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UNITED
STATES
SECURITIES
AND EXCHANGE COMMISSION
Washington,
D.C. 20549
FORM
8-K
CURRENT
REPORT
Pursuant
to Section 13 or 15(d)
of
the Securities Exchange Act of 1934
Date
of Report (Date of earliest event reported): March 5, 2026
CALIDI
BIOTHERAPEUTICS, INC.
(Exact
name of registrant as specified in its charter)
| Delaware |
|
001-40789 |
|
86-2967193 |
(State
or other jurisdiction
of
incorporation) |
|
(Commission
File
Number) |
|
(I.R.S.
Employer
Identification
No.) |
4475
Executive Drive, Suite 200,
San
Diego, California |
|
92121 |
| (Address
of principal executive offices) |
|
(Zip
Code) |
(858)
794-9600
(Registrant’s
telephone number, including area code)
N/A
(Former
name or former address, if changed since last report)
Check
the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under
any of the following provisions (see General Instruction A.2. below):
| ☐ |
Written
communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425) |
| |
|
| ☐ |
Soliciting
material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) |
| |
|
| ☐ |
Pre-commencement
communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) |
| |
|
| ☐ |
Pre-commencement
communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) |
| Title
of Each Class |
|
Trading
Symbol(s) |
|
Name
of Each Exchange on Which Registered |
| Common
stock, par value $0.0001 per share |
|
CLDI |
|
NYSE
American LLC |
Indicate
by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405
of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).
Emerging
growth company ☒
If
an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying
with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act.
Item
1.01 Entry into a Material Definitive Agreement.
Underwritten
Public Offering
On
March 6, 2026, Calidi Biotherapeutics, Inc. (the “Company”) entered into an underwriting agreement (the “Underwriting
Agreement”) with Ladenburg Thalmann & Co. Inc., as sole underwriter (“Underwriter”), in connection with the issuance
and sale (the “Offering”) of: (i) 2,278,731 common stock units (“Common Stock Units”), which includes 1,575,000
Common Stock Units purchased pursuant to the exercise, in full, of the Over-Allotment Option and (ii) 9,815,900 pre-funded warrant units
(“Pre-Funded Units”), resulting in gross proceeds of approximately $6.03 million, before deducting underwriting discounts
and commissions and other estimated offering expenses. The Company intends to use the proceeds from the sale of its securities for working
capital and general corporate purposes. In connection with the Offering, the Company also issued to the Underwriter (or its designees)
a warrant (the “Underwriter’s Warrant”) to purchase up to 604,732 shares of common stock of the Company, par value
$0.0001 (the “Common Stock”). The Underwriter’s Warrant has an exercise price of $0.625, is exercisable on or after
the date of issuance, and will expire on March 9, 2031.
Each
Common Stock Unit consisted of (i) one share of Common Stock, (ii) one Series J common stock warrant (“Series J Warrants”)
to purchase one share of Common Stock (or pre-funded warrants to purchase one share of Common Stock in lieu thereof), (iii) one Series
K common stock warrant (“Series K Warrants”) to purchase one share of Common Stock (or pre-funded warrants to purchase one
share of Common Stock in lieu thereof), and (iv) one Series L common stock warrant (“Series L Warrants” and together with
the Series J Warrants and the Series K Warrants, the “Common Warrants”) to purchase one share of Common Stock (or pre-funded
warrants to purchase one share of Common Stock in lieu thereof). Each Pre-Funded Unit consisted of (i) one pre-funded warrant (the “Pre-Funded
Warrants”), (ii) one Series J Warrant, (iii) one Series K Warrant, and (iv) one Series L Warrant. The Common Warrants included
in the Pre-Funded Units are identical to the Common Warrants included in the Common Stock Units.
Each
Common Stock Unit was sold to the public at a price of $0.50 per Common Stock Unit and each Pre-Funded Unit was sold to the public at
a price of $0.499 per Pre-Funded Unit (which represents the public offering price of each Common Stock Unit less the $0.001 per share
nominal exercise price for each Pre-Funded Warrant). The Series J Warrants have an initial exercise price of $0.50 per share. The Series
J Warrants are exercisable immediately, subject to certain limitations described herein. The Series J Warrants expire five (5) years
from the date of issuance. The Series K Warrants have an initial exercise price of $0.50 per share. The Series K Warrants are exercisable
immediately, subject to certain limitations described herein. The Series K Warrants will expire one (1) year from the date of issuance.
The Series L Warrants have an initial exercise price of $0.50 per share. The Series L Warrants are exercisable immediately, subject to
certain limitations described herein. The Series L Warrants expire six (6) months from the date of issuance. The Common Warrants each
include provisions in relation to the reset of the exercise price on two separate occasions: (i) on the forty-fifth (45th)
calendar day following the date of issuance and (ii) the sixth (6th) trading day immediately following the date on which a
reverse stock split of the Common Stock is approved and deemed effective during the fiscal year ended December 31, 2026, to a price equal
to the lesser of (i) the then exercise price and (ii) 90% of the lowest five-day volume weighted average prices for the five (5) trading
days immediately preceding the date that is forty-five calendar days after issuance of the Series J Warrants, the Series K Warrants and
the Series L Warrants, as applicable. Notwithstanding the foregoing, in no event at any time prior to, or including, the reset trigger
date that is the forty-fifth (45th) calendar day following the date of issuance, shall the exercise price be adjusted to a
price that is less than $0.25. Each Pre-Funded Warrant is immediately exercisable, entitles the holder to purchase one share of Common
Stock and may be exercised at any time until exercised in full.
The
Common Stock and accompanying Common Warrants included in each Common Stock Unit were issued separately, and the Pre-Funded Warrants
and the accompanying Common Warrants included in each Pre-Funded Unit were issued separately. A holder of the Common Warrants or the
Pre-funded Warrants (together with its affiliates) may not exercise any portion of the Common Warrant or Pre-Funded Warrant to the extent
that the holder would own more than 4.99% (or 9.99%, at the election of the holder) of the outstanding shares of Common Stock immediately
after exercise, except that upon at least 61 days’ prior notice from the holder to the Company, the holder may elect to increase
such holding. The Common Stock Units, the Pre-Funded Units, the shares of Common Stock comprising the Common Stock Units, the Common
Warrants, the Pre-Funded Warrants, the shares of Common Stock issuable upon exercise of the Common Warrants and the Pre-Funded Warrants,
are collectively referred to herein as the “Securities.”
The
Securities were offered by the Company pursuant to a shelf registration statement on Form S-3 (File No. 333-284229), that was filed with
the Securities Exchange Commission (“SEC”) on January 10, 2025 and declared effective on February 7, 2025, including the
prospectus forming a part of the registration statement, a final prospectus supplement thereto, which was filed with the SEC on March
9, 2026, pursuant to Rule 424(b) under the Securities Act of 1933, as amended (the “Securities Act”), and the related registration
statement filed with the SEC on March 5, 2026 under Rule 462(b) of the Securities Act, which became automatically effective upon filing.
The Offering closed on March 9, 2026 (the “Closing Date”).
On
March 6, 2026, the Company also entered into a warrant agency agreement (the “Warrant Agency Agreement”) with Equiniti Trust
Company, LLC, as warrant agent (the “Warrant Agent”). The Warrant Agency Agreement sets forth certain terms and conditions
with respect to the Warrant Agent’s service as warrant agent for the Common Warrants and Pre-Funded Warrants.
The
Underwriting Agreement contains customary representations, warranties and agreements by the Company, customary conditions to closing,
indemnification obligations of the Company and the various underwriters, including for liabilities under the Securities Act, other obligations
of the parties and termination provisions. Pursuant to the terms of the Underwriting Agreement, and subject to certain exceptions as
set forth therein, until sixty (60) days following the Closing Date, the Company has agreed not to issue (or enter into any agreement
to issue) any shares of Common Stock or Common Stock equivalents. The Company has further agreed not to enter into an agreement involving
a variable rate transaction until six (6) months following the Closing Date, provided however that the prohibition on “at-the-market
offerings” and the issuance of common stock pursuant to an equity line of credit shall expire on the six-month anniversary of the
closing date of this Offering, and subject to certain exceptions. In addition, each of the Company’s directors and executive officers
have entered into lock-up agreements pursuant to which each of them has agreed not to, for a period of ninety (90) days, from the closing
of the Offering, offer, sell, transfer or otherwise dispose of the Company’s securities, subject to certain exceptions.
The
foregoing does not purport to be a complete description of each of the Underwriting Agreement, the Pre-Funded Warrants, the Series J
Warrants, the Series K Warrants, the Series L Warrants, the Underwriter’s Warrant and the Warrant Agency Agreement, and each is
qualified in its entirety by reference to the full text of each of such document, the forms of which are filed as Exhibits 1.1, 4.1,
4.2, 4.3, 4.4, 4.5 and 10.1, respectively, to this Current Report on Form 8-K, and are incorporated herein by reference.
Warrant
Amendments
On
March 5, 2026, the Company entered into an Amendment to Common Stock Purchase Warrants Agreement (the “Warrant Amendment”)
with certain investors, that participated in the Offering described in Item 1.01 above, in connection with the terms of certain of our
outstanding common warrants to purchase shares of Common Stock (the “Existing Warrants”). As originally issued, the Existing
Warrants provided for the purchase of:
| ● | 504,417
shares of common stock, on exercise of the series G common stock warrants at an exercise
price of $8.3448 per share; |
| ● | 279,168
shares of common stock, on exercise of the series H common stock warrants at an exercise
price of $8.40 per share; and |
| ● | 2,190,000
shares of common stock, on exercise of the series I common stock warrants at an exercise
price of $2.00 per share. |
Per
the Warrant Amendment, the exercise price for each of such Existing Warrants was reduced to $0.50 per share, subject to further adjustment
as set forth in the Existing Warrants and any other document governing the terms thereunder. All other terms and conditions of the Existing
Warrants remain unchanged and in full force and effect. The foregoing description of the Warrant Amendment does not purport to be complete
and is qualified in its entirety by reference to the full text of the Warrant Amendment, a copy of which is filed as Exhibit 4.6 to this
Current Report on Form 8-K and is incorporated herein by reference.
As
of March 11, 2026, the Company has 10,545,725 shares of Common Stock outstanding, including 150,000 non-voting shares of Common Stock held
in escrow.
Item
3.02 Unregistered Sales of Equity Securities.
Reference
is made to the disclosure under Item 1.01 above which is hereby incorporated in this Item 3.02 by reference.
The
Underwriter’s Warrant and the shares issuable upon exercise of the Underwriter Warrant have not been registered under the Securities
Act, or the securities laws of any state, and were offered and sold in reliance on the exemption from registration under the Securities
Act, afforded by Section 4(a)(2) under the Securities Act and Regulation D promulgated thereunder.
Item
8.01 Other Events.
On
March 5, 2026, the Company issued a press release announcing the launch of the Offering. A copy of the press release is furnished as
Exhibit 99.1 to this Form 8-K.
On
March 6, 2026, the Company issued a press release announcing the pricing of the Offering. A copy of the press release is furnished as
Exhibit 99.2 to this Form 8-K.
On
March 9, 2026, the Company issued a press release announcing the closing of the Offering. A copy of the press release is furnished as
Exhibit 99.3 to this Form 8-K.
Item 9.01
Financial Statements and Exhibits.
(d)
Exhibits.
| Exhibit
No. |
|
Description |
| 1.1 |
|
Underwriting Agreement, dated March 6, 2026 |
| 4.1 |
|
Form of Pre-funded Warrant |
| 4.2 |
|
Form of Series J Common Warrant |
| 4.3 |
|
Form of Series K Common Warrant |
| 4.4 |
|
Form of Series L Common Warrant |
| 4.5 |
|
Form of Representative Warrant |
| 4.6 |
|
Form of Warrant Amendment |
| 10.1 |
|
Form of Warrant Agency Agreement |
| 99.1 |
|
Launch Press Release dated March 5, 2026. |
| 99.2 |
|
Pricing Press Release dated March 6, 2026. |
| 99.3 |
|
Closing Press Release dated March 9, 2026 |
| 104 |
|
Cover
Page Interactive Data File (embedded within the Inline XBRL document). |
SIGNATURES
Pursuant
to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by
the undersigned hereunto duly authorized.
| |
CALIDI
BIOTHERAPEUTICS, INC. |
| Dated:
March 11, 2026 |
|
|
| |
By: |
/s/
Andrew Jackson |
| |
Name: |
Andrew
Jackson |
| |
Title: |
Chief
Financial Officer |
Exhibit
99.1

Calidi
Biotherapeutics Announces Proposed Public Offering
SAN
DIEGO, March 05, 2026 (GLOBE NEWSWIRE) — Calidi Biotherapeutics, Inc. (NYSE AMERICAN: CLDI) (“Calidi” or the “Company”),
a biotechnology company pioneering the development of targeted genetic medicines, today announced that it intends to offer and sell,
subject to market and other conditions, units consisting of shares of its common stock and, in lieu of common stock to certain investors
that so choose, pre-funded warrants to purchase shares of its common stock, in an underwritten public offering. Each share of common
stock or pre-funded warrant will be sold with accompanying common warrants to purchase shares of common stock (or a pre-funded warrant
in lieu thereof). The shares of common stock, pre-funded warrants and/or common warrants comprising the units will be separated immediately
upon issuance. The purchase price of each pre-funded warrant will equal the price per share at which shares of common stock are being
sold to the public in the offering, minus $0.001, the per share exercise price of each pre-funded warrant. In addition, the Company expects
to grant the underwriters a 45-day option to purchase up to an additional 15% of the number of shares of common stock and/or common warrants
to purchase shares of its common stock offered in the public offering at the public offering price, less the underwriting discounts and
commissions. All of the shares of common stock, pre-funded warrants and common warrants are being offered by the Company.
The
proposed offering is subject to market and other conditions, and there can be no assurance as to whether or when the offering may be
completed, or as to the actual size or terms of the offering.
Ladenburg
Thalmann & Co. Inc. is acting as sole book-running manager for the offering.
Calidi
intends to use the net proceeds from the offering for working capital and for general corporate purposes.
The
securities described are being offered pursuant to a shelf registration statement on Form S-3 (File No. 333-284229), which was declared
effective by the United States Securities and Exchange Commission (“SEC”) on February 7, 2025. The offering will be made
only by means of a written prospectus. A preliminary prospectus supplement and accompanying prospectus describing the terms of the offering
has been or will be filed with the SEC on its website at www.sec.gov. Copies of the preliminary prospectus supplement and the
accompanying prospectus relating to the offering may also be obtained by contacting Ladenburg Thalmann & Co. Inc., Prospectus Department,
640 Fifth Avenue, 4th Floor, New York, New York 10019 or by email at prospectus@ladenburg.com. Before investing in this offering,
interested parties should read in their entirety the preliminary prospectus supplement and the accompanying prospectus and the other
documents that the Company has filed with the SEC that are incorporated by reference in such preliminary prospectus supplement and the
accompanying prospectus, which provide more information about the Company and such offering.
This
press release shall not constitute an offer to sell or the solicitation of an offer to buy any of the securities described therein, nor
shall there be any sales of these securities in any jurisdiction in which such offer, solicitation or sale would be unlawful prior to
registration or qualification under the securities laws of such jurisdiction.
About
Calidi
Calidi
Biotherapeutics (NYSE American: CLDI) is a biotechnology company pioneering the development of targeted therapies with the potential
to deliver genetic medicines to distal sites of disease. The company’s proprietary Redtail platform features an engineered enveloped
oncolytic virus designed for systemic delivery and targeting of metastatic sites. This advanced enveloped technology is intended to shield
the virus from immune clearance, allowing virotherapy to effectively reach tumor sites, induce tumor lysis, and deliver potent genetic
medicine(s) to metastatic locations.
CLD-401,
the lead candidate from the Redtail platform, currently in IND-enabling studies, targets non-small cell lung cancer, head and neck cancer,
and other tumor types with high unmet medical need. Calidi continues to advance its pipeline utilizing the Redtail platform including
its novel approach to incorporate BiTEs in solid tumors.
Calidi
Biotherapeutics is headquartered in San Diego, California. For more information, please visit www.calidibio.com or view Calidi’s
Corporate Presentation here.
Forward-Looking
Statements
This
press release may contain forward-looking statements for purposes of the “safe harbor” provisions under the United States
Private Securities Litigation Reform Act of 1995. Terms such as “anticipates,” “believe,” “continue,”
“could,” “estimate,” “expect,” “intends,” “may,” “might,” “plan,”
“possible,” “potential,” “predicts,” “project,” “should,” “towards,”
“would” as well as similar terms, are forward-looking in nature, but the absence of these words does not mean that a statement
is not forward-looking. These forward-looking statements include, but are not limited to, statements concerning key milestones, including
certain pre-clinical data, planned clinical trials, and statements relating to the safety and efficacy of Calidi’s therapeutic
candidates in development. Any forward-looking statements contained in this discussion are based on Calidi’s current expectations
and beliefs concerning future developments and their potential effects and are subject to multiple risks and uncertainties that could
cause actual results to differ materially and adversely from those set forth or implied in such forward-looking statements. These risks
and uncertainties include, but are not limited to, the risk that Calidi is not able to raise sufficient capital to support its current
and anticipated clinical trials, the risk that early results of clinical trials do not necessarily predict final results and that one
or more of the clinical outcomes may materially change following more comprehensive review of the data, and as more patient data becomes
available, the risk that Calidi may not receive FDA approval for some or all of its therapeutic candidates. Other risks and uncertainties
are set forth in the section entitled “Risk Factors” and “Cautionary Note Regarding Forward-Looking Statements”
in the Company’s annual report filed with the SEC on Form 10-K on March 31, 2025, as may be amended or supplemented by other reports
we file with the SEC from time to time. We disclaim any obligation to update any forward-looking statement to reflect events or circumstances
after the date of this press release or to reflect the occurrence of unanticipated events.
For
Investors:
Dave
Gentry, CEO
RedChip
Companies, Inc.
1-407-644-4256
CLDI@redchip.com
Exhibit
99.2

Calidi
Biotherapeutics Announces Pricing of $5.2 Million Underwritten Public Offering
Short
Term Tranche Warrants Potentially Raise $10.4 Million within 12 months of Closing
SAN
DIEGO, March 06, 2026 (GLOBE NEWSWIRE) — Calidi Biotherapeutics, Inc. (NYSE AMERICAN: CLDI) (“Calidi” or the “Company”),
a biotechnology company pioneering the development of targeted genetic medicines, today announced the pricing of its underwritten public
offering of 10,519,631 units, with each unit consisting of one share of common stock (or pre-funded warrant in lieu thereof), (ii) one
6 month warrant to purchase one share of common stock, (iii) one 12 month warrant to purchase one share of common stock and (iv) one
five year warrant to purchase one share of common stock (collectively, the “Warrants”) .
Ladenburg
Thalmann & Co. Inc. is acting as sole book-running manager for the offering.
Each
unit is being sold to the public at a price of $0.50 per unit and each pre-funded unit is being sold to the public at the public offering
price of each unit less the $0.001 per share nominal exercise price for each pre-funded warrant. The gross proceeds to the Company from
this offering are expected to be approximately $5.2 million, before deducting underwriting discounts and commissions and other estimated
offering expenses.
The
Company has granted the underwriter a 45-day option to purchase up to an additional 1,575,000 shares of common stock and/or warrants
to purchase up to 1,575,000 shares of common stock for each series of warrants described above (or up to an aggregate of 4,725,000 shares
of common stock), or any combination thereof, solely to cover over-allotments, if any, at the public offering price, less underwriting
discounts and commissions.
Calidi
intends to use the net proceeds from the offering for working capital and for general corporate purposes.
The
Warrants will be immediately exercisable and will entitle the holder to purchase one share of common stock (or pre-funded warrant in
lieu thereof) at an exercise price of $0.50 per share. Each pre-funded warrant will be immediately exercisable, will entitle the holder
to purchase one share of common stock and may be exercised at any time until exercised in full. The common stock (or pre-funded warrant
in lieu thereof) and Warrants can only be purchased together as part of the units in the offering but will be immediately be issued separately.
This
offering is expected to close on or about March 9, 2026, subject to the satisfaction of customary closing conditions.
The
Company also has agreed that certain existing warrants held by investors in the offering to purchase up to an aggregate of 2,973,585
shares of the Company’s common stock that were previously issued to the investors will be amended effective upon the closing of
the offering so that such warrants will have a reduced exercise price of $0.50 per share.
The
securities described are being offered pursuant to a shelf registration statement on Form S-3 (File No. 333-284229), which was declared
effective by the United States Securities and Exchange Commission (“SEC”) on February 7, 2025 and the related registration
statement filed under Rule 462(b) of the Securities Act of 1933, as amended, which became automatically effective upon filing. The offering
will be made only by means of a written prospectus. A final prospectus supplement and accompanying prospectus describing the terms of
the offering will be filed with the SEC on its website at www.sec.gov. Copies of the final prospectus supplement and the accompanying
prospectus relating to the offering may also be obtained by contacting Ladenburg Thalmann & Co. Inc., Prospectus Department, 640
Fifth Avenue, 4th Floor, New York, New York 10019 or by email at prospectus@ladenburg.com.
This
press release shall not constitute an offer to sell or the solicitation of an offer to buy any of the securities described therein, nor
shall there be any sales of these securities in any jurisdiction in which such offer, solicitation or sale would be unlawful prior to
registration or qualification under the securities laws of such jurisdiction.
About
Calidi
Calidi
Biotherapeutics (NYSE American: CLDI) is a biotechnology company pioneering the development of targeted therapies with the potential
to deliver genetic medicines to distal sites of disease. The company’s proprietary Redtail platform features an engineered enveloped
oncolytic virus designed for systemic delivery and targeting of metastatic sites. This advanced enveloped technology is intended to shield
the virus from immune clearance, allowing virotherapy to effectively reach tumor sites, induce tumor lysis, and deliver potent genetic
medicine(s) to metastatic locations.
CLD-401,
the lead candidate from the Redtail platform, currently in IND-enabling studies, targets non-small cell lung cancer, head and neck cancer,
and other tumor types with high unmet medical need. Calidi continues to advance its pipeline utilizing the Redtail platform including
its novel approach to incorporate BiTEs in solid tumors.
Calidi
Biotherapeutics is headquartered in San Diego, California. For more information, please visit www.calidibio.com or view Calidi’s
Corporate Presentation here.
Forward-Looking
Statements
This
press release may contain forward-looking statements for purposes of the “safe harbor” provisions under the United States
Private Securities Litigation Reform Act of 1995. Terms such as “anticipates,” “believe,” “continue,”
“could,” “estimate,” “expect,” “intends,” “may,” “might,” “plan,”
“possible,” “potential,” “predicts,” “project,” “should,” “towards,”
“would” as well as similar terms, are forward-looking in nature, but the absence of these words does not mean that a statement
is not forward-looking. These forward-looking statements include, but are not limited to, statements concerning key milestones, including
certain pre-clinical data, planned clinical trials, and statements relating to the safety and efficacy of Calidi’s therapeutic
candidates in development. Any forward-looking statements contained in this discussion are based on Calidi’s current expectations
and beliefs concerning future developments and their potential effects and are subject to multiple risks and uncertainties that could
cause actual results to differ materially and adversely from those set forth or implied in such forward-looking statements. These risks
and uncertainties include, but are not limited to, the risk that Calidi is not able to raise sufficient capital to support its current
and anticipated clinical trials, the risk that early results of clinical trials do not necessarily predict final results and that one
or more of the clinical outcomes may materially change following more comprehensive review of the data, and as more patient data becomes
available, the risk that Calidi may not receive FDA approval for some or all of its therapeutic candidates. Other risks and uncertainties
are set forth in the section entitled “Risk Factors” and “Cautionary Note Regarding Forward-Looking Statements”
in the Company’s annual report filed with the SEC on Form 10-K on March 31, 2025, as may be amended or supplemented by other reports
we file with the SEC from time to time. We disclaim any obligation to update any forward-looking statement to reflect events or circumstances
after the date of this press release or to reflect the occurrence of unanticipated events.
For
Investors:
Dave
Gentry, CEO
RedChip
Companies, Inc.
1-407-644-4256
CLDI@redchip.com
Exhibit 99.3

Calidi
Biotherapeutics Announces Closing of $6.0 Million Underwritten Public Offering and Full Exercise of Underwriters’
Over-Allotment Option
$12
Million of Tranche Warrants Potential Financing Within One Year From Closing
SAN
DIEGO, March 09, 2026 (GLOBE NEWSWIRE) — Calidi Biotherapeutics, Inc. (NYSE AMERICAN: CLDI) (“Calidi” or the “Company”),
a biotechnology company pioneering the development of targeted genetic medicines, today announced the closing of its previously announced
underwritten public offering and the exercise in full of the underwriters’ over-allotment option for gross proceeds of approximately
$6.0 million, prior to deducting underwriting commissions and offering expenses.
In
connection with the offering, the Company sold 12,094,631 shares of common stock (or pre-funded warrants in lieu thereof) Series J warrants
to purchase 12,094,631 shares of common stock, Series K warrants to purchase 12,094,631 shares of common stock, and Series L warrants
to purchase 12,094,631 shares of common stock, including the full exercise of the underwriter’s option to purchase 1,575,000 shares
of common stock and accompanying warrants..
Ladenburg
Thalmann & Co. Inc. acted as sole book-running manager for the offering.
The
securities described above were offered pursuant to a shelf registration statement on Form S-3 (File No. 333-284229), which was declared
effective by the United States Securities and Exchange Commission (“SEC”) on February 7, 2025 and the related registration
statement filed under Rule 462(b) of the Securities Act of 1933, as amended, which became automatically effective upon filing. A final
prospectus supplement was filed with the SEC and is available on the SEC’s website at http://www.sec.gov. Electronic copies
of the final prospectus may also be obtained by contacting Ladenburg Thalmann & Co. Inc., Prospectus Department, 640 Fifth Avenue,
4th Floor, New York, New York 10019 or by email at prospectus@ladenburg.com.
The
Series J warrant has an initial exercise price of $0.50 per share, is exercisable upon issuance, and has a term expiring five years from
issuance. The Series K warrant has an initial exercise price of $0.50 per share, is exercisable upon issuance, and has a term expiring
one year from issuance. The Series L warrant has an initial exercise price of $0.50 per share, is exercisable upon issuance, and has
a term expiring six months from issuance. The warrants issued in this offering each include a reset of the exercise price on two separate
occasions: (i) on the forty-fifth (45th) calendar day following the date of issuance and (ii) the sixth (6th) trading
day immediately following the date on which a reverse stock split is approved and deemed effective during the fiscal year ended December
31, 2026.
This
press release does not constitute an offer to sell or the solicitation of an offer to buy, nor will there be any sales of these securities
in any jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities
laws of such jurisdiction.
About
Calidi Biotherapeutics
Calidi
Biotherapeutics (NYSE American: CLDI) is a biotechnology company pioneering the development of targeted therapies with the potential
to deliver genetic medicines to distal sites of disease. The company’s proprietary Redtail platform features an engineered enveloped
oncolytic virus designed for systemic delivery and targeting of metastatic sites. This advanced enveloped technology is intended to shield
the virus from immune clearance, allowing virotherapy to effectively reach tumor sites, induce tumor lysis, and deliver potent genetic
medicine(s) to metastatic locations.
CLD-401,
the lead candidate from the Redtail platform, currently in IND-enabling studies, targets non-small cell lung cancer, head and neck cancer,
and other tumor types with high unmet medical need. Calidi continues to advance its pipeline utilizing the Redtail platform including
its novel approach to incorporate BiTEs in solid tumors.
Calidi
Biotherapeutics is headquartered in San Diego, California. For more information, please visit www.calidibio.com or view Calidi’s
Corporate Presentation here.
Forward-Looking
Statements
This
press release may contain forward-looking statements for purposes of the “safe harbor” provisions under the United States
Private Securities Litigation Reform Act of 1995. Terms such as “anticipates,” “believe,” “continue,”
“could,” “estimate,” “expect,” “intends,” “may,” “might,” “plan,”
“possible,” “potential,” “predicts,” “project,” “should,” “towards,”
“would” as well as similar terms, are forward-looking in nature, but the absence of these words does not mean that a statement
is not forward-looking. These forward-looking statements include, but are not limited to, statements concerning key milestones, including
certain pre-clinical data, planned clinical trials, and statements relating to the safety and efficacy of Calidi’s therapeutic
candidates in development. Any forward-looking statements contained in this discussion are based on Calidi’s current expectations
and beliefs concerning future developments and their potential effects and are subject to multiple risks and uncertainties that could
cause actual results to differ materially and adversely from those set forth or implied in such forward-looking statements. These risks
and uncertainties include, but are not limited to, the risk that Calidi is not able to raise sufficient capital to support its current
and anticipated clinical trials, the risk that early results of clinical trials do not necessarily predict final results and that one
or more of the clinical outcomes may materially change following more comprehensive review of the data, and as more patient data becomes
available, the risk that Calidi may not receive FDA approval for some or all of its therapeutic candidates. Other risks and uncertainties
are set forth in the section entitled “Risk Factors” and “Cautionary Note Regarding Forward-Looking Statements”
in the Company’s annual report filed with the SEC on Form 10-K on March 31, 2025, as may be amended or supplemented by other reports
we file with the SEC from time to time. We disclaim any obligation to update any forward-looking statement to reflect events or circumstances
after the date of this press release or to reflect the occurrence of unanticipated events.
For
Investors:
Dave
Gentry, CEO
RedChip Companies, Inc.
1-407-644-4256
CLDI@redchip.com