Disc Medicine (IRON): FMR LLC, Abigail Johnson report 12.8% ownership of common stock

Rhea-AI Filing Summary

FMR LLC and Abigail P. Johnson report updated ownership of DISC MEDICINE INC common stock in Amendment No. 4 to a Schedule 13G filing. They beneficially own 4,875,472.97 shares of common stock, representing 12.8% of the class.

FMR LLC has sole voting power over 4,875,263 shares and sole dispositive power over 4,875,472.97 shares. Abigail P. Johnson reports sole dispositive power over the same 4,875,472.97 shares, with no voting power. One or more other persons may receive dividends or sale proceeds, but no such person holds more than 5% of the class.

Key Figures

Beneficial ownership: 4,875,472.97 shares Percent of class: 12.8% FMR sole voting power: 4,875,263 shares +4 more

7 metrics

Beneficial ownership 4,875,472.97 shares Amount beneficially owned by FMR LLC and Abigail P. Johnson in Item 4(a)

Percent of class 12.8% Percentage of DISC MEDICINE INC common stock class reported in Item 4(b)

FMR sole voting power 4,875,263 shares Sole power to vote or direct the vote reported for FMR LLC

FMR sole dispositive power 4,875,472.97 shares Sole power to dispose or direct disposition reported for FMR LLC

Abigail Johnson sole dispositive power 4,875,472.97 shares Sole power to dispose or direct disposition reported for Abigail P. Johnson

Shared voting power 0.00 Shared power to vote or direct the vote reported as zero

Shared dispositive power 0.00 Shared power to dispose or direct disposition reported as zero

Key Terms

beneficially owned, sole power to vote or to direct the vote, sole power to dispose or to direct the disposition, Ownership of more than 5 Percent on Behalf of Another Person, +1 more

5 terms

beneficially owned financial

"Item 4. | Ownership (a) | Amount beneficially owned: 4875472.97"

Beneficially owned describes securities or assets where a person has the economic rights and control—such as the right to receive dividends and to direct voting—even if legal title is held in another name. Think of it like having the keys and using a car that’s registered to someone else: you get the benefits and make decisions. Investors care because beneficial ownership reveals who truly controls value and voting power, affecting corporate decisions and takeover dynamics.

sole power to vote or to direct the vote financial

"(i) Sole power to vote or to direct the vote: Please see the responses"

sole power to dispose or to direct the disposition financial

"(iii) Sole power to dispose or to direct the disposition of: 4875472.97"

Ownership of more than 5 Percent on Behalf of Another Person financial

"Item 6. | Ownership of more than 5 Percent on Behalf of Another Person."

parent holding company financial

"If a parent holding company has filed this schedule, pursuant to (ii)(G)"

AI-generated analysis. How Rhea-AI works. Not financial advice.

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FAQ

What percentage of DISC MEDICINE INC (IRON) does FMR LLC report owning?

FMR LLC reports beneficial ownership of 12.8% of DISC MEDICINE INC’s common stock. This corresponds to 4,875,472.97 shares as disclosed in Item 4 of the Schedule 13G/A filing.

How many DISC MEDICINE INC (IRON) shares are beneficially owned by FMR LLC and Abigail P. Johnson?

They report beneficial ownership of 4,875,472.97 shares of DISC MEDICINE INC common stock. This share amount represents 12.8% of the outstanding common stock class according to the Schedule 13G/A.

What voting power does FMR LLC have over DISC MEDICINE INC (IRON) shares?

FMR LLC has sole voting power over 4,875,263 shares of DISC MEDICINE INC. It reports no shared voting power, and all remaining reported beneficially owned shares are subject to sole dispositive power.

What authority does Abigail P. Johnson report over DISC MEDICINE INC (IRON) shares?

Abigail P. Johnson reports sole dispositive power over 4,875,472.97 shares of DISC MEDICINE INC common stock. She reports no voting power (sole or shared) and no shared dispositive power over these securities.

Do other investors share in the economic interest of FMR LLC’s DISC MEDICINE INC (IRON) holdings?

Yes. The filing states that one or more other persons may receive dividends or sale proceeds from the DISC MEDICINE INC shares. However, no such person has an interest exceeding 5% of the total outstanding common stock.

What type of filing is this Schedule 13G/A for DISC MEDICINE INC (IRON)?

This is Amendment No. 4 to a Schedule 13G filed by FMR LLC and Abigail P. Johnson. It updates their reported beneficial ownership and voting and dispositive powers over DISC MEDICINE INC common stock.

SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

UNDER THE SECURITIES EXCHANGE ACT OF 1934

(Amendment No. 4)

DISC MEDICINE INC

(Name of Issuer)

COMMON STOCK

(Title of Class of Securities)

254604101

(CUSIP Number)

06/30/2026

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

Rule 13d-1(b)

Rule 13d-1(c)

Rule 13d-1(d)

schemaVersion:

SCHEDULE 13G

CUSIP Number(s): 254604101

1

Names of Reporting Persons

FMR LLC

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

DELAWARE

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 4,875,263.00
6	Shared Voting Power 0.00
7	Sole Dispositive Power 4,875,472.97
8	Shared Dispositive Power 0.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

4,875,472.97

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

12.8 %

12

Type of Reporting Person (See Instructions)

HC

SCHEDULE 13G

CUSIP Number(s): 254604101

1

Names of Reporting Persons

Abigail P. Johnson

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

UNITED STATES

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 0.00
7	Sole Dispositive Power 4,875,472.97
8	Shared Dispositive Power 0.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

4,875,472.97

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

12.8 %

12

Type of Reporting Person (See Instructions)

IN

SCHEDULE 13G

Item 1.
(a)	Name of issuer: DISC MEDICINE INC
(b)	Address of issuer's principal executive offices: 321 ARSENAL STREET,SUITE 101,WATERTOWN,MA,US,02472
Item 2.
(a)	Name of person filing: FMR LLC
(b)	Address or principal business office or, if none, residence: 245 Summer Street, Boston, Massachusetts 02210
(c)	Citizenship: Not applicable
(d)	Title of class of securities: COMMON STOCK
(e)	CUSIP No.: 254604101
Item 3.	If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
(a)	Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
(b)	Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
(c)	Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
(d)	Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
(e)	An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
(f)	An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
(g)	A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
(h)	A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
(i)	A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
(j)	A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J), please specify the type of institution:
(k)	Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).
Item 4.	Ownership
(a)	Amount beneficially owned: 4875472.97
(b)	Percent of class: 12.8 %
(c)	Number of shares as to which the person has:
	(i) Sole power to vote or to direct the vote: Please see the responses to Items 5 and 6 on the cover page.
	(ii) Shared power to vote or to direct the vote: 0.00
	(iii) Sole power to dispose or to direct the disposition of: 4875472.97
	(iv) Shared power to dispose or to direct the disposition of: 0.00
Item 5.	Ownership of 5 Percent or Less of a Class.
	Not Applicable
Item 6.	Ownership of more than 5 Percent on Behalf of Another Person.
	If any other person is known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, such securities, a statement to that effect should be included in response to this item and, if such interest relates to more than 5 percent of the class, such person should be identified. A listing of the shareholders of an investment company registered under the Investment Company Act of 1940 or the beneficiaries of employee benefit plan, pension fund or endowment fund is not required. One or more other persons are known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, the COMMON STOCK of DISC MEDICINE INC. No one other person's interest in the COMMON STOCK of DISC MEDICINE INC is more than five percent of the total outstanding COMMON STOCK.
Item 7.	Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
	If a parent holding company has filed this schedule, pursuant to Rule 13d-1(b)(ii)(G), so indicate under Item 3(g) and attach an exhibit stating the identity and the Item 3 classification of the relevant subsidiary. If a parent holding company has filed this schedule pursuant to Rule 13d-1(c) or Rule 13d-1(d), attach an exhibit stating the identification of the relevant subsidiary. See attached Exhibit 99.
Item 8.	Identification and Classification of Members of the Group.
	Not Applicable
Item 9.	Notice of Dissolution of Group.
	Not Applicable

Item 10.

Certifications:

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

FMR LLC

Signature:	Stephanie J. Brown
Name/Title:	Duly authorized under Power of Attorney effective as of January 3, 2023, by and on behalf of FMR LLC and its direct and indirect subsidiaries*
Date:	08/05/2026

Abigail P. Johnson

Signature:	Stephanie J. Brown
Name/Title:	Duly authorized under Power of Attorney effective as of January 26, 2023, by and on behalf of Abigail P. Johnson**
Date:	08/05/2026

Comments accompanying signature: * This power of attorney is incorporated herein by reference to Exhibit 24 to the Schedule 13G filed by FMR LLC on January 10, 2023, accession number: 0000315066-23-000003. ** This power of attorney is incorporated herein by reference to Exhibit 24 to the Schedule 13G filed by FMR LLC on January 31, 2023, accession number: 0000315066-23-000038.

Exhibit Information

Please see Exhibit 99 for 13d-1(k) (1) agreement.