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Clearside Biomedical, Inc. (CLSD) Financials

CLSD
Trailing 12 months to September 30, 2025
Revenue $3.3M -56.8% YoY
Net Income -$26.0M +18.5% YoY
EPS (Diluted) -$0.47 FY2024 annual
Free Cash Flow -$21.7M -10.9% YoY
Source SEC Filings (10-K/10-Q) Latest period Q3 FY2025, ended Sep 30, 2025 Reported Currency USD FYE December

Newest figures come from the 10-Q for Q3 FY2025, filed Nov 14, 2025. Each column of the statement tables below links to the filing it was taken from, and every filing is listed on the CLSD SEC filings page.

Clearside Biomedical, Inc. (CLSD) reported $3.3M in revenue over the twelve months to Sep 30, 2025, down 56.8% from the prior twelve months. This page shows its income statement, balance sheet, cash flow statement, and key financial ratios. View 11 years of annual fundamentals and quarterly data, with year-over-year growth rates and compound annual growth rates (CAGR). All figures are derived from SEC filings (10-K and 10-Q reports).

Rhea AI CLSD FY2024

This development-stage business spends far more on research than it earns, leaving financing—not revenue—to support operations.

In FY2024, research and development consumed $18.6M against revenue of just $1.7M, while operating cash flow was -$24.7M. That combination means reported sales are not yet funding the development effort; the business remains financed primarily through capital raised rather than internally generated cash.

The balance sheet has shifted from positive to negative equity: liabilities reached $64.0M against assets of $25.1M in FY2024, making solvency—not short-term bill coverage—the more informative balance-sheet lens. The current ratio remained 4.4x, so current assets exceeded current liabilities even as total obligations exceeded total assets.

Cash consumption is overwhelmingly operational rather than investment-driven. FY2024 free cash flow was -$25.7M versus operating cash flow of -$24.7M, indicating capital spending added relatively little to the cash requirement. Revenue also remained far below its FY2021 level of $29.6M, showing that the earlier commercial scale was not sustained.

[ NOT FINANCIAL ADVICE ]

Financial Health Signals

Cash Runway Dilution R&DIntensity Revenue Progress BurnTrend BalanceSheet 43 / 100
Financial Health Score 43/100
Scored as: Emerging companies peer group

Scored against emerging companies for FY2024. Each of the six dimensions is a percentile rank within that peer group; the overall is their average, with missing dimensions counted as zero out of six. A high score means strong standing among peers, not absolute cross-industry strength. How this score is calculated →

Health score ≠ stock price. This rates the quality of Clearside Biomedical, Inc.'s business: profitability, growth, balance sheet strength. It doesn't tell you whether the stock is a good buy at today's price. Not financial advice. Use it alongside valuation analysis and your own research.

Cash Runway
0

Not available for Clearside Biomedical, Inc., and counted as zero in the overall score.

Dilution
96

Clearside Biomedical, Inc. had 5M shares outstanding at the end of fiscal year 2024, against 63M in fiscal year 2023. Dilution ranks emerging companies on how fast that count has grown over three years, where a slower rise is the better one, and Clearside Biomedical, Inc. scores 96/100 among other emerging companies.

R&D Intensity
84

Clearside Biomedical, Inc. spent $18.6M on research and development in fiscal year 2024, which was 60.9% of its operating costs that year. R&D Intensity ranks emerging companies on the share of operating costs that goes into research, and Clearside Biomedical, Inc. scores 84/100 among other emerging companies.

Revenue Progress
58

Clearside Biomedical, Inc. reported revenue of $1.7M in fiscal year 2024, against $8.2M in fiscal year 2023. Revenue Progress ranks emerging companies on the three-year path of that line, and Clearside Biomedical, Inc. scores 58/100 among other emerging companies.

Burn Trend
21

Clearside Biomedical, Inc.'s operations used $24.7M of cash in fiscal year 2024, against $18.1M used in fiscal year 2023. Burn Trend ranks emerging companies on which way that figure has moved over three years, and Clearside Biomedical, Inc. scores 21/100 among other emerging companies.

Balance Sheet
0

Not available for Clearside Biomedical, Inc., and counted as zero in the overall score.

Altman Z-Score Distress
-22.72

Clearside Biomedical, Inc. scores -22.72, below the 1.81 distress threshold. The score is driven primarily by a large market capitalization ($2.1M) relative to total liabilities ($64.0M). This indicates elevated financial distress risk and warrants close attention to liquidity and debt levels.

Distress-screening estimate for non-financial companies. Not computed for banks or insurers, where the Altman model does not apply.

Piotroski F-Score Partial
3/8

Clearside Biomedical, Inc. passes 3 of 8 computable financial strength tests (1 of the nine could not be computed from available data). 1 of 4 profitability signals pass, all 2 leverage/liquidity signals pass, neither operating efficiency signal passes.

Earnings Quality No Cash Backing
N/A

Clearside Biomedical, Inc. reported a net loss of $34.4M while operations used $24.7M of cash. With neither figure positive, the ratio between the two carries no quality signal.

Key Financial Metrics

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Earnings & Revenue

Revenue
$201K
YoY-80.6%
QoQ-59.1%
5Y CAGR-43.3%

Clearside Biomedical, Inc. generated $201K in revenue in Q3 2025. This represents a decrease of 80.6% from the same quarter a year earlier. Against the prior quarter it is down 59.1%.

Net Income
-$6.0M
YoY+22.3%
QoQ-32.9%

Clearside Biomedical, Inc. reported -$6.0M in net income in Q3 2025. This represents an increase of 22.3% from the same quarter a year earlier. Against the prior quarter it is down 32.9%.

EPS (Diluted)
-$1.14
YoY+26.0%

Clearside Biomedical, Inc. earned -$1.14 per diluted share (EPS) in Q3 2025. This represents an increase of 26.0% from the same quarter a year earlier.

EBITDA

Not reported for Q3 2025.

Cash & Balance Sheet

Free Cash Flow
-$5.5M
YoY+8.1%
QoQ-15.9%

Clearside Biomedical, Inc. recorded an outflow of $5.5M in free cash flow in Q3 2025, representing a cash shortfall after capex. This represents an increase of 8.1% from the same quarter a year earlier. Against the prior quarter it is down 15.9%.

Cash & Debt
$6.8M
YoY-51.0%
QoQ-27.5%
5Y CAGR-14.4%
10Y CAGR+5.0%

Clearside Biomedical, Inc. held $6.8M in cash as of Q3 2025; long-term debt is not reported for that period.

Shares Outstanding
5M
YoY-93.1%
5Y CAGR-35.9%

Clearside Biomedical, Inc. had 5M shares outstanding in Q3 2025. This represents a decrease of 93.1% from the same quarter a year earlier.

Dividends Per Share

Not reported for Q3 2025.

Margins & Returns

Gross Margin
100.0%
YoY0.0pp
QoQ0.0pp

Clearside Biomedical, Inc.'s gross margin was 100.0% in Q3 2025, indicating the percentage of revenue retained after direct costs. That is unchanged from the same quarter a year earlier. It is unchanged from the prior quarter.

Operating Margin

Not shown for Q3 2025: the reported ratio is below -100.0% of revenue, so it does not read as a share of revenue.

Net Margin

Not shown for Q3 2025: the reported ratio is below -100.0% of revenue, so it does not read as a share of revenue.

Return on Equity

Not reported for Q3 2025.

Capital Allocation

R&D Spending
$2.9M
YoY-28.9%
QoQ+85.2%
5Y CAGR-3.4%

Clearside Biomedical, Inc. invested $2.9M in research and development in Q3 2025. This represents a decrease of 28.9% from the same quarter a year earlier. Against the prior quarter it is up 85.2%.

Capital Expenditures
$0
YoY-100.0%

Clearside Biomedical, Inc. reported no capital expenditure in Q3 2025. This represents a decrease of 100.0% from the same quarter a year earlier.

Share Buybacks

Not reported for Q3 2025.

CLSD Income Statement

Figures in USD, abbreviated K (thousand), M (million), B (billion), T (trillion). Negative values carry a minus sign and red type. Each change compares the year with the year before it, and each quarter with the same quarter a year earlier.

CLSD quarterly income statement
MetricQ3'2510-QQ2'2510-QQ1'25Q4'2410-QQ3'2410-QQ2'2410-QQ1'24Q4'23
Revenue$201K-80.6%$492K+446.7%$2.3M+913.0%$306K-95.2%$1.0M+20.8%$90K-91.2%$230K+5650.0%$6.3M+1822.7%
Cost of Revenue$0$0$248K$149K$0-100.0%$0-100.0%$0N/A
Gross Profit$201K-80.6%$492K+446.7%$2.1M+805.2%$157K$1.0M+44.8%$90K-88.8%$230KN/A
R&D Expenses$2.9M-28.9%$1.6M-65.6%$4.5M-20.5%$4.2M-32.8%$4.1M-19.6%$4.6M-7.0%$5.6M+26.2%$6.3M+25.6%
SG&A Expenses$4.3M+51.5%$2.5M-19.5%$2.8M0.0%$3.1M+3.9%$2.8M+7.8%$3.1M-1.6%$2.8M-10.6%$2.9M-7.0%
Operating Income-$7.0M-18.6%-$3.6M+53.0%-$5.2M+36.6%-$7.1M-145.2%-$5.9M+15.9%-$7.6M-4.4%-$8.2M-7.9%-$2.9M+63.9%
EBITDAN/AN/A-$5.1M+37.4%N/AN/AN/A-$8.2M-7.8%N/A
Income Tax$0$0$715KN/A$0$0$0N/A
Net Income-$6.0M+22.3%-$4.5M+40.8%-$8.2M+30.1%-$7.3M-51.2%-$7.7M+17.0%-$7.6M+16.6%-$11.8M-26.8%-$4.8M+50.0%
EPS (Basic)-$1.14+26.0%-$0.06+40.0%-$0.11+35.3%N/A-$1.54-926.7%-$0.10+33.3%-$0.17-13.3%N/A
EPS (Diluted)-$1.14+26.0%-$0.06+40.0%-$0.11+35.3%N/A-$1.54-$0.10+33.3%-$0.17-13.3%N/A
Diluted Shares (Avg)5M+5.0%78M+4.2%77M+10.1%N/A5M75M+21.2%70M+14.2%N/A

Not reported in any period shown, so not listed: Interest Expense.

CLSD Balance Sheet

Figures in USD, abbreviated K (thousand), M (million), B (billion), T (trillion). Negative values carry a minus sign and red type. Each change compares the year with the year before it, and each quarter with the same quarter a year earlier.

CLSD quarterly balance sheet
MetricQ3'2510-QQ2'2510-QQ1'25Q4'2410-QQ3'2410-QQ2'2410-QQ1'24Q4'23
Total Assets$11.6M-60.1%$15.3M-54.8%$19.7M-51.0%$25.1M-26.1%$29.2M-15.3%$33.9M-13.4%$40.1M-10.2%$34.0M-33.7%
Current Assets$8.3M-67.1%$11.8M-60.4%$16.0M-55.8%$21.3M-29.4%$25.1M-18.5%$29.8M-17.6%$36.1M-15.2%$30.1M-39.0%
Cash & Equivalents$6.8M-51.0%$9.4M-48.6%$13.6M-61.5%$20.0M-30.8%$13.9M-51.8%$18.2M-47.9%$35.4M-14.6%$28.9M-40.1%
Accounts Receivable$266K-66.2%$816K$1.5M$507K+8.6%$788K-10.7%$0-100.0%$0$467K
Total Liabilities$65.6M+2.6%$64.1M+3.0%$65.6M+5.9%$64.0M+28.1%$64.0M+35.3%$62.2M+40.9%$62.0M+47.5%$49.9M+22.7%
Current Liabilities$2.8M-50.5%$3.0M-48.1%$5.0M-15.8%$4.8M-29.6%$5.6M-4.1%$5.9M+11.4%$6.0M+19.4%$6.8M+17.8%
Non-Current Liabilities$62.8M+7.6%$61.0M+8.3%$60.6M+8.1%$59.2M+37.3%$58.4M+40.8%$56.3M+44.9%$56.0M+51.3%$43.1M+23.5%
Total Equity-$54.0M-55.1%-$48.7M-72.3%-$45.9M-110.5%-$38.9M-144.2%-$34.8M-170.8%-$28.3M-468.8%-$21.8M-907.8%-$15.9M-250.0%
Retained Earnings-$374.0M-7.5%-$368.0M-8.1%-$363.5M-9.3%-$355.3M-10.7%-$348.0M-10.1%-$340.3M-10.9%-$332.7M-11.7%-$320.9M-11.3%

Not reported in any period shown, so not listed: Short-Term Investments, Inventory, Long-Term Investments, Goodwill, Long-Term Debt.

CLSD Cash Flow Statement

Figures in USD, abbreviated K (thousand), M (million), B (billion), T (trillion). Negative values carry a minus sign and red type. Each change compares the year with the year before it, and each quarter with the same quarter a year earlier.

CLSD quarterly cash flow statement
MetricQ3'2510-QQ2'2510-QQ1'25Q4'2410-QQ3'2410-QQ2'2410-QQ1'24Q4'23
Operating Cash Flow-$5.5M+7.3%-$4.7M+16.7%-$5.8M+25.7%-$5.3M-1161.4%-$5.9M+2.7%-$5.7M-6.4%-$7.9M-8.8%$495K+108.8%
Depreciation & AmortizationN/AN/A$85K+203.6%N/AN/AN/A$28K+86.7%N/A
Stock-Based CompensationN/AN/A$721K-32.1%N/AN/AN/A$1.1M+2.0%N/A
Capital Expenditures$0-100.0%$0-100.0%$9K-84.2%$444K+270.0%$53K-88.1%$423K-61.4%$57K-50.4%$120K+31.9%
Free Cash Flow-$5.5M+8.1%-$4.7M+22.5%-$5.8M+26.2%-$5.7M-1619.5%-$6.0M+8.5%-$6.1M+5.2%-$7.9M-7.9%$375K+106.6%
Investing Cash Flow$0-100.0%$0+100.0%-$9K+84.2%$9.3M+7855.8%$1.5M+448.1%-$11.4M-942.6%-$57K+50.4%-$120K-31.9%
Financing Cash Flow$2.9M+20650.0%$477K-$553K-103.9%$2.1M+908.9%$14K-95.6%$0-100.0%$14.3M+4220.2%-$257K-144.7%

Not reported in any period shown, so not listed: Dividends Paid, Share Buybacks.

CLSD Financial Ratios

Margins and returns are percentages; the remaining ratios are unitless multiples. Each change compares the year with the year before it, and each quarter with the same quarter a year earlier.

CLSD quarterly financial ratios
MetricQ3'2510-QQ2'2510-QQ1'25Q4'2410-QQ3'2410-QQ2'2410-QQ1'24Q4'23
Gross Margin100.0%0.0pp100.0%0.0pp89.4%-10.6pp51.3%100.0%+16.5pp100.0%+20.9pp100.0%N/A
Operating Margin-3502.5%-725.2%-223.4%-2336.3%-571.7%-8433.3%-3569.1%-45.9%
Net Margin-2971.1%-913.6%-352.9%-2387.6%-740.7%-8438.9%-5114.4%-76.1%
Return on Assets-51.3%-24.9pp-29.3%-6.9pp-41.8%-12.5pp-29.1%-14.9pp-26.4%+0.6pp-22.4%+0.9pp-29.3%-8.5pp-14.2%+4.6pp
Current Ratio2.98-1.5x3.87-1.2x3.19-2.9x4.440.0x4.49-0.8x5.07-1.8x6.07-2.5x4.42-4.1x
Asset Turnover0.020.0x0.030.0x0.12+0.1x0.01-0.2x0.040.0x0.000.0x0.010.0x0.19+0.2x
FCF Margin-2726.4%-961.2%-250.6%-1862.1%-574.8%-6781.1%-3438.3%5.9%

Not reported in any period shown, so not listed: Return on Equity, Debt-to-Equity.

Reported as filed but not readable as a share of revenue in the periods where the ratio runs further from zero than a revenue base allows; no change figure is given where either compared period is one of those: Operating Margin, Net Margin, FCF Margin.

Note: Shareholder equity is negative (-$38.9M), which causes debt-to-equity and return on equity ratios to appear negative or not meaningful. This can occur from accumulated losses or large share buyback programs.

Similar Companies

Newest fiscal year on record for each company. The health score is the peer-relative Financial Health Score for that year; a dash means no score is published for it.

Company Fiscal year Revenue Net income Net margin Market cap Health score
Clearside Biomedical, Inc. CLSD FY2024 $1.7M -$34.4M N/A $2.1M 43/100
Tenax Therapeutics, Inc. TENX FY2025 $0 -$52.6M N/A $70.0M —
Neuphoria Therapeutics Inc. NEUP FY2026 $1.2M -$13.5M N/A $18.2M 48/100
Dare Bioscience, Inc. DARE FY2025 $1.0M -$13.4M N/A $15.2M 61/100
Allarity Therapeutics, Inc. ALLR FY2025 $320K -$11.2M N/A $15.8M —
REVIVA PHARMA HLDGS INC RVPH FY2025 N/A -$19.9M N/A $10.2M —

Frequently Asked Questions

What is Clearside Biomedical, Inc.'s annual revenue?

Clearside Biomedical, Inc. (CLSD) reported $1.7M in total revenue for fiscal year 2024. This represents a -79.8% change compared to the previous fiscal year. Revenue measures the total income earned from the company's primary business operations before any expenses are deducted.

How fast is Clearside Biomedical, Inc.'s revenue growing?

Clearside Biomedical, Inc. (CLSD) revenue declined by 79.8% year-over-year, from $8.2M to $1.7M in fiscal year 2024.

Is Clearside Biomedical, Inc. profitable?

No, Clearside Biomedical, Inc. (CLSD) reported a net income of -$34.4M in fiscal year 2024.

Clearside Biomedical, Inc. (CLSD) reported diluted earnings per share of -$0.47 for fiscal year 2024. This represents a 11.3% change compared to the previous fiscal year. EPS represents the portion of a company's net income allocated to each outstanding share of common stock and is widely used to evaluate profitability on a per-share basis.

Clearside Biomedical, Inc. (CLSD) had EBITDA of -$29.2M in fiscal year 2024, measuring earnings before interest, taxes, depreciation, and amortization.

Clearside Biomedical, Inc. (CLSD) had a gross margin of 91.0% in fiscal year 2024, indicating the percentage of revenue retained after direct costs of goods sold.

Clearside Biomedical, Inc. (CLSD) recorded an outflow of $25.7M in free cash flow during fiscal year 2024. This represents a -28.9% change compared to the previous fiscal year. Free cash flow represents the cash a company generates after accounting for capital expenditures, and is widely used to assess financial flexibility and shareholder value.

Clearside Biomedical, Inc. (CLSD) recorded an outflow of $24.7M in operating cash flow during fiscal year 2024, representing cash used by core business activities.

Clearside Biomedical, Inc. (CLSD) had $25.1M in total assets as of fiscal year 2024, including both current and long-term assets.

Clearside Biomedical, Inc. (CLSD) invested $977K in capital expenditures during fiscal year 2024, funding long-term assets and infrastructure.

Clearside Biomedical, Inc. (CLSD) invested $18.6M in research and development during fiscal year 2024.

Clearside Biomedical, Inc. (CLSD) had 5M shares outstanding as of fiscal year 2024.

Clearside Biomedical, Inc. (CLSD) had a current ratio of 4.44 as of fiscal year 2024, which is generally considered healthy.

Clearside Biomedical, Inc. (CLSD) had a return on assets of -136.7% for fiscal year 2024, measuring how efficiently the company uses its assets to generate profit.

Clearside Biomedical, Inc. (CLSD) has negative shareholder equity of -$38.9M as of fiscal year 2024, so no debt-to-equity ratio is reported: dividing debt by equity that is not positive produces a number that cannot be read as leverage. This can occur when accumulated losses exceed invested capital, or after large share buyback programs. Other solvency metrics like the current ratio or interest coverage may be more informative.

Clearside Biomedical, Inc. (CLSD) has an Altman Z-Score of -22.72, placing it in the Distress Zone (elevated bankruptcy risk). The Z-Score combines five financial ratios (working capital, retained earnings, EBIT, market capitalization, and revenue relative to total assets) to predict the likelihood of bankruptcy. Scores above 2.99 indicate financial safety while scores below 1.81 suggest financial distress. Learn more in our complete guide to financial health indicators.

Clearside Biomedical, Inc. (CLSD) has a Piotroski F-Score of 3 out of 8 computable signals; 1 of the nine could not be computed from available data, so the full-scale strength rating is not shown. The F-Score evaluates nine binary signals across profitability (positive ROA, positive cash flow, improving ROA, earnings quality), leverage (decreasing debt, improving liquidity, no share dilution), and operating efficiency (improving gross margin, improving asset turnover). Scores of 7 to 9 indicate strong and improving fundamentals. Learn more in our complete guide to financial health indicators.

Clearside Biomedical, Inc. (CLSD) reported a net loss of $34.4M while operations used $24.7M of cash. With neither figure positive, the ratio between the two carries no quality signal. This ratio compares operating cash flow to net income. A ratio above 1.0x means the company generates more cash than its reported earnings, indicating sustainable, cash-backed profits. Ratios below 1.0x suggest earnings rely on accounting accruals rather than actual cash generation. Learn more in our complete guide to financial health indicators.

Clearside Biomedical, Inc. (CLSD) scores 43 out of 100 on our Financial Health Score, indicating moderate standing within its emerging companies peer group. The score is a 0-100 composite of six dimensions (Cash Runway, Dilution, R&D Intensity, Revenue Progress, Burn Trend, Balance Sheet), each ranked as a percentile relative to companies in the same scoring family (banks against banks, REITs against REITs, and so on) rather than across all industries. It rates the quality of the business, not whether the stock is fairly priced, and is not financial advice. Learn more in our complete guide to financial health indicators.

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