| UNITED STATES |
| SECURITIES AND EXCHANGE COMMISSION |
| Washington, D.C. 20549 |
| Notice of Effectiveness |
| Effectiveness Date: |
December 16,
2025 |
| Accession Number: |
0001104659-25-121247 |
| Submission Type: |
POS AM |
| CIK: |
0001644963 |
| Company Name: |
AVENUE THERAPEUTICS, INC. |
| File Number: |
333-279125 |
|
