STOCK TITAN

[Form 4] Mineralys Therapeutics, Inc. Insider Trading Activity

Filing Impact
(Neutral)
Filing Sentiment
(Negative)
Form Type
4
Rhea-AI Filing Summary

Schedule 13G Filing – iOThree Limited (Ticker: IOTR)

The filing discloses the beneficial ownership of iOThree Limited’s ordinary shares (par value $0.00625) as of 30 June 2025. A total of 25,650,000 ordinary shares are stated as issued and outstanding. Three reporting persons cross-filed the statement:

  • Eng Chye Koh (Singapore citizen) – 19,209,600 shares, representing 74.89 % of the outstanding class, with sole voting and dispositive power.
  • iO3 Strategic Investments Ltd. (British Virgin Islands) – 14,282,400 shares, representing 55.68 %, with sole voting and dispositive power.
  • All Wealthy International Ltd. (British Virgin Islands) – 4,927,200 shares, representing 19.21 %, with sole voting and dispositive power.

The percentages are calculated by each filer against the same 25.65 million share base. Each filer certifies no shared voting or dispositive authority. The reporting persons have executed a joint filing agreement (Exhibit 1) and attest that the information is true, complete and correct as of the signature date, 15 July 2025.

Key observations for investors:

  • Eng Chye Koh alone exceeds the 50 % threshold, implying effective control of corporate actions requiring shareholder approval.
  • Two British Virgin Islands entities—likely investment vehicles—also cross the 5 % reporting threshold, further concentrating ownership.
  • Because the combined disclosed stakes are well above 80 % of total shares, the effective public float appears limited, which may affect trading liquidity and governance dynamics.

Deposito Schedule 13G – iOThree Limited (Ticker: IOTR)

Il deposito rivela la proprietà effettiva delle azioni ordinarie di iOThree Limited (valore nominale $0,00625) al 30 giugno 2025. Sono dichiarate emesse e in circolazione complessivamente 25.650.000 azioni ordinarie. Tre soggetti segnalanti hanno presentato congiuntamente la dichiarazione:

  • Eng Chye Koh (cittadino di Singapore) – 19.209.600 azioni, pari al 74,89% della classe in circolazione, con potere esclusivo di voto e disposizione.
  • iO3 Strategic Investments Ltd. (Isole Vergini Britanniche) – 14.282.400 azioni, pari al 55,68%, con potere esclusivo di voto e disposizione.
  • All Wealthy International Ltd. (Isole Vergini Britanniche) – 4.927.200 azioni, pari al 19,21%, con potere esclusivo di voto e disposizione.

Le percentuali sono calcolate da ciascun dichiarante sulla base dello stesso totale di 25,65 milioni di azioni. Ogni dichiarante certifica di non avere poteri di voto o di disposizione condivisi. I soggetti segnalanti hanno sottoscritto un accordo congiunto di deposito (Allegato 1) e attestano che le informazioni sono veritiere, complete e corrette alla data della firma, 15 luglio 2025.

Osservazioni chiave per gli investitori:

  • Eng Chye Koh da solo supera la soglia del 50%, implicando un controllo effettivo sulle azioni societarie che richiedono l'approvazione degli azionisti.
  • Due entità delle Isole Vergini Britanniche – presumibilmente veicoli di investimento – superano anch’esse la soglia di segnalazione del 5%, concentrando ulteriormente la proprietà.
  • Poiché le partecipazioni complessivamente dichiarate superano l'80% del totale delle azioni, il flottante effettivo pubblico sembra limitato, con possibili impatti sulla liquidità del trading e sulla dinamica di governance.

Presentación Schedule 13G – iOThree Limited (Ticker: IOTR)

La presentación revela la propiedad beneficiaria de las acciones ordinarias de iOThree Limited (valor nominal $0.00625) al 30 de junio de 2025. Se indica un total de 25,650,000 acciones ordinarias emitidas y en circulación. Tres personas informantes presentaron conjuntamente la declaración:

  • Eng Chye Koh (ciudadano de Singapur) – 19,209,600 acciones, que representan el 74.89% de la clase en circulación, con poder exclusivo de voto y disposición.
  • iO3 Strategic Investments Ltd. (Islas Vírgenes Británicas) – 14,282,400 acciones, que representan el 55.68%, con poder exclusivo de voto y disposición.
  • All Wealthy International Ltd. (Islas Vírgenes Británicas) – 4,927,200 acciones, que representan el 19.21%, con poder exclusivo de voto y disposición.

Los porcentajes se calculan por cada declarante sobre la misma base de 25.65 millones de acciones. Cada declarante certifica no compartir autoridad de voto ni disposición. Las personas informantes han firmado un acuerdo conjunto de presentación (Anexo 1) y certifican que la información es verdadera, completa y correcta a la fecha de la firma, 15 de julio de 2025.

Observaciones clave para inversores:

  • Eng Chye Koh por sí solo supera el umbral del 50%, lo que implica un control efectivo sobre las acciones corporativas que requieren aprobación accionarial.
  • Dos entidades de las Islas Vírgenes Británicas – probablemente vehículos de inversión – también superan el umbral de reporte del 5%, concentrando aún más la propiedad.
  • Dado que las participaciones combinadas declaradas superan el 80% del total de acciones, el flotante público efectivo parece limitado, lo que puede afectar la liquidez del mercado y la dinámica de gobernanza.

Schedule 13G 제출 – iOThree Limited (티커: IOTR)

본 제출서는 2025년 6월 30일 기준 iOThree Limited의 보통주(액면가 $0.00625)에 대한 실질 소유권을 공개합니다. 총 25,650,000주의 보통주가 발행 및 유통 중임을 명시합니다. 세 명의 보고자가 공동으로 제출하였습니다:

  • Eng Chye Koh (싱가포르 시민) – 19,209,600주, 유통 주식의 74.89%에 해당하며 단독 의결권 및 처분권 보유.
  • iO3 Strategic Investments Ltd. (영국령 버진아일랜드) – 14,282,400주, 55.68% 보유, 단독 의결권 및 처분권 보유.
  • All Wealthy International Ltd. (영국령 버진아일랜드) – 4,927,200주, 19.21% 보유, 단독 의결권 및 처분권 보유.

비율은 각 보고자가 동일한 2,565만 주 기준으로 계산하였으며, 각 보고자는 의결권 또는 처분권을 공유하지 않음을 인증합니다. 보고자들은 공동 제출 계약서(첨부문서 1)를 체결하였으며, 2025년 7월 15일 서명일 기준 정보가 진실되고 완전하며 정확함을 확인합니다.

투자자를 위한 주요 관찰 사항:

  • Eng Chye Koh 단독으로 50% 이상의 지분을 보유하여 주주 승인 필요한 기업 행위에 대한 실질적 통제를 의미합니다.
  • 영국령 버진아일랜드 소재 두 법인—투자 목적의 법인일 가능성이 높음—도 5% 보고 기준을 넘으며 소유권 집중을 더욱 심화합니다.
  • 공개된 지분 합계가 총 주식의 80%를 훨씬 상회하여, 실제 공중 유통 주식 수가 제한적일 가능성이 있어 거래 유동성과 지배구조에 영향을 줄 수 있습니다.

Dépôt Schedule 13G – iOThree Limited (Symbole : IOTR)

Le dépôt révèle la propriété bénéficiaire des actions ordinaires d’iOThree Limited (valeur nominale de 0,00625 $) au 30 juin 2025. Un total de 25 650 000 actions ordinaires sont déclarées émises et en circulation. Trois personnes déclarantes ont déposé conjointement la déclaration :

  • Eng Chye Koh (citoyen de Singapour) – 19 209 600 actions, représentant 74,89 % de la catégorie en circulation, avec un pouvoir exclusif de vote et de disposition.
  • iO3 Strategic Investments Ltd. (Îles Vierges britanniques) – 14 282 400 actions, représentant 55,68 %, avec un pouvoir exclusif de vote et de disposition.
  • All Wealthy International Ltd. (Îles Vierges britanniques) – 4 927 200 actions, représentant 19,21 %, avec un pouvoir exclusif de vote et de disposition.

Les pourcentages sont calculés par chaque déclarant sur la même base de 25,65 millions d’actions. Chaque déclarant certifie ne pas partager l’autorité de vote ou de disposition. Les personnes déclarantes ont signé un accord de dépôt conjoint (Exhibit 1) et attestent que les informations sont vraies, complètes et exactes à la date de signature, le 15 juillet 2025.

Points clés pour les investisseurs :

  • Eng Chye Koh dépasse seul le seuil de 50 %, impliquant un contrôle effectif des actions corporatives nécessitant l’approbation des actionnaires.
  • Deux entités des Îles Vierges britanniques – probablement des véhicules d’investissement – dépassent également le seuil de déclaration de 5 %, concentrant davantage la propriété.
  • Étant donné que les participations combinées déclarées dépassent largement 80 % du total des actions, le flottant public effectif semble limité, ce qui peut affecter la liquidité des échanges et la dynamique de gouvernance.

Schedule 13G Meldung – iOThree Limited (Ticker: IOTR)

Die Meldung gibt die wirtschaftliche Eigentümerschaft der Stammaktien von iOThree Limited (Nennwert $0,00625) zum 30. Juni 2025 bekannt. Insgesamt sind 25.650.000 Stammaktien ausgegeben und ausstehend. Drei meldende Personen haben die Erklärung gemeinsam eingereicht:

  • Eng Chye Koh (Staatsbürger von Singapur) – 19.209.600 Aktien, was 74,89 % der ausstehenden Aktienklasse entspricht, mit alleinigen Stimm- und Verfügungsrechten.
  • iO3 Strategic Investments Ltd. (Britische Jungferninseln) – 14.282.400 Aktien, entsprechend 55,68 %, mit alleinigen Stimm- und Verfügungsrechten.
  • All Wealthy International Ltd. (Britische Jungferninseln) – 4.927.200 Aktien, entsprechend 19,21 %, mit alleinigen Stimm- und Verfügungsrechten.

Die Prozentsätze wurden von jedem Melder auf derselben Basis von 25,65 Millionen Aktien berechnet. Jeder Melder bestätigt, keine gemeinsame Stimm- oder Verfügungsbefugnis zu haben. Die meldenden Personen haben eine gemeinsame Einreichungsvereinbarung (Anlage 1) unterzeichnet und bestätigen, dass die Angaben zum Unterschriftsdatum, dem 15. Juli 2025, wahr, vollständig und korrekt sind.

Wichtige Beobachtungen für Investoren:

  • Eng Chye Koh überschreitet allein die 50%-Schwelle, was eine effektive Kontrolle über unternehmensbezogene Maßnahmen, die der Zustimmung der Aktionäre bedürfen, bedeutet.
  • Zwei Gesellschaften der Britischen Jungferninseln – vermutlich Investmentvehikel – überschreiten ebenfalls die Meldegrenze von 5 %, was die Eigentumskonzentration weiter erhöht.
  • Da die zusammengerechneten Anteile deutlich über 80 % der Gesamtaktien liegen, erscheint der effektive Streubesitz begrenzt, was die Handelsliquidität und Governance-Dynamik beeinflussen könnte.
Positive
  • High insider commitment: Eng Chye Koh’s 74.89 % stake indicates strong alignment with the company’s long-term performance.
Negative
  • Concentrated control: A single shareholder can unilaterally dictate corporate actions, reducing minority influence.
  • Limited public float: With over 80 % of shares in insider hands, trading liquidity and index eligibility may be constrained.

Insights

TL;DR: Filing confirms overwhelming insider control (75 %) by Eng Chye Koh; float is small, liquidity and governance minority risk rise.

This Schedule 13G shows that Eng Chye Koh controls roughly three-quarters of iOThree’s outstanding shares, granting him near-absolute authority over shareholder votes, director elections and strategic decisions. Two affiliated BVI companies also individually exceed 5 %, reinforcing concentrated ownership. While such alignment can signal strong founder commitment, it simultaneously limits the influence of minority shareholders and may reduce free float, potentially increasing share-price volatility and limiting institutional participation. Because no financial results are provided, the main investment takeaway is structural rather than operational. Overall impact is material, as control dynamics are a key valuation input for small-cap issuers.

TL;DR: Majority control triggers governance red flags; minority protections crucial.

The 13G highlights a classical controlled-company setup. With 74.89 % ownership and sole voting power, Eng Chye Koh can pass ordinary and special resolutions unilaterally. The BVI entities, each above 5 %, might be related, but the filing does not clarify this. Investors should recognize that board independence, related-party transactions and takeover defenses could be influenced by the controlling shareholder. Limited public float (<20 % by implication) may also affect listing-standard exemptions. While not inherently negative, these facts are materially relevant for governance-risk assessment.

Deposito Schedule 13G – iOThree Limited (Ticker: IOTR)

Il deposito rivela la proprietà effettiva delle azioni ordinarie di iOThree Limited (valore nominale $0,00625) al 30 giugno 2025. Sono dichiarate emesse e in circolazione complessivamente 25.650.000 azioni ordinarie. Tre soggetti segnalanti hanno presentato congiuntamente la dichiarazione:

  • Eng Chye Koh (cittadino di Singapore) – 19.209.600 azioni, pari al 74,89% della classe in circolazione, con potere esclusivo di voto e disposizione.
  • iO3 Strategic Investments Ltd. (Isole Vergini Britanniche) – 14.282.400 azioni, pari al 55,68%, con potere esclusivo di voto e disposizione.
  • All Wealthy International Ltd. (Isole Vergini Britanniche) – 4.927.200 azioni, pari al 19,21%, con potere esclusivo di voto e disposizione.

Le percentuali sono calcolate da ciascun dichiarante sulla base dello stesso totale di 25,65 milioni di azioni. Ogni dichiarante certifica di non avere poteri di voto o di disposizione condivisi. I soggetti segnalanti hanno sottoscritto un accordo congiunto di deposito (Allegato 1) e attestano che le informazioni sono veritiere, complete e corrette alla data della firma, 15 luglio 2025.

Osservazioni chiave per gli investitori:

  • Eng Chye Koh da solo supera la soglia del 50%, implicando un controllo effettivo sulle azioni societarie che richiedono l'approvazione degli azionisti.
  • Due entità delle Isole Vergini Britanniche – presumibilmente veicoli di investimento – superano anch’esse la soglia di segnalazione del 5%, concentrando ulteriormente la proprietà.
  • Poiché le partecipazioni complessivamente dichiarate superano l'80% del totale delle azioni, il flottante effettivo pubblico sembra limitato, con possibili impatti sulla liquidità del trading e sulla dinamica di governance.

Presentación Schedule 13G – iOThree Limited (Ticker: IOTR)

La presentación revela la propiedad beneficiaria de las acciones ordinarias de iOThree Limited (valor nominal $0.00625) al 30 de junio de 2025. Se indica un total de 25,650,000 acciones ordinarias emitidas y en circulación. Tres personas informantes presentaron conjuntamente la declaración:

  • Eng Chye Koh (ciudadano de Singapur) – 19,209,600 acciones, que representan el 74.89% de la clase en circulación, con poder exclusivo de voto y disposición.
  • iO3 Strategic Investments Ltd. (Islas Vírgenes Británicas) – 14,282,400 acciones, que representan el 55.68%, con poder exclusivo de voto y disposición.
  • All Wealthy International Ltd. (Islas Vírgenes Británicas) – 4,927,200 acciones, que representan el 19.21%, con poder exclusivo de voto y disposición.

Los porcentajes se calculan por cada declarante sobre la misma base de 25.65 millones de acciones. Cada declarante certifica no compartir autoridad de voto ni disposición. Las personas informantes han firmado un acuerdo conjunto de presentación (Anexo 1) y certifican que la información es verdadera, completa y correcta a la fecha de la firma, 15 de julio de 2025.

Observaciones clave para inversores:

  • Eng Chye Koh por sí solo supera el umbral del 50%, lo que implica un control efectivo sobre las acciones corporativas que requieren aprobación accionarial.
  • Dos entidades de las Islas Vírgenes Británicas – probablemente vehículos de inversión – también superan el umbral de reporte del 5%, concentrando aún más la propiedad.
  • Dado que las participaciones combinadas declaradas superan el 80% del total de acciones, el flotante público efectivo parece limitado, lo que puede afectar la liquidez del mercado y la dinámica de gobernanza.

Schedule 13G 제출 – iOThree Limited (티커: IOTR)

본 제출서는 2025년 6월 30일 기준 iOThree Limited의 보통주(액면가 $0.00625)에 대한 실질 소유권을 공개합니다. 총 25,650,000주의 보통주가 발행 및 유통 중임을 명시합니다. 세 명의 보고자가 공동으로 제출하였습니다:

  • Eng Chye Koh (싱가포르 시민) – 19,209,600주, 유통 주식의 74.89%에 해당하며 단독 의결권 및 처분권 보유.
  • iO3 Strategic Investments Ltd. (영국령 버진아일랜드) – 14,282,400주, 55.68% 보유, 단독 의결권 및 처분권 보유.
  • All Wealthy International Ltd. (영국령 버진아일랜드) – 4,927,200주, 19.21% 보유, 단독 의결권 및 처분권 보유.

비율은 각 보고자가 동일한 2,565만 주 기준으로 계산하였으며, 각 보고자는 의결권 또는 처분권을 공유하지 않음을 인증합니다. 보고자들은 공동 제출 계약서(첨부문서 1)를 체결하였으며, 2025년 7월 15일 서명일 기준 정보가 진실되고 완전하며 정확함을 확인합니다.

투자자를 위한 주요 관찰 사항:

  • Eng Chye Koh 단독으로 50% 이상의 지분을 보유하여 주주 승인 필요한 기업 행위에 대한 실질적 통제를 의미합니다.
  • 영국령 버진아일랜드 소재 두 법인—투자 목적의 법인일 가능성이 높음—도 5% 보고 기준을 넘으며 소유권 집중을 더욱 심화합니다.
  • 공개된 지분 합계가 총 주식의 80%를 훨씬 상회하여, 실제 공중 유통 주식 수가 제한적일 가능성이 있어 거래 유동성과 지배구조에 영향을 줄 수 있습니다.

Dépôt Schedule 13G – iOThree Limited (Symbole : IOTR)

Le dépôt révèle la propriété bénéficiaire des actions ordinaires d’iOThree Limited (valeur nominale de 0,00625 $) au 30 juin 2025. Un total de 25 650 000 actions ordinaires sont déclarées émises et en circulation. Trois personnes déclarantes ont déposé conjointement la déclaration :

  • Eng Chye Koh (citoyen de Singapour) – 19 209 600 actions, représentant 74,89 % de la catégorie en circulation, avec un pouvoir exclusif de vote et de disposition.
  • iO3 Strategic Investments Ltd. (Îles Vierges britanniques) – 14 282 400 actions, représentant 55,68 %, avec un pouvoir exclusif de vote et de disposition.
  • All Wealthy International Ltd. (Îles Vierges britanniques) – 4 927 200 actions, représentant 19,21 %, avec un pouvoir exclusif de vote et de disposition.

Les pourcentages sont calculés par chaque déclarant sur la même base de 25,65 millions d’actions. Chaque déclarant certifie ne pas partager l’autorité de vote ou de disposition. Les personnes déclarantes ont signé un accord de dépôt conjoint (Exhibit 1) et attestent que les informations sont vraies, complètes et exactes à la date de signature, le 15 juillet 2025.

Points clés pour les investisseurs :

  • Eng Chye Koh dépasse seul le seuil de 50 %, impliquant un contrôle effectif des actions corporatives nécessitant l’approbation des actionnaires.
  • Deux entités des Îles Vierges britanniques – probablement des véhicules d’investissement – dépassent également le seuil de déclaration de 5 %, concentrant davantage la propriété.
  • Étant donné que les participations combinées déclarées dépassent largement 80 % du total des actions, le flottant public effectif semble limité, ce qui peut affecter la liquidité des échanges et la dynamique de gouvernance.

Schedule 13G Meldung – iOThree Limited (Ticker: IOTR)

Die Meldung gibt die wirtschaftliche Eigentümerschaft der Stammaktien von iOThree Limited (Nennwert $0,00625) zum 30. Juni 2025 bekannt. Insgesamt sind 25.650.000 Stammaktien ausgegeben und ausstehend. Drei meldende Personen haben die Erklärung gemeinsam eingereicht:

  • Eng Chye Koh (Staatsbürger von Singapur) – 19.209.600 Aktien, was 74,89 % der ausstehenden Aktienklasse entspricht, mit alleinigen Stimm- und Verfügungsrechten.
  • iO3 Strategic Investments Ltd. (Britische Jungferninseln) – 14.282.400 Aktien, entsprechend 55,68 %, mit alleinigen Stimm- und Verfügungsrechten.
  • All Wealthy International Ltd. (Britische Jungferninseln) – 4.927.200 Aktien, entsprechend 19,21 %, mit alleinigen Stimm- und Verfügungsrechten.

Die Prozentsätze wurden von jedem Melder auf derselben Basis von 25,65 Millionen Aktien berechnet. Jeder Melder bestätigt, keine gemeinsame Stimm- oder Verfügungsbefugnis zu haben. Die meldenden Personen haben eine gemeinsame Einreichungsvereinbarung (Anlage 1) unterzeichnet und bestätigen, dass die Angaben zum Unterschriftsdatum, dem 15. Juli 2025, wahr, vollständig und korrekt sind.

Wichtige Beobachtungen für Investoren:

  • Eng Chye Koh überschreitet allein die 50%-Schwelle, was eine effektive Kontrolle über unternehmensbezogene Maßnahmen, die der Zustimmung der Aktionäre bedürfen, bedeutet.
  • Zwei Gesellschaften der Britischen Jungferninseln – vermutlich Investmentvehikel – überschreiten ebenfalls die Meldegrenze von 5 %, was die Eigentumskonzentration weiter erhöht.
  • Da die zusammengerechneten Anteile deutlich über 80 % der Gesamtaktien liegen, erscheint der effektive Streubesitz begrenzt, was die Handelsliquidität und Governance-Dynamik beeinflussen könnte.
SEC Form 4
FORM 4 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
OMB APPROVAL
OMB Number: 3235-0287
Estimated average burden
hours per response: 0.5
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
1. Name and Address of Reporting Person*
Rodman David Malcom

(Last) (First) (Middle)
150 N. RADNOR CHESTER ROAD,
SUITE F200

(Street)
RADNOR PA 19087

(City) (State) (Zip)
2. Issuer Name and Ticker or Trading Symbol
Mineralys Therapeutics, Inc. [ MLYS ]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
Director 10% Owner
X Officer (give title below) Other (specify below)
Chief Medical Officer
3. Date of Earliest Transaction (Month/Day/Year)
07/14/2025
4. If Amendment, Date of Original Filed (Month/Day/Year)
6. Individual or Joint/Group Filing (Check Applicable Line)
X Form filed by One Reporting Person
Form filed by More than One Reporting Person
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 07/14/2025 M(1) 6,349 A $1.08 109,273(2) D
Common Stock 07/14/2025 S(1) 11,366 D $14.5943(3) 97,907 D
Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 6. Date Exercisable and Expiration Date (Month/Day/Year) 7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Stock Option $1.08 07/14/2025 M(1) 6,349 (4) 07/11/2032 Common Stock 6,349 $0 88,880 D
Explanation of Responses:
1. These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on October 25, 2024.
2. This balance includes 1,273 shares purchased under the Mineralys Therapeutics, Inc. 2023 Employee Stock Purchase Plan that were not previously reported.
3. The price reported in Column 4 is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $14.0700 to $14.7594. The Reporting Person undertakes to provide to the Issuer, any securityholder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (3) to this Form 4.
4. The stock option vested with respect to 25% of the underlying shares on July 12, 2022, and vests with respect to the remaining shares in 36 substantially equal monthly installments thereafter.
Remarks:
/s/ Adam Levy, Attorney-in-fact 07/15/2025
** Signature of Reporting Person Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

FAQ

How many iOThree (IOTR) shares does Eng Chye Koh own?

Eng Chye Koh beneficially owns 19,209,600 ordinary shares, or 74.89 % of the outstanding class.

What percentage of iOThree Limited is owned by iO3 Strategic Investments Limited?

iO3 Strategic Investments Limited reports ownership of 14,282,400 shares, representing 55.68 % of the company.

Why was this Schedule 13G filed for IOTR?

Each reporting person surpassed the 5 % beneficial ownership threshold, triggering the SEC’s Schedule 13G reporting requirement.

Does any reporting person share voting power over IOTR shares?

No. All three filers report sole voting and dispositive power and 0 shared authority.

When was the ownership information for iOThree effective?

The ownership figures are stated as of 30 June 2025, with signatures dated 15 July 2025.
Mineralys Therapeutics, Inc.

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