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LeonaBio: Sermonix exercises warrants for 777K shares

A 19.99% beneficial-ownership limit prevented the Master Fund and PXV II from exercising any of their warrants as of the report date.

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Form Type
4

Rhea-AI Filing Summary

LeonaBio, Inc. (LONA) reports that Sermonix Pharmaceuticals, Inc. exercised pre-funded warrants for 776,648 common shares on October 26, 2026, at an exercise price of $0.0010 per share.

Perceptive Advisors LLC, Joseph Edelman (a director and ten-percent owner), and Perceptive Life Sciences Master Fund Ltd. are the reporting persons; each is identified as a director and ten-percent owner. They reported Sermonix’s entire interest, not a proportionate amount, and disclaim beneficial ownership except to the extent of any indirect pecuniary interest. Holding entries list warrants exercisable for 457,645 shares held by Perceptive Xontogeny Venture Fund II, LP (PXV II), 1,372,935 shares held by the Master Fund, and 2,352,932 shares distributed by Sermonix to PXV II. The 19.99% beneficial-ownership limitation did not permit the Master Fund or PXV II to exercise any warrants as of the report date.

Insider PERCEPTIVE ADVISORS LLC, EDELMAN JOSEPH, PERCEPTIVE LIFE SCIENCES MASTER FUND LTD
Role Director, 10% Owner | Director, 10% Owner | Director, 10% Owner
Type Security Shares Price Value
Exercise Pre-Funded Warrant (right to buy) F4, F5, F6, F1, F7 776,648 -- --
Exercise Common Stock F1, F7 776,648 $0.001 $776.65
holding Pre-Funded Warrant (right to buy) F9, F6, F3, F7 -- -- --
holding Pre-Funded Warrant (right to warrant) F9, F6, F2, F7 -- -- --
holding Pre-Funded Warrant (right to buy) F4, F9, F6, F3, F7, F8 -- -- --
holding Common Stock F2, F7 -- -- --
holding Common Stock F3, F7 -- -- --
Holdings After Transaction: Pre-Funded Warrant (right to buy) — 2,810,577 contracts (Indirect, See Footnotes); Common Stock — 2,635,970 shares (Indirect, See Footnotes); Pre-Funded Warrant (right to warrant) — 1,372,935 contracts (Indirect, See Footnotes)
Footnotes (9)
  1. F1. The securities are directly held by Sermonix Pharmaceuticals, Inc. ("Sermonix"). An affiliate of Perceptive Advisors LLC (the "Advisor") currently holds approximately 29% of the outstanding capital stock of Sermonix (excluding securities convertible into shares of Sermonix capital stock). Pursuant to General Instruction 4.b.(iv) of Form 4, the Reporting Persons with this filing have reported the entire amount of Sermonix's interest in the securities, rather than the Reporting Person's proportionate interest in the securities held by Sermonix.
  2. F2. The securities are directly held by Perceptive Life Sciences Master Fund Ltd. (the "Master Fund"). The Advisor serves as the investment manager of Master Fund. Joseph Edelman is the managing member of the Advisor.
  3. F3. The securities are directly held by Perceptive Xontogeny Venture Fund II, LP ("PXV II"). Perceptive Venture Advisors, LLC serves as the investment manager of PXV II and is controlled by the Advisor, and Perceptive Xontogeny Venture II GP, LLC ("PXV GP") is the general partner of PXV II. Mr. Edelman is the managing member of PXV GP and the Advisor.
  4. F4. The securities were issued to Sermonix in exchange for the grant of certain licenses and rights by Sermonix to the Issuer. The Pre-Funded Warrants became exercisable on March 18, 2026 upon receipt by the Issuer of stockholder approval such that the Pre-Funded Warrants can be exercised at any time without restriction or additional stockholder approval.
  5. F5. The Pre-Funded Warrants may not be exercised if, after such exercise, Sermonix, together with its Attribution Parties (as defined in the warrants) would beneficially own, as determined in accordance with Section 13(d) of the Securities Exchange Act of 1934, as amended, more than 49.99% of the shares of Common Stock then issued and outstanding after giving effect to such exercise.
  6. F6. The Pre-Funded Warrants do not expire.
  7. F7. Each of Mr. Edelman, the Advisor, the Master Fund and PXV II disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that any of the Reporting Persons is the beneficial owner of such securities for purposes of Section 16 or for any other purposes.
  8. F8. On October 26, 2026, PXV II received from Sermonix Pre-Funded Warrants exercisable for 2,352,932 shares of Common Stock pursuant to a distribution of securities held by Sermonix to holders of Sermonix common stock.
  9. F9. The Pre-Funded Warrants may not be exercised if, after such exercise, the Master Fund or PVX II, together with its Attribution Parties (as defined in the warrants) would beneficially own, as determined in accordance with Section 13(d) of the Securities Exchange Act of 1934, as amended, more than 19.99% of the shares of Common Stock then issued and outstanding after giving effect to such exercise (the "Beneficial Ownership Limitation"). As of the date hereof, the Beneficial Ownership Limitation does not permit the Master Fund or PXV II to exercise any of its Warrants.
Common shares acquired through warrant exercise 776,648 shares October 26, 2026
Warrant exercise price $0.0010 per share Exercise of pre-funded warrants
Warrant underlying shares held by PXV II 457,645 shares Holding entry
Warrant underlying shares held by the Master Fund 1,372,935 shares Holding entry
Warrant underlying shares distributed to PXV II 2,352,932 shares Distributed by Sermonix on October 26, 2026
Beneficial-ownership limitation 19.99% Applies to warrant exercises by the Master Fund or PXV II and their Attribution Parties
Pre-Funded Warrants financial
"The Pre-Funded Warrants do not expire."
Pre-funded warrants are financial instruments that give investors the right to purchase a company's stock at a set price, but with most or all of the purchase price paid upfront. They function like a coupon or gift card for stock, allowing investors to buy shares later at a fixed price, which can be beneficial if they want to avoid future price increases. This makes them important for investors seeking flexibility and certainty in their investment plans.
Attribution Parties regulatory
"together with its Attribution Parties"
Beneficial Ownership Limitation regulatory
"the “Beneficial Ownership Limitation”"
A beneficial ownership limitation is a rule that caps the percentage of a company’s shares an investor can be treated as owning or controlling for voting, regulatory or tax purposes. It matters to investors because it can restrict how many shares a person or group can buy or vote, affect takeover chances, and influence share liquidity and value — like a speed limit that prevents any single driver from taking over the whole road.

FAQ

AI-generated questions and answers. How Rhea-AI works. Not financial advice.

How many LONA shares did Sermonix acquire through warrant exercise, and at what price?

Sermonix Pharmaceuticals, Inc. exercised pre-funded warrants for 776,648 LeonaBio common shares on October 26, 2026, at an exercise price of $0.0010 per share. Perceptive Advisors LLC, Joseph Edelman, and Perceptive Life Sciences Master Fund Ltd. reported Sermonix’s entire interest rather than a proportionate amount.

What exercise limit applies to the Master Fund and PXV II LONA warrants?

Warrants held by Perceptive Life Sciences Master Fund Ltd. and Perceptive Xontogeny Venture Fund II, LP cannot be exercised if doing so would cause either, together with its Attribution Parties, to own more than 19.99% of LeonaBio common stock then issued and outstanding. As of the report date, the limit did not permit either to exercise any warrants.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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SEC Form 4
FORM 4UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
OMB APPROVAL
OMB Number:3235-0287
Estimated average burden
hours per response:0.5
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.
1. Name and Address of Reporting Person*
PERCEPTIVE ADVISORS LLC

(Last)(First)(Middle)
51 ASTOR PLACE, 10TH FLOOR

(Street)
NEW YORK NEW YORK 10003

(City)(State)(Zip)

UNITED STATES

(Country)
2. Issuer Name and Ticker or Trading Symbol
LeonaBio, Inc. [ LONA ]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
XDirectorX10% Owner
Officer (give title below)Other (specify below)
2a. Foreign Trading Symbol
3. Date of Earliest Transaction (Month/Day/Year)
10/26/2026
6. Individual or Joint/Group Filing (Check Applicable Line)
Form filed by One Reporting Person
XForm filed by More than One Reporting Person
4. If Amendment, Date of Original Filed (Month/Day/Year)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year)2A. Deemed Execution Date, if any (Month/Day/Year)3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeVAmount(A) or (D)Price
Common Stock10/26/2026M776,648A$0.001776,648ISee Footnotes(1)(7)
Common Stock1,529,566ISee Footnotes(2)(7)
Common Stock329,756ISee Footnotes(3)(7)
Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year)3A. Deemed Execution Date, if any (Month/Day/Year)4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 6. Date Exercisable and Expiration Date (Month/Day/Year)7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeV(A)(D)Date ExercisableExpiration DateTitleAmount or Number of Shares
Pre-Funded Warrant (right to buy)$0.00110/26/2026M776,648 (4)(5) (6)Common Stock776,648(4)0ISee Footnotes(1)(7)
Pre-Funded Warrant (right to buy)$0.00112/23/2025(9) (6)Common Stock457,645457,645ISee Footnotes(3)(7)
Pre-Funded Warrant (right to warrant)$0.00112/23/2025(9) (6)Common Stock1,372,9351,372,935ISee Footnotes(2)(7)
Pre-Funded Warrant (right to buy)$0.001 (4)(9) (6)Common Stock2,352,9322,352,932ISee Footnotes(3)(7)(8)
1. Name and Address of Reporting Person*
PERCEPTIVE ADVISORS LLC

(Last)(First)(Middle)
51 ASTOR PLACE, 10TH FLOOR

(Street)
NEW YORK NEW YORK 10003

(City)(State)(Zip)

UNITED STATES

(Country)

Relationship of Reporting Person(s) to Issuer
XDirectorX10% Owner
Officer (give title below)Other (specify below)
1. Name and Address of Reporting Person*
EDELMAN JOSEPH

(Last)(First)(Middle)
51 ASTOR PL, 10TH FLOOR

(Street)
NEW YORK NEW YORK 10003

(City)(State)(Zip)

UNITED STATES

(Country)

Relationship of Reporting Person(s) to Issuer
XDirectorX10% Owner
Officer (give title below)Other (specify below)
1. Name and Address of Reporting Person*
PERCEPTIVE LIFE SCIENCES MASTER FUND LTD

(Last)(First)(Middle)
51 ASTOR PLACE, 10TH FLOOR

(Street)
NEW YORK NEW YORK 10003

(City)(State)(Zip)

UNITED STATES

(Country)

Relationship of Reporting Person(s) to Issuer
XDirectorX10% Owner
Officer (give title below)Other (specify below)
Explanation of Responses:
1. The securities are directly held by Sermonix Pharmaceuticals, Inc. ("Sermonix"). An affiliate of Perceptive Advisors LLC (the "Advisor") currently holds approximately 29% of the outstanding capital stock of Sermonix (excluding securities convertible into shares of Sermonix capital stock). Pursuant to General Instruction 4.b.(iv) of Form 4, the Reporting Persons with this filing have reported the entire amount of Sermonix's interest in the securities, rather than the Reporting Person's proportionate interest in the securities held by Sermonix.
2. The securities are directly held by Perceptive Life Sciences Master Fund Ltd. (the "Master Fund"). The Advisor serves as the investment manager of Master Fund. Joseph Edelman is the managing member of the Advisor.
3. The securities are directly held by Perceptive Xontogeny Venture Fund II, LP ("PXV II"). Perceptive Venture Advisors, LLC serves as the investment manager of PXV II and is controlled by the Advisor, and Perceptive Xontogeny Venture II GP, LLC ("PXV GP") is the general partner of PXV II. Mr. Edelman is the managing member of PXV GP and the Advisor.
4. The securities were issued to Sermonix in exchange for the grant of certain licenses and rights by Sermonix to the Issuer. The Pre-Funded Warrants became exercisable on March 18, 2026 upon receipt by the Issuer of stockholder approval such that the Pre-Funded Warrants can be exercised at any time without restriction or additional stockholder approval.
5. The Pre-Funded Warrants may not be exercised if, after such exercise, Sermonix, together with its Attribution Parties (as defined in the warrants) would beneficially own, as determined in accordance with Section 13(d) of the Securities Exchange Act of 1934, as amended, more than 49.99% of the shares of Common Stock then issued and outstanding after giving effect to such exercise.
6. The Pre-Funded Warrants do not expire.
7. Each of Mr. Edelman, the Advisor, the Master Fund and PXV II disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that any of the Reporting Persons is the beneficial owner of such securities for purposes of Section 16 or for any other purposes.
8. On October 26, 2026, PXV II received from Sermonix Pre-Funded Warrants exercisable for 2,352,932 shares of Common Stock pursuant to a distribution of securities held by Sermonix to holders of Sermonix common stock.
9. The Pre-Funded Warrants may not be exercised if, after such exercise, the Master Fund or PVX II, together with its Attribution Parties (as defined in the warrants) would beneficially own, as determined in accordance with Section 13(d) of the Securities Exchange Act of 1934, as amended, more than 19.99% of the shares of Common Stock then issued and outstanding after giving effect to such exercise (the "Beneficial Ownership Limitation"). As of the date hereof, the Beneficial Ownership Limitation does not permit the Master Fund or PXV II to exercise any of its Warrants.
/s/ Joseph Edelman - for Perceptive Advisors LLC, By: Joseph Edelman, its managing member10/26/2026
/s/ Joseph Edelman - for Perceptive Life Sciences Master Fund Ltd., By: Perceptive Advisors LLC, its investment manager, By: Joseph Edelman, its managing member10/26/2026
/s/ Joseph Edelman10/26/2026
** Signature of Reporting PersonDate
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
* Form 4: SEC 1474 (03-26)

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