AIM ImmunoTech Announces the Presentation of Ampligen Oncology Data at the Recent Annual Meeting of the American Association of Immunologists

Rhea-AI Summary

AIM ImmunoTech (NYSE: AIM) presented clinical trial data for its drug Ampligen at the Annual Meeting of the American Association of Immunologists. Dr. Pawel Kalinski's presentation highlighted Ampligen's unique two-level selectivity when combined with PD-1 blockade or chemotherapy. The drug demonstrated the ability to: 1. Selectively induce CTL-attracting chemokines without triggering counterproductive Treg-attracting chemokines 2. Preferentially activate cancer tissues over healthy tissues The research showed that Ampligen's selective impact on tumor microenvironment stems from its ability to avoid helicase-dependent activation of NFkB, differentiating it from poly-I:C and other TLR ligands.

Positive

• Ampligen demonstrated selective activation of cancer tissues while sparing healthy tissues
• The drug showed unique dual-selectivity in clinical trials
• Ampligen avoided triggering undesirable inflammatory and suppressive factors

Negative

• None.

OCALA, Fla., May 08, 2025 (GLOBE NEWSWIRE) -- AIM ImmunoTech Inc. (NYSE American: AIM) (OTC Pink: AIMI) (“AIM” or the “Company”) today announced the presentation of clinical trial data involving AIM’s drug Ampligen by Pawel Kalinski, MD, PhD, at the recent Annual Meeting of the American Association of Immunologists held May 3-7, 2025, in Honolulu, HI.

The paper, titled “Systemic Infusion of dsRNA (Rintatolimod) plus IFN Promotes Selective Influx of CTLs (but not Treg) into the TME — Counteracting Chemokine Heterogeneity of the TME,” discussed the unique two-level selectivity of action of Ampligen when used as a part of chemokine modulation and combined with PD-1 blockade or chemotherapy. Dr. Kalinski discussed the preclinical data and data from recently completed clinical trials showing the ability of Ampligen to selectively induce the desirable CTL-attracting chemokines, but not the counterproductive Treg-attracting chemokines, which differentiated it from poly-I:C. The second level of selectivity was the preferential activation of cancer tissues, rather than healthy tissues. The mechanistic data discussed by Dr. Kalinski indicate that the selectivity of Ampligen’s impact on the tumor microenvironment result from its avoidance of helicase-dependent activation of NFkB. This allows Ampligen to avoid the induction of TNFα and other NFkB-dependent undesirable inflammatory and suppressive factors, which are commonly induced by poly-I:C and other TLR ligands, and to focus its impact on the tumor tissues, which display elevated levels of endogenous NFkB.

AIM CEO Thomas K. Equels commented: “These findings and Dr. Kalinski’s analysis further support our belief in the potential of Ampligen as a powerful therapeutic for unmet medical needs, including deadly cancers.”

About AIM ImmunoTech Inc.

AIM ImmunoTech Inc. is an immuno-pharma company focused on the research and development of therapeutics to treat multiple types of cancers, immune disorders and viral diseases, including COVID-19. The Company’s lead product is a first-in-class investigational drug called Ampligen^® (rintatolimod), a dsRNA and highly selective TLR3 agonist immuno-modulator with broad spectrum activity in clinical trials for globally important cancers, viral diseases and disorders of the immune system.

For more information, please visit aimimmuno.com and connect with the Company on X, LinkedIn, and Facebook.

Cautionary Statement

This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 (the “PSLRA”). Words such as “may,” “will,” “expect,” “plan,” “anticipate,” “continue,” “believe,” “potential,” “upcoming” and other variations thereon and similar expressions (as well as other words or expressions referencing future events or circumstances) are intended to identify forward-looking statements. Many of these forward-looking statements involve a number of risks and uncertainties. Data, pre-clinical success and clinical success seen to date do not guarantee that Ampligen will be approved as a therapy in oncology. The Company urges investors to consider specifically the various risk factors identified in its most recent Form 10-K, and any risk factors or cautionary statements included in any subsequent Form 10-Q or Form 8-K, filed with the U.S. Securities and Exchange Commission. You are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date of this press release. Among other things, for those statements, the Company claims the protection of the safe harbor for forward-looking statements contained in the PSLRA. The Company does not undertake to update any of these forward-looking statements to reflect events or circumstances that occur after the date hereof.

Investor Contact:

JTC Team, LLC
Jenene Thomas
908.824.0775
AIM@jtcir.com

FAQ

What are the key findings about AIM ImmunoTech's Ampligen drug presented at the immunology conference?

The key findings showed Ampligen's unique two-level selectivity: it selectively induces CTL-attracting chemokines without triggering Treg-attracting chemokines, and preferentially activates cancer tissues over healthy tissues.

How does AIM's Ampligen differ from poly-I:C in cancer treatment?

Ampligen avoids helicase-dependent activation of NFkB, preventing the induction of TNFα and other undesirable inflammatory factors commonly triggered by poly-I:C, allowing more focused impact on tumor tissues.

What is the mechanism of action for AIM ImmunoTech's Ampligen in treating cancer?

Ampligen works through a two-level selective mechanism, inducing desirable CTL-attracting chemokines while avoiding Treg-attracting chemokines, and preferentially targeting cancer tissues due to their elevated NFkB levels.

What potential applications does AIM stock's Ampligen drug target?

According to AIM's CEO, Ampligen shows potential as a therapeutic for unmet medical needs, particularly in treating deadly cancers.