[144] Spyre Therapeutics, Inc. SEC Filing

Rhea-AI Filing Summary

SYRE filed a Rule 144 notice reporting a planned sale of 16,667 shares via exercise of stock options on 06/03/2026. The filing also lists prior 10b5-1 sales: 78,333 shares on 05/01/2026 for $5,600,884.57 and 7,958 shares on 04/01/2026 for $397,900.00.

Key Figures

Planned sale via option exercise: 16,667 shares 10b5-1 sale (May): 78,333 shares 10b5-1 sale (Apr): 7,958 shares +1 more

4 metrics

Planned sale via option exercise 16,667 shares Exercise of Stock Options on 06/03/2026

10b5-1 sale (May) 78,333 shares Sale on 05/01/2026 for $5,600,884.57

10b5-1 sale (Apr) 7,958 shares Sale on 04/01/2026 for $397,900.00

Settlement method Cash Exercise and settlement method listed for 06/03/2026 transaction

Key Terms

10b5-1, Exercise of Stock Options, Rule 144

3 terms

10b5-1 regulatory

"10b5-1 Sales for SHELDON SLOAN 221 Crescent Street Building 23"

A 10b5-1 plan is a pre-set schedule that lets company insiders buy or sell shares according to written instructions made when they do not possess material, nonpublic information. Think of it as a timed automatic payment for stock trades: it helps insiders avoid accusations of trading on secret information and gives outside investors a clearer signal about whether sales are routine or potentially informative about the company’s prospects.

Exercise of Stock Options financial

"Securities To Be Sold | Common | 06/03/2026 | Exercise of Stock Options"

Rule 144 regulatory

"Filer Information | 144: Filer Information"

Rule 144 is a U.S. securities regulation that sets conditions under which restricted or insider-held shares can be legally resold to the public, such as required holding periods, availability of public information, limits on how much can be sold at once, and certain filing requirements. For investors it matters because it determines when previously locked-up shares can enter the market — like a release valve that can increase supply, affect share price, and signal insider intent.

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Form 144 Filer Information	UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 144 NOTICE OF PROPOSED SALE OF SECURITIES PURSUANT TO RULE 144 UNDER THE SECURITIES ACT OF 1933
FORM 144

144: Filer Information

Filer CIK
Filer CCC
Is this a LIVE or TEST Filing?	LIVE TEST
Submission Contact Information
Name
Phone
E-Mail Address

144: Issuer Information

Name of Issuer

SEC File Number

Address of Issuer

Phone

Name of Person for Whose Account the Securities are To Be Sold

See the definition of "person" in paragraph (a) of Rule 144. Information is to be given not only as to the person for whose account the securities are to be sold but also as to all other persons included in that definition. In addition, information shall be given as to sales by all persons whose sales are required by paragraph (e) of Rule 144 to be aggregated with sales for the account of the person filing this notice.

Relationship to Issuer

144: Securities Information

Title of the Class of Securities To Be Sold	Name and Address of the Broker	Number of Shares or Other Units To Be Sold	Aggregate Market Value	Number of Shares or Other Units Outstanding	Approximate Date of Sale	Name the Securities Exchange
Common	Morgan Stanley Smith Barney LLC Executive Financial Services 1 New York Plaza 8th Floor New York NY 10004	16667	1152689.72	86841253	06/03/2026	NASDAQ

Furnish the following information with respect to the acquisition of the securities to be sold and with respect to the payment of all or any part of the purchase price or other consideration therefor:

144: Securities To Be Sold

Title of the Class	Date you Acquired	Nature of Acquisition Transaction	Name of Person from Whom Acquired	Is this a Gift?	Date Donor Acquired	Amount of Securities Acquired	Date of Payment	Nature of Payment *
Common	06/03/2026	Exercise of Stock Options	Issuer			16667	06/03/2026	Cash

* If the securities were purchased and full payment therefor was not made in cash at the time of purchase, explain in the table or in a note thereto the nature of the consideration given. If the consideration consisted of any note or other obligation, or if payment was made in installments describe the arrangement and state when the note or other obligation was discharged in full or the last installment paid.

Furnish the following information as to all securities of the issuer sold during the past 3 months by the person for whose account the securities are to be sold.

144: Securities Sold During The Past 3 Months

Name and Address of Seller	Title of Securities Sold	Date of Sale	Amount of Securities Sold	Gross Proceeds
10b5-1 Sales for SHELDON SLOAN 221 Crescent Street Building 23 Waltham MA 02453	Common	05/01/2026	78333	5600884.57
10b5-1 Sales for SHELDON SLOAN 221 Crescent Street Building 23 Waltham MA 02453	Common	04/01/2026	7958	397900.00

144: Remarks and Signature

Remarks

Date of Notice

Date of Plan Adoption or Giving of Instruction, If Relying on Rule 10b5-1

ATTENTION:

The person for whose account the securities to which this notice relates are to be sold hereby represents by signing this notice that he does not know any material adverse information in regard to the current and prospective operations of the Issuer of the securities to be sold which has not been publicly disclosed. If such person has adopted a written trading plan or given trading instructions to satisfy Rule 10b5-1 under the Exchange Act, by signing the form and indicating the date that the plan was adopted or the instruction given, that person makes such representation as of the plan adoption or instruction date.

Signature

ATTENTION: Intentional misstatements or omission of facts constitute Federal Criminal Violations (See 18 U.S.C. 1001)