[Form 4] Septerna, Inc. Insider Trading Activity

Rhea-AI Filing Summary

Samira Shaikhly, identified as Chief People Officer of Septerna, Inc. (SEPN), acquired a derivative award disclosed on Form 4. The filing reports a grant of a stock option to purchase 30,000 shares of Septerna common stock with an exercise price of $11.70; the transaction date is 08/07/2025 and the Form 4 is signed on 08/11/2025.

The option is owned directly, the instrument lists an expiration date of 08/06/2035, and the grant vests in 1/48th of the shares monthly on each monthly anniversary of August 1, 2025, subject to continuous service. Following the transaction the reporting person beneficially owns 30,000 options.

Positive

• Grant of 30,000 stock options reported, providing clear disclosure of executive compensation
• Exercise price disclosed: $11.70 per share
• Detailed vesting schedule: 1/48th monthly installments beginning Aug 1, 2025, is specified
• Direct beneficial ownership: 30,000 options held directly following the transaction

Negative

• None.

Insights

Securities Analyst

TL;DR: Routine officer equity grant—30,000 options at $11.70 strike, monthly vesting over 48 months, long exercise window to 2035.

The Form 4 documents a standard executive equity award rather than an open-market transaction. Key facts: 30,000 options, $11.70 exercise price, acquisition date 08/07/2025, direct ownership and expiration on 08/06/2035. The monthly 1/48th vesting schedule ties compensation to continued service; the long expiration is typical for option grants. This disclosure is material as a compensation and governance item but appears routine for executive awards.

Corporate Governance Expert

TL;DR: Governance disclosure shows officer-level grant with time-based vesting; standard signature by attorney-in-fact on Form 4.

The filing identifies the reporting person as an officer (Chief People Officer) and shows the option grant reported via Form 4, signed by an attorney-in-fact (Ran Xiao) on 08/11/2025. The explicit vesting language—1/48th monthly installments beginning Aug 1, 2025—and direct ownership of 30,000 options are clear governance items for stakeholders monitoring executive compensation. No other governance actions or departures are disclosed.

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:			3235-0287
Estimated average burden
hours per response:			0.5

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

Shaikhly Samira

(Last) (First) (Middle)

C/O SEPTERNA, INC.

250 EAST GRAND AVENUE

(Street)

SOUTH SAN FRANCISCO CA 94080

(City) (State) (Zip)

2. Issuer Name and Ticker or Trading Symbol
Septerna, Inc. [ SEPN ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

	Director		10% Owner
X	Officer (give title below)		Other (specify below)
	Chief People Officer

3. Date of Earliest Transaction (Month/Day/Year)
08/07/2025

4. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Stock Option (Right to Buy)	$11.7	08/07/2025		A		30,000		(1)	08/06/2035	Common Stock	30,000	$0	30,000	D

Explanation of Responses:

1. 1/48th of the shares subject to such option shall vest and become exercisable in substantially equal monthly installments on each monthly anniversary of August 1, 2025, subject to the Reporting Person's continuous service to the Issuer on each such date.

	/s/ Ran Xiao, Attorney-in-Fact	08/11/2025
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

FAQ

What did SEPN insider Samira Shaikhly acquire on 08/07/2025?

She was granted a stock option to purchase 30,000 shares with an exercise price of $11.70; transaction date 08/07/2025.

What is the vesting schedule for the options reported by SEPN (Form 4)?

The options vest in 1/48th of the shares each month on monthly anniversaries beginning August 1, 2025, subject to continuous service.

When do the options expire and what ownership form was reported?

The option lists an expiration date of 08/06/2035, and the filing reports direct beneficial ownership of 30,000 options.

Who signed the Form 4 and when was it filed?

The Form 4 is signed by Ran Xiao, Attorney-in-Fact on 08/11/2025; the reported transaction date is 08/07/2025.

What is the reporting person's role at Septerna (SEPN)?

The reporting person is identified as Chief People Officer and the form indicates it was filed by one reporting person.