Form 144: 15,000-Share Sale Notice for SYRE

Morgan Stanley Smith Barney LLC Executive Financial Services filed a Form 144 notice for the sale of 15,000 shares of Common stock in connection with a stock option exercise to occur on 06/25/2026.

Rhea-AI Filing Summary

Morgan Stanley Smith Barney LLC Executive Financial Services filed a Form 144 notice for the sale of 15,000 shares of Common stock in connection with a stock option exercise to occur on 06/25/2026. The filing lists three prior sales by Scott Burrows totaling 27,500 shares on 04/01/2026, 05/01/2026, and 06/01/2026 with aggregate proceeds reported.

Insights

Corporate Governance Specialist

Notice documents an affiliate sale following option exercise and prior dispositions.

The filing records a planned sale of 15,000 shares tied to a stock option exercise scheduled for 06/25/2026. It also lists three prior reported sales by Scott Burrows totaling 27,500 shares across 04/01/2026, 05/01/2026, and 06/01/2026.

These notices are administrative: cash‑flow treatment and whether transactions are discretionary or pursuant to a plan are not disclosed in the excerpt; subsequent filings may provide additional details on timing or method.

Key Figures

Planned sale: 15,000 shares Prior sale - Apr: 7,500 shares Prior sale - May: 12,500 shares +2 more

5 metrics

Planned sale 15,000 shares Stock Option Exercise, 06/25/2026

Prior sale - Apr 7,500 shares Sale on 04/01/2026 by Scott Burrows

Prior sale - May 12,500 shares Sale on 05/01/2026 by Scott Burrows

Prior sale - Jun 7,500 shares Sale on 06/01/2026 by Scott Burrows

Proceeds shown (example) $532,948.25 Proceeds from 06/01/2026 sale (7,500 shares)

Key Terms

Form 144, Stock Option Exercise, Issuer

3 terms

Form 144 regulatory

"Filed notice for proposed sale of securities by an affiliate"

Form 144 is a document that investors must file with the government when they plan to sell a large number of shares of a company's stock. It helps ensure transparency so everyone knows how many shares are being sold and when, which can impact the stock's price.

Stock Option Exercise financial

"Method listed for the 15,000-share sale scheduled 06/25/2026"

A stock option exercise is the act of using a previously granted right to buy shares of a company's stock at a specific, predetermined price by paying that price and receiving the shares. It matters to investors because exercising changes who owns the shares (which can dilute existing ownership), can trigger taxable events and shift potential gains or losses, and affects voting power and the company’s outstanding share count—like turning a voucher into an actual product that becomes part of circulating supply.

Issuer financial

"Role listed alongside the stock option exercise and settlement method"

FAQ

AI-generated questions and answers. How Rhea-AI works. Not financial advice.

What does SYRE's Form 144 filing report?

It reports a proposed sale of 15,000 shares tied to a stock option exercise scheduled for 06/25/2026. The notice documents the intended disposition method and timing as stated in the filing.

Who previously sold shares according to the filing?

The filing lists prior sales by Scott Burrows of 7,500 shares on 04/01/2026, 12,500 shares on 05/01/2026, and 7,500 shares on 06/01/2026. Aggregate proceeds are shown for each sale.

What transaction method is shown for the 15,000 shares?

The excerpt states the method as a Stock Option Exercise with the seller listed as Issuer and the settlement method as Cash on 06/25/2026, per the Form 144 fields.

Does the filing state who receives proceeds from the sale?

The filing identifies the transaction as an exercise and sale linked to the Issuer and notes Cash settlement, but it does not specify recipient breakdown beyond the named parties in the excerpt.

Are the amounts from prior sales included in the Form 144 summary?

Yes. The filing shows prior transactions by Scott Burrows totaling 27,500 shares across three dates with listed proceeds for each trade in the excerpt.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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Accepted by SEC EDGAR 06/25/2026 - 04:03 PM EDT Learn about SEC filing dates

Form 144 Filer Information	UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 144 NOTICE OF PROPOSED SALE OF SECURITIES PURSUANT TO RULE 144 UNDER THE SECURITIES ACT OF 1933
FORM 144

144: Filer Information

Filer CIK	0001853327
Filer CCC	XXXXXXXX
Is this a LIVE or TEST Filing?	LIVE TEST
Submission Contact Information
Name
Phone
E-Mail Address

144: Issuer Information

Name of Issuer	SPYRE THERAPEUTICS, INC.
SEC File Number	001-37722
Address of Issuer	221 Crescent Street Building 23, Suite 105 Waltham MASSACHUSETTS 02453
Phone	(617) 651-5940
Name of Person for Whose Account the Securities are To Be Sold	SCOTT BURROWS
See the definition of "person" in paragraph (a) of Rule 144. Information is to be given not only as to the person for whose account the securities are to be sold but also as to all other persons included in that definition. In addition, information shall be given as to sales by all persons whose sales are required by paragraph (e) of Rule 144 to be aggregated with sales for the account of the person filing this notice.
Relationship to Issuer	Officer

144: Securities Information

Title of the Class of Securities To Be Sold	Name and Address of the Broker	Number of Shares or Other Units To Be Sold	Aggregate Market Value	Number of Shares or Other Units Outstanding	Approximate Date of Sale	Name the Securities Exchange
Common	Morgan Stanley Smith Barney LLC Executive Financial Services 1 New York Plaza 8th Floor New York NY 10004	15000	1306980.00	86841253	06/25/2026	NASDAQ

Furnish the following information with respect to the acquisition of the securities to be sold and with respect to the payment of all or any part of the purchase price or other consideration therefor:

144: Securities To Be Sold

Title of the Class	Date you Acquired	Nature of Acquisition Transaction	Name of Person from Whom Acquired	Is this a Gift?	Date Donor Acquired	Amount of Securities Acquired	Date of Payment	Nature of Payment *
Common	06/25/2026	Stock Option Exercise	Issuer			15000	06/25/2026	Cash

* If the securities were purchased and full payment therefor was not made in cash at the time of purchase, explain in the table or in a note thereto the nature of the consideration given. If the consideration consisted of any note or other obligation, or if payment was made in installments describe the arrangement and state when the note or other obligation was discharged in full or the last installment paid.

Furnish the following information as to all securities of the issuer sold during the past 3 months by the person for whose account the securities are to be sold.

144: Securities Sold During The Past 3 Months

Name and Address of Seller	Title of Securities Sold	Date of Sale	Amount of Securities Sold	Gross Proceeds
SCOTT BURROWS 221 Crescent Street Building 23, Suite 105 Waltham MA 02453	Common	06/01/2026	7500	532948.25
SCOTT BURROWS 221 Crescent Street Building 23, Suite 105 Waltham MA 02453	Common	05/01/2026	12500	892168.75
SCOTT BURROWS 221 Crescent Street Building 23, Suite 105 Waltham MA 02453	Common	04/01/2026	7500	370066.25

144: Remarks and Signature

Remarks
Date of Notice	06/25/2026
ATTENTION:
The person for whose account the securities to which this notice relates are to be sold hereby represents by signing this notice that he does not know any material adverse information in regard to the current and prospective operations of the Issuer of the securities to be sold which has not been publicly disclosed. If such person has adopted a written trading plan or given trading instructions to satisfy Rule 10b5-1 under the Exchange Act, by signing the form and indicating the date that the plan was adopted or the instruction given, that person makes such representation as of the plan adoption or instruction date.
Signature	/s/ Scott Burrows
ATTENTION: Intentional misstatements or omission of facts constitute Federal Criminal Violations (See 18 U.S.C. 1001)