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Monopar Therapeutics Announces Inclusion in the Russell 3000® and Russell 2000® Indexes

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Monopar Therapeutics (MNPR) announced its upcoming inclusion in the Russell 3000® Index and Russell 2000® Index, effective after market close on June 27, 2025. This inclusion follows announcements made on May 23 and May 30, 2025, as part of the annual Russell U.S. Indexes reconstitution. The Russell 2000® Index, a subset of the Russell 3000®, tracks small-cap U.S. equity performance. The inclusion automatically places MNPR in relevant growth and value style indexes for one year. The Russell U.S. Indexes serve as benchmarks for approximately $10.6 trillion in assets as of May 2025. CFO Quan Vu attributed this milestone to the company's transformation and growing recognition of their late-stage ALXN1840 drug candidate for Wilson disease.
Monopar Therapeutics (MNPR) ha annunciato la sua prossima inclusione negli indici Russell 3000® e Russell 2000®, a partire dalla chiusura del mercato del 27 giugno 2025. Questa inclusione segue gli annunci del 23 e 30 maggio 2025, nell'ambito della ristrutturazione annuale degli indici Russell USA. Il Russell 2000®, sottoinsieme del Russell 3000®, monitora la performance delle azioni statunitensi a piccola capitalizzazione. L'inclusione inserisce automaticamente MNPR negli indici di stile crescita e valore pertinenti per un anno. Gli indici Russell USA rappresentano benchmark per circa 10,6 trilioni di dollari in asset a maggio 2025. Il CFO Quan Vu ha attribuito questo traguardo alla trasformazione della società e al crescente riconoscimento del loro candidato farmaco ALXN1840 in fase avanzata per la malattia di Wilson.
Monopar Therapeutics (MNPR) anunció su próxima inclusión en los índices Russell 3000® y Russell 2000®, efectiva tras el cierre del mercado el 27 de junio de 2025. Esta inclusión sigue a los anuncios realizados el 23 y 30 de mayo de 2025, como parte de la reconstitución anual de los índices Russell de EE. UU. El índice Russell 2000®, un subconjunto del Russell 3000®, sigue el rendimiento de acciones estadounidenses de pequeña capitalización. La inclusión coloca automáticamente a MNPR en los índices de estilo de crecimiento y valor relevantes durante un año. Los índices Russell de EE. UU. sirven como referencia para aproximadamente $10.6 billones en activos a mayo de 2025. El CFO Quan Vu atribuyó este hito a la transformación de la compañía y al creciente reconocimiento de su candidato farmacéutico en etapa avanzada ALXN1840 para la enfermedad de Wilson.
Monopar Therapeutics(MNPR)는 2025년 6월 27일 시장 마감 후 발효되는 Russell 3000® 지수와 Russell 2000® 지수에 포함될 예정임을 발표했습니다. 이번 포함은 2025년 5월 23일과 30일에 발표된 연례 Russell 미국 지수 재구성의 일환입니다. Russell 2000® 지수는 Russell 3000®의 하위 집합으로, 미국 소형주 주식 성과를 추적합니다. 이 포함으로 MNPR는 1년 동안 관련 성장 및 가치 스타일 지수에 자동으로 편입됩니다. Russell 미국 지수는 2025년 5월 기준 약 10.6조 달러 자산의 벤치마크 역할을 합니다. CFO Quan Vu는 이 성과를 회사의 변화와 윌슨병 치료를 위한 후기 단계 ALXN1840 후보약물에 대한 인지도 증가 덕분으로 평가했습니다.
Monopar Therapeutics (MNPR) a annoncé son inclusion prochaine dans les indices Russell 3000® et Russell 2000®, effective après la clôture du marché le 27 juin 2025. Cette inclusion fait suite aux annonces des 23 et 30 mai 2025, dans le cadre de la reconstitution annuelle des indices Russell américains. L'indice Russell 2000®, sous-ensemble du Russell 3000®, suit la performance des actions américaines à petite capitalisation. Cette inclusion place automatiquement MNPR dans les indices de style croissance et valeur pertinents pour une durée d'un an. Les indices Russell américains servent de référence pour environ 10,6 trillions de dollars d'actifs en mai 2025. Le directeur financier Quan Vu a attribué cette étape clé à la transformation de l'entreprise et à la reconnaissance croissante de leur candidat médicament en phase avancée ALXN1840 pour la maladie de Wilson.
Monopar Therapeutics (MNPR) gab bekannt, dass das Unternehmen ab dem Börsenschluss am 27. Juni 2025 in den Russell 3000®-Index und den Russell 2000®-Index aufgenommen wird. Diese Aufnahme folgt auf Ankündigungen vom 23. und 30. Mai 2025 im Rahmen der jährlichen Neustrukturierung der Russell US-Indizes. Der Russell 2000®, ein Teil des Russell 3000®, verfolgt die Performance von US-Aktien mit kleiner Marktkapitalisierung. Die Aufnahme führt dazu, dass MNPR automatisch für ein Jahr in die entsprechenden Wachstums- und Value-Stilindizes aufgenommen wird. Die Russell US-Indizes dienen als Benchmark für Vermögenswerte in Höhe von etwa 10,6 Billionen US-Dollar im Mai 2025. CFO Quan Vu führte diesen Meilenstein auf die Transformation des Unternehmens und die zunehmende Anerkennung ihres fortgeschrittenen ALXN1840-Arzneimittelkandidaten für die Wilson-Krankheit zurück.
Positive
  • Inclusion in widely-followed Russell 3000® and Russell 2000® Indexes increases visibility to institutional investors
  • Automatic inclusion in growth and value style indexes broadens potential investor exposure
  • Recognition reflects company's growth and development of late-stage drug candidate ALXN1840
Negative
  • None.

Insights

Monopar's Russell index inclusion will increase institutional visibility and potential passive fund inflows, though fundamentals remain unchanged.

Monopar Therapeutics' addition to the Russell 3000® and Russell 2000® indexes represents a noteworthy development for this clinical-stage biopharmaceutical company. With approximately $10.6 trillion in assets benchmarked against Russell U.S. Indexes, this inclusion creates a structural catalyst for potential increased demand for MNPR shares.

The mechanics behind index inclusion are straightforward but impactful. Once effective after market close on June 27, passive investment vehicles tracking these indexes will need to purchase MNPR shares to mirror the indexes' composition. This typically provides small-cap companies with several benefits:

  • Enhanced trading liquidity as institutional ownership increases
  • Broader visibility among investment professionals
  • Potential stabilization of ownership structure
  • Inclusion in growth and value style indexes, expanding exposure to different investment styles

While index inclusion doesn't alter Monopar's fundamental business operations or accelerate their clinical programs, it does reflect the company's increased market capitalization. The CFO's statement connecting this milestone to their "late-stage ALXN1840 drug candidate for Wilson disease" suggests this program has been a key driver behind their recent market recognition.

For a clinical-stage company without commercial products, improved market access can be particularly valuable for potential future capital raising activities that may be necessary to fund ongoing development programs. The one-year guaranteed membership provides a stable window of enhanced market visibility.

This institutional recognition comes at an interesting time in the company's development, with their Wilson disease candidate apparently progressing through later clinical stages. However, investors should remember that while index inclusion is positive for visibility, clinical trial outcomes and regulatory decisions will remain the primary value drivers for MNPR's long-term prospects.

WILMETTE, Ill., June 03, 2025 (GLOBE NEWSWIRE) -- Monopar Therapeutics Inc. (“Monopar” or the “Company”) (Nasdaq: MNPR), a clinical‐stage biopharmaceutical company focused on developing innovative treatments for patients with unmet medical needs, today announced that it will be added to the broad-market Russell 3000® Index, with automatic inclusion in the small-cap Russell 2000® Index, after the close of U.S. equity markets on June 27, 2025. The inclusion follows the initial announcement on Friday, May 23, and the subsequent update on Friday, May 30, 2025, in connection with the annual reconstitution of the Russell U.S. Indexes.

The Russell 2000® Index tracks the performance of the small-cap segment of the U.S. equity market and is a subset of the Russell 3000® Index – a market capitalization-weighted equity index representing the largest 3,000 U.S. stocks. Inclusion in the Russell 3000® Index also leads to automatic inclusion in the relevant growth and value style indexes. Membership remains in effect for one year until the next reconstitution.

Russell U.S. Indexes, provided by FTSE Russell, are widely used by investment managers and institutional investors as benchmarks for active and passive investment strategies. As of May 2025, approximately $10.6 trillion in assets are benchmarked against the Russell U.S. Indexes.

“This is an important milestone for Monopar and reflects the significant transformation and growth we have experienced over the past year,” said Quan Vu, Monopar’s Chief Financial Officer. “We are honored to be joining the Russell U.S. Indexes, an achievement driven largely by the growing recognition of our late-stage ALXN1840 drug candidate for Wilson disease.”

For more information on the Russell 2000® Index and Russell 3000® Index and the annual reconstitution, please visit the “Russell Reconstitution” section on the FTSE Russell website.

About Monopar Therapeutics Inc.

Monopar Therapeutics is a clinical-stage biopharmaceutical company with late-stage ALXN1840 for Wilson disease, and radiopharmaceutical programs including Phase 1-stage MNPR-101-Zr for imaging advanced cancers, and Phase 1a-stage MNPR-101-Lu and late preclinical-stage MNPR-101-Ac for the treatment of advanced cancers. For more information, visit: www.monopartx.com.

Forward-Looking Statements

Statements contained in this press release regarding matters that are not historical facts are "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995. The words “may,” “will,” “could,” “would,” “should,” “expect,” “plan,” “anticipate,” “intend,” “believe,” “estimate,” “predict,” “project,” “potential,” “continue,” “target” and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. The forward-looking statements involve risks and uncertainties including, but not limited to: uncertainties related to the regulatory process that Monopar intends to initiate related to ALXN1840 and the outcome thereof; the rate of market acceptance and competitiveness in terms of pricing, efficacy and safety, of any products for which Monopar receives marketing approval, and Monopar’s ability to competitively market any such products as compared to larger pharmaceutical firms; Monopar’s ability to raise sufficient funds in order for the Company to support continued preclinical, clinical, regulatory, precommercial and commercial development of its programs and to make contractual milestone payments, as well as its ability to further raise additional funds in the future to support any existing or future product candidate programs through completion of clinical trials, the approval processes and, if applicable, commercialization; and the significant general risks and uncertainties surrounding the research, development, regulatory approval, and commercialization of imaging agents and therapeutics. Actual results may differ materially from those expressed or implied by such forward-looking statements. Risks are described more fully in Monopar's filings with the Securities and Exchange Commission. All forward-looking statements contained in this press release speak only as of the date on which they were made. Monopar undertakes no obligation to update such statements to reflect events that occur or circumstances that exist after the date on which they were made. Any forward-looking statements contained in this press release represent Monopar’s views only as of the date hereof and should not be relied upon as representing its views as of any subsequent date.
  

CONTACT:  

Monopar Therapeutics Inc.
Investor Relations  
Quan Vu  
Chief Financial Officer  
vu@monopartx.com  

Follow Monopar on social media for updates: 

X: @MonoparTx  LinkedIn: Monopar Therapeutics


FAQ

When will Monopar Therapeutics (MNPR) be added to the Russell 3000 and Russell 2000 Indexes?

Monopar Therapeutics will be added to both indexes after the close of U.S. equity markets on June 27, 2025.

What is the significance of MNPR joining the Russell indexes?

The inclusion indicates significant company growth and provides exposure to institutional investors, as approximately $10.6 trillion in assets are benchmarked against Russell U.S. Indexes.

How long will MNPR remain in the Russell indexes?

Membership in the Russell indexes remains in effect for one year until the next annual reconstitution.

What is Monopar's main drug candidate mentioned in relation to this milestone?

ALXN1840, a late-stage drug candidate for Wilson disease, was mentioned as a key factor in the company's growth and recognition.

How many assets are benchmarked against the Russell U.S. Indexes?

As of May 2025, approximately $10.6 trillion in assets are benchmarked against the Russell U.S. Indexes.
Monopar Therapeutics Inc

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198.50M
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Biotechnology
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WILMETTE