Schedule 13G: Point72, Steven A. Cohen Report 4.7M AMLX Shares (5.3%)

Rhea-AI Filing Summary

Key disclosure: On 24 June 2025 Point72 Asset Management, Point72 Capital Advisors and founder Steven A. Cohen jointly filed a Schedule 13G regarding Amylyx Pharmaceuticals, Inc. (AMLX).

The filing shows 4,717,709 AMLX common shares held through Point72 Associates, equivalent to 5.3 % of the company’s outstanding stock. All voting and dispositive authority is listed as “shared,” with zero sole power reported. The report is passive, made under Rule 13d-1(b), and classifies the reporting persons as: Point72 Asset Management – “PN” (Partnership), Point72 Capital Advisors – “CO” (Corporation), and Mr. Cohen – “IN” (Individual).

Ownership is indirect: Point72 Asset Management manages the securities, Point72 Capital Advisors is its general partner, and Mr. Cohen controls both entities. The principal business address for all parties is 72 Cummings Point Road, Stamford, CT 06902. A joint-filing agreement (Exhibit 99.1) formalises combined reporting.

This disclosure elevates Point72 to the roster of ≥5 % institutional holders of Amylyx, giving the hedge fund material visibility in the share register; however, the filing contains no purchase prices, transaction timetables, or stated strategic intentions beyond passive investment.

Positive

• Point72 Asset Management and affiliates disclosed ownership of 4.72 million AMLX shares (5.3 % of outstanding), adding a prominent institutional holder to the register.

Negative

• None.

Insights

Securities Analyst

TL;DR: Point72 now owns 5.3 % of AMLX, signalling meaningful institutional backing without activist intentions.

Point72’s accumulation of 4.72 million shares pushes its ownership above the 5 % reporting threshold, obligating this Schedule 13G. Because it checked Rule 13d-1(b), the stake is deemed passive rather than activist, reducing immediate governance risk while still highlighting heightened hedge-fund interest. The holding represents a sizable block relative to AMLX’s free float and could improve trading liquidity and analyst coverage. No leverage, derivatives or lock-up clauses are disclosed, so the position appears straightforward common-stock ownership held through Point72 Associates.

Corporate Governance Expert

TL;DR: New ≥5 % holder adds oversight visibility; shared voting power limits unilateral influence.

From a governance standpoint, Point72, Point72 Capital Advisors and Steven A. Cohen declare only shared voting/dispositive rights, indicating coordination within the Point72 complex but no single entity can act alone. The passive filing (13G vs. 13D) means Point72 is not presently seeking to change control or board composition. Nonetheless, any future shift above 10 % or a switch to a 13D would warrant closer monitoring. For now, the addition of a highly regulated, professional investor generally strengthens Amylyx’s shareholder base without triggering defensive measures.

SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

UNDER THE SECURITIES EXCHANGE ACT OF 1934

Amylyx Pharmaceuticals, Inc.

(Name of Issuer)

Common Stock, par value $0.0001 per share

(Title of Class of Securities)

03237H101

(CUSIP Number)

06/24/2025

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

Rule 13d-1(b)

Rule 13d-1(c)

Rule 13d-1(d)

SCHEDULE 13G

CUSIP No. 03237H101

1

Names of Reporting Persons

Point72 Asset Management, L.P.

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

DELAWARE

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 4,717,709.00
7	Sole Dispositive Power 0.00
8	Shared Dispositive Power 4,717,709.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

4,717,709.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

5.3 %

12

Type of Reporting Person (See Instructions)

PN

SCHEDULE 13G

CUSIP No. 03237H101

1

Names of Reporting Persons

Point72 Capital Advisors, Inc.

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

DELAWARE

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 4,717,709.00
7	Sole Dispositive Power 0.00
8	Shared Dispositive Power 4,717,709.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

4,717,709.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

5.3 %

12

Type of Reporting Person (See Instructions)

CO

SCHEDULE 13G

CUSIP No. 03237H101

1

Names of Reporting Persons

Steven A. Cohen

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

UNITED STATES

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 4,717,709.00
7	Sole Dispositive Power 0.00
8	Shared Dispositive Power 4,717,709.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

4,717,709.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

5.3 %

12

Type of Reporting Person (See Instructions)

IN

SCHEDULE 13G

Item 1.
(a)	Name of issuer: Amylyx Pharmaceuticals, Inc.
(b)	Address of issuer's principal executive offices: 43 THORNDIKE STREET CAMBRIDGE MA 02141
Item 2.
(a)	Name of person filing: This statement is filed by: (i) Point72 Asset Management, L.P. ("Point72 Asset Management") with respect to the shares of common stock, par value $0.0001 per share ("Shares"), of Amylyx Pharmaceuticals, Inc. held by Point72 Associates, LLC, an investment fund it manages ("Point72 Associates"); (ii) Point72 Capital Advisors, Inc. ("Point72 Capital Advisors Inc.") with respect to Shares held by Point72 Associates; and (iii) Steven A. Cohen ("Mr. Cohen") with respect to Shares beneficially owned by Point72 Asset Management and Point72 Capital Advisors Inc. Each of Cubist Systematic Strategies, LLC, Point72 (DIFC) Limited, and Point72 Asia (Singapore) Pte. Ltd. are advisors under common control with Point72 Asset Management, and each acts as a sub-advisor with respect to a portion of the Shares reported herein. Point72 Asset Management, Point72 Capital Advisors Inc., and Mr. Cohen have entered into a Joint Filing Agreement, a copy of which is filed with this Schedule 13G as Exhibit 99.1, pursuant to which they have agreed to file this Schedule 13G jointly in accordance with the provisions of Rule 13d-1(k) of the Securities Exchange Act of 1934 (the "Act").
(b)	Address or principal business office or, if none, residence: The address of the principal business office of Point72 Asset Management, Point72 Capital Advisors Inc., and Mr. Cohen is 72 Cummings Point Road, Stamford, CT 06902.
(c)	Citizenship: Point72 Asset Management is a Delaware limited partnership. Point72 Capital Advisors Inc. is a Delaware corporation. Mr. Cohen is a United States citizen.
(d)	Title of class of securities: Common Stock, par value $0.0001 per share
(e)	CUSIP No.: 03237H101
Item 3.	If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
(a)	Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
(b)	Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
(c)	Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
(d)	Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
(e)	An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
(f)	An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
(g)	A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
(h)	A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
(i)	A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
(j)	A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J), please specify the type of institution:
(k)	Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).
Item 4.	Ownership
(a)	Amount beneficially owned: The information required by Item 4(a) is set forth in Row 9 of the cover page for each of the Reporting Persons and is incorporated herein by reference. Such information is as of the close of business on June 24, 2025. Point72 Asset Management, Point72 Capital Advisors Inc., and Mr. Cohen own directly no Shares. Pursuant to an investment management agreement, Point72 Asset Management maintains investment and voting power with respect to the securities held by Point72 Associates. Point72 Capital Advisors Inc. is the general partner of Point72 Asset Management. Mr. Cohen controls each of Point72 Asset Management and Point72 Capital Advisors Inc. The filing of this statement should not be construed as an admission that any of the foregoing persons or any Reporting Person is, for the purposes of Section 13 of the Act, the beneficial owner of the Shares reported herein.
(b)	Percent of class: 5.3%
(c)	Number of shares as to which the person has:
	(i) Sole power to vote or to direct the vote: The information required by Item 4(c)(i) is set forth in Row 5 of the cover page for each of the Reporting Persons and is incorporated herein by reference. Such information is as of the close of business on June 24, 2025.
	(ii) Shared power to vote or to direct the vote: The information required by Item 4(c)(ii) is set forth in Row 6 of the cover page for each of the Reporting Persons and is incorporated herein by reference. Such information is as of the close of business on June 24, 2025.
	(iii) Sole power to dispose or to direct the disposition of: The information required by Item 4(c)(iii) is set forth in Row 7 of the cover page for each of the Reporting Persons and is incorporated herein by reference. Such information is as of the close of business on June 24, 2025.
	(iv) Shared power to dispose or to direct the disposition of: The information required by Item 4(c)(iv) is set forth in Row 8 of the cover page for each of the Reporting Persons and is incorporated herein by reference. Such information is as of the close of business on June 24, 2025.
Item 5.	Ownership of 5 Percent or Less of a Class.
Item 6.	Ownership of more than 5 Percent on Behalf of Another Person.
	If any other person is known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, such securities, a statement to that effect should be included in response to this item and, if such interest relates to more than 5 percent of the class, such person should be identified. A listing of the shareholders of an investment company registered under the Investment Company Act of 1940 or the beneficiaries of employee benefit plan, pension fund or endowment fund is not required. Point72 Associates has the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, more than 5 percent of the outstanding Shares.
Item 7.	Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
	Not Applicable
Item 8.	Identification and Classification of Members of the Group.
	Not Applicable
Item 9.	Notice of Dissolution of Group.
	Not Applicable

Item 10.

Certifications:

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

Point72 Asset Management, L.P.

Signature:	/s/ Jason M. Colombo
Name/Title:	Jason M. Colombo, Authorized Person
Date:	06/25/2025

Point72 Capital Advisors, Inc.

Signature:	/s/ Jason M. Colombo
Name/Title:	Jason M. Colombo, Authorized Person
Date:	06/25/2025

Steven A. Cohen

Signature:	/s/ Jason M. Colombo
Name/Title:	Jason M. Colombo, Authorized Person
Date:	06/25/2025

Exhibit Information

Exhibit 99.1: Joint Filing Agreement

FAQ

How many Amylyx (AMLX) shares does Point72 own?

4,717,709 common shares as reported in the Schedule 13G.

What percentage of AMLX does the 4.72 million-share stake represent?

The filing states 5.3 % of Amylyx’s outstanding common stock.

When did the ownership threshold requiring this filing occur?

The relevant event date is 24 June 2025.

Is Point72’s filing activist or passive?

It is passive, filed under Rule 13d-1(b) (Schedule 13G).

Who signed the filing on behalf of Point72?

The Schedule is filed jointly by Point72 Asset Management, Point72 Capital Advisors Inc., and Steven A. Cohen.

Does Point72 have sole or shared voting power over the AMLX shares?

The filing lists 0 sole and 4,717,709 shared votes/dispositive power.