Repligen Reports Fourth Quarter and Full Year 2025 Financial Results and Provides 2026 Financial Guidance

Rhea-AI Summary

Repligen (NASDAQ:RGEN) reported Q4 2025 revenue of $198M (up 18% reported, 14% organic) and full-year 2025 revenue of $738M (up 16% reported, 14% organic non-COVID). GAAP net income for FY2025 was $49M, adjusted net income was $97M, and cash plus marketable securities totaled $768M.

For 2026 the company guided to $810M–$840M revenue, 9%–13% organic growth, and adjusted operating margin expansion of ~150 basis points at the midpoint.

Positive

• Revenue +16% for FY2025 to $738M
• Q4 revenue +18% to $198M (14% organic)
• FY2025 adjusted net income of $97M
• Cash and marketable securities of $768M
• FY2026 guidance of $810M–$840M revenue

Negative

• Guidance assumes a two-point gene therapy headwind
• Q4 adjusted net income margin declined to 14.0% from 15.0%

Key Figures

Q4 2025 Revenue: $198M FY 2025 Revenue: $738M 2026 Revenue Guidance: $810M–$840M +5 more

8 metrics

Q4 2025 Revenue $198M Up 18% reported, 14% organic vs prior-year quarter

FY 2025 Revenue $738M Up 16% reported and organic non-COVID vs FY 2024

2026 Revenue Guidance $810M–$840M Implied 10%–14% reported growth, 9%–13% organic

2026 Op Margin Guide 15.1%–15.5% Adjusted operating margin, ~150 bps expansion at midpoint

Q4 2025 GAAP EPS $0.23 Fully diluted, vs ($0.60) in Q4 2024

Q4 2025 Adj EPS $0.49 Fully diluted, vs $0.44 in Q4 2024

Cash & Securities $768M Balance at Dec 31, 2025 vs $757M at Dec 31, 2024

2026 EPS Guidance $1.93–$2.01 Adjusted diluted EPS guidance for full year 2026

Market Reality Check

Price: $135.40 Vol: Volume 940,701 is 22% abo...

normal vol

$135.40 Last Close

Volume Volume 940,701 is 22% above the 20-day average of 768,506, indicating elevated interest ahead of earnings. normal

Technical Shares at $135.40 are trading below the 200-day MA of $139.06, reflecting a still-cautious intermediate trend pre-release.

Peers on Argus

RGEN was down 0.21% pre-release with mixed peers: TFX -2.10%, STVN -0.37%, BLCO ...

RGEN was down 0.21% pre-release with mixed peers: TFX -2.10%, STVN -0.37%, BLCO -0.39%, MMSI -0.07%, while ATR rose 1.55%, suggesting stock-specific focus rather than a sector-wide move.

Previous Earnings Reports

5 past events · Latest: Oct 28 (Positive)

Same Type Pattern 5 events

Date	Event	Sentiment	Move	Catalyst
Oct 28	Q3 2025 earnings	Positive	-5.9%	Strong Q3 growth and guidance raise for FY2025.
Jul 29	Q2 2025 earnings	Positive	+4.7%	Double-digit non-COVID growth and raised full-year guidance.
Apr 29	Q1 2025 earnings	Positive	-2.9%	Solid revenue growth and acquisition-driven portfolio expansion.
Feb 20	FY 2024 results	Positive	+7.9%	Q4 acceleration and outlook for resumed growth in 2025.
Nov 12	Q3 2024 earnings	Positive	+6.5%	10% revenue growth and narrowed full-year 2024 guidance.

Pattern Detected

Earnings releases have generally been positive but produced mixed reactions, with three aligned and two divergent moves over the last five events.

Recent Company History

Over the past five earnings cycles, Repligen has consistently reported year-over-year revenue growth and maintained or raised guidance. Q3 2025 results featured $189M in revenue and a guidance raise, while Q2 and Q1 2025 also delivered double‑digit organic growth and stronger adjusted profitability. Full-year 2024 results set the baseline with $634M revenue and a return to adjusted profitability. Today’s Q4 2025 and 2025 results, plus 2026 guidance, extend this pattern of steady growth and margin improvement within bioprocessing.

Historical Comparison

+2.1% avg move · Across the last 5 earnings-related releases, RGEN’s shares moved an average of 2.06% in 24 hours, in...

earnings

+2.1%

Average Historical Move earnings

Across the last 5 earnings-related releases, RGEN’s shares moved an average of 2.06% in 24 hours, indicating typically moderate reactions to results and guidance.

Earnings releases show progression from FY2024 revenue of $634M through sequential 2025 quarterly growth, culminating in FY2025 revenue of $738M and continued guidance for double-digit organic expansion.

Market Pulse Summary

This announcement highlights continued revenue growth to $198M in Q4 and $738M for 2025, alongside i...

Analysis

This announcement highlights continued revenue growth to $198M in Q4 and $738M for 2025, alongside improved GAAP profitability and higher adjusted margins. Initial 2026 guidance of $810M–$840M in revenue and EPS of $1.93–$2.01 underscores expectations for further expansion. Historically, earnings updates have prompted moderate share moves, so investors may watch execution versus guidance, margin trends, and product portfolio progress through 2026.

Key Terms

organic growth, adjusted operating margin, non-GAAP, GAAP, +2 more

6 terms

organic growth financial

"Fourth quarter revenue of $198 million, a year-over-year increase of 18% as reported, 14% organic..."

Organic growth is the increase in a company's sales or profits that comes from its own activities, such as selling more products or services, rather than through acquisitions or mergers. It is like a plant growing taller on its own, without needing outside help. For investors, it indicates the company's ability to expand steadily and sustainably through its existing business efforts.

adjusted operating margin financial

"...organic and adjusted operating margin expansion of 150 bps at the midpoint..."

Adjusted operating margin shows how much profit a company makes from its core business activities, after removing unusual or one-time costs and income. It helps investors see the company's true profitability by providing a clearer picture, similar to removing unexpected expenses to understand the regular performance. This metric is useful for comparing companies or tracking performance over time, as it highlights consistent earning power.

non-GAAP financial

"All adjusted figures are non-GAAP and, except for earnings per share..."

Non-GAAP refers to financial measures that companies use to show their earnings or performance without including certain expenses or income that are often added back to give a different picture. It matters because it can make a company's results look better or more favorable, but it may also hide important costs, so investors need to look at both GAAP (official rules) and non-GAAP numbers to get a full understanding.

GAAP financial

"Q4 GAAP gross profit was $104 million, compared to $39 million."

GAAP, or Generally Accepted Accounting Principles, are a set of standardized rules and guidelines that companies follow when preparing their financial statements. They ensure consistency, transparency, and comparability across different companies, making it easier for investors to understand and compare financial information accurately. This helps investors make informed decisions based on trustworthy and uniform financial reports.

EBITDA margin financial

"EBITDA Margin | | 20.0% | | 20.9% | | 19.0% | | 18.5%"

EBITDA margin is the share of each dollar of sales that a company keeps as operating cash profit before interest, taxes, and accounting for equipment wear and long-term investments. Think of it like the cash a store has left from every sale after paying day-to-day running costs but before paying rent, loan interest or replacing old machinery. Investors use it to compare core profitability and operational efficiency across companies by removing financing and accounting differences.

fully diluted financial

"Q4 GAAP earnings (loss) per share was $0.23 on a fully diluted basis..."

Fully diluted is the total number of a company's shares that would exist if every potential share from stock options, warrants, convertible debt and other claims were converted into common stock — like counting every reserved pizza slice as if everyone who could request one already had it. Investors use the fully diluted share count to see the realistic ownership picture and how those future claims could lower each shareholder’s percentage, earnings per share and implied valuation.

AI-generated analysis. Not financial advice.

• Fourth quarter revenue of $198 million, a year-over-year increase of 18% as reported, 14% organic with continued momentum in orders in the quarter
• Full year 2025 revenue of $738 million, a year-over-year increase of 16% for both reported and organic non-COVID
• Full year 2026 revenue guidance of $810 million - $840 million, 10% to 14% reported revenue growth, 9% to 13% organic and adjusted operating margin expansion of 150 bps at the midpoint
  

WALTHAM, Mass., Feb. 24, 2026 (GLOBE NEWSWIRE) -- Repligen Corporation (NASDAQ:RGEN), a life sciences company focused on bioprocessing technology leadership, today reported financial results for its fourth quarter of 2025, covering the three- and twelve- month periods ended December 31, 2025. The Company is also providing financial guidance for the full year 2026.

Olivier Loeillot, President and Chief Executive Officer of Repligen said, “We had a great finish to 2025 with 14% organic growth in the quarter led by Analytics and Proteins. As a result, we exceeded the high end of our October revenue and adjusted operating income guidance. We are thrilled by our strong performance in 2025 with 16% organic non-COVID growth driven by traction across our differentiated portfolio, while continuing to expand margins.

“As we turn the page to 2026, we are excited about our product portfolio, the team we've built, and the strategy we are executing. We are investing with intention: expanding our commercial presence and scaling our operations for greater agility. We remain focused on innovation that enables customers to accelerate development and improve yields. Our initial 2026 guidance calls for 10% - 14% revenue growth, which we believe is an appropriate starting point for the year and includes a two-point gene therapy headwind. In addition, we expect 150 bps of adjusted operating margin expansion at the midpoint.”

Q4 2025 BUSINESS HIGHLIGHTS

• Executed on All 2025 Strategic Priorities.
  • Delivered 14% organic growth in FY25, which surpassed the high end of our initial guidance range and meaningfully outpaced market growth.
  • Increased FY adjusted operating margins by 90 bps or 240 bps excluding the impact of M&A and foreign exchange, while making key investments across our portfolio and becoming more fit for growth.
  • Expanded our Analytics portfolio via M&A and launched multiple new products across our Analytics, Filtration, and Proteins franchises.
• Proteins Launch. Launched three new high® performance chromatography resins: AVIPure HiPer™ AAV9 and AVIPure® HiPer™ AAV8 affinity resins, along with HiPer™ QA anion exchange resin, expanding the Company’s growing proteins portfolio and reinforcing our commitment to innovation in next-generation bioprocessing.
• APAC Investments. In the fourth quarter, we opened a new office in Singapore and expanded our footprint in Japan. This builds on our growing APAC presence as we continue to invest in the region to support future growth.

FINANCIAL PERFORMANCE

Q4 and Full Year 2025 Financial Performance (compared to prior year periods except as noted)

All adjusted figures are non-GAAP and, except for earnings per share, are rounded to the nearest million, and are reconciled in the tables included later in this press release.

• Q4 reported revenue was $198 million, compared to $168 million, an increase of 18% as reported and 14% organic, bringing our full year 2025 revenue to $738 million, compared to $634 million, an increase of 16% as reported and 14% organic.
• Q4 GAAP gross profit was $104 million, compared to $39 million. Adjusted gross profit was $104 million, compared to $85 million. For the full year 2025, GAAP gross profit was $386 million, compared to $275 million. Adjusted gross profit was $388 million, compared to $320 million.
• Q4 GAAP income (loss) from operations was $18 million, compared to ($37) million. Adjusted income from operations was $30 million, compared to $25 million. For the full year 2025, GAAP income (loss) from operations was $55 million, compared to ($35) million. Adjusted income from operations was $102 million, compared to $82 million.
• Q4 GAAP net income (loss) was $13 million, compared to ($34) million. Adjusted net income was $28 million, compared to $25 million. For the full year 2025, GAAP net income (loss) was $49 million, compared to ($26) million. Adjusted net income was $97 million, compared to $89 million.
• Q4 GAAP earnings (loss) per share was $0.23 on a fully diluted basis, compared to ($0.60). Adjusted earnings per share was $0.49 on a fully diluted basis, compared to $0.44. For the full year 2025, GAAP earnings (loss) per share was $0.86 on a fully diluted basis, compared to ($0.46). Adjusted earnings per share was $1.71 on a fully diluted basis, compared to $1.58.
  

MARGIN SUMMARY

GAAP Margins		Q4 2025		Q4 2024		FY 2025		FY 2024
Gross Margin		52.5%		23.2%		52.3%		43.3%
Operating (EBIT) Margin		9.0%		(21.8)%		7.5%		(5.5)%
Net Income (Loss) Margin		6.7%		(20.2)%		6.6%		(4.0)%
Adjusted (non-GAAP) Margins		Q4 2025		Q4 2024		FY 2025		FY 2024
Gross Margin		52.4%		50.7%		52.6%		50.4%
Operating (EBIT) Margin		15.0%		14.9%		13.8%		12.9%
Net Income Margin		14.0%		15.0%		13.1%		14.0%
EBITDA Margin		20.0%		20.9%		19.0%		18.5%

Cash, cash equivalents and marketable securities at December 31, 2025, were $768 million, compared to $757 million at December 31, 2024.

FINANCIAL GUIDANCE FOR FULL YEAR 2026

All Adjusted figures are non-GAAP

Our financial guidance for the full year 2026 is based on expectations for our existing business. Our Adjusted (non-GAAP) guidance excludes the impact of any potential or pending business acquisitions in 2026, and future fluctuations in foreign currency exchange rates. 

		CURRENT GUIDANCE
		(at February 24, 2026)
FY 2026		Adjusted (non-GAAP)
Total Reported Revenue		$810M - $840M
Reported Growth		10% - 14%
Organic Growth		9% - 13%
Gross Margin		53.6% - 54.1%
Income from Operations		$122M - $130M
Operating Margin		15.1% - 15.5%
Other Income (Expense)		~$18M
Adjusted EBITDA Margin		20% - 20.5%
Tax Rate on Pre-Tax Income		22% - 23%
Net Income		$109M - $114M
Earnings Per Share - Diluted		$1.93 - $2.01

Revenue guidance reflects just under a one point benefit from foreign currency and M&A.

Conference Call and Webcast Access

Repligen will host a conference call and webcast today, February 24, 2026, at 8:30 a.m. ET, to discuss fourth quarter 2025 financial results, corporate developments and financial guidance for 2026. The conference call will be accessible by dialing toll-free (800) 715-9871 for domestic callers or (646) 307-1963 for international callers. No passcode is required for the live call. In addition, a webcast will be accessible via the Investor Relations section of the Company’s website. Both the conference call and webcast will be archived for a period following the live event. You can access the replay on the Investor Relations section of the Company's website.

About Repligen Corporation

Repligen Corporation is a global life sciences company that develops and commercializes highly innovative bioprocessing technologies and systems that enable efficiencies in the process of manufacturing biological drugs. We are “inspiring advances in bioprocessing” for the customers we serve; primarily biopharmaceutical drug developers and contract development and manufacturing organizations (CDMOs) worldwide. Our focus areas are Filtration and Fluid Management, Chromatography, Process Analytics and Proteins. Our corporate headquarters are located in Waltham, Massachusetts, and the majority of our manufacturing sites are in the U.S., with additional key sites in Estonia, France, Germany, Ireland, the Netherlands and Sweden. For more information about the company see our website at www.repligen.com, and follow us on LinkedIn.

Non-GAAP Measures of Financial Performance

To supplement our financial statements, which are presented on the basis of U.S. generally accepted accounting principles (“GAAP”), the following Adjusted (“non-GAAP”) measures of financial performance are included in this release: organic non-COVID revenue and non-COVID revenue growth; organic revenue and organic revenue growth; adjusted cost of goods sold, adjusted gross profit and adjusted gross margin; adjusted R&D expense and adjusted SG&A expense; adjusted income from operations and adjusted operating margin; organic adjusted operating margin year-over-year change; adjusted pre-tax income; adjusted net income and adjusted net income margin; adjusted earnings per share (diluted); adjusted earnings before interest, taxes, depreciation and amortization (EBITDA), and adjusted EBITDA margin. The Company provides the impact of foreign currency translation, to enable determination of revenue and margin growth rates at constant currency. To calculate the impact of foreign currency translation, the Company converts the reported amounts from local currency to U.S. dollars using constant foreign currency exchange rates in the current and prior year periods.

The Company’s non-GAAP financial results and/or non-GAAP guidance exclude the impact of: acquisition and integration costs; restructuring charges including the costs of severance and accelerated depreciation among other non-cash charges; inventory step-up costs and adjustments; incremental costs attributed to CEO transition; contingent consideration related to the Company’s acquisitions; intangible amortization costs; non-cash interest expense related to the accretion of the debt discount; amortization of debt issuance costs related to Company’s convertible debt; foreign currency impact of certain intercompany loans; and, the related impact on tax of non-GAAP charges. These costs are excluded because management believes that such expenses do not have a direct correlation to future business operations, nor do the resulting charges recorded accurately reflect the performance of our ongoing operations for the period in which such charges are recorded. Further, organic adjusted operating margin year-over-year change excludes the effect of adjustments above, as well as the impact of mergers and acquisitions and foreign exchange. This measure is used by the Company in periods of acquisition because the timing, size and number of such transactions and their related impact on the financial statements may vary and make comparison of long-term results difficult.

All reconciliations of above GAAP figures to adjusted (non-GAAP) figures are detailed in the tables included later in this press release. When analyzing the Company’s operating performance and guidance, investors should not consider non-GAAP measures as a substitute for the comparable financial measures prepared in accordance with GAAP.

The Company does not provide GAAP financial measures on a forward looking basis as the Company is unable to provide a quantitative reconciliation of forward-looking non-GAAP measures to the most directly comparable forward-looking GAAP measure, without unreasonable effort. The Company cannot reasonably predict items including, but not limited to, the timing and amount of future restructuring, cost-savings actions and acquisition and integration related costs. These items are generally uncertain and are not indicative of ongoing operations of the business, and the impact could be material to our results in accordance with GAAP.

Forward-Looking Statements

This press release contains forward-looking statements, which are made pursuant to and in reliance upon the safe harbor provisions of federal securities laws, including the Private Securities Litigation Reform Act of 1995, Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. Any statements contained herein which do not describe historical facts, including, among others, any express or implied statements or guidance regarding current or future financial performance and position, including our 2026 financial guidance and related assumptions; expected demand in the markets in which we operate; expectations regarding the acquisition of 908 Devices’ bioprocessing portfolio; and the expected performance of our business and momentum across our portfolio, are based on management’s current expectations and beliefs and are forward-looking statements which involve risks and uncertainties that could cause actual results to differ materially from those discussed in such forward-looking statements.

Such risks and uncertainties include, among others, our ability to successfully grow our bioprocessing business; our ability to manage through and predict headwinds; the risk that we have assumed that markets and franchises will improve and grow as predicted; our ability to achieve our 2026 financial guidance; our ability to develop and commercialize products and the market acceptance of our products; our ability to successfully integrate any acquired businesses and relevant personnel in a timely manner or at all, and to achieve the expected benefits of such acquisitions; the risk that demand for our products could decline, which could adversely impact our future revenues, cash flows, results of operations and financial condition; our ability to compete with larger, better financed bioprocessing companies; risks around the Company’s effectiveness of disclosure controls and procedures and the effectiveness of our internal control over financial reporting; our compliance with all U.S. Food and Drug Administration and European Medicines Evaluation Agency regulations; our volatile stock price; the impact of tariffs on our business, and other risks and uncertainties detailed in Repligen’s filings with the U.S. Securities and Exchange Commission (the Commission), including our Annual Report on Form 10-K for the year ended December 31, 2024 and in subsequently filed reports with the Commission, including our Quarterly Reports on Form 10-Q and Current Reports on Form 8-K, as well as our upcoming Annual Report on form 10-K for the year ended December 31, 2025 and any subsequent filings made with the Commission, which are available at the Commission’s website at www.sec.gov. Actual results may differ materially from those Repligen contemplated by these forward-looking statements, which reflect management’s current views, expectations, and assumptions regarding the future of our business, future plans and strategies, projections, anticipated events and trends, the economy and other future conditions, and are based only on information currently available to us. Repligen cautions you not to place undue reliance on any forward-looking statements, which speak only as of the date they are made. Repligen disclaims any obligation to update or revise any such statements to reflect any change in expectations or in events, conditions or circumstances on which any such statements may be based, or that may affect the likelihood that actual results will differ from those set forth in the forward-looking statements.

Repligen Contact:

Jacob Johnson
VP, Investor Relations
(781) 419-0204
investors@repligen.com

REPLIGEN CORPORATION
CONSOLIDATED BALANCE SHEETS
(Unaudited, amounts in thousands, except share data)
		December 31,
		2025				2024
ASSETS
Current assets:
Cash and cash equivalents		$	566,021			$	757,355
Marketable securities			201,607				—
Accounts receivable, net of allowances of $2,767 and $1,832 at December 31, 2025 and December 31, 2024, respectively			158,587				134,115
Inventories, net			170,458				142,964
Prepaid expenses and other current assets			40,712				31,607
Total current assets			1,137,385				1,066,041
Noncurrent assets:
Property, plant and equipment, net			186,614				197,738
Intangible assets, net			386,147				397,897
Goodwill			1,114,408				1,030,995
Deferred tax assets			694				749
Operating lease right of use assets			119,538				135,378
Other noncurrent assets			4,913				868
Total noncurrent assets			1,812,314				1,763,625
Total assets		$	2,949,699			$	2,829,666
LIABILITIES AND STOCKHOLDERS' EQUITY
Current liabilities:
Accounts payable		$	30,010			$	32,134
Operating lease liabilities			21,559				15,104
Contingent consideration			5,049				17,126
Accrued liabilities			79,208				62,423
Total current liabilities			135,826				126,787
Noncurrent liabilities:
Convertible Senior Notes due 2028, net			542,213				525,567
Deferred tax liabilities			22,496				22,775
Noncurrent operating lease liabilities			126,176				145,576
Noncurrent contingent consideration			1,304				19,662
Other noncurrent liabilities			15,555				16,581
Total noncurrent liabilities			707,744				730,161
Total liabilities			843,570				856,948
Stockholders' equity:
Preferred stock, $0.01 par value, 5,000,000 shares authorized, no shares issued or outstanding			—				—
Common stock, $0.01 par value; 80,000,000 shares authorized; 56,325,429 shares at December 31, 2025 and 56,091,677 shares at December 31, 2024 issued and outstanding			563				561
Additional paid-in capital			1,651,849				1,617,336
Accumulated other comprehensive loss			(2,531	)			(52,533	)
Retained earnings			456,248				407,354
Total stockholders’ equity			2,106,129				1,972,718
Total liabilities and stockholders’ equity		$	2,949,699			$	2,829,666

REPLIGEN CORPORATION
CONSOLIDATED STATEMENTS OF OPERATIONS
(Unaudited, amounts in thousands, except per share data)
		Three Months Ended December 31,								Year Ended December 31,
		2025				2024				2025				2024
Revenue:
Product		$	197,728			$	167,394			$	737,960			$	634,178
Royalty and other revenue			185				153				296				261
Total revenue			197,913				167,547				738,256				634,439
Costs and operating expenses:
Cost of goods sold			94,082				128,706				352,011				359,794
Research and development			13,120				11,677				54,177				43,200
Selling, general and administrative			74,363				60,474				290,508				263,368
Change in fair value of contingent consideration			(1,520	)			3,191				(13,607	)			3,191
Total costs and operating expenses			180,045				204,048				683,089				669,553
Income (loss) from operations			17,868				(36,501	)			55,167				(35,114	)
Other income (expense), net:
Investment income			6,754				8,293				27,574				35,827
Interest expense			(5,495	)			(5,462	)			(21,513	)			(20,731	)
Amortization of debt issuance costs			(417	)			(411	)			(1,660	)			(1,843	)
Other income (expense), net			403				(4,527	)			2,815				(5,174	)
Other income (expense), net			1,245				(2,107	)			7,216				8,079
Income (loss) before income taxes			19,113				(38,608	)			62,383				(27,035	)
Income tax provision (benefit)			5,826				(4,739	)			13,489				(1,521	)
Net income (loss)		$	13,287			$	(33,869	)		$	48,894			$	(25,514	)
Earnings (loss) per share:
Basic		$	0.24			$	(0.60	)		$	0.87			$	(0.46	)
Diluted		$	0.23			$	(0.60	)		$	0.86			$	(0.46	)
Weighted average common shares outstanding:
Basic			56,310				56,057				56,234				55,937
Diluted			56,659				56,057				56,561				55,937

REPLIGEN CORPORATION
CONSOLIDATED STATEMENTS OF CASH FLOWS
(Unaudited, amounts in thousands)
		Year Ended December 31,
		2025				2024
Cash flows from operating activities
Net income (loss)		$	48,894			$	(25,514	)
Adjustments to reconcile net income (loss) to net cash provided by operating activities:
Depreciation and amortization			78,745				69,673
Amortization of debt discount and issuance costs			16,646				15,588
Inventory step-up amortization			1,560				—
Stock-based compensation			32,605				48,070
Deferred income taxes, net			(3,373	)			(16,790	)
Change in fair value of contingent consideration			(13,607	)			3,191
Net unrealized foreign exchange gain			(13,014	)			—
Operating lease right of use asset amortization			18,211				16,889
Other adjustments and non-cash items			1,630				3,366
Changes in operating assets and liabilities, excluding impact of acquisitions:
Accounts receivable			(17,165	)			(14,031	)
Inventories			(14,947	)			56,895
Prepaid expenses and other current assets			(7,756	)			1,553
Other noncurrent assets			(1,560	)			471
Accounts payable			(4,150	)			12,898
Accrued liabilities			11,813				6,106
Operating lease liabilities			(15,556	)			(8,292	)
Noncurrent liabilities			(1,559	)			5,321
Total cash provided by operating activities			117,417				175,394
Cash flows for investing activities
Acquisitions, net of cash acquired			(70,328	)			(54,765	)
Purchases of marketable securities			(200,257	)			—
Additions to capitalized software costs			(2,211	)			(4,222	)
Purchases of property, plant and equipment			(23,519	)			(25,677	)
Sale of property, plant and equipment			238				—
Purchase of intellectual property			—				(3,006	)
Other investing activities			(2,397	)			1,287
Total cash used in investing activities			(298,474	)			(86,383	)
Cash flows for financing activities
Proceeds from exercise of stock options			3,176				4,294
Payment of tax withholding obligation on vesting of restricted stock			(8,833	)			(9,882	)
Repayment of 2019 Notes			—				(69,939	)
Payment of earnout consideration			(9,548	)			(7,375	)
Total cash used in financing activities			(15,205	)			(82,902	)
Effect of exchange rate changes on cash and cash equivalents			4,928				(77	)
Net (decrease) increase in cash and cash equivalents			(191,334	)			6,032
Cash and cash equivalents, beginning of period			757,355				751,323
Cash and cash equivalents, end of period		$	566,021			$	757,355

REPLIGEN CORPORATION
RECONCILIATIONS OF GAAP TO NON-GAAP FINANCIAL MEASURES

(Unaudited, amounts in thousands, except percentage and earnings per share data)
In all tables below, totals may not add due to rounding

Reconciliation of Total Revenue (GAAP) Growth to Organic Non-COVID Revenue Growth (Non-GAAP)

		Three Months Ended December 31,								Year Ended December 31,
		2025				2024				2025				2024
TOTAL REPORTED REVENUE (GAAP) GROWTH			18	%			1	%			16	%			0	%
Acquisition revenue			(1	)%			0	%			(1	)%			(2	)%
Currency exchange			(2	)%			2	%			(1	)%			1	%
ORGANIC REVENUE GROWTH (NON-GAAP)			14	%			3	%			14	%			(1	)%
COVID revenue			0	%			13	%			2	%			2	%
ORGANIC NON-COVID REVENUE GROWTH (NON-GAAP)			14	%			16	%			16	%			1	%

Reconciliation of Income (Loss) from Operations (GAAP) to Adjusted Income from Operations (Non-GAAP)

		Three Months Ended December 31,								Year Ended December 31,
		2025				2024				2025				2024
INCOME (LOSS) FROM OPERATIONS (GAAP)		$	17,868			$	(36,501	)		$	55,167			$	(35,114	)
ADJUSTMENTS TO INCOME (LOSS) FROM OPERATIONS (GAAP):
Acquisition and integration costs			3,346				2,450				18,067				7,347
Restructuring activities and other related charges(1)			(1,138	)			45,232				(49	)			47,171
Incremental costs attributed to CEO transition(2)			—				16				—				22,362
Intangible amortization			9,769				8,689				39,057				34,615
Contingent Consideration			(1,520	)			3,191				(13,607	)			3,191
Inventory step-up charges			491				—				1,560				—
Other(4)			921				1,922				1,628				2,508
ADJUSTED INCOME FROM OPERATIONS (NON-GAAP)		$	29,737			$	24,999			$	101,823			$	82,080
OPERATING (EBIT) MARGIN (GAAP)			9.0	%			(21.8	)%			7.5	%			(5.5	)%
ADJUSTED OPERATING (EBIT) MARGIN (NON-GAAP)			15.0	%			14.9	%			13.8	%			12.9	%

Reconciliation of Operating (EBIT) Margin Growth to Organic Adjusted Operating Margin Growth (Non-GAAP)

		Three Months Ended December 31, 2025				Year Ended December 31, 2025
OPERATING (EBIT) MARGIN (GAAP) YEAR-OVER-YEAR CHANGE			30.8	%			13.0	%
Acquisition and integration costs			0.2	%			1.3	%
Restructuring activities and other related charges(1)			(27.6	)%			(7.4	)%
Incremental costs attributed to CEO transition(2)			(0.0	)%			(3.5	)%
Intangible amortization			(0.3	)%			(0.2	)%
Contingent Consideration			(2.7	)%			(2.3	)%
Inventory step-up charges			0.2	%			0.2	%
Other(4)			(0.7	)%			(0.2	)%
ADJUSTED OPERATING (EBIT) MARGIN (NON-GAAP) YEAR-OVER-YEAR CHANGE			0.1	%			0.9	%
Impact of mergers and acquisitions			1.7	%			1.7	%
Currency exchange			(0.4	)%			(0.2	)%
ORGANIC ADJUSTED OPERATING MARGIN (NON-GAAP) YEAR-OVER-YEAR CHANGE			1.4	%			2.4	%

Reconciliation of Net Income (Loss) (GAAP) to Adjusted Net Income (Non-GAAP)

		Three Months Ended December 31,								Year Ended December 31,
		2025				2024				2025				2024
NET INCOME (LOSS) (GAAP)		$	13,287			$	(33,869	)		$	48,894			$	(25,514	)
ADJUSTMENTS TO NET INCOME (LOSS) (GAAP):
Acquisition and integration costs			3,346				2,450				18,067				7,347
Restructuring activities and other related charges(1)			(1,138	)			45,232				(49	)			46,937
Incremental costs attributed to CEO transition(2)			—				16				—				22,362
Intangible amortization			9,769				8,689				39,057				34,615
Contingent Consideration			(1,435	)			3,191				(16,720	)			3,191
Inventory step-up charges			491				—				1,560				—
Non-cash interest expense			3,990				3,681				15,471				14,291
Amortization of debt issuance costs			417				411				1,660				1,843
Foreign currency impact of certain intercompany loans(3)			(867	)			4,883				(867	)			5,509
Other(4)			921				1,922				1,628				2,508
Tax effect of non-GAAP charges			(1,094	)			(11,479	)			(11,756	)			(24,288	)
ADJUSTED NET INCOME (NON-GAAP)		$	27,687			$	25,127			$	96,945			$	88,801
NET INCOME (LOSS) MARGIN (GAAP)			6.7	%			(20.2	)%			6.6	%			(4.0	)%
ADJUSTED NET INCOME MARGIN (NON-GAAP)			14.0	%			15.0	%			13.1	%			14.0	%

Reconciliation of Earnings (Loss) Per Share (GAAP) to Adjusted Earnings Per Share (Non-GAAP)

		Three Months Ended December 31,								Year Ended December 31,
		2025				2024				2025				2024
EARNINGS (LOSS) PER SHARE (GAAP) - DILUTED		$	0.23			$	(0.60	)		$	0.86			$	(0.46	)
ADJUSTMENTS TO EARNINGS (LOSS) PER SHARE (GAAP) - DILUTED:
Acquisition and integration costs			0.06				0.04				0.32				0.13
Restructuring activities and other related charges(1)			(0.02	)			0.80				—				0.83
Incremental costs attributed to CEO transition(2)			—				—				—				0.40
Intangible amortization			0.17				0.15				0.69				0.61
Contingent Consideration			(0.03	)			0.06				(0.30	)			0.06
Inventory step-up charges			0.01				—				0.03				—
Non-cash interest expense			0.07				0.07				0.27				0.25
Amortization of debt issuance costs			0.01				0.01				0.03				0.03
Foreign currency impact of certain intercompany loans(3)			(0.02	)			0.09				(0.02	)			0.10
Other(4)			0.02				0.03				0.03				0.04
Tax effect of non-GAAP charges			(0.02	)			(0.21	)			(0.21	)			(0.41	)
ADJUSTED EARNINGS PER SHARE (NON-GAAP) - DILUTED(5)		$	0.49			$	0.44			$	1.71			$	1.58

Reconciliation of Net Income (Loss) (GAAP) to Adjusted EBITDA (Non-GAAP)

		Three Months Ended December 31,								Year Ended December 31,
		2025				2024				2025				2024
NET INCOME (LOSS) (GAAP)		$	13,287			$	(33,869	)		$	48,894			$	(25,514	)
ADJUSTMENTS:
Investment income			(6,754	)			(8,293	)			(27,574	)			(35,827	)
Interest expense			5,495				5,462				21,513				20,731
Amortization of debt issuance costs			417				411				1,660				1,843
Income tax provision			5,826				(4,739	)			13,489				(1,521	)
Depreciation			10,183				9,670				39,689				34,967
Intangible amortization			9,769				8,717				39,057				34,726
EBITDA (NON-GAAP)		$	38,223			$	(22,641	)		$	136,728			$	29,405
OTHER ADJUSTMENTS:
Acquisition and integration costs			3,346				2,450				18,067				7,347
Restructuring activities and other related charges(1)(6)			(1,138	)			45,232				(49	)			46,937
Incremental costs attributed to CEO transition(2)			—				16				—				22,362
Contingent Consideration			(1,435	)			3,191				(16,720	)			3,191
Inventory step-up charges			491				—				1,560				—
Foreign currency impact of certain intercompany loans(3)			(867	)			4,883				(867	)			5,509
Other(4)			921				1,922				1,628				2,508
ADJUSTED EBITDA (NON-GAAP)		$	39,541			$	35,053			$	140,347			$	117,259
NET INCOME (LOSS) MARGIN (GAAP)			6.7	%			(20.2	)%			6.6	%			(4.0	)%
ADJUSTED EBITDA MARGIN (NON-GAAP)			20.0	%			20.9	%			19.0	%			18.5	%

Reconciliation of Cost of Goods Sold (GAAP) to Adjusted Cost Goods Sold (Non-GAAP)

		Three Months Ended December 31,								Year Ended December 31,
		2025				2024				2025				2024
COST OF GOODS SOLD (GAAP)		$	94,082			$	128,706			$	352,011			$	359,794
ADJUSTMENT TO COST OF GOODS SOLD (GAAP):
Acquisition and integration costs			(521	)			(533	)			(1,630	)			(822	)
Restructuring activities and other related charges(1)			1,416				(45,079	)			2,217				(44,029	)
Intangible amortization			(276	)			(471	)			(1,023	)			(471	)
Inventory step-up charges			(491	)			—				(1,560	)			—
ADJUSTED COST OF GOODS SOLD (NON-GAAP)		$	94,210			$	82,623			$	350,015			$	314,472
GROSS MARGIN (GAAP)			52.5	%			23.2	%			52.3	%			43.3	%
ADJUSTED GROSS MARGIN (NON-GAAP)			52.4	%			50.7	%			52.6	%			50.4	%

Reconciliation of R&D Expense (GAAP) to Adjusted R&D Expense (Non-GAAP)

		Three Months Ended December 31,								Year Ended December 31,
		2025				2024				2025				2024
R&D EXPENSE (GAAP)		$	13,120			$	11,677			$	54,177			$	43,200
ADJUSTMENT TO R&D EXPENSE (GAAP):
Acquisition and integration costs			(315	)			(164	)			(1,996	)			(364	)
Restructuring activities and other related charges(1)			(58	)			—				(889	)			(449	)
Intangible amortization			(563	)			(121	)			(2,073	)			(121	)
ADJUSTED R&D EXPENSE (NON-GAAP)		$	12,184			$	11,392			$	49,219			$	42,266

Reconciliation of SG&A Expense (GAAP) to Adjusted SG&A Expense (Non-GAAP)

		Three Months Ended December 31,								Year Ended December 31,
		2025				2024				2025				2024
SG&A EXPENSE (GAAP)		$	74,363			$	60,474			$	290,508			$	263,368
ADJUSTMENTS TO SG&A EXPENSE (GAAP):
Acquisition and integration costs			(2,510	)			(1,753	)			(14,441	)			(6,161	)
Restructuring activities and other related charges(1)			(220	)			(153	)			(1,279	)			(2,693	)
Incremental costs attributed to CEO transition(2)			—				(16	)			—				(22,362	)
Intangible amortization			(8,930	)			(8,097	)			(35,961	)			(34,023	)
Other(4)			(921	)			(1,922	)			(1,628	)			(2,508	)
ADJUSTED SG&A EXPENSE (NON-GAAP)		$	61,782			$	48,533			$	237,199			$	195,621

FOOTNOTES FOR ALL TABLES ABOVE (amounts in thousands, except share data):
(1)	In July 2023, we began restructuring activities to simplify and streamline our organization and strengthen the overall effectiveness of our operations. The Company continued further restructuring activities during 2025 including severance, employee-related and facility exit costs. Cost of goods sold includes the benefit received from the sale of inventory that had previously been reserved as part of the restructuring plan of $1,704 and $4,972 for the three and twelve months ended December 31, 2025, respectively.
(2)	Includes $16 and $22,362, of incremental stock compensation expense, recorded during the three and twelve months ended December 31, 2024, respectively, attributable to the transition of the Company’s Chief Executive Officer (“CEO”) to Executive Chair of the Board announced by the Company on June 12, 2024. The incremental stock compensation expense was the result of the modification of the unvested equity awards held by the CEO immediately prior to the modification. This resulted in the revalue of his unvested awards and a change in his remaining requisite service period due to his change in duties upon transitioning to Executive Chair of the Board.
(3)	During the three months ended December 31, 2025 and 2024, we recorded foreign currency (gains) and losses on certain intercompany loans of ($867) and $4,883, respectively, and ($867) and $5,509 for the twelve months ended December 31, 2025 and 2024, respectively. The impact is recorded in Other (expenses) income, net within the Consolidated Statements of Operations.
(4)	Includes other expenses that are non-indicative of our ongoing performance and one-time events relating to a cybersecurity incident, net of insurance, and costs associated with the restatement of previously issued financial statements.
(5)	GAAP loss per share - diluted for the three and twelve months ended December 31, 2024, was determined excluding the effect of dilutive shares as the impact of such shares would have been antidilutive due to the net loss for the period, while the adjusted earnings per share - diluted for the same period was determined based upon diluted shares.
(6)	Excludes $19 of accelerated depreciation related to the restructuring plan for the twelve months ended December 31, 2024. This amount is included in the depreciation line item of this table for that period.

FAQ

What were Repligen (RGEN) Q4 2025 revenue and organic growth figures?

Q4 2025 revenue was $198 million, up 18% reported and 14% organic. According to the company, Analytics and Proteins led momentum in the quarter and organic growth reflected continued order strength across franchises.

What is Repligen's full-year 2026 revenue guidance (RGEN) and growth outlook?

Repligen guided FY2026 revenue to $810M–$840M, implying 10%–14% reported growth and 9%–13% organic growth. According to the company, guidance excludes potential M&A and anticipates a two-point gene therapy headwind.

How did Repligen (RGEN) margins and profitability change in FY2025?

FY2025 GAAP net income was $49M and adjusted net income was $97M, with adjusted operating margin improving year-over-year. According to the company, adjusted operating margin expanded while investments supported future growth.

What cash position did Repligen (RGEN) report at December 31, 2025?

Repligen reported $768 million in cash, cash equivalents and marketable securities at year-end 2025. According to the company, this compares to $757 million at year-end 2024 and supports planned investments and commercial expansion.

What specific headwinds did Repligen (RGEN) cite for 2026 guidance?

The company cited a two-point gene therapy headwind included in its 2026 revenue outlook. According to the company, that adjustment is already reflected in the FY2026 organic growth range.

Will Repligen (RGEN) expand margins in 2026 and by how much?

Repligen expects adjusted operating margin expansion of about 150 basis points at the midpoint of 2026 guidance. According to the company, margin improvement reflects operational scaling and targeted investments.