[SCHEDULE 13G/A] Exact Sciences Corp SEC Filing

Rhea-AI Filing Summary

FMR LLC and Abigail P. Johnson report shared beneficial ownership of 18,588,183.06 shares of Exact Sciences Corp common stock, representing 9.8% of the class. FMR LLC is shown with 17,584,537.69 shares of sole voting power and 18,588,183.06 shares of sole dispositive power. The filing states these securities are held in the ordinary course of business and not for the purpose of changing or influencing control of the issuer. An exhibit is referenced for a related 13d-1(k) agreement.

Positive

• Material ownership disclosed: 18,588,183.06 shares representing 9.8% of Exact Sciences common stock
• Clear voting/dispositive breakdown: FMR LLC reports 17,584,537.69 sole voting power and 18,588,183.06 sole dispositive power
• Certification of passive intent: Filing states holdings are in the ordinary course of business and not for changing control

Negative

• None.

Insights

Institutional Investor / Portfolio Manager

TL;DR: A large passive stake of 9.8% disclosed; indicates meaningful economic interest without asserted intent to influence control.

The filing documents a near-10% ownership by FMR LLC and Abigail P. Johnson, with clear sole dispositive authority over 18,588,183.06 shares and substantial sole voting power reported for FMR LLC. Because the filer certified the holdings are in the ordinary course of business and not intended to change control, this reads as a passive institutional position rather than an activist move. Investors should view this as a disclosure of sizable ownership that may affect liquidity and perceived investor base, but not as an active governance campaign.

Corporate Governance Expert

TL;DR: Material ownership disclosed, but explicit certification limits governance implications.

The Schedule 13G indicates a material stake just under 10% of outstanding common stock. Item 10's certification that the shares are held in the ordinary course and not to influence control is important: it classifies this as a passive disclosure under Rule 13d-1 rather than an active 13D filing. The filing also references an exhibit regarding a 13d-1(k) agreement; examiners and governance teams may review that exhibit to confirm any coordination or voting arrangements. Absent contrary exhibits, this is a significant passive ownership disclosure with limited immediate governance consequences.

SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

UNDER THE SECURITIES EXCHANGE ACT OF 1934

(Amendment No. 2)

EXACT SCIENCES CORP

(Name of Issuer)

COMMON STOCK

(Title of Class of Securities)

30063P105

(CUSIP Number)

08/29/2025

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

Rule 13d-1(b)

Rule 13d-1(c)

Rule 13d-1(d)

SCHEDULE 13G

CUSIP No. 30063P105

1

Names of Reporting Persons

FMR LLC

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

DELAWARE

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 17,584,537.69
6	Shared Voting Power 0.00
7	Sole Dispositive Power 18,588,183.06
8	Shared Dispositive Power 0.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

18,588,183.06

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

9.8 %

12

Type of Reporting Person (See Instructions)

HC

SCHEDULE 13G

CUSIP No. 30063P105

1

Names of Reporting Persons

Abigail P. Johnson

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

UNITED STATES

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 0.00
7	Sole Dispositive Power 18,588,183.06
8	Shared Dispositive Power 0.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

18,588,183.06

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

9.8 %

12

Type of Reporting Person (See Instructions)

IN

SCHEDULE 13G

Item 1.
(a)	Name of issuer: EXACT SCIENCES CORP
(b)	Address of issuer's principal executive offices: 5505 ENDEAVOR LANE,MADISON,WI,USA,53719
Item 2.
(a)	Name of person filing: FMR LLC
(b)	Address or principal business office or, if none, residence: 245 Summer Street, Boston, Massachusetts 02210
(c)	Citizenship: Not applicable
(d)	Title of class of securities: COMMON STOCK
(e)	CUSIP No.: 30063P105
Item 3.	If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
(a)	Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
(b)	Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
(c)	Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
(d)	Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
(e)	An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
(f)	An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
(g)	A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
(h)	A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
(i)	A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
(j)	A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J), please specify the type of institution:
(k)	Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).
Item 4.	Ownership
(a)	Amount beneficially owned: 18588183.06
(b)	Percent of class: 9.8 %
(c)	Number of shares as to which the person has:
	(i) Sole power to vote or to direct the vote: Please see the responses to Items 5 and 6 on the cover page.
	(ii) Shared power to vote or to direct the vote: 0.00
	(iii) Sole power to dispose or to direct the disposition of: 18588183.06
	(iv) Shared power to dispose or to direct the disposition of: 0.00
Item 5.	Ownership of 5 Percent or Less of a Class.
Item 6.	Ownership of more than 5 Percent on Behalf of Another Person.
	If any other person is known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, such securities, a statement to that effect should be included in response to this item and, if such interest relates to more than 5 percent of the class, such person should be identified. A listing of the shareholders of an investment company registered under the Investment Company Act of 1940 or the beneficiaries of employee benefit plan, pension fund or endowment fund is not required. One or more other persons are known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, the COMMON STOCK of EXACT SCIENCES CORP. No one other person's interest in the COMMON STOCK of EXACT SCIENCES CORP is more than five percent of the total outstanding COMMON STOCK.
Item 7.	Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
	If a parent holding company has filed this schedule, pursuant to Rule 13d-1(b)(ii)(G), so indicate under Item 3(g) and attach an exhibit stating the identity and the Item 3 classification of the relevant subsidiary. If a parent holding company has filed this schedule pursuant to Rule 13d-1(c) or Rule 13d-1(d), attach an exhibit stating the identification of the relevant subsidiary. See attached Exhibit 99.
Item 8.	Identification and Classification of Members of the Group.
	Not Applicable
Item 9.	Notice of Dissolution of Group.
	Not Applicable

Item 10.

Certifications:

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

FMR LLC

Signature:	Stephanie J. Brown
Name/Title:	Duly authorized under Power of Attorney effective as of January 3, 2023, by and on behalf of FMR LLC and its direct and indirect subsidiaries*
Date:	09/05/2025

Abigail P. Johnson

Signature:	Stephanie J. Brown
Name/Title:	Duly authorized under Power of Attorney effective as of January 26, 2023, by and on behalf of Abigail P. Johnson**
Date:	09/05/2025

Comments accompanying signature: * This power of attorney is incorporated herein by reference to Exhibit 24 to the Schedule 13G filed by FMR LLC on January 10, 2023, accession number: 0000315066-23-000003. ** This power of attorney is incorporated herein by reference to Exhibit 24 to the Schedule 13G filed by FMR LLC on January 31, 2023, accession number: 0000315066-23-000038.

Exhibit Information

Please see Exhibit 99 for 13d-1(k) (1) agreement.

FAQ

Who filed the Schedule 13G/A for Exact Sciences (EXAS)?

The Schedule 13G/A was filed by FMR LLC and reports beneficial ownership associated with Abigail P. Johnson.

How many Exact Sciences shares are reported and what percent of the class do they represent?

The filing reports 18,588,183.06 shares, representing 9.8% of the outstanding common stock.

What voting and dispositive powers are reported by FMR LLC?

FMR LLC reports 17,584,537.69 shares of sole voting power and 18,588,183.06 shares of sole dispositive power; shared powers are reported as 0.00.

Does this filing indicate an intent to influence control of Exact Sciences?

No. The filing includes a certification that the securities are held in the ordinary course of business and were not acquired to change or influence the issuer's control.

Is there any referenced agreement or exhibit in the filing?

Yes. The filing references Exhibit 99 for a 13d-1(k) agreement and incorporates related powers of attorney by reference to prior filings.