STOCK TITAN

Alto Neuroscience CFO sells 134,886 shares

The reported option exercises and sales occurred under a Rule 10b5-1 plan adopted June 30, 2026.

(Neutral)

Sentiment and the balance of points

Rhea-AI Sentiment reads the wording of the document, how positive or negative its language is on a 1 to 5 scale. The balance of points shown with the takes weighs what the document actually discloses, so the two can disagree, for example when a trial that missed its main goal is described in upbeat language.

Form Type
4

Rhea-AI Filing Summary

Alto Neuroscience, Inc. (ANRO) President and CFO Nicholas Conrad Smith exercised options to acquire 134,886 common shares at $2.35 per share on September 29 and 30, 2026, and sold 134,886 shares across those dates. On September 29, he sold 110,830 shares at a weighted average $26.5826 per share. On September 30, he sold 23,170 shares at $25.7786 and 886 shares at $26.87. The transactions were made under a Rule 10b5-1 trading plan adopted June 30, 2026.

Insider Smith Nicholas Conrad
Role PRESIDENT AND CFO
Sold 134,886 shs ($3.57M)
Approx. gross sale proceeds $3.57M
Approx. exercise cost $317K
Approx. pre-tax spread $3.25M
Type Security Shares Price Value
Exercise Employee Stock Option (Right to Buy) F1, F3 24,056 $0.00 $0.00
Exercise Common Stock F1 24,056 $2.35 $57K
Sale Common Stock F1 23,170 $25.7786 $597K
Sale Common Stock F1 886 $26.87 $24K
Exercise Employee Stock Option (Right to Buy) F1, F3 56,455 $0.00 $0.00
Exercise Employee Stock Option (Right to Buy) F1, F4 54,375 $0.00 $0.00
Exercise Common Stock F1 56,455 $2.35 $133K
Exercise Common Stock F1 54,375 $2.35 $128K
Sale Common Stock F1, F2 110,830 $26.5826 $2.95M
Holdings After Transaction: Employee Stock Option (Right to Buy) — 157,443 contracts (Direct); Common Stock — 24,060 shares (Direct)
Footnotes (4)
  1. F1. This transaction was pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 30, 2026.
  2. F2. This price is a weighted average price. These securities were sold in multiple transactions at prices ranging from $26.5513 to $26.5902 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of securities sold at each separate price within the range set forth in this footnote.
  3. F3. One-third (1/3rd) of the shares underlying the option vested upon the completion of the Issuer's initial public offering and two-thirds (2/3) of the shares underlying the option vested or shall vest over a period of four years. 25% of the shares underlying the time-based portion vested on December 20, 2024, and 1/48 of the shares underlying the time-based portion vested or shall vest on a monthly basis thereafter, subject to the Reporting Person's continuous service through such vesting date.
  4. F4. 25% of the shares underlying the option vested on March 1, 2025, and one forty-eighth (1/48th) of the shares underlying the option vested or shall vest in monthly installments thereafter, subject to the Reporting Person's continuous service through each such vesting date.
Common shares acquired through option exercises 134,886 shares September 29 and 30, 2026
Option exercise price $2.35 per share Reported option exercises
Common shares sold 134,886 shares September 29 and 30, 2026
September 29 sale 110,830 shares at a weighted average $26.5826 per share September 29, 2026
September 29 sale price range $26.5513 to $26.5902 per share Inclusive range across multiple transactions
September 30 sale 23,170 shares at $25.7786 per share September 30, 2026
September 30 sale 886 shares at $26.87 per share September 30, 2026
Rule 10b5-1 trading plan regulatory
"pursuant to a Rule 10b5-1 trading plan"
A Rule 10b5-1 trading plan is a pre-arranged schedule that allows company insiders to buy or sell stock at specific times, even if they have inside information. It helps prevent accusations of unfair trading by making these transactions look planned and transparent, rather than sneaky or illegal.
weighted average price financial
"This price is a weighted average price"
Weighted average price is the average price of a security where each trade or component is counted according to its size, so bigger trades pull the average more than smaller ones. Think of it like calculating the average cost of a grocery haul where items you bought more of have greater influence on the final per-item cost. Investors use it to understand the true average price paid or received, judge execution quality, and compare trading performance against market movement.
vested financial
"25% of the shares underlying the option vested"

FAQ

AI-generated questions and answers. How Rhea-AI works. Not financial advice.

How many ANRO shares did the president and CFO sell?

Nicholas Conrad Smith sold 110,830 shares on September 29, 2026, at a weighted average $26.5826 per share, then sold 23,170 shares at $25.7786 and 886 shares at $26.87 on September 30.

Were Nicholas Conrad Smith's ANRO transactions under a 10b5-1 plan?

Yes. The transactions were made under a Rule 10b5-1 trading plan adopted June 30, 2026.

What was the price range for Nicholas Conrad Smith's September 29 ANRO sales?

The shares were sold in multiple transactions at prices ranging from $26.5513 to $26.5902 per share, inclusive. The reported weighted average price was $26.5826 per share.

AI-generated analysis. How Rhea-AI works. Not financial advice.

See more from StockTitan in Google Search and AI answers. Adds StockTitan as a preferred source · opens Google
Add on Google
Learn about SEC filing dates
SEC Form 4
FORM 4UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
OMB APPROVAL
OMB Number:3235-0287
Estimated average burden
hours per response:0.5
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.
1. Name and Address of Reporting Person*
Smith Nicholas Conrad

(Last)(First)(Middle)
C/O ALTO NEUROSCIENCE, INC.
650 CASTRO STREET, SUITE 450

(Street)
MOUNTAIN VIEW CALIFORNIA 94041

(City)(State)(Zip)

UNITED STATES

(Country)
2. Issuer Name and Ticker or Trading Symbol
Alto Neuroscience, Inc. [ ANRO ]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
Director10% Owner
XOfficer (give title below)Other (specify below)
PRESIDENT AND CFO
2a. Foreign Trading Symbol
3. Date of Earliest Transaction (Month/Day/Year)
09/29/2026
6. Individual or Joint/Group Filing (Check Applicable Line)
XForm filed by One Reporting Person
Form filed by More than One Reporting Person
4. If Amendment, Date of Original Filed (Month/Day/Year)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year)2A. Deemed Execution Date, if any (Month/Day/Year)3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeVAmount(A) or (D)Price
Common Stock09/29/2026M(1)56,455A$2.3580,515D
Common Stock09/29/2026M(1)54,375A$2.35134,890D
Common Stock09/29/2026S(1)110,830D$26.5826(2)24,060D
Common Stock09/30/2026M(1)24,056A$2.3548,116D
Common Stock09/30/2026S(1)23,170D$25.778624,946D
Common Stock09/30/2026S(1)886D$26.8724,060D
Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year)3A. Deemed Execution Date, if any (Month/Day/Year)4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 6. Date Exercisable and Expiration Date (Month/Day/Year)7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeV(A)(D)Date ExercisableExpiration DateTitleAmount or Number of Shares
Employee Stock Option (Right to Buy)$2.3509/29/2026M(1)56,455 (3)12/19/2033Common Stock56,455$0145,874D
Employee Stock Option (Right to Buy)$2.3509/29/2026M(1)54,375 (4)02/28/2034Common Stock54,375$035,625D
Employee Stock Option (Right to Buy)$2.3509/30/2026M(1)24,056 (3)12/19/2033Common Stock24,056$0121,818D
Explanation of Responses:
1. This transaction was pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 30, 2026.
2. This price is a weighted average price. These securities were sold in multiple transactions at prices ranging from $26.5513 to $26.5902 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of securities sold at each separate price within the range set forth in this footnote.
3. One-third (1/3rd) of the shares underlying the option vested upon the completion of the Issuer's initial public offering and two-thirds (2/3) of the shares underlying the option vested or shall vest over a period of four years. 25% of the shares underlying the time-based portion vested on December 20, 2024, and 1/48 of the shares underlying the time-based portion vested or shall vest on a monthly basis thereafter, subject to the Reporting Person's continuous service through such vesting date.
4. 25% of the shares underlying the option vested on March 1, 2025, and one forty-eighth (1/48th) of the shares underlying the option vested or shall vest in monthly installments thereafter, subject to the Reporting Person's continuous service through each such vesting date.
Remarks:
/s/ Erin R. McQuade, Attorney-in-Fact10/01/2026
** Signature of Reporting PersonDate
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
* Form 4: SEC 1474 (03-26)

Keep reading