New LifeVantage Research Explores How Protandim® Nrf2 Supports Cellular Defense Against Five Modern Environmental Toxins*

The findings concern cellular responses under laboratory conditions, not toxin removal or prevention of exposure.

Rhea-AI Summary

LifeVantage (LFVN) reported laboratory research examining Protandim Nrf2 and cellular responses to five categories of environmental toxins in controlled conditions. The study tested liver, skin/connective-tissue and intestinal-lining cells, comparing unexposed cells with cells exposed to toxins alone or toxins plus Protandim Nrf2.

Across all five categories, treated cells showed significantly lower oxidative stress signals than cells exposed to toxins alone; some signals were comparable to unexposed cells. These are cell-study findings, not evidence that the product removes toxins or prevents exposure. LifeVantage also launched Cell Care, an educational campaign with a quiz about habits and potential exposures.

Key Figures

Oxidative-stress marker reduction: 40% Environmental toxin categories: 5 Cell types: 3

Oxidative-stress marker reduction

40%

Prior human clinical study; after 30 days

Environmental toxin categories

5

Toxins examined in the in vitro study

Cell types

3

Liver, skin/connective tissue, and intestinal lining cells

Key Terms

in vitro, oxidative stress, cell viability, fluorescent imaging

4 terms

in vitro technical

"its latest in vitro research study examining how five modern environmental toxins"

In vitro describes laboratory tests performed on cells, tissues, or biological molecules outside a living body—literally “in glass,” such as in test tubes or dishes. For investors, in vitro results are an early sign that a drug or technology has a desired effect under controlled conditions, but they don’t guarantee it will work or be safe in animals or people; think of them as a prototype tested on a bench rather than in real-world use.

oxidative stress medical

"evaluate the beneficial effects of Protandim® Nrf2 on oxidative stress"

Oxidative stress is a biological imbalance where damaging, unstable molecules overwhelm the body’s neutralizing defenses, similar to how rust forms when metal is exposed to oxygen and moisture. Investors should care because oxidative stress is linked to many diseases and aging processes, influencing demand for drugs, diagnostics, supplements, and healthcare spending, and it can affect the commercial value and regulatory outlook of related products.

cell viability technical

"researchers evaluated cell viability and used fluorescent imaging"

Cell viability measures how many cells in a sample are alive and functioning versus dead or damaged, similar to counting how many apples in a crate are fresh enough to sell. It matters to investors because high or improving viability can signal a treatment is effective and safe, a manufacturing process is reliable, or a diagnostic is accurate—factors that directly influence clinical trial success, regulatory approval, production yields, and a company’s financial outlook.

fluorescent imaging technical

"used fluorescent imaging to make oxidative stress visible"

A laboratory and clinical imaging technique that makes molecules, cells, or tissues visible by detecting light emitted from fluorescent dyes or proteins after those substances are illuminated with a specific wavelength. It works by applying or expressing a fluorophore that absorbs excitation light and emits a longer-wavelength signal collected by filters and cameras or microscopes; used for cell-level research, diagnostic staining, intraoperative guidance, and some noninvasive clinical imaging. Fluorescent imaging requires a fluorescent agent or intrinsic tissue fluorescence and is limited by light scattering and absorption in tissue, depth penetration, background autofluorescence, and photobleaching of the signal.

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SALT LAKE CITY, Oct. 29, 2026 (GLOBE NEWSWIRE) -- LifeVantage Corporation® (Nasdaq: LFVN) continues to lead the next generation of healthy aging with its latest in vitro research study examining how five modern environmental toxins—pollution, microplastics, ultra-processed foods, hormone disruptors, and pesticides—affect cells and the role Protandim® Nrf2 can play in helping protect against their impact.^† These findings further reinforce LifeVantage’s position as a pioneer in nutrigenomics and the science behind its products that ignite the human body’s natural defense systems.

“Modern life exposes people to things they cannot always see or avoid. Our work begins with a powerful belief: the body has remarkable systems designed to defend itself,” said LifeVantage CEO, Terrence Moorehead. “This research advances our understanding of how Protandim® Nrf2 can support those natural capabilities so people can continue living fully.”* 

Making Cellular Stress Visible
A two-part cell study was designed to further evaluate the beneficial effects of Protandim® Nrf2 on oxidative stress associated with modern toxins encountered in everyday life: microplastics, pollution (fine particulate matter), hormone disruptors (phthalates), pesticides (glyphosate), and ultra-processed foods and diet (methylglyoxal).

Three cell types—from the liver (HepG2), skin and connective tissue (Fibroblasts), and intestinal lining (Caco-2)—were selected to create a multi-tissue exposure platform based on their roles in the body’s defenses against toxin exposure. Each cell type was evaluated under three conditions: without toxin exposure, with toxin exposure, and with toxin exposure combined with Protandim® Nrf2.

“When people hear 'oxidative stress' or ‘environmental toxins,’ they often picture something far removed from their own lives like industrial factories or farming equipment,” said Lisa Barnes, Vice President of Research and Development at LifeVantage. “We wanted to study exposures that feel familiar and modern: the air around us, the foods we eat, and the products we use. What excites me about these findings is the possibility of empowering the human body to meet those everyday challenges by activating the powerful defenses it already has within.”*^†

The Results
The researchers evaluated cell viability and used fluorescent imaging to make oxidative stress visible, with more green indicating a higher oxidative stress signal and less green indicating a lower signal.

The viability data showed that all five tested environmental toxins adversely affected the three cell types: higher exposure levels caused cell death, while lower levels caused considerable cellular damage. Across all five categories, cells exposed to the toxins and then to Protandim® Nrf2 showed significantly lower oxidative stress signals than cells exposed to the stressor alone. In some cases, these signals returned to levels comparable to those observed in unexposed cells.*^†

Example: Microplastics in HepG2

These findings suggest that Protandim® Nrf2 can help support cellular defenses against oxidative stress associated with the tested environmental toxins.*^† The research does not demonstrate that the product removes toxins or prevents exposure but shows how cells responded under controlled laboratory conditions.

The new findings add to previous human clinical research showing that Protandim® Nrf2 reduced a marker of oxidative stress by an average of 40% after 30 days.^††*

Read the full study at LifeVantage.com

Bringing the Science to Everyday Life
Alongside the research, LifeVantage launched Cell Care, a new campaign designed to make cellular health more personal, visible and easy to understand. As part of the campaign, the new Cellular Stress Quiz asks 15 simple questions about everyday habits and potential exposures. Participants receive an educational Modern Life Exposure Score and information about supporting the body’s natural cellular defenses.*

“Cell Care turns complex science into a simple, personal question: What is your everyday routine asking of your cells?” said Wendy Freedman, Vice President of Global Marketing at LifeVantage. “The quiz helps people recognize exposures they may never have considered and gives them an easy way to start a conversation about supporting their bodies from within. Ultimately, it is about helping people make proactive choices and live healthier, longer.”*

For more information about Protandim® Nrf2 and to take the Cellular Stress Quiz, visit www.LifeVantage.com.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. † Results based on a cell study on Protandim® Nrf2. †† Results from a human clinical study. (S.K. Nelson, et al.) on Protandim® Nrf2 showed reduction of oxidative stress by 40% in 30 days.

About LifeVantage Corporation
LifeVantage Corporation (Nasdaq: LFVN), is a pioneer in nutrigenomics—the study of how nutrition and naturally occurring compounds can unlock your genes and the health coded within. Its products work with your unique biology and help your body make what it needs for health. The line of scientifically validated activators includes the flagship Protandim® family of products, TrueScience® Liquid Collagen, MindBody GLP-1 System®, and the comprehensive gut activator, P84, and activation-supporting nutrients such as Omega, D3+, and the Rise AM & Reset PM System®, as well as AXIO® nootropic energy drink mixes, the full TrueScience® line of skin and hair care products, and Petandim®, a pet supplement formulated to combat oxidative stress in dogs.* LifeVantage was founded in 2003 and is headquartered in Lehi, Utah. For more information, visit www.lifevantage.com.

Investor Relations Contact:
Reed Anderson, ICR
(646) 277-1260
reed.anderson@icrinc.com

A photo accompanying this announcement is available at https://www.globenewswire.com/NewsRoom/AttachmentNg/5998c163-bfa3-48f3-9862-39d04e2a4cdf

 

FAQ

AI-generated questions and answers. How Rhea-AI works. Not financial advice.

What did LifeVantage's Protandim Nrf2 environmental toxin study find?

Cells exposed to toxins and then Protandim Nrf2 showed significantly lower oxidative stress signals than cells exposed to the stressor alone across all five tested categories. In some cases, signals were comparable to those in unexposed cells. The results came from controlled laboratory cell experiments.

Which environmental toxins did LifeVantage test with Protandim Nrf2?

The study tested microplastics, fine particulate matter, phthalates, glyphosate and methylglyoxal. These represented the study's categories of microplastics, pollution, hormone disruptors, pesticides, and ultra-processed foods and diet, respectively.