |
|
Chairman |
|
July
8, 2026 |
| Hoyoung
Huh, M.D., Ph.D. |
|
|
|
|
| |
|
|
|
|
| * |
|
Director |
|
July
8, 2026 |
| Ray
Prudo, M.D. |
|
|
|
|
| |
|
|
|
|
| * |
|
Director |
|
July
8, 2026 |
| Samir
R. Patel, M.D. |
|
|
|
|
| |
|
|
|
|
| * |
|
Director |
|
July
8, 2026 |
| Sandip
I. Patel |
|
|
|
|
| |
|
|
|
|
| * |
|
Director |
|
July
8, 2026 |
| Robert
Bazemore |
|
|
|
|
| |
|
|
|
|
| *
By: /s/ Abizer Gaslightwala |
|
|
|
|
| Abizer
Gaslightwala |
|
|
|
|
| Attorney-in-fact |
|
|
|
|