A multiple compares the market's price with a filed figure; it says what the market pays, not how the business is doing. The market capitalization is the vendor's as of Oct 23, 2026; every other figure is from the SEC filings on this page. Not financial advice.
Newest figures come from the 20-F for FY2025, filed Mar 12, 2026. Each column of the statement tables below links to the filing it was taken from, and every filing is listed on the PRQR SEC filings page.
ProQR Therapeutics N.V. (PRQR) reported $18.7M in revenue for fiscal year 2025, down 4.6% from the prior fiscal year. This page shows its income statement, balance sheet, cash flow statement, and key financial ratios. View 11 years of annual fundamentals and quarterly data, with year-over-year growth rates and compound annual growth rates (CAGR). All figures are derived from SEC filings (10-K and 10-Q reports).
Financial Health Signals
ProQR Therapeutics N.V. does not currently provide enough eligible data for a peer-relative financial health score, so none is published. The signals and metrics below are current.
ProQR Therapeutics N.V. scores -4.75, below the 1.81 distress threshold. The score is pulled down most by an accumulated deficit of $548.7M against total assets of $132.3M. This indicates elevated financial distress risk and warrants close attention to liquidity and debt levels.
Distress-screening estimate for non-financial companies. Not computed for banks or insurers, where the Altman model does not apply.
ProQR Therapeutics N.V. passes 1 of 8 computable financial strength tests (1 of the nine could not be computed from available data). No profitability signals pass, no leverage/liquidity signals pass (rising debt, declining liquidity, or share dilution), the one computable operating efficiency signal (asset turnover improving) passes.
ProQR Therapeutics N.V. reported a net loss of $49.5M while operations used $62.0M of cash. With neither figure positive, the ratio between the two carries no quality signal.
ProQR Therapeutics N.V. reported an operating loss of $51.0M against $1.1M in interest expense. There is no operating profit to cover interest, so interest must be met from cash reserves or from financing rather than from operations.
Key Financial Metrics
Earnings & Revenue
ProQR Therapeutics N.V. generated $5.5M in revenue in Q4 2025. This represents an increase of 23.4% from the same quarter a year earlier. Against the prior quarter it is up 62.7%.
ProQR Therapeutics N.V. reported a net loss of $10.5M in Q4 2025. The change from the same quarter a year earlier is not meaningful, because that figure was zero or negative. The change from the prior quarter is not meaningful, because that quarter’s figure was zero or negative.
ProQR Therapeutics N.V. earned -$0.09 per diluted share (EPS) in Q4 2025. The change from the same quarter a year earlier is not meaningful, because that figure was zero or negative. The change from the prior quarter is not meaningful, because that quarter’s figure was zero or negative.
Not reported for Q4 2025.
Cash & Balance Sheet
ProQR Therapeutics N.V. recorded an outflow of $16.3M in free cash flow in Q4 2025, representing a cash shortfall after capex. The change from the same quarter a year earlier is not meaningful, because that figure was zero or negative. The change from the prior quarter is not meaningful, because that quarter’s figure was zero or negative.
ProQR Therapeutics N.V. held $108.5M in cash against $0 in long-term debt as of Q4 2025.
Not reported for Q4 2025.
Margins & Returns
ProQR Therapeutics N.V.'s quarterly ROE was -18.1% in Q4 2025: one quarter's net income over shareholder equity, not annualized. This is down 7.6 percentage points from the same quarter a year earlier. Against the prior quarter it is up 1.2 percentage points.
Not reported for Q4 2025.
Not shown for Q4 2025: the reported ratio is below -100.0% of revenue, so it does not read as a share of revenue.
Not shown for Q4 2025: the reported ratio is below -100.0% of revenue, so it does not read as a share of revenue.
Capital Allocation
ProQR Therapeutics N.V. invested $11.6M in research and development in Q4 2025. This represents an increase of 6.0% from the same quarter a year earlier. Against the prior quarter it is down 10.4%.
ProQR Therapeutics N.V. invested $617K in capex in Q4 2025, funding long-term assets and infrastructure. This represents an increase of 348.4% from the same quarter a year earlier. Against the prior quarter it is up 211.3%.
Not reported for Q4 2025.
PRQR Income Statement
Figures in USD, abbreviated K (thousand), M (million), B (billion), T (trillion). Negative values carry a minus sign and red type. Each change compares the year with the year before it, and each quarter with the same quarter a year earlier.
| Metric | Q4'2520-F | Q3'256-K | Q2'256-K | Q1'256-K | Q4'2420-F | Q3'246-K | Q2'246-K | Q1'246-K |
|---|---|---|---|---|---|---|---|---|
| Revenue | $5.5M+23.4% | $3.4M-21.0% | $4.5M-33.5% | $4.9M+1.6% | $4.5M+22.7% | $4.3M+195.4% | $6.8M+413.2% | $4.8M+574.3% |
| R&D Expenses | $11.6M+6.0% | $13.0M+23.9% | $13.4M+77.9% | $13.3M+32.8% | $11.0M+28.4% | $10.5M+82.0% | $7.5M+17.0% | $10.0M+52.0% |
| Operating Income | -$10.7Mn/m | -$13.2Mn/m | -$14.4Mn/m | -$11.7Mn/m | -$10.4Mn/m | -$9.7Mn/m | -$3.9Mn/m | -$8.7Mn/m |
| Interest Expense | $2Kn/m | $329K-37.1% | $226K-58.9% | $491K-6.7% | -$407K-140.2% | $523K+36.0% | $549K+7.1% | $527Kn/m |
| Income Tax | N/A | N/A | $21Kn/m | N/A | N/A | N/A | -$214Kn/m | $3K |
| Net Income | -$10.5Mn/m | -$12.9Mn/m | -$14.3Mn/m | -$10.9Mn/m | -$9.6Mn/m | -$9.0Mn/m | -$2.9Mn/m | -$8.3Mn/m |
| EPS (Basic) | -$0.09n/m | -$0.12n/m | -$0.14n/m | -$0.11n/m | -$0.09n/m | -$0.11n/m | -$0.03n/m | -$0.10n/m |
| EPS (Diluted) | -$0.09n/m | -$0.12n/m | -$0.14n/m | -$0.11n/m | -$0.09n/m | -$0.11n/m | -$0.03n/m | -$0.10n/m |
| Diluted Shares (Avg) | N/A | 105M+29.0% | 105M+29.0% | 105M+29.1% | N/A | 82M+0.8% | 82M+0.9% | 82M+0.8% |
Not reported in any period shown, so not listed: Cost of Revenue, Gross Profit, SG&A Expenses, EBITDA.
PRQR Balance Sheet
Figures in USD, abbreviated K (thousand), M (million), B (billion), T (trillion). Negative values carry a minus sign and red type. Each change compares the year with the year before it, and each quarter with the same quarter a year earlier.
| Metric | Q4'2520-F | Q3'256-K | Q2'256-K | Q1'256-K | Q4'2420-F | Q3'246-K | Q2'246-K | Q1'246-K |
|---|---|---|---|---|---|---|---|---|
| Total Assets | $132.3M-23.9% | $145.9M+22.5% | $161.9M+28.0% | $163.8M+22.5% | $173.9M+14.0% | $119.1M-20.8% | $126.4M-21.8% | $133.7M-22.2% |
| Current Assets | $117.5M-26.2% | $130.6M+26.8% | $146.3M+34.2% | $149.1M+28.9% | $159.2M+19.0% | $103.0M-22.0% | $109.0M-23.9% | $115.6M-24.9% |
| Cash & Equivalents | $108.5M-29.9% | $125.4M+25.9% | $141.0M+66.7% | $143.0M+54.6% | $154.7M+17.6% | $99.6M-21.9% | $84.6M-39.8% | $92.5M-38.8% |
| Accounts Receivable | $8.0M+105.8% | N/A | N/A | N/A | $3.9M | N/A | N/A | N/A |
| Total Liabilities | $74.4M-9.5% | $79.0M-13.5% | $83.0M-9.0% | $78.5M-18.3% | $82.2M-23.0% | $91.2M-9.9% | $91.3M-13.4% | $96.1M-11.0% |
| Current Liabilities | $38.1M-5.5% | $38.9M-12.0% | $38.9M-2.5% | $36.4M-2.0% | $40.3M+6.4% | $44.2M+56.6% | $39.9M+59.1% | $37.1M+99.1% |
| Non-Current Liabilities | $36.3M-13.4% | $40.1M-14.9% | $44.1M-14.1% | $42.1M-28.5% | $41.9M-39.2% | $47.1M-35.6% | $51.3M-36.1% | $59.0M-34.0% |
| Long-Term Debt | $0n/m | $0-100.0% | $0-100.0% | $0-100.0% | $0-100.0% | $5.0M+64.3% | $4.8M+21.7% | $4.7M+11.0% |
| Total Equity | $57.9M-36.8% | $67.0M+140.5% | $78.8M+124.0% | $85.2M+126.8% | $91.7M+100.2% | $27.8M-43.2% | $35.2M-37.8% | $37.6M-41.4% |
| Retained Earnings | -$548.7Mn/m | N/A | N/A | N/A | -$442.2Mn/m | N/A | N/A | N/A |
Not reported in any period shown, so not listed: Short-Term Investments, Inventory, Long-Term Investments, Goodwill.
PRQR Cash Flow Statement
Figures in USD, abbreviated K (thousand), M (million), B (billion), T (trillion). Negative values carry a minus sign and red type. Each change compares the year with the year before it, and each quarter with the same quarter a year earlier.
| Metric | Q4'2520-F | Q3'256-K | Q2'256-K | Q1'256-K | Q4'2420-F | Q3'246-K | Q2'246-K | Q1'246-K |
|---|---|---|---|---|---|---|---|---|
| Operating Cash Flow | -$15.7Mn/m | -$14.4Mn/m | -$13.4Mn/m | -$17.1Mn/m | -$9.7Mn/m | -$6.3Mn/m | -$6.7Mn/m | -$16.3M-133.6% |
| Capital Expenditures | $617K+348.4% | $198K-37.8% | $119K-58.4% | $242K-69.4% | $138K-79.3% | $319K-11.2% | $286K-10.9% | $790K+434.2% |
| Free Cash Flow | -$16.3Mn/m | -$14.6Mn/m | -$13.5Mn/m | -$17.3Mn/m | -$9.8Mn/m | -$6.6Mn/m | -$7.0Mn/m | -$17.1M-135.3% |
| Investing Cash Flow | -$617Kn/m | -$198K-101.1% | -$119Kn/m | -$242Kn/m | -$2.9M-152.2% | $18.6Mn/m | -$286Kn/m | -$19.1Mn/m |
| Financing Cash Flow | -$703K-101.0% | -$521Kn/m | -$345Kn/m | -$540Kn/m | $73.9Mn/m | -$505Kn/m | -$302Kn/m | -$452Kn/m |
Not reported in any period shown, so not listed: Depreciation & Amortization, Stock-Based Compensation, Dividends Paid, Share Buybacks.
PRQR Financial Ratios
Margins and returns are percentages; the remaining ratios are unitless multiples. Each change compares the year with the year before it, and each quarter with the same quarter a year earlier.
| Metric | Q4'2520-F | Q3'256-K | Q2'256-K | Q1'256-K | Q4'2420-F | Q3'246-K | Q2'246-K | Q1'246-K |
|---|---|---|---|---|---|---|---|---|
| Operating Margin | -194.0% | -391.5% | -320.9% | -239.3% | -234.1% | -226.8% | -57.1% | -181.5% |
| Net Margin | -190.3% | -381.9% | -319.1% | -223.0% | -216.0% | -211.0% | -42.7% | -172.1% |
| Return on Equity | -18.1%-7.6pp | -19.3%+13.2pp | -18.2%-10.0pp | -12.8%+9.2pp | -10.5%+2.7pp | -32.5%-20.1pp | -8.2%+7.2pp | -22.0%-6.9pp |
| Return on Assets | -7.9%-2.4pp | -8.8%-1.3pp | -8.9%-6.6pp | -6.6%-0.5pp | -5.5%-1.6pp | -7.6%-3.6pp | -2.3%+3.1pp | -6.2%-0.5pp |
| Current Ratio | 3.09-0.9x | 3.36+1.0x | 3.76+1.0x | 4.10+1.0x | 3.95+0.4x | 2.33-2.3x | 2.73-3.0x | 3.11-5.1x |
| Debt-to-Equity | 0.000.0x | 0.00-0.2x | 0.00-0.1x | 0.00-0.1x | 0.00-0.1x | 0.18+0.1x | 0.14+0.1x | 0.13+0.1x |
| Liabilities-to-Equity | 1.28+0.4x | 1.18-2.1x | 1.05-1.5x | 0.92-1.6x | 0.90-1.4x | 3.28+1.2x | 2.59+0.7x | 2.56+0.9x |
| Asset Turnover | 0.040.0x | 0.020.0x | 0.030.0x | 0.030.0x | 0.030.0x | 0.040.0x | 0.050.0x | 0.040.0x |
| FCF Margin | -296.1% | -430.4% | -301.3% | -354.5% | -220.1% | -154.6% | -103.5% | -356.5% |
Not reported in any period shown, so not listed: Gross Margin.
Reported as filed but not readable as a share of revenue in the periods where the ratio runs further from zero than a revenue base allows; no change figure is given where either compared period is one of those: Operating Margin, Net Margin, FCF Margin.
Similar Companies
Newest fiscal year on record for each company. The health score is the peer-relative Financial Health Score for that year; a dash means no score is published for it.
| Company | Fiscal year | Revenue | Net income | Net margin | Market cap | Health score |
|---|---|---|---|---|---|---|
| ProQR Therapeutics N.V. PRQR | FY2025 | $18.7M | -$49.5M | N/A | $182.0M | — |
| Editas Medicine, Inc. EDIT | FY2025 | $40.5M | -$160.1M | N/A | $368.6M | 44/100 |
| Silence Therapeutics Plc SLN | FY2025 | $559K | -$88.6M | N/A | $1.2B | — |
| Vor Biopharma Inc. VOR | FY2025 | N/A | -$696.0M | N/A | $1.1B | — |
Where ProQR Therapeutics N.V. Ranks
Frequently Asked Questions
What is ProQR Therapeutics N.V.'s annual revenue?
ProQR Therapeutics N.V. (PRQR) reported $18.7M in total revenue for fiscal year 2025. This represents a -4.6% change compared to the previous fiscal year. Revenue measures the total income earned from the company's primary business operations before any expenses are deducted.
How fast is ProQR Therapeutics N.V.'s revenue growing?
ProQR Therapeutics N.V. (PRQR) revenue declined by 4.6% year-over-year, from $19.6M to $18.7M in fiscal year 2025.
Is ProQR Therapeutics N.V. profitable?
No, ProQR Therapeutics N.V. (PRQR) reported a net loss of $49.5M in fiscal year 2025.
How much debt does ProQR Therapeutics N.V. have?
As of fiscal year 2025, ProQR Therapeutics N.V. (PRQR) had $108.5M in cash and equivalents against $0 in long-term debt.
What is ProQR Therapeutics N.V.'s return on equity (ROE)?
ProQR Therapeutics N.V. (PRQR) has a return on equity of -85.4% for fiscal year 2025, measuring how efficiently the company generates profit from shareholder equity.
What is ProQR Therapeutics N.V.'s free cash flow?
ProQR Therapeutics N.V. (PRQR) recorded an outflow of $63.2M in free cash flow during fiscal year 2025. The change from the previous fiscal year is not meaningful, because that year’s figure was zero or negative. Free cash flow represents the cash a company generates after accounting for capital expenditures, and is widely used to assess financial flexibility and shareholder value.
What is ProQR Therapeutics N.V.'s operating cash flow?
ProQR Therapeutics N.V. (PRQR) recorded an outflow of $62.0M in operating cash flow during fiscal year 2025, representing cash used by core business activities.
What are ProQR Therapeutics N.V.'s total assets?
ProQR Therapeutics N.V. (PRQR) had $132.3M in total assets as of fiscal year 2025, including both current and long-term assets.
What are ProQR Therapeutics N.V.'s capital expenditures?
ProQR Therapeutics N.V. (PRQR) invested $1.2M in capital expenditures during fiscal year 2025, funding long-term assets and infrastructure.
How much does ProQR Therapeutics N.V. spend on research and development?
ProQR Therapeutics N.V. (PRQR) invested $52.5M in research and development during fiscal year 2025.
What is ProQR Therapeutics N.V.'s current ratio?
ProQR Therapeutics N.V. (PRQR) had a current ratio of 3.09 as of fiscal year 2025, which is generally considered healthy.
What is ProQR Therapeutics N.V.'s debt-to-equity ratio?
ProQR Therapeutics N.V. (PRQR) had a debt-to-equity ratio of 0.00 as of fiscal year 2025. We compute it as long-term debt divided by total shareholder equity, where long-term debt is the noncurrent part of the company's borrowings, so debt due within the next twelve months is not counted.
What is ProQR Therapeutics N.V.'s liabilities-to-equity ratio?
ProQR Therapeutics N.V. (PRQR) had a liabilities-to-equity ratio of 1.28 as of fiscal year 2025, which is total liabilities divided by total shareholder equity. Total liabilities counts every obligation on the balance sheet (payables, deposits, insurance reserves and deferred taxes as well as borrowings), so this ratio usually runs well above debt-to-equity.
What is ProQR Therapeutics N.V.'s return on assets (ROA)?
ProQR Therapeutics N.V. (PRQR) had a return on assets of -37.4% for fiscal year 2025, measuring how efficiently the company uses its assets to generate profit.
What is ProQR Therapeutics N.V.'s P/E ratio?
ProQR Therapeutics N.V. (PRQR) has no price-to-earnings ratio at the moment: net loss, so no earnings multiple (FY2025). The market capitalization is $182.0M as of Oct 23, 2026; a multiple compares that price with a filed figure and says nothing about the quality of the business.
What is ProQR Therapeutics N.V.'s price-to-sales ratio?
ProQR Therapeutics N.V. (PRQR) trades at 9.8x sales, its market capitalization divided by $18.7M revenue, FY2025. The market capitalization is $182.0M as of Oct 23, 2026; a multiple compares that price with a filed figure and says nothing about the quality of the business.
What is ProQR Therapeutics N.V.'s Altman Z-Score?
ProQR Therapeutics N.V. (PRQR) has an Altman Z-Score of -4.75, placing it in the Distress Zone (elevated bankruptcy risk). The Z-Score combines five financial ratios (working capital, retained earnings, EBIT, market capitalization, and revenue relative to total assets) to predict the likelihood of bankruptcy. Scores above 2.99 indicate financial safety while scores below 1.81 suggest financial distress. Learn more in our complete guide to financial health indicators.
What is ProQR Therapeutics N.V.'s Piotroski F-Score?
ProQR Therapeutics N.V. (PRQR) has a Piotroski F-Score of 1 out of 8 computable signals; 1 of the nine could not be computed from available data, so the full-scale strength rating is not shown. The F-Score evaluates nine binary signals across profitability (positive ROA, positive cash flow, improving ROA, earnings quality), leverage (decreasing debt, improving liquidity, no share dilution), and operating efficiency (improving gross margin, improving asset turnover). Scores of 7 to 9 indicate strong and improving fundamentals. Learn more in our complete guide to financial health indicators.
Are ProQR Therapeutics N.V.'s earnings high quality?
ProQR Therapeutics N.V. (PRQR) reported a net loss of $49.5M while operations used $62.0M of cash. With neither figure positive, the ratio between the two carries no quality signal. This ratio compares operating cash flow to net income. A ratio above 1.0x means the company generates more cash than its reported earnings, indicating sustainable, cash-backed profits. Ratios below 1.0x suggest earnings rely on accounting accruals rather than actual cash generation. Learn more in our complete guide to financial health indicators.
Can ProQR Therapeutics N.V. cover its interest payments?
ProQR Therapeutics N.V. (PRQR) reported an operating loss of $51.0M against $1.1M in interest expense. There is no operating profit to cover interest, so interest must be met from cash reserves or from financing rather than from operations. This ratio divides operating income by interest expense. Ratios above 5x indicate strong debt-servicing ability, while ratios below 2x suggest the company may face difficulty meeting interest payments if earnings decline. Learn more in our complete guide to financial health indicators.