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ProQR Therapeutics N.V. (PRQR) Financials

PRQR
FY2025 annual
Revenue $18.7M -4.6% YoY
Net Income -$49.5M n/m YoY
EPS (Diluted) -$0.47 n/m YoY
Free Cash Flow -$63.2M n/m YoY
Market Cap $182.0M as of Oct 23, 2026
Price / Sales 9.8x on $18.7M revenue, FY2025
Price / Earnings n/m net loss, so no earnings multiple, FY2025
Price / Book 3.1x on $57.9M equity, Q4 FY2025

A multiple compares the market's price with a filed figure; it says what the market pays, not how the business is doing. The market capitalization is the vendor's as of Oct 23, 2026; every other figure is from the SEC filings on this page. Not financial advice.

Source SEC Filings (20-F/6-K) Latest period FY2025, ended Dec 31, 2025 Reported Currency USD FYE December

Newest figures come from the 20-F for FY2025, filed Mar 12, 2026. Each column of the statement tables below links to the filing it was taken from, and every filing is listed on the PRQR SEC filings page.

ProQR Therapeutics N.V. (PRQR) reported $18.7M in revenue for fiscal year 2025, down 4.6% from the prior fiscal year. This page shows its income statement, balance sheet, cash flow statement, and key financial ratios. View 11 years of annual fundamentals and quarterly data, with year-over-year growth rates and compound annual growth rates (CAGR). All figures are derived from SEC filings (10-K and 10-Q reports).

Financial Health Signals

Financial health score not available

ProQR Therapeutics N.V. does not currently provide enough eligible data for a peer-relative financial health score, so none is published. The signals and metrics below are current.

Altman Z-Score Distress
-4.75

ProQR Therapeutics N.V. scores -4.75, below the 1.81 distress threshold. The score is pulled down most by an accumulated deficit of $548.7M against total assets of $132.3M. This indicates elevated financial distress risk and warrants close attention to liquidity and debt levels.

Distress-screening estimate for non-financial companies. Not computed for banks or insurers, where the Altman model does not apply.

Piotroski F-Score Partial
1/8

ProQR Therapeutics N.V. passes 1 of 8 computable financial strength tests (1 of the nine could not be computed from available data). No profitability signals pass, no leverage/liquidity signals pass (rising debt, declining liquidity, or share dilution), the one computable operating efficiency signal (asset turnover improving) passes.

Earnings Quality No Cash Backing
N/A

ProQR Therapeutics N.V. reported a net loss of $49.5M while operations used $62.0M of cash. With neither figure positive, the ratio between the two carries no quality signal.

Interest Coverage At Risk
N/A

ProQR Therapeutics N.V. reported an operating loss of $51.0M against $1.1M in interest expense. There is no operating profit to cover interest, so interest must be met from cash reserves or from financing rather than from operations.

Key Financial Metrics

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Earnings & Revenue

Revenue
$5.5M
YoY+23.4%
QoQ+62.7%

ProQR Therapeutics N.V. generated $5.5M in revenue in Q4 2025. This represents an increase of 23.4% from the same quarter a year earlier. Against the prior quarter it is up 62.7%.

Net Income
-$10.5M
YoYn/m
QoQn/m
5Y CAGRn/m

ProQR Therapeutics N.V. reported a net loss of $10.5M in Q4 2025. The change from the same quarter a year earlier is not meaningful, because that figure was zero or negative. The change from the prior quarter is not meaningful, because that quarter’s figure was zero or negative.

EPS (Diluted)
-$0.09
YoYn/m
QoQn/m
5Y CAGRn/m

ProQR Therapeutics N.V. earned -$0.09 per diluted share (EPS) in Q4 2025. The change from the same quarter a year earlier is not meaningful, because that figure was zero or negative. The change from the prior quarter is not meaningful, because that quarter’s figure was zero or negative.

EBITDA

Not reported for Q4 2025.

Cash & Balance Sheet

Free Cash Flow
-$16.3M
YoYn/m
QoQn/m
5Y CAGRn/m

ProQR Therapeutics N.V. recorded an outflow of $16.3M in free cash flow in Q4 2025, representing a cash shortfall after capex. The change from the same quarter a year earlier is not meaningful, because that figure was zero or negative. The change from the prior quarter is not meaningful, because that quarter’s figure was zero or negative.

Cash & Debt
$108.5M
YoY-29.9%
QoQ-13.5%
5Y CAGR+3.2%

ProQR Therapeutics N.V. held $108.5M in cash against $0 in long-term debt as of Q4 2025.

Shares Outstanding
105M
YoY+0.1%
QoQ0.0%

ProQR Therapeutics N.V. had 105M shares outstanding in Q4 2025. This represents an increase of 0.1% from the same quarter a year earlier. It is unchanged from the prior quarter.

Dividends Per Share

Not reported for Q4 2025.

Margins & Returns

Return on Equity
-18.1%
YoY-7.6pp
QoQ+1.2pp
5Y change+5.1pp

ProQR Therapeutics N.V.'s quarterly ROE was -18.1% in Q4 2025: one quarter's net income over shareholder equity, not annualized. This is down 7.6 percentage points from the same quarter a year earlier. Against the prior quarter it is up 1.2 percentage points.

Gross Margin

Not reported for Q4 2025.

Operating Margin

Not shown for Q4 2025: the reported ratio is below -100.0% of revenue, so it does not read as a share of revenue.

Net Margin

Not shown for Q4 2025: the reported ratio is below -100.0% of revenue, so it does not read as a share of revenue.

Capital Allocation

R&D Spending
$11.6M
YoY+6.0%
QoQ-10.4%
5Y CAGR+2.5%

ProQR Therapeutics N.V. invested $11.6M in research and development in Q4 2025. This represents an increase of 6.0% from the same quarter a year earlier. Against the prior quarter it is down 10.4%.

Capital Expenditures
$617K
YoY+348.4%
QoQ+211.3%
5Y CAGR+33.7%

ProQR Therapeutics N.V. invested $617K in capex in Q4 2025, funding long-term assets and infrastructure. This represents an increase of 348.4% from the same quarter a year earlier. Against the prior quarter it is up 211.3%.

Share Buybacks

Not reported for Q4 2025.

PRQR Income Statement

Figures in USD, abbreviated K (thousand), M (million), B (billion), T (trillion). Negative values carry a minus sign and red type. Each change compares the year with the year before it, and each quarter with the same quarter a year earlier.

PRQR quarterly income statement
MetricQ4'2520-FQ3'256-KQ2'256-KQ1'256-KQ4'2420-FQ3'246-KQ2'246-KQ1'246-K
Revenue$5.5M+23.4%$3.4M-21.0%$4.5M-33.5%$4.9M+1.6%$4.5M+22.7%$4.3M+195.4%$6.8M+413.2%$4.8M+574.3%
R&D Expenses$11.6M+6.0%$13.0M+23.9%$13.4M+77.9%$13.3M+32.8%$11.0M+28.4%$10.5M+82.0%$7.5M+17.0%$10.0M+52.0%
Operating Income-$10.7Mn/m-$13.2Mn/m-$14.4Mn/m-$11.7Mn/m-$10.4Mn/m-$9.7Mn/m-$3.9Mn/m-$8.7Mn/m
Interest Expense$2Kn/m$329K-37.1%$226K-58.9%$491K-6.7%-$407K-140.2%$523K+36.0%$549K+7.1%$527Kn/m
Income TaxN/AN/A$21Kn/mN/AN/AN/A-$214Kn/m$3K
Net Income-$10.5Mn/m-$12.9Mn/m-$14.3Mn/m-$10.9Mn/m-$9.6Mn/m-$9.0Mn/m-$2.9Mn/m-$8.3Mn/m
EPS (Basic)-$0.09n/m-$0.12n/m-$0.14n/m-$0.11n/m-$0.09n/m-$0.11n/m-$0.03n/m-$0.10n/m
EPS (Diluted)-$0.09n/m-$0.12n/m-$0.14n/m-$0.11n/m-$0.09n/m-$0.11n/m-$0.03n/m-$0.10n/m
Diluted Shares (Avg)N/A105M+29.0%105M+29.0%105M+29.1%N/A82M+0.8%82M+0.9%82M+0.8%

Not reported in any period shown, so not listed: Cost of Revenue, Gross Profit, SG&A Expenses, EBITDA.

PRQR Balance Sheet

Figures in USD, abbreviated K (thousand), M (million), B (billion), T (trillion). Negative values carry a minus sign and red type. Each change compares the year with the year before it, and each quarter with the same quarter a year earlier.

PRQR quarterly balance sheet
MetricQ4'2520-FQ3'256-KQ2'256-KQ1'256-KQ4'2420-FQ3'246-KQ2'246-KQ1'246-K
Total Assets$132.3M-23.9%$145.9M+22.5%$161.9M+28.0%$163.8M+22.5%$173.9M+14.0%$119.1M-20.8%$126.4M-21.8%$133.7M-22.2%
Current Assets$117.5M-26.2%$130.6M+26.8%$146.3M+34.2%$149.1M+28.9%$159.2M+19.0%$103.0M-22.0%$109.0M-23.9%$115.6M-24.9%
Cash & Equivalents$108.5M-29.9%$125.4M+25.9%$141.0M+66.7%$143.0M+54.6%$154.7M+17.6%$99.6M-21.9%$84.6M-39.8%$92.5M-38.8%
Accounts Receivable$8.0M+105.8%N/AN/AN/A$3.9MN/AN/AN/A
Total Liabilities$74.4M-9.5%$79.0M-13.5%$83.0M-9.0%$78.5M-18.3%$82.2M-23.0%$91.2M-9.9%$91.3M-13.4%$96.1M-11.0%
Current Liabilities$38.1M-5.5%$38.9M-12.0%$38.9M-2.5%$36.4M-2.0%$40.3M+6.4%$44.2M+56.6%$39.9M+59.1%$37.1M+99.1%
Non-Current Liabilities$36.3M-13.4%$40.1M-14.9%$44.1M-14.1%$42.1M-28.5%$41.9M-39.2%$47.1M-35.6%$51.3M-36.1%$59.0M-34.0%
Long-Term Debt$0n/m$0-100.0%$0-100.0%$0-100.0%$0-100.0%$5.0M+64.3%$4.8M+21.7%$4.7M+11.0%
Total Equity$57.9M-36.8%$67.0M+140.5%$78.8M+124.0%$85.2M+126.8%$91.7M+100.2%$27.8M-43.2%$35.2M-37.8%$37.6M-41.4%
Retained Earnings-$548.7Mn/mN/AN/AN/A-$442.2Mn/mN/AN/AN/A

Not reported in any period shown, so not listed: Short-Term Investments, Inventory, Long-Term Investments, Goodwill.

PRQR Cash Flow Statement

Figures in USD, abbreviated K (thousand), M (million), B (billion), T (trillion). Negative values carry a minus sign and red type. Each change compares the year with the year before it, and each quarter with the same quarter a year earlier.

PRQR quarterly cash flow statement
MetricQ4'2520-FQ3'256-KQ2'256-KQ1'256-KQ4'2420-FQ3'246-KQ2'246-KQ1'246-K
Operating Cash Flow-$15.7Mn/m-$14.4Mn/m-$13.4Mn/m-$17.1Mn/m-$9.7Mn/m-$6.3Mn/m-$6.7Mn/m-$16.3M-133.6%
Capital Expenditures$617K+348.4%$198K-37.8%$119K-58.4%$242K-69.4%$138K-79.3%$319K-11.2%$286K-10.9%$790K+434.2%
Free Cash Flow-$16.3Mn/m-$14.6Mn/m-$13.5Mn/m-$17.3Mn/m-$9.8Mn/m-$6.6Mn/m-$7.0Mn/m-$17.1M-135.3%
Investing Cash Flow-$617Kn/m-$198K-101.1%-$119Kn/m-$242Kn/m-$2.9M-152.2%$18.6Mn/m-$286Kn/m-$19.1Mn/m
Financing Cash Flow-$703K-101.0%-$521Kn/m-$345Kn/m-$540Kn/m$73.9Mn/m-$505Kn/m-$302Kn/m-$452Kn/m

Not reported in any period shown, so not listed: Depreciation & Amortization, Stock-Based Compensation, Dividends Paid, Share Buybacks.

PRQR Financial Ratios

Margins and returns are percentages; the remaining ratios are unitless multiples. Each change compares the year with the year before it, and each quarter with the same quarter a year earlier.

PRQR quarterly financial ratios
MetricQ4'2520-FQ3'256-KQ2'256-KQ1'256-KQ4'2420-FQ3'246-KQ2'246-KQ1'246-K
Operating Margin-194.0%-391.5%-320.9%-239.3%-234.1%-226.8%-57.1%-181.5%
Net Margin-190.3%-381.9%-319.1%-223.0%-216.0%-211.0%-42.7%-172.1%
Return on Equity-18.1%-7.6pp-19.3%+13.2pp-18.2%-10.0pp-12.8%+9.2pp-10.5%+2.7pp-32.5%-20.1pp-8.2%+7.2pp-22.0%-6.9pp
Return on Assets-7.9%-2.4pp-8.8%-1.3pp-8.9%-6.6pp-6.6%-0.5pp-5.5%-1.6pp-7.6%-3.6pp-2.3%+3.1pp-6.2%-0.5pp
Current Ratio3.09-0.9x3.36+1.0x3.76+1.0x4.10+1.0x3.95+0.4x2.33-2.3x2.73-3.0x3.11-5.1x
Debt-to-Equity0.000.0x0.00-0.2x0.00-0.1x0.00-0.1x0.00-0.1x0.18+0.1x0.14+0.1x0.13+0.1x
Liabilities-to-Equity1.28+0.4x1.18-2.1x1.05-1.5x0.92-1.6x0.90-1.4x3.28+1.2x2.59+0.7x2.56+0.9x
Asset Turnover0.040.0x0.020.0x0.030.0x0.030.0x0.030.0x0.040.0x0.050.0x0.040.0x
FCF Margin-296.1%-430.4%-301.3%-354.5%-220.1%-154.6%-103.5%-356.5%

Not reported in any period shown, so not listed: Gross Margin.

Reported as filed but not readable as a share of revenue in the periods where the ratio runs further from zero than a revenue base allows; no change figure is given where either compared period is one of those: Operating Margin, Net Margin, FCF Margin.

Similar Companies

Newest fiscal year on record for each company. The health score is the peer-relative Financial Health Score for that year; a dash means no score is published for it.

Company Fiscal year Revenue Net income Net margin Market cap Health score
ProQR Therapeutics N.V. PRQR FY2025 $18.7M -$49.5M N/A $182.0M —
Editas Medicine, Inc. EDIT FY2025 $40.5M -$160.1M N/A $368.6M 44/100
Silence Therapeutics Plc SLN FY2025 $559K -$88.6M N/A $1.2B —
Vor Biopharma Inc. VOR FY2025 N/A -$696.0M N/A $1.1B —

Frequently Asked Questions

What is ProQR Therapeutics N.V.'s annual revenue?

ProQR Therapeutics N.V. (PRQR) reported $18.7M in total revenue for fiscal year 2025. This represents a -4.6% change compared to the previous fiscal year. Revenue measures the total income earned from the company's primary business operations before any expenses are deducted.

How fast is ProQR Therapeutics N.V.'s revenue growing?

ProQR Therapeutics N.V. (PRQR) revenue declined by 4.6% year-over-year, from $19.6M to $18.7M in fiscal year 2025.

Is ProQR Therapeutics N.V. profitable?

No, ProQR Therapeutics N.V. (PRQR) reported a net loss of $49.5M in fiscal year 2025.

ProQR Therapeutics N.V. (PRQR) reported diluted earnings per share of -$0.47 for fiscal year 2025. The change from the previous fiscal year is not meaningful, because that year’s figure was zero or negative. EPS represents the portion of a company's net income allocated to each outstanding share of common stock and is widely used to evaluate profitability on a per-share basis.

As of fiscal year 2025, ProQR Therapeutics N.V. (PRQR) had $108.5M in cash and equivalents against $0 in long-term debt.

ProQR Therapeutics N.V. (PRQR) has a return on equity of -85.4% for fiscal year 2025, measuring how efficiently the company generates profit from shareholder equity.

ProQR Therapeutics N.V. (PRQR) recorded an outflow of $63.2M in free cash flow during fiscal year 2025. The change from the previous fiscal year is not meaningful, because that year’s figure was zero or negative. Free cash flow represents the cash a company generates after accounting for capital expenditures, and is widely used to assess financial flexibility and shareholder value.

ProQR Therapeutics N.V. (PRQR) recorded an outflow of $62.0M in operating cash flow during fiscal year 2025, representing cash used by core business activities.

ProQR Therapeutics N.V. (PRQR) had $132.3M in total assets as of fiscal year 2025, including both current and long-term assets.

ProQR Therapeutics N.V. (PRQR) invested $1.2M in capital expenditures during fiscal year 2025, funding long-term assets and infrastructure.

ProQR Therapeutics N.V. (PRQR) invested $52.5M in research and development during fiscal year 2025.

ProQR Therapeutics N.V. (PRQR) had 105M shares outstanding as of fiscal year 2025.

ProQR Therapeutics N.V. (PRQR) had a current ratio of 3.09 as of fiscal year 2025, which is generally considered healthy.

ProQR Therapeutics N.V. (PRQR) had a debt-to-equity ratio of 0.00 as of fiscal year 2025. We compute it as long-term debt divided by total shareholder equity, where long-term debt is the noncurrent part of the company's borrowings, so debt due within the next twelve months is not counted.

ProQR Therapeutics N.V. (PRQR) had a liabilities-to-equity ratio of 1.28 as of fiscal year 2025, which is total liabilities divided by total shareholder equity. Total liabilities counts every obligation on the balance sheet (payables, deposits, insurance reserves and deferred taxes as well as borrowings), so this ratio usually runs well above debt-to-equity.

ProQR Therapeutics N.V. (PRQR) had a return on assets of -37.4% for fiscal year 2025, measuring how efficiently the company uses its assets to generate profit.

ProQR Therapeutics N.V. (PRQR) has no price-to-earnings ratio at the moment: net loss, so no earnings multiple (FY2025). The market capitalization is $182.0M as of Oct 23, 2026; a multiple compares that price with a filed figure and says nothing about the quality of the business.

ProQR Therapeutics N.V. (PRQR) trades at 9.8x sales, its market capitalization divided by $18.7M revenue, FY2025. The market capitalization is $182.0M as of Oct 23, 2026; a multiple compares that price with a filed figure and says nothing about the quality of the business.

ProQR Therapeutics N.V. (PRQR) has an Altman Z-Score of -4.75, placing it in the Distress Zone (elevated bankruptcy risk). The Z-Score combines five financial ratios (working capital, retained earnings, EBIT, market capitalization, and revenue relative to total assets) to predict the likelihood of bankruptcy. Scores above 2.99 indicate financial safety while scores below 1.81 suggest financial distress. Learn more in our complete guide to financial health indicators.

ProQR Therapeutics N.V. (PRQR) has a Piotroski F-Score of 1 out of 8 computable signals; 1 of the nine could not be computed from available data, so the full-scale strength rating is not shown. The F-Score evaluates nine binary signals across profitability (positive ROA, positive cash flow, improving ROA, earnings quality), leverage (decreasing debt, improving liquidity, no share dilution), and operating efficiency (improving gross margin, improving asset turnover). Scores of 7 to 9 indicate strong and improving fundamentals. Learn more in our complete guide to financial health indicators.

ProQR Therapeutics N.V. (PRQR) reported a net loss of $49.5M while operations used $62.0M of cash. With neither figure positive, the ratio between the two carries no quality signal. This ratio compares operating cash flow to net income. A ratio above 1.0x means the company generates more cash than its reported earnings, indicating sustainable, cash-backed profits. Ratios below 1.0x suggest earnings rely on accounting accruals rather than actual cash generation. Learn more in our complete guide to financial health indicators.

ProQR Therapeutics N.V. (PRQR) reported an operating loss of $51.0M against $1.1M in interest expense. There is no operating profit to cover interest, so interest must be met from cash reserves or from financing rather than from operations. This ratio divides operating income by interest expense. Ratios above 5x indicate strong debt-servicing ability, while ratios below 2x suggest the company may face difficulty meeting interest payments if earnings decline. Learn more in our complete guide to financial health indicators.

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